Detailed information for compound 2072044

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 305.418 | Formula: C16H27N5O
  • H donors: 1 H acceptors: 2 LogP: 0.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CCN(CC1)CCN1CCOC(C1)CNc1cccnn1
  • InChi: 1S/C16H27N5O/c1-2-7-20(8-3-1)9-10-21-11-12-22-15(14-21)13-17-16-5-4-6-18-19-16/h4-6,15H,1-3,7-14H2,(H,17,19)
  • InChiKey: NWHVTTIBRPZNNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.001 0.0056 0.0092
Loa Loa (eye worm) RasGEF domain-containing protein 0.0011 0.0068 0.0111
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0377 0.615 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0179 0.0179
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0143 0.0233
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0781 0.0781
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0179 0.0179
Onchocerca volvulus 0.0018 0.0187 0.0246
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0318 0.5176 0.7373
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.001 0.0056 0.0056
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0039 0.0531 0.097
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0357 0.0581
Schistosoma mansoni inositol monophosphatase 0.0033 0.0424 0.0424
Brugia malayi regulator of G-protein signaling rgs-7 0.0018 0.0179 0.0291
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0043 0.06 0.4505
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.001 0.0056 0.0059
Giardia lamblia hypothetical protein 0.001 0.0056 0.0318
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0034 0.045 0.0732
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0357 0.0581
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0077 0.1168 1
Onchocerca volvulus 0.0032 0.041 0.0565
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.0111
Brugia malayi N-terminal motif family protein 0.0011 0.0068 0.0111
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Echinococcus multilocularis ras GTP exchange factor 0.0011 0.0068 0.0068
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0179 0.0179
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Brugia malayi hypothetical protein 0.0113 0.1763 0.2867
Schistosoma mansoni survival motor neuron protein 0.0053 0.0761 0.0761
Echinococcus granulosus single minded 2 0.0032 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0092
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.011
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0179 0.0179
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0016 0.0143 0.0233
Entamoeba histolytica protein kinase, putative 0.0032 0.0411 0.962
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0011 0.0071 0.0124
Entamoeba histolytica hypothetical protein 0.0018 0.0179 0.3104
Echinococcus granulosus segment polarity protein dishevelled 0.0016 0.0143 0.0143
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0182 0.0182
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0018 0.0182 0.0296
Schistosoma mansoni ras GTP exchange factor 0.0011 0.0068 0.0068
Trypanosoma cruzi hypothetical protein 0.0011 0.0068 0.01
Echinococcus granulosus Protein son of sevenless 0.0011 0.0068 0.0068
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0179 0.0179
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0769 0.1251
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0082 0.1249 0.203
Brugia malayi Sulfatase family protein 0.0008 0.0015 0.0025
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0011 0.0068 0.0068
Brugia malayi Doublecortin family protein 0.0018 0.0187 0.0304
Echinococcus granulosus neuropeptide s receptor 0.0411 0.6722 0.6722
Loa Loa (eye worm) RGS-3 protein 0.0018 0.0179 0.0291
Loa Loa (eye worm) GMP reductase 0.0034 0.045 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0179 0.0234
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0011 0.0071 0.0124
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0082 0.1249 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0056 0.0059
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.001 0.0056 0.0056
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0043 0.06 0.1099
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.001 0.0056 0.0056
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0016 0.0143 0.0233
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Brugia malayi Pre-SET motif family protein 0.0377 0.615 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0328 0.5335 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Echinococcus granulosus lamin dm0 0.0053 0.0769 0.0769
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0075 0.1137 0.1849
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0483
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0424 0.0584
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Echinococcus multilocularis regulator of G protein signaling 7 0.0033 0.0439 0.0439
Leishmania major protein kinase, putative 0.0018 0.0185 0.1484
Brugia malayi intermediate filament protein 0.0053 0.0769 0.1251
Schistosoma mansoni z-protein (S1r protein) 0.0033 0.0439 0.0439
Trichomonas vaginalis set domain proteins, putative 0.0429 0.7015 1
Schistosoma mansoni hypothetical protein 0.0053 0.0761 0.0761
Onchocerca volvulus 0.0018 0.0187 0.0246
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.001 0.0056 0.0092
Echinococcus multilocularis regulator of G protein signaling 7 0.0033 0.0439 0.0439
Brugia malayi PXA domain containing protein 0.0018 0.0179 0.0291
Echinococcus multilocularis Regulator of G protein signaling 20 0.0018 0.0179 0.0179
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0424 0.3084
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0187 0.0187
Schistosoma mansoni lamin 0.0053 0.0769 0.0769
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.001 0.0056 0.0056
Schistosoma mansoni aryl hydrocarbon receptor 0.0043 0.0596 0.0596
Onchocerca volvulus 0.0053 0.0769 0.1077
Schistosoma mansoni microtubule-associated protein tau 0.0609 1 1
Plasmodium falciparum LCCL domain-containing protein 0.0018 0.0187 0.1603
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0011 0.0068 0.011
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.419 0.419
Echinococcus multilocularis tumor protein p63 0.037 0.6038 0.6038
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0018 0.0179 0.0179
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.001 0.0056 0.0056
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0209 0.335 0.5447
Leishmania major cAMP-specific phosphodiesterase, putative 0.001 0.0056 0.0451
Brugia malayi Ribonuclease 2-5A family protein 0.0032 0.0411 0.0668
Plasmodium vivax multidomain scavenger receptor, putative 0.0018 0.0187 0.1177
Loa Loa (eye worm) hypothetical protein 0.0018 0.0179 0.0291
Echinococcus granulosus Regulator of G protein signaling 20 0.0018 0.0179 0.0179
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0082 0.1249 0.2319
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Loa Loa (eye worm) hypothetical protein 0.0026 0.031 0.0505
Onchocerca volvulus 0.0054 0.0783 0.1098
Echinococcus multilocularis aryl hydrocarbon receptor 0.0011 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0179 0.0291
Schistosoma mansoni regulator of G protein signaling 0.0033 0.0439 0.0439
Echinococcus granulosus tumor protein p63 0.037 0.6038 0.6038
Brugia malayi bHLH-PAS transcription factor 0.0032 0.041 0.0667
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0179 0.0234
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0086 0.1311 0.1311
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.001 0.0056 0.0056
Echinococcus multilocularis serine:threonine protein kinase:endoribonuclease 0.0032 0.0411 0.0411
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0075 0.1137 0.1849
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0011 0.0068 0.0068
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0086 0.1311 0.1311
Brugia malayi RasGEF domain containing protein 0.0011 0.0068 0.0111
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Brugia malayi hypothetical protein 0.0008 0.0015 0.0025
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0424 0.3084
Brugia malayi RasGEF domain containing protein 0.0011 0.0068 0.0111
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Onchocerca volvulus 0.0429 0.7015 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0029 0.0367 0.0662
Plasmodium vivax SET domain protein, putative 0.0054 0.0781 0.6525
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0179 0.0179
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0018 0.0179 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0411 0.0411
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0179 0.0179
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Echinococcus multilocularis segment polarity protein dishevelled 0.0016 0.0143 0.0143
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0483
Leishmania major protein kinase, putative 0.0011 0.0071 0.0569
Echinococcus multilocularis beta adrenergic receptor kinase 0.0018 0.0182 0.0182
Plasmodium falciparum phosphodiesterase delta, putative 0.001 0.0056 0.0483
Brugia malayi N-terminal motif family protein 0.0011 0.0068 0.0111
Loa Loa (eye worm) RasGEF domain-containing protein 0.0011 0.0068 0.0111
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0033 0.0424 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Entamoeba histolytica hypothetical protein 0.0018 0.0179 0.3104
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.001 0.0056 0.0056
Brugia malayi hypothetical protein 0.0259 0.419 0.6814
Trichomonas vaginalis adenylate cyclase, putative 0.0011 0.0068 0.0075
Toxoplasma gondii IMP dehydrogenas 0.0082 0.1249 0.9526
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0082 0.1249 1
Echinococcus multilocularis musashi 0.0053 0.0769 0.0769
Leishmania major guanosine monophosphate reductase 0.0082 0.1249 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0033 0.0424 0.0584
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0011 0.0068 0.0097
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0424 0.3084
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0051 0.0736 0.0736
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0187 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0056 0.0059
Trypanosoma brucei GMP reductase 0.0082 0.1249 1
Loa Loa (eye worm) doublecortin family protein 0.0018 0.0187 0.0304
Brugia malayi hypothetical protein 0.0018 0.0179 0.0291
Echinococcus granulosus lamin 0.0053 0.0769 0.0769
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0182 0.0182
Schistosoma mansoni loxhd1 0.0018 0.0187 0.0187
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0039 0.0531 0.3925
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0033 0.0424 0.3235
Schistosoma mansoni single-minded 0.0043 0.0596 0.0596
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.001 0.0056 0.0092
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0068 0.0075
Schistosoma mansoni lamin 0.0053 0.0769 0.0769
Loa Loa (eye worm) PDE1B protein 0.001 0.0056 0.0092
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0179 0.0291
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Schistosoma mansoni rab6-interacting 0.0018 0.0187 0.0187
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0016 0.0143 0.0143
Brugia malayi follicle stimulating hormone receptor 0.0209 0.335 0.5447
Loa Loa (eye worm) DIX domain-containing protein 0.0016 0.0143 0.0233
Loa Loa (eye worm) hypothetical protein 0.0144 0.2275 0.37
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0781 0.0781
Echinococcus multilocularis inositol monophosphatase 1 0.0033 0.0424 0.0424
Loa Loa (eye worm) PXA domain-containing protein 0.0018 0.0179 0.0291
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0033 0.0424 0.0769
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0082 0.1249 0.1249
Loa Loa (eye worm) IMP dehydrogenase 1 0.0082 0.1249 0.203
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0056 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0179 0.0234
Onchocerca volvulus Putative GMP reductase 0.0034 0.045 0.0622
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Echinococcus granulosus Pleckstrin G protein interacting region 0.0016 0.0143 0.0143
Mycobacterium ulcerans putative regulatory protein 0.0032 0.041 0.0743
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0478
Loa Loa (eye worm) hypothetical protein 0.0052 0.0753 0.1224
Loa Loa (eye worm) hypothetical protein 0.0318 0.5176 0.8417
Brugia malayi Inositol-1 0.0033 0.0424 0.069
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0054 0.0781 0.0781
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0011 0.0068 0.0068
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0068 0.0075
Schistosoma mansoni dishevelled 0.0016 0.0143 0.0143
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0011 0.0068 0.0068
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.001 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0086 0.1311 0.2131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0781 0.0781
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.001 0.0056 0.0056
Echinococcus granulosus intermediate filament protein 0.0053 0.0769 0.0769
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0082 0.1249 0.1249
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0781 0.0781
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0054 0.0781 0.5961
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0011 0.0059 0.0059
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.001 0.0056 0.0056
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.001 0.0056 0.0059
Onchocerca volvulus 0.0054 0.0781 0.1095
Brugia malayi PXA domain containing protein 0.0018 0.0179 0.0291
Brugia malayi N-terminal motif family protein 0.0318 0.5176 0.8417
Loa Loa (eye worm) hypothetical protein 0.0054 0.0783 0.1274
Echinococcus granulosus regulator of G protein signaling 7 0.0033 0.0439 0.0439
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.001 0.0056 0.0056
Loa Loa (eye worm) RasGEF domain-containing protein 0.0011 0.0068 0.0111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0179 0.0291
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.001 0.0056 0.0056
Echinococcus granulosus aryl hydrocarbon receptor 0.0011 0.0068 0.0068
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0187 0.0304
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0011 0.0071 0.0124
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0018 0.0179 0.0179
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0011 0.0068 0.01
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0077 0.1168 0.2166
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0011 0.0068 0.0076
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0086 0.1311 0.1311
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0018 0.0182 0.0296
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0783 0.0783
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.001 0.0056 0.0092
Echinococcus granulosus inositol monophosphatase 1 0.0033 0.0424 0.0424
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.001 0.0056 0.0056
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0082 0.1249 1
Echinococcus multilocularis expressed protein 0.0347 0.565 0.565
Leishmania major hypothetical protein, conserved 0.001 0.0056 0.0451
Brugia malayi GMP reductase 0.0034 0.045 0.0732
Loa Loa (eye worm) hypothetical protein 0.0033 0.0439 0.0714
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0179 0.0179
Giardia lamblia Hypothetical protein 0.001 0.0056 0.0318
Schistosoma mansoni polycystin 1-related 0.0018 0.0187 0.0187
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.001 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0068 0.0075
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0179 0.0291
Brugia malayi hypothetical protein 0.0016 0.0143 0.0233
Leishmania major hypothetical protein, conserved 0.001 0.0056 0.0451
Echinococcus multilocularis son of sevenless 1 0.0011 0.0068 0.0068
Brugia malayi hypothetical protein 0.0018 0.0187 0.0304
Loa Loa (eye worm) IRE protein kinase 0.0032 0.0411 0.0668
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0179 0.0234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0179 0.0291
Trypanosoma cruzi hypothetical protein 0.0011 0.0068 0.01
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0033 0.0424 0.0584
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.001 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0295 0.4784 0.778
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0011 0.0068 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0068 0.0075
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0011 0.0068 0.5
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0086 0.1311 0.1311
Schistosoma mansoni intermediate filament proteins 0.0053 0.0769 0.0769
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.031 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0179 0.0234
Echinococcus granulosus RUN 0.0018 0.0187 0.0187
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.001 0.0056 0.0092
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0011 0.0068 0.0075
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.001 0.0056 0.0092
Brugia malayi regulator of G-protein signaling egl-10 0.0033 0.0439 0.0714
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Brugia malayi hypothetical protein 0.0018 0.0187 0.0304
Echinococcus granulosus ras GTP exchange factor 0.0011 0.0068 0.0068
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0082 0.1249 0.2319
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.001 0.0056 0.0056
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0187 0.0187
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0033 0.0424 0.3396
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0016 0.0143 0.0183
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0011 0.0068 0.0068
Echinococcus multilocularis microtubule associated protein 2 0.0609 1 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0011 0.0068 0.0543
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0051 0.0736 0.0736
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Loa Loa (eye worm) hypothetical protein 0.0011 0.0068 0.0111
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.419 0.419
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0179 0.0179
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.031 0.031
Echinococcus multilocularis regulator of G protein signaling 0.0018 0.0179 0.0179
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0016 0.0143 0.0143
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.0187 0.0187
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0077 0.1168 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Onchocerca volvulus 0.0011 0.0068 0.0076
Echinococcus multilocularis lamin 0.0053 0.0769 0.0769
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0032 0.0407 0.056
Brugia malayi PAS domain containing protein 0.0043 0.0596 0.0969
Echinococcus granulosus son of sevenless 1 0.0011 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0179 0.0234
Loa Loa (eye worm) hypothetical protein 0.0018 0.0187 0.0304
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0082 0.1249 1
Echinococcus multilocularis transfer RNA-Lys 0.0032 0.041 0.041
Plasmodium falciparum phosphodiesterase gamma, putative 0.001 0.0056 0.0483
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0011 0.0071 0.0124
Brugia malayi hypoxia-induced factor 1 0.0133 0.209 0.3399
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.001 0.0056 0.0056
Trypanosoma cruzi GMP reductase 0.0082 0.1249 1
Echinococcus multilocularis RUN 0.0018 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0018 0.0179 0.0291
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Schistosoma mansoni lipoxygenase 0.0018 0.0187 0.0187
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0011 0.0068 0.0075
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0011 0.0068 0.0068
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.001 0.0056 0.0451
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0179 0.0179
Brugia malayi RasGEF domain containing protein 0.0011 0.0068 0.0111
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0082 0.1249 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0478
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Loa Loa (eye worm) hypothetical protein 0.0053 0.0769 0.1251
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0011 0.0068 0.0068
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0082 0.1249 1
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0179 0.0179
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0068 0.0075
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0179 0.0179
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0054 0.0781 0.0781
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.001 0.0056 0.0056
Brugia malayi A-kinase anchor protein 10, precursor 0.0018 0.0179 0.0291
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0086 0.1311 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0781 0.1271
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Loa Loa (eye worm) hypothetical protein 0.0259 0.419 0.6814
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.001 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0008 0.0015 0.0025
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0781 0.0781
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.001 0.0056 0.0092
Echinococcus granulosus neuropeptide receptor A26 0.0411 0.6722 0.6722
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0068 0.0075
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0407 0.056
Echinococcus granulosus expressed protein 0.0347 0.565 0.565
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.001 0.0056 0.0056
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0082 0.1249 0.1249
Onchocerca volvulus 0.0016 0.0143 0.0183
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0034 0.045 0.0732
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Echinococcus granulosus serine:threonine protein kinase:endoribonuclease 0.0032 0.0411 0.0411
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0011 0.0068 0.0068
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0179 0.0179
Toxoplasma gondii hypothetical protein 0.0016 0.0143 0.1091
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Schistosoma mansoni dep domain containing protein 0.0016 0.0143 0.0143
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0052 0.0748 0.0748
Trichomonas vaginalis ras GTP exchange factor, putative 0.0011 0.0068 0.0076
Entamoeba histolytica hypothetical protein 0.0018 0.0179 0.3104
Echinococcus multilocularis lamin dm0 0.0053 0.0769 0.0769
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.001 0.0056 0.0092
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0075 0.1137 0.1137
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.001 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0018 0.0187 0.0187
Loa Loa (eye worm) inositol-1 0.0033 0.0424 0.069
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0011 0.0068 0.0076
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0769 0.1251
Entamoeba histolytica protein kinase, putative 0.0032 0.0411 0.962
Echinococcus granulosus segment polarity protein dishevelled 0.0016 0.0143 0.0143
Brugia malayi Pre-SET motif family protein 0.0054 0.0781 0.1271
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0761 0.1238
Brugia malayi hypothetical protein 0.0144 0.2275 0.37
Schistosoma mansoni inositol monophosphatase 0.0033 0.0424 0.0424
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0086 0.1311 1
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0011 0.0068 0.0068
Schistosoma mansoni rab6-interacting 0.0018 0.0187 0.0187
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0033 0.0439 0.0714
Onchocerca volvulus 0.0053 0.0769 0.1077
Leishmania major inosine-5-monophosphate dehydrogenase 0.0082 0.1249 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.001 0.0056 0.0059
Onchocerca volvulus 0.0011 0.0068 0.0075
Trichomonas vaginalis guanylate cyclase, putative 0.0011 0.0068 0.0075
Brugia malayi DIX domain containing protein 0.0016 0.0143 0.0233
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Schistosoma mansoni dishevelled 0.0016 0.0143 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0182 0.0182
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.001 0.0056 0.043
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0029 0.0367 0.2536
Echinococcus multilocularis neuropeptide receptor A26 0.0411 0.6722 0.6722
Echinococcus multilocularis segment polarity protein dishevelled 0.0016 0.0143 0.0143
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.001 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0143 0.0233
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0018 0.0179 0.0179
Echinococcus granulosus regulator of G protein signaling 7 0.0033 0.0439 0.0439
Schistosoma mansoni lipoxygenase 0.0051 0.0736 0.0736
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0075 0.1137 0.1137
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0011 0.0068 0.0076
Loa Loa (eye worm) hypoxia-induced factor 1 0.0133 0.209 0.3399
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.001 0.0056 0.0059
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.0187 0.0187
Echinococcus multilocularis neuropeptide s receptor 0.0411 0.6722 0.6722
Onchocerca volvulus 0.0053 0.0761 0.1066
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.001 0.0056 0.0059
Brugia malayi hypothetical protein 0.0018 0.0179 0.0291
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0328 0.5335 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0086 0.1311 0.1311
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0179 0.0179
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0011 0.0068 0.0075
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0018 0.0182 0.0296
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0769 0.1251
Plasmodium falciparum cGMP-specific phosphodiesterase 0.001 0.0056 0.0483
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0011 0.0068 0.0068
Brugia malayi hypothetical protein 0.0016 0.0143 0.0233
Trichomonas vaginalis ras GTP exchange factor, putative 0.0011 0.0068 0.0076
Trypanosoma cruzi GMP reductase 0.0082 0.1249 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.001 0.0056 0.0483
Echinococcus multilocularis Protein son of sevenless 0.0011 0.0068 0.0068
Echinococcus granulosus beta-adrenergic receptor kinase 0.0018 0.0182 0.0182

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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