Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0292 | 0.0292 |
Trypanosoma brucei | GMP reductase | 0.0106 | 0.211 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0106 | 0.211 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0292 | 0.0542 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0766 | 0.189 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0502 | 0.114 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0044 | 0.068 | 0.068 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0766 | 0.0766 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0292 | 0.0292 |
Schistosoma mansoni | lamin | 0.0027 | 0.0292 | 0.0542 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0292 | 0.0542 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0106 | 0.211 | 0.2291 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0106 | 0.211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1317 | 0.1317 |
Mycobacterium tuberculosis | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas | 0.0071 | 0.1317 | 0.1386 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0106 | 0.211 | 0.5712 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | runx1 | 0.0056 | 0.096 | 0.096 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0048 | 0.0766 | 0.189 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.087 | 0.2185 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.0079 | 0.1486 | 0.1486 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0106 | 0.211 | 0.211 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.0079 | 0.1486 | 0.743 |
Giardia lamblia | Hypothetical protein | 0.0079 | 0.1486 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0106 | 0.211 | 0.1597 |
Brugia malayi | GMP reductase | 0.0044 | 0.068 | 0.068 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0292 | 0.0542 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0044 | 0.068 | 0.068 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0292 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0766 | 0.0766 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0766 | 0.0766 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0048 | 0.0766 | 0.189 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0055 | 0.0948 | 0.0965 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Schistosoma mansoni | biotin-protein ligase | 0.0071 | 0.1317 | 0.3457 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.0079 | 0.1486 | 0.6892 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3618 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0281 | 0.0281 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0055 | 0.0948 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0502 | 0.114 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.211 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0292 | 0.0542 |
Echinococcus granulosus | geminin | 0.0171 | 0.3618 | 1 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0397 | 0.8869 | 1 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0397 | 0.8869 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 0.3618 | 1 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0397 | 0.8869 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0292 | 0.0292 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.0079 | 0.1486 | 0.6892 |
Onchocerca volvulus | Putative GMP reductase | 0.0044 | 0.068 | 0.0399 |
Plasmodium falciparum | biotin protein ligase, putative | 0.0079 | 0.1486 | 0.743 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.005 | 0.0825 | 0.0825 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0099 | 0.1965 | 0.2125 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0161 | 0.3385 | 0.3744 |
Trypanosoma cruzi | GMP reductase | 0.0106 | 0.211 | 1 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0106 | 0.211 | 1 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.0079 | 0.1486 | 0.1486 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0766 | 0.0766 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 0.6892 |
Echinococcus granulosus | lamin | 0.0027 | 0.0292 | 0.0542 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0099 | 0.1965 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.211 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0106 | 0.211 | 0.5712 |
Echinococcus granulosus | carboxylesterase 5A | 0.0048 | 0.0766 | 0.189 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0106 | 0.211 | 1 |
Echinococcus multilocularis | Protein lozenge | 0.0056 | 0.096 | 0.244 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0102 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0502 | 0.114 |
Schistosoma mansoni | lozenge | 0.0056 | 0.096 | 0.244 |
Schistosoma mansoni | biotin-protein ligase | 0.0079 | 0.1486 | 0.3937 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0106 | 0.211 | 0.2291 |
Toxoplasma gondii | IMP dehydrogenas | 0.0106 | 0.211 | 0.2291 |
Chlamydia trachomatis | biotin synthetase | 0.0079 | 0.1486 | 1 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0071 | 0.1317 | 0.0611 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0102 | 0.0102 |
Loa Loa (eye worm) | GMP reductase | 0.0044 | 0.068 | 0.068 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0106 | 0.211 | 0.5712 |
Echinococcus granulosus | acetylcholinesterase | 0.0048 | 0.0766 | 0.189 |
Echinococcus granulosus | 5'partial|biotin protein ligase | 0.0071 | 0.1317 | 0.3457 |
Leishmania major | guanosine monophosphate reductase | 0.0106 | 0.211 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0106 | 0.211 | 0.211 |
Echinococcus multilocularis | acetylcholinesterase | 0.0048 | 0.0766 | 0.189 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0292 | 0.0542 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0168 | 0.3554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0048 | 0.0766 | 0.189 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.211 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3618 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0502 | 0.114 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0502 | 0.0502 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0099 | 0.1965 | 1 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 0.6892 |
Echinococcus multilocularis | N terminal of biotin protein ligase | 0.0071 | 0.1317 | 0.3457 |
Echinococcus multilocularis | biotin protein ligase | 0.0079 | 0.1486 | 0.3937 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0048 | 0.0766 | 0.0766 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0397 | 0.8869 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0766 | 0.0766 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.0071 | 0.1317 | 0.3457 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.0079 | 0.1486 | 0.743 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0292 | 0.0542 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0102 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Echinococcus multilocularis | biotin protein ligase | 0.0079 | 0.1486 | 0.3937 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1317 | 0.1317 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 0.6892 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0292 | 0.0292 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Onchocerca volvulus | 0.0446 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.