Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.0079 | 0.1486 | 0.1486 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0106 | 0.211 | 1 |
Plasmodium falciparum | biotin protein ligase, putative | 0.0079 | 0.1486 | 0.743 |
Onchocerca volvulus | Putative GMP reductase | 0.0044 | 0.068 | 0.0399 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.0079 | 0.1486 | 0.6892 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.005 | 0.0825 | 0.0825 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0161 | 0.3385 | 0.3744 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0099 | 0.1965 | 0.2125 |
Trypanosoma cruzi | GMP reductase | 0.0106 | 0.211 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0106 | 0.211 | 0.2291 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Mycobacterium leprae | POSSIBLE BIFUNCTIONAL PROTEIN BirA: BIOTIN OPERON REPRESSOR + BIOTIN--[ACETYL-COA-CARBOXYLASE] SYNTHETASE (BIOTIN--PROTEIN LIGAS | 0.0071 | 0.1317 | 0.0611 |
Toxoplasma gondii | IMP dehydrogenas | 0.0106 | 0.211 | 0.2291 |
Chlamydia trachomatis | biotin synthetase | 0.0079 | 0.1486 | 1 |
Loa Loa (eye worm) | GMP reductase | 0.0044 | 0.068 | 0.068 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0102 | 0.0102 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0099 | 0.1965 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0292 | 0.0542 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0766 | 0.0766 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.211 | 1 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 0.6892 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0106 | 0.211 | 0.5712 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0106 | 0.211 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0502 | 0.114 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0102 | 0.5 |
Echinococcus multilocularis | Protein lozenge | 0.0056 | 0.096 | 0.244 |
Echinococcus granulosus | carboxylesterase 5A | 0.0048 | 0.0766 | 0.189 |
Schistosoma mansoni | biotin-protein ligase | 0.0079 | 0.1486 | 0.3937 |
Schistosoma mansoni | lozenge | 0.0056 | 0.096 | 0.244 |
Echinococcus multilocularis | acetylcholinesterase | 0.0048 | 0.0766 | 0.189 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3618 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0502 | 0.114 |
Echinococcus multilocularis | N terminal of biotin protein ligase | 0.0071 | 0.1317 | 0.3457 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 0.6892 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0502 | 0.0502 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0099 | 0.1965 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0048 | 0.0766 | 0.0766 |
Echinococcus multilocularis | biotin protein ligase | 0.0079 | 0.1486 | 0.3937 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0106 | 0.211 | 0.5712 |
Echinococcus granulosus | 5'partial|biotin protein ligase | 0.0071 | 0.1317 | 0.3457 |
Echinococcus granulosus | acetylcholinesterase | 0.0048 | 0.0766 | 0.189 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0292 | 0.0542 |
Echinococcus multilocularis | acetylcholinesterase | 0.0048 | 0.0766 | 0.189 |
Leishmania major | guanosine monophosphate reductase | 0.0106 | 0.211 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0106 | 0.211 | 0.211 |
Treponema pallidum | biotin--acetyl-CoA-carboxylase ligase | 0.0168 | 0.3554 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Echinococcus multilocularis | biotin protein ligase | 0.0079 | 0.1486 | 0.3937 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0292 | 0.0292 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1317 | 0.1317 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 0.6892 |
Onchocerca volvulus | 0.0446 | 1 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0766 | 0.0766 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.0397 | 0.8869 | 1 |
Echinococcus granulosus | N terminal of biotin protein ligase | 0.0071 | 0.1317 | 0.3457 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0292 | 0.0542 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.0079 | 0.1486 | 0.743 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0102 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0766 | 0.189 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0292 | 0.0542 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0044 | 0.068 | 0.068 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0292 | 0.0292 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0766 | 0.0766 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0502 | 0.114 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0292 | 0.0542 |
Schistosoma mansoni | lamin | 0.0027 | 0.0292 | 0.0542 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0292 | 0.0292 |
Trypanosoma brucei | GMP reductase | 0.0106 | 0.211 | 1 |
Trypanosoma cruzi | GMP reductase | 0.0106 | 0.211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.087 | 0.2185 |
Echinococcus granulosus | acetylcholinesterase | 0.0048 | 0.0766 | 0.189 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.0079 | 0.1486 | 0.1486 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.0079 | 0.1486 | 0.743 |
Giardia lamblia | Hypothetical protein | 0.0079 | 0.1486 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0106 | 0.211 | 0.211 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0102 | 0.0102 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0106 | 0.211 | 0.2291 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0106 | 0.211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1317 | 0.1317 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0106 | 0.211 | 0.5712 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0292 | 0.0292 |
Mycobacterium tuberculosis | Possible bifunctional protein BirA: biotin operon repressor + biotin--[acetyl-CoA-carboxylase] synthetase (biotin--protein ligas | 0.0071 | 0.1317 | 0.1386 |
Loa Loa (eye worm) | runx1 | 0.0056 | 0.096 | 0.096 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0048 | 0.0766 | 0.189 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0055 | 0.0948 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0766 | 0.0766 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0502 | 0.2895 |
Schistosoma mansoni | biotin-protein ligase | 0.0071 | 0.1317 | 0.3457 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.3618 | 1 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.0079 | 0.1486 | 0.6892 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0292 | 0.0542 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0044 | 0.068 | 0.068 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0106 | 0.211 | 0.1597 |
Brugia malayi | GMP reductase | 0.0044 | 0.068 | 0.068 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0292 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0766 | 0.0766 |
Echinococcus granulosus | geminin | 0.0171 | 0.3618 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0292 | 0.0292 |
Echinococcus multilocularis | geminin | 0.0171 | 0.3618 | 1 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0397 | 0.8869 | 1 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.0397 | 0.8869 | 1 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.0397 | 0.8869 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0071 | 0.1317 | 0.8779 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0055 | 0.0948 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0281 | 0.0281 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0502 | 0.114 |
Schistosoma mansoni | lamin | 0.0027 | 0.0292 | 0.0542 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0106 | 0.211 | 1 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.0079 | 0.1486 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.