Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ornithine aminotransferase, putative | 0.0024 | 0 | 0.5 |
Plasmodium falciparum | ornithine aminotransferase | 0.0024 | 0 | 0.5 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0091 | 0.273 | 0.864 |
Echinococcus granulosus | acetylcholinesterase | 0.0091 | 0.273 | 0.8783 |
Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | 0.0024 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.273 | 0.864 |
Echinococcus multilocularis | acetylcholinesterase | 0.0091 | 0.273 | 0.8783 |
Echinococcus multilocularis | acetylcholinesterase | 0.0091 | 0.273 | 0.8783 |
Mycobacterium leprae | Probable Acetylornithine aminotransferase ArgD | 0.0024 | 0 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0074 | 0.2029 | 0.1484 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0269 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0092 | 0.2796 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3108 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.273 | 0.2233 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.004 | 0.0639 | 0.2287 |
Loa Loa (eye worm) | carboxylesterase | 0.0091 | 0.273 | 0.864 |
Loa Loa (eye worm) | glutamate receptor | 0.0081 | 0.2341 | 0.7241 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0068 | 0.1802 | 0.5799 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0091 | 0.273 | 0.8783 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0081 | 0.2341 | 0.1818 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0024 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0091 | 0.273 | 0.2233 |
Echinococcus granulosus | acetylcholinesterase | 0.0091 | 0.273 | 0.8783 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.01 | 0.3108 | 1 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0068 | 0.1802 | 0.6446 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.01 | 0.3108 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0068 | 0.1802 | 0.5799 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0091 | 0.273 | 0.9764 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0269 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.273 | 0.864 |
Echinococcus granulosus | carboxylesterase 5A | 0.0091 | 0.273 | 0.8783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.