Detailed information for compound 2073040

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.51 | Formula: C27H27F3N2O3
  • H donors: 3 H acceptors: 3 LogP: 5.35 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)[C@H](N1CCc2c([C@@H]1CCc1ccc(cc1)C(F)(F)F)cc(c(c2)O)O)c1ccccc1
  • InChi: 1S/C27H27F3N2O3/c1-31-26(35)25(18-5-3-2-4-6-18)32-14-13-19-15-23(33)24(34)16-21(19)22(32)12-9-17-7-10-20(11-8-17)27(28,29)30/h2-8,10-11,15-16,22,25,33-34H,9,12-14H2,1H3,(H,31,35)/t22-,25+/m0/s1
  • InChiKey: CKPMZERRTCMUKQ-WIOPSUGQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0064 0.0716
Echinococcus granulosus neutral alpha glucosidase AB 0.0021 0.0102 0.0238
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0381 1
Trichomonas vaginalis Heterochromatin protein, putative 0.0014 0.0034 0.0124
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0021 0.0102 0.1594
Echinococcus multilocularis X box binding protein 1 0.0164 0.1535 0.3999
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0011 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0368 0.1335
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0124
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0034 0.012
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0293 0.2827 0.2827
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0293 0.2827 1
Brugia malayi Thioredoxin reductase 0.0048 0.0381 0.1346
Trypanosoma brucei trypanothione reductase 0.0048 0.0381 1
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.1001 0.1001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Echinococcus granulosus GPCR family 2 0.0018 0.0076 0.0169
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0383 0.0976
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.1124 0.1124
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.1001 0.1001
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0064 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.023 0.0835
Brugia malayi intermediate filament protein 0.0015 0.005 0.0176
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0076 0.0268
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0064 0.0716
Loa Loa (eye worm) hypothetical protein 0.0018 0.0076 0.0203
Loa Loa (eye worm) hypothetical protein 0.0056 0.046 0.1235
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.002 0.0069
Loa Loa (eye worm) hypothetical protein 0.0047 0.0368 0.0987
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0034 0.006
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0034 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0257 0.0689
Schistosoma mansoni alpha glucosidase 0.0021 0.0102 0.0238
Onchocerca volvulus 0.0028 0.0178 0.0628
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.004 0.0164
Onchocerca volvulus 0.0015 0.005 0.0176
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0124
Schistosoma mansoni hypothetical protein 0.0018 0.0076 0.0169
Echinococcus granulosus tumor protein p63 0.0192 0.1819 0.4742
Brugia malayi Muscleblind-like protein 0.0085 0.0746 0.2639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0011 0.003
Brugia malayi Heterochromatin protein 1 0.0084 0.0738 0.2609
Loa Loa (eye worm) hypothetical protein 0.0028 0.0178 0.0477
Onchocerca volvulus 0.0286 0.2757 0.9752
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0047 0.0126
Mycobacterium tuberculosis Probable reductase 0.011 0.1001 0.1001
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.013 0.1196 0.3107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0064 0.0716
Loa Loa (eye worm) hypothetical protein 0.0037 0.0266 0.0714
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0464 0.1243
Echinococcus multilocularis GPCR, family 2 0.0018 0.0076 0.0169
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0381 0.0381
Onchocerca volvulus 0.0014 0.0034 0.012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0034 0.0124
Chlamydia trachomatis recombinase RecA 0.0061 0.051 0.1614
Schistosoma mansoni lamin 0.0015 0.005 0.0101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0124
Echinococcus granulosus lamin dm0 0.0015 0.005 0.0101
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0257 0.0644
Schistosoma mansoni hypothetical protein 0.0039 0.0284 0.0716
Schistosoma mansoni alpha-glucosidase 0.008 0.0694 0.1792
Brugia malayi glutathione reductase 0.0048 0.0381 0.1346
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0257 0.0644
Mycobacterium ulcerans recombinase A 0.0061 0.051 1
Brugia malayi MH2 domain containing protein 0.0068 0.0576 0.2035
Onchocerca volvulus 0.0011 0.0011 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0124
Echinococcus multilocularis chromobox protein 1 0.0084 0.0738 0.1906
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0064 0.0716
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0021 0.0102 0.1961
Echinococcus multilocularis tumor protein p63 0.0192 0.1819 0.4742
Loa Loa (eye worm) hypothetical protein 0.0085 0.0746 0.2002
Plasmodium falciparum thioredoxin reductase 0.0017 0.0064 0.0868
Loa Loa (eye worm) intermediate filament protein 0.0015 0.005 0.0133
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0034 0.0124
Chlamydia trachomatis glutamate symporter 0.0293 0.2827 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2757 1
Brugia malayi hypothetical protein 0.0014 0.0034 0.012
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.004 0.0164
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0124
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0034 0.006
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0368 0.1302
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0091
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.1124 0.1124
Chlamydia trachomatis neutral amino acid transporter 0.013 0.1196 0.4094
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0011 0.003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Schistosoma mansoni microtubule-associated protein tau 0.0393 0.3822 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0011 0.004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0034 0.0124
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0064 0.0139
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.013 0.1196 0.3107
Entamoeba histolytica heat shock transcription factor, putative 0.0056 0.046 1
Echinococcus granulosus microtubule associated protein 2 0.0393 0.3822 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0102 0.037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0257 0.0644
Schistosoma mansoni hypothetical protein 0.0096 0.086 0.2228
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0064 0.0868
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0076 0.0169
Trichomonas vaginalis sucrase-isomaltase, putative 0.0021 0.0102 0.037
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0244 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0124
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0464 0.1639
Trypanosoma cruzi DNA repair protein, putative 0.0019 0.0085 0.1338
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0011 0.004
Echinococcus granulosus lysosomal alpha glucosidase 0.0093 0.0823 0.213
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0064 0.0716
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0284 0.1005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0076 0.0169
Echinococcus granulosus neuropeptide receptor A26 0.0263 0.2527 0.6602
Schistosoma mansoni hypothetical protein 0.0164 0.1535 0.3999
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0064 1
Leishmania major alpha glucosidase II subunit, putative 0.0021 0.0102 0.1827
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0064 0.0868
Brugia malayi ecdysteroid receptor 0.0011 0.0011 0.004
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0034 0.006
Echinococcus granulosus chromobox protein 2 0.0014 0.0034 0.006
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0257 0.0644
Echinococcus multilocularis neutral alpha glucosidase AB 0.0021 0.0102 0.0238
Loa Loa (eye worm) hypothetical protein 0.0057 0.0464 0.1243
Echinococcus granulosus X box binding protein 1 0.0164 0.1535 0.3999
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0034 0.0124
Echinococcus multilocularis neuropeptide s receptor 0.0263 0.2527 0.6602
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0124
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0102 0.037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0011 0.004
Echinococcus granulosus lamin 0.0015 0.005 0.0101
Loa Loa (eye worm) helicase 0.0014 0.0034 0.0091
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0064 0.0716
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0102 0.037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0124
Echinococcus granulosus intermediate filament protein 0.0015 0.005 0.0101
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0021 0.0102 0.0274
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0368 0.1335
Toxoplasma gondii thioredoxin reductase 0.0048 0.0381 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.023 0.0835
Schistosoma mansoni hypothetical protein 0.0018 0.0076 0.0169
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0395 0.1006
Echinococcus multilocularis neutral amino acid transporter A 0.0293 0.2827 0.739
Schistosoma mansoni chromobox protein 0.0014 0.0034 0.006
Onchocerca volvulus 0.0014 0.0034 0.012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0124
Echinococcus multilocularis muscleblind protein 1 0.0085 0.0746 0.1928
Treponema pallidum glutamate transporter 0.013 0.1196 1
Plasmodium falciparum glutathione reductase 0.0017 0.0064 0.0868
Echinococcus granulosus Chromobox protein 3 0.0014 0.0034 0.006
Schistosoma mansoni cellular tumor antigen P53 0.0028 0.0178 0.0437
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0464 0.1639
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0011 0.004
Brugia malayi Intermediate filament tail domain containing protein 0.0015 0.005 0.0176
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.0949 0.9386 0.9386
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0091
Echinococcus multilocularis lysosomal alpha glucosidase 0.0093 0.0823 0.213
Schistosoma mansoni chromobox protein 0.0014 0.0034 0.006
Schistosoma mansoni chromobox protein 0.0084 0.0738 0.1906
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0107
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0076 0.0169
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0034 0.0124
Echinococcus granulosus neuropeptide s receptor 0.0263 0.2527 0.6602
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0011 0.004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0064 0.1257
Brugia malayi Protein cec-1. 0.0014 0.0034 0.012
Echinococcus granulosus excitatory amino acid transporter 3 0.0293 0.2827 0.739
Echinococcus granulosus chromobox protein 1 0.0084 0.0738 0.1906
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0011 0.003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0015 0.005 0.0133
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0064 0.0868
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0011 0.004
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.1001 0.1001
Trypanosoma cruzi DNA repair protein, putative 0.0019 0.0085 0.1338
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0076 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0102 0.1827
Brugia malayi nuclear receptor NHR-88 0.0011 0.0011 0.004
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0064 0.0716
Echinococcus multilocularis neuropeptide receptor A26 0.0263 0.2527 0.6602
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0064 0.0716
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0011 0.004
Trypanosoma brucei glucosidase, putative 0.0021 0.0102 0.1827
Echinococcus granulosus geminin 0.0096 0.086 0.2228
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0011 0.004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0064 0.0227
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.002 0.0069
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0102 0.037
Loa Loa (eye worm) hypothetical protein 0.0085 0.0746 0.2002
Onchocerca volvulus 0.0037 0.0266 0.0941
Schistosoma mansoni chromobox protein 0.0084 0.0738 0.1906
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0034 0.006
Brugia malayi Excitatory amino acid transporter 0.0293 0.2827 1
Echinococcus multilocularis musashi 0.0015 0.005 0.0101
Plasmodium vivax ataxin-2 like protein, putative 0.0014 0.004 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0064 0.0716
Mycobacterium leprae Conserved hypothetical protein 0.036 0.3497 1
Echinococcus granulosus excitatory amino acid transporter 2 0.0293 0.2827 0.739
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.1124 0.1124
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0381 0.1021
Plasmodium falciparum thioredoxin reductase 0.0048 0.0381 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0011 0.003
Echinococcus multilocularis Excitatory amino acid transporter 0.0293 0.2827 0.739
Schistosoma mansoni hypothetical protein 0.0014 0.0034 0.006
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0019 0.0085 0.1338
Plasmodium falciparum glutathione reductase 0.0048 0.0381 1
Brugia malayi Pre-SET motif family protein 0.0251 0.241 0.8523
Schistosoma mansoni hypothetical protein 0.0096 0.086 0.2228
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0011 0.003
Loa Loa (eye worm) transcription factor SMAD2 0.0068 0.0576 0.1544
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0124
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0064 0.0139
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0034 0.0091
Schistosoma mansoni hypothetical protein 0.0018 0.0076 0.0169
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0404 0.1428
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0064 0.0716
Entamoeba histolytica heat shock transcription factor, putative 0.0056 0.046 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0034 0.006
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0404 0.1465
Plasmodium vivax SET domain protein, putative 0.0036 0.0257 0.6431
Plasmodium vivax glutathione reductase, putative 0.0048 0.0381 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0068 0.0576 0.1544
Onchocerca volvulus 0.005 0.0395 0.1396
Loa Loa (eye worm) excitatory amino acid transporter 0.0293 0.2827 0.7585
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0064 0.1257
Trichomonas vaginalis maltase-glucoamylase, putative 0.0021 0.0102 0.037
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0064 0.0233
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0076 0.0203
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0034 0.012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0011 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0124
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0293 0.2827 1
Treponema pallidum recombinase A 0.0061 0.051 0.3943
Brugia malayi Glycosyl hydrolases family 31 protein 0.0093 0.0823 0.2911
Echinococcus granulosus neutral amino acid transporter 0.0293 0.2827 0.739
Entamoeba histolytica heat shock transcription factor, putative 0.0056 0.046 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0064 0.0868
Echinococcus multilocularis excitatory amino acid transporter 2 0.0293 0.2827 0.739
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0064 0.0716
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0091
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0064 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0011 0.004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.1001 0.1001
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0011 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0064 0.0716
Schistosoma mansoni lamin 0.0015 0.005 0.0101
Brugia malayi Pre-SET motif family protein 0.0036 0.0257 0.0908
Brugia malayi chromobox protein homolog 3 0.0047 0.0368 0.1302
Brugia malayi hypothetical protein 0.0014 0.004 0.0141
Echinococcus multilocularis neutral amino acid transporter A 0.0293 0.2827 0.739
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0034 0.0124
Echinococcus multilocularis geminin 0.0096 0.086 0.2228
Echinococcus multilocularis chromobox protein 2 0.0014 0.0034 0.006
Echinococcus multilocularis excitatory amino acid transporter 3 0.0293 0.2827 0.739
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0257 0.6431
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0034 0.012
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0404 0.1465
Leishmania major trypanothione reductase 0.0048 0.0381 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0293 0.2827 0.739
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Schistosoma mansoni hypothetical protein 0.0018 0.0076 0.0169
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0738 0.2676
Echinococcus multilocularis Chromo domain 0.0014 0.0034 0.006
Brugia malayi HSF-type DNA-binding domain containing protein 0.0056 0.046 0.1628
Brugia malayi Glycosyl hydrolases family 31 protein 0.0021 0.0102 0.0361
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0034 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0124
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0034 0.006
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0102 0.037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0257 0.0644
Onchocerca volvulus 0.0054 0.0432 0.1529
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0738 0.1979
Schistosoma mansoni alpha-glucosidase 0.008 0.0694 0.1792
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0011 0.003
Echinococcus multilocularis microtubule associated protein 2 0.0393 0.3822 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0011 0.004
Echinococcus multilocularis muscleblind protein 0.0085 0.0746 0.1928
Echinococcus multilocularis lysosomal alpha glucosidase 0.0093 0.0823 0.213
Echinococcus multilocularis chromobox protein 1 0.0084 0.0738 0.1906
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0102 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0124
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.1124 0.2055
Echinococcus multilocularis excitatory amino acid transporter 2 0.0293 0.2827 0.739
Echinococcus granulosus muscleblind protein 0.0085 0.0746 0.1928
Echinococcus granulosus neutral amino acid transporter A 0.0293 0.2827 0.739
Onchocerca volvulus 0.0015 0.005 0.0176
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0293 0.2827 0.739
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0034 0.0124
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0064 0.0716
Echinococcus granulosus Chromo domain 0.0014 0.0034 0.006
Echinococcus granulosus neutral amino acid transporter A 0.0293 0.2827 0.739
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0011 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0257 0.0644
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0064 0.0716
Loa Loa (eye worm) hypothetical protein 0.0383 0.3728 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0011 0.004
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0034 0.012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.241 0.6465
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0011 0.003
Schistosoma mansoni intermediate filament proteins 0.0015 0.005 0.0101
Brugia malayi steroid hormone receptor 0.0011 0.0011 0.004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0011 0.004
Echinococcus granulosus Excitatory amino acid transporter 0.0293 0.2827 0.739
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0021 0.0102 0.1594
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0064 0.0868
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0056 0.046 0.1628
Echinococcus granulosus Excitatory amino acid transporter 0.0293 0.2827 0.739
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0293 0.2827 0.739
Echinococcus multilocularis lamin 0.0015 0.005 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0034 0.0124
Echinococcus granulosus chromobox protein 1 0.0084 0.0738 0.1906
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0076 0.0169
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0064 0.0233
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0034 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0102 0.037
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0034 0.006
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0061 0.051 0.1614
Echinococcus granulosus excitatory amino acid transporter 2 0.0293 0.2827 0.739
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.013 0.1196 0.3107
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0011 0.004
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.1001 0.1642
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0011 0.004
Echinococcus granulosus sodium:dicarboxylate symporter 0.0293 0.2827 0.739
Brugia malayi nuclear hormone receptor 0.0011 0.0011 0.004
Brugia malayi CHD4 protein 0.0014 0.0034 0.012
Trichomonas vaginalis hypothetical protein 0.0014 0.0034 0.0124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0011 0.004
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0383 0.0976
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0064 0.0716
Toxoplasma gondii LsmAD domain-containing protein 0.0014 0.004 0.0164
Brugia malayi hypothetical protein 0.0147 0.1366 0.4833
Echinococcus multilocularis Excitatory amino acid transporter 0.0293 0.2827 0.739
Echinococcus multilocularis lamin dm0 0.0015 0.005 0.0101
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0738 0.2676
Echinococcus multilocularis neutral amino acid transporter A 0.0293 0.2827 0.739
Loa Loa (eye worm) hypothetical protein 0.0039 0.0284 0.0762
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0064 0.0139
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0034 0.0124
Brugia malayi SET domain containing protein 0.0015 0.0047 0.0167
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0064 0.0868
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0093 0.0823 0.2208
Loa Loa (eye worm) glutathione reductase 0.0048 0.0381 0.1021
Treponema pallidum glutamate/aspartate transporter 0.013 0.1196 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0064 0.1257
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.1001 0.1001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0064 0.0064
Echinococcus multilocularis sodium:dicarboxylate symporter 0.013 0.1196 0.3107
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0011 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0102 0.1827

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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