Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0192 | 0.1488 | 0.4056 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0754 | 0.7301 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0403 | 0.3669 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.045 | 0.416 | 0.4597 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0047 | 0 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0403 | 0.3669 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.045 | 0.416 | 0.5 |
Onchocerca volvulus | 0.0403 | 0.3669 | 0.5 | |
Entamoeba histolytica | thymidine kinase, putative | 0.0754 | 0.7301 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0403 | 0.3669 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0754 | 0.7301 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.045 | 0.416 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0754 | 0.7301 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0754 | 0.7301 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0192 | 0.1488 | 0.4056 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0754 | 0.7301 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0403 | 0.3669 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0403 | 0.3669 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0403 | 0.3669 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0403 | 0.3669 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0754 | 0.7301 | 1 |
Leishmania major | thymidine kinase, putative | 0.0754 | 0.7301 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.045 | 0.416 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0403 | 0.3669 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.