Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0087 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0298 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0298 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Onchocerca volvulus | 0.0298 | 1 | 1 | |
Giardia lamblia | CDC8 | 0.0087 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0142 | 0.2602 | 0.2602 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0087 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0298 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0142 | 0.2602 | 0.2602 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0298 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0298 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0298 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0298 | 1 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0092 | 0.0222 | 0.0222 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0142 | 0.2602 | 1 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0087 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0298 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0222 | 0.0222 |
Chlamydia trachomatis | thymidylate kinase | 0.0087 | 0 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0142 | 0.2602 | 0.2602 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Retention_time (ADMET) | = 15.7 min | Retention time in cryopreserved human hepatocytes assessed as aldehyde oxidase-mediated metabolite formation treated with 10 uM of XK-469 by LC-MS extracted ion chromatogram analysis | ChEMBL. | 22031625 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.