TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 647.241 | Formula: C23H23I2NO5
H donors: 2 H acceptors: 3 LogP: 2.75 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CCNCCOc1c(I)cc(cc1I)C(=O)c1c(CCCC(=O)O)oc2c1cccc2
InChi: 1S/C23H23I2NO5/c1-2-26-10-11-30-23-16(24)12-14(13-17(23)25)22(29)21-15-6-3-4-7-18(15)31-19(21)8-5-9-20(27)28/h3-4,6-7,12-13,26H,2,5,8-11H2,1H3,(H,27,28)
InChiKey: KBPQHFRENBEXBB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	allatostatin A receptor	0.0028	0.0135	0.0526
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	ap endonuclease	0.0022	0.0075	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0034	0.0179	0.0419
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.0135	0.0135
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.0135	0.0135
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	hypothetical protein	0.0194	0.1573	0.6136
Schistosoma mansoni	opsin-like receptor	0.0028	0.0135	0.0526
Giardia lamblia	Deoxynucleoside kinase	0.0407	0.3413	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.0135	0.0526
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0135	0.0135
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	hypothetical protein	0.0194	0.1573	0.6136
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0075	0.4845
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0135	0.0135
Brugia malayi	Melatonin receptor type 1A	0.0028	0.0135	0.0526
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0075	0.0293
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0135	0.0526
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.0135	0.0135
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.0135	0.0135
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0034	0.0179	0.0419
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	adenoreceptor	0.0028	0.0135	0.0526
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0114	0.0878	0.3427
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	myosin xvIII	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0135	0.0526
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0135	0.0526
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0135	0.0135
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0075	0.0293
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0135	0.0135
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0111	0.0851	0.3318
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.0135	0.0135
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.0135	0.0526
Echinococcus granulosus	somatostatin receptor	0.0028	0.0135	0.0526
Entamoeba histolytica	acetyltransferase, GNAT family	0.0031	0.0155	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0034	0.0179	0.07
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0075	0.0293
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.0135	0.0526
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.0135	0.0135
Onchocerca volvulus		0.0309	0.2563	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.0135	0.0526
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0135	0.0526
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0075	0.022
Schistosoma mansoni	amine GPCR	0.0028	0.0135	0.0526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0135	0.0526
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0309	0.2563	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Brugia malayi	G-protein coupled receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	thymidylate synthase	0.0309	0.2563	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0135	0.0135
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0135	0.0526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0135	0.0526
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0147	0.1161	0.4529
Brugia malayi	acetyltransferase, GNAT family protein	0.0114	0.0878	0.3427
Echinococcus multilocularis	thymidylate synthase	0.0309	0.2563	0.2563
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0135	0.0526
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.0135	0.0135
Schistosoma mansoni	opsin-like receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0135	0.0526
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0135	0.0135
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0135	0.0135
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0135	0.0135
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0075	0.0293
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.0135	0.0526
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0075	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0135	0.0526
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.0135	0.0526
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0135	0.0135
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.0135	0.0135
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.0135	0.0526
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0135	0.0135
Brugia malayi	ORL1-like opioid receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	amine GPCR	0.0028	0.0135	0.0526
Echinococcus multilocularis	somatostatin receptor	0.0028	0.0135	0.0135
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.0135	0.0526
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0135	0.0526
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0034	0.0179	0.1545
Echinococcus granulosus	fmrfamide receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.0135	0.0135
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	thymidylate synthase	0.0309	0.2563	1
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.0135	0.0135
Schistosoma mansoni	amine GPCR	0.0028	0.0135	0.0526
Schistosoma mansoni	opsin-like receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0034	0.0179	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0075	0.0293
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Brugia malayi	Dopamine receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Brugia malayi	Serotonin receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	acetyltransferase	0.0114	0.0878	0.3427
Schistosoma mansoni	histamine h1 receptor	0.0028	0.0135	0.0526
Brugia malayi	Dopamine receptor protein 2	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.0135	0.0526
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0309	0.2563	1
Schistosoma mansoni	amine GPCR	0.0028	0.0135	0.0526
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0135	0.0526
Brugia malayi	GnHR receptor homolog	0.0028	0.0135	0.0526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0135	0.0526
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0075	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.0135	0.0135
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0135	0.0526
Brugia malayi	hypothetical protein	0.0147	0.1161	0.4529
Mycobacterium ulcerans	thymidylate synthase	0.0309	0.2563	1
Brugia malayi	Serotonin receptor	0.0028	0.0135	0.0526
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0135	0.0135
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0309	0.2563	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0135	0.0135
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.0135	0.0526
Plasmodium falciparum	histone acetyltransferase GCN5	0.0031	0.0155	0.0321
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.0135	0.0135
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.0135	0.0526
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	ap endonuclease	0.0022	0.0075	0.0293
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0135	0.0135
Echinococcus granulosus	serotonin receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0135	0.0526
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.0135	0.0526
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0135	0.0526
Echinococcus multilocularis	sex peptide receptor	0.0028	0.0135	0.0135
Echinococcus multilocularis	serotonin receptor	0.0028	0.0135	0.0135
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Brugia malayi	G protein-coupled receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0309	0.2563	1
Echinococcus multilocularis	geminin	0.0194	0.1573	0.1573
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.0135	0.0526
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0309	0.2563	1
Brugia malayi	G-protein coupled receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Brugia malayi	sulfakinin receptor protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0135	0.0526
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0135	0.0526
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0309	0.2563	1
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0075	0.0293
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0075	0.0293
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0135	0.0135
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0135	0.0526
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.0135	0.0526
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0114	0.0878	0.0878
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.0135	0.0526
Echinococcus multilocularis	serotonin receptor	0.0028	0.0135	0.0135
Brugia malayi	putative neuropeptide receptor	0.0028	0.0135	0.0526
Brugia malayi	neuropeptide F receptor	0.0028	0.0135	0.0526
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0034	0.0179	0.1545
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0135	0.0526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0135	0.0526
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.0135	0.0526
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0135	0.0526
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0075	0.0293
Brugia malayi	larval opioid receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.0135	0.0135
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0135	0.0135
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0135	0.0135
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	hypothetical protein	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0075	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	amine GPCR	0.0028	0.0135	0.0526
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.0135	0.0526
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0309	0.2563	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0135	0.0526
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	orexin receptor type 2	0.0028	0.0135	0.0526
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0075	0.5
Schistosoma mansoni	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0135	0.0135
Brugia malayi	RE15519p	0.0028	0.0135	0.0526
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0075	0.0075
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0135	0.0526
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0135	0.0135
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.0135	0.0135
Brugia malayi	thymidylate synthase	0.0309	0.2563	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0135	0.0526
Schistosoma mansoni	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.0135	0.0526
Brugia malayi	neuropeptide F receptor	0.0028	0.0135	0.0526
Mycobacterium tuberculosis	Hypothetical protein	0.0147	0.1161	0.4529
Echinococcus granulosus	sex peptide receptor	0.0028	0.0135	0.0526
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0135	0.0526
Giardia lamblia	Histone acetyltransferase GCN5	0.0031	0.0155	0.0454
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0135	0.0135
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.1161	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0135	0.0135
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0075	0.0293
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.0135	0.0526
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0309	0.2563	1
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.0135	0.0526
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0309	0.2563	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Brugia malayi	Dopamine receptor protein 1	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	geminin	0.0194	0.1573	0.6136
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0135	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Brugia malayi	AKH receptor	0.0028	0.0135	0.0526
Brugia malayi	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0135	0.0526
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.0135	0.0526

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3527058

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2073131