Detailed information for compound 2073139

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 663.587 | Formula: C31H33Cl2FN4O5S
  • H donors: 2 H acceptors: 5 LogP: 4.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(cc1)S(=O)(=O)O.COc1cc2c(cc1OC[C@@H]1C[C@H]3[C@@H](C1)CN(C3)C)ncnc2Nc1ccc(c(c1F)Cl)Cl
  • InChi: 1S/C24H25Cl2FN4O2.C7H8O3S/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27;1-6-2-4-7(5-3-6)11(8,9)10/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30);2-5H,1H3,(H,8,9,10)/t13-,14-,15+;
  • InChiKey: GQLLAIBEWDUUBQ-QIYAQLFNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0002 0.007
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0002 0.007
Echinococcus granulosus allatostatin A receptor 0.0009 0.0002 0.007
Onchocerca volvulus 0.0022 0.0013 0.0464
Onchocerca volvulus 0.0022 0.0013 0.0464
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0002 0.007
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0002 0.007
Echinococcus multilocularis serotonin receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0007 0.000003447 0.0001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0013 0.0532
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi Cytochrome P450 family protein 0.001 0.0003 0.0102
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0002 0.0071
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0002 0.007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0002 0.007
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0002 0.007
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.007
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0002 0.007
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0002 0.007
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0002 0.007
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.029 0.0252 0.0137
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0002 0.007
Echinococcus multilocularis sex peptide receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0002 0.007
Schistosoma mansoni amine GPCR 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus multilocularis lamin dm0 0.0022 0.0013 0.0531
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.029 0.0252 1
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Schistosoma mansoni biogenic amine receptor 0.0009 0.0002 0.007
Echinococcus granulosus lamin 0.0022 0.0013 0.0531
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0002 0.007
Brugia malayi Dopamine receptor protein 1 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0124
Brugia malayi Serotonin receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.029 0.0252 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0002 0.0071
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0002 0.007
Schistosoma mansoni biogenic amine receptor 0.0009 0.0002 0.007
Leishmania major dihydrofolate reductase-thymidylate synthase 0.029 0.0252 1
Schistosoma mansoni amine GPCR 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0002 0.007
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0002 0.007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus granulosus hypothetical protein 0.0009 0.0002 0.007
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.007
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0138 0.0116 0.4581
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0002 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0517
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0002 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0002 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0002 0.007
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0002 0.007
Brugia malayi G-protein coupled receptor 0.0009 0.0002 0.007
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0002 0.007
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0002 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0002 0.007
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0002 0.007
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0002 0.007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0002 0.007
Brugia malayi hypothetical protein 0.0138 0.0116 0.4622
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0002 0.007
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0002 0.007
Mycobacterium ulcerans FAD-dependent thymidylate synthase 1.1228 1 1
Brugia malayi Serotonin receptor 0.0009 0.0002 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0002 0.007
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0002 0.007
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0002 0.007
Schistosoma mansoni lamin 0.0022 0.0013 0.0531
Schistosoma mansoni opsin-like receptor 0.0009 0.0002 0.007
Brugia malayi AKH receptor 0.0009 0.0002 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0002 0.007
Echinococcus granulosus lamin dm0 0.0022 0.0013 0.0531
Schistosoma mansoni neuropeptide receptor 0.0009 0.0002 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0002 0.007
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0007 0.000003447 0.0001
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0002 0.007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0002 0.0071
Echinococcus granulosus g protein coupled receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) CYP4Cod1 0.001 0.0003 0.0103
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0002 0.007
Schistosoma mansoni intermediate filament proteins 0.0022 0.0013 0.0531
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0002 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0002 0.007
Brugia malayi neuropeptide F receptor 0.0009 0.0002 0.007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0002 0.007
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0241
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0011 0.0003 0.0123
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0002 0.007
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0002 0.007
Echinococcus granulosus serotonin receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus multilocularis thymidylate synthase 0.029 0.0252 1
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.007
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0138 0.0116 1
Echinococcus granulosus thymidylate synthase 0.029 0.0252 1
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0003 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0002 0.007
Echinococcus multilocularis serotonin receptor 0.0009 0.0002 0.007
Schistosoma mansoni amine GPCR 0.0009 0.0002 0.007
Brugia malayi cytoplasmic intermediate filament protein 0.0012 0.0004 0.0165
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi putative neuropeptide receptor 0.0009 0.0002 0.007
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0002 0.007
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.029 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0002 0.007
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Schistosoma mansoni adenoreceptor 0.0009 0.0002 0.007
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0002 0.0071
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0002 0.007
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.011
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0002 0.007
Schistosoma mansoni neuropeptide receptor 0.0009 0.0002 0.007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0532
Brugia malayi Melatonin receptor type 1A 0.0009 0.0002 0.007
Echinococcus granulosus sex peptide receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0002 0.007
Echinococcus granulosus bloom syndrome protein 0.0018 0.0009 0.0366
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0002 0.007
Echinococcus granulosus somatostatin receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0002 0.007
Brugia malayi Bloom's syndrome protein homolog 0.0018 0.0009 0.0366
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus granulosus g protein coupled receptor 0.0009 0.0002 0.007
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi ORL1-like opioid receptor 0.0009 0.0002 0.007
Onchocerca volvulus 0.029 0.0252 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0004 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0002 0.007
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0002 0.007
Schistosoma mansoni lamin 0.0022 0.0013 0.0531
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0002 0.007
Brugia malayi G-protein coupled receptor 0.0009 0.0002 0.007
Giardia lamblia Sgs1 DNA helicase, putative 0.0007 0.000003447 0.5
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0199 0.0171 0.6791
Loa Loa (eye worm) thymidylate synthase 0.029 0.0252 1
Brugia malayi thymidylate synthase 0.029 0.0252 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0002 0.007
Schistosoma mansoni biogenic amine receptor 0.0009 0.0002 0.007
Echinococcus multilocularis bloom syndrome protein 0.0018 0.0009 0.0366
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0002 0.0071
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0002 0.007
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0003 0.0103
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.029 0.0252 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0002 0.007
Schistosoma mansoni amine GPCR 0.0009 0.0002 0.007
Schistosoma mansoni opsin-like receptor 0.0009 0.0002 0.007
Trichomonas vaginalis DNA helicase recq1, putative 0.0018 0.0009 0.0639
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0002 0.0071
Echinococcus multilocularis somatostatin receptor 0.0009 0.0002 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0002 0.007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Leishmania major cytochrome p450-like protein 0.001 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus granulosus fmrfamide receptor 0.0009 0.0002 0.007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0002 0.007
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0013 0.0531
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0002 0.007
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0003 0.0103
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0002 0.007
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0002 0.007
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0002 0.007
Entamoeba histolytica recQ family helicase, putative 0.0009 0.0002 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0002 0.007
Echinococcus multilocularis lamin 0.0022 0.0013 0.0531
Schistosoma mansoni neuropeptide receptor 0.0009 0.0002 0.007
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0002 0.007
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0002 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0002 0.007
Trichomonas vaginalis DNA helicase recq, putative 0.0018 0.0009 0.0639
Brugia malayi GnHR receptor homolog 0.0009 0.0002 0.007
Echinococcus granulosus g protein coupled receptor 0.0009 0.0002 0.007
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0002 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0002 0.007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0012 0.0004 0.0166
Brugia malayi Dopamine receptor protein 2 0.0009 0.0002 0.007
Echinococcus multilocularis musashi 0.0022 0.0013 0.0531
Brugia malayi neuropeptide F receptor 0.0009 0.0002 0.007
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0002 0.007
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0002 0.007
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0002 0.007
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Brugia malayi Cytochrome P450 family protein 0.001 0.0003 0.0102
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0002 0.007
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0002 0.007
Echinococcus granulosus orexin receptor type 2 0.0009 0.0002 0.007
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0013 0.0532
Brugia malayi larval opioid receptor 0.0009 0.0002 0.007
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0002 0.007
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0002 0.007
Schistosoma mansoni opsin-like receptor 0.0009 0.0002 0.007
Brugia malayi Dopamine receptor 0.0009 0.0002 0.007
Schistosoma mansoni myosin xvIII 0.0009 0.0002 0.007
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.029 0.0252 1
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi intermediate filament protein 0.0022 0.0013 0.0531
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0002 0.007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0002 0.007
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus granulosus intermediate filament protein 0.0022 0.0013 0.0531
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0002 0.0071
Brugia malayi RE15519p 0.0009 0.0002 0.007
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0003 0.0027
Brugia malayi hypothetical protein 0.0009 0.0002 0.007
Mycobacterium tuberculosis Probable thymidylate synthase ThyX (ts) (TSase) 1.1228 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0002 0.007
Schistosoma mansoni blooms syndrome DNA helicase 0.0014 0.0006 0.0235
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0002 0.0071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0007 0.000003447 0.00000000011721
Brugia malayi follicle stimulating hormone receptor 0.0199 0.0171 0.6791
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi sulfakinin receptor protein 0.0009 0.0002 0.007
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0002 0.0071
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0002 0.007
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0002 0.007
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0002 0.007
Schistosoma mansoni histamine h1 receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0002 0.007
Trypanosoma brucei cytochrome P450, putative 0.001 0.0003 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0002 0.007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0011 0.0003 0.0123
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0002 0.007
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Brugia malayi G protein-coupled receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) RecQ helicase 0.0018 0.0009 0.0367
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Mycobacterium ulcerans thymidylate synthase 0.029 0.0252 0.0249
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0015 0.0007 0.029
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0002 0.007
Echinococcus granulosus neuropeptide receptor 0.0009 0.0002 0.007
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0002 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0002 0.007
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0002 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.029 0.0252 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0071
Schistosoma mansoni neuropeptide receptor 0.0009 0.0002 0.007
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.007
Echinococcus granulosus neuropeptide receptor 0.0009 0.0002 0.007
Schistosoma mansoni amine GPCR 0.0009 0.0002 0.007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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