Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0111 | 0.0144 |
Trichomonas vaginalis | DNA polymerase zeta catalytic subunit, putative | 0.0221 | 0.0181 | 0.0485 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0461 | 0.0431 | 0.0521 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0461 | 0.0431 | 0.1174 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0523 | 0.0497 | 0.1353 |
Schistosoma mansoni | phosphoglucomutase | 0.0097 | 0.0052 | 0.0067 |
Echinococcus granulosus | acetylcholinesterase | 0.0154 | 0.0111 | 0.0144 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0182 | 0.014 | 0.0181 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.9609 | 1 | 1 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0523 | 0.0497 | 0.1353 |
Plasmodium falciparum | DNA polymerase delta catalytic subunit | 0.0221 | 0.0181 | 0.0221 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0097 | 0.0052 | 0.0131 |
Echinococcus granulosus | DNA polymerase delta catalytic subunit | 0.0221 | 0.0181 | 0.0234 |
Brugia malayi | Carboxylesterase family protein | 0.0154 | 0.0111 | 0.0144 |
Leishmania major | thymidylate kinase-like protein | 0.0523 | 0.0497 | 0.0565 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0523 | 0.0497 | 1 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0159 | 0.0116 | 0.015 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0119 | 0.0074 | 0.0073 |
Loa Loa (eye worm) | thymidylate kinase | 0.0523 | 0.0497 | 0.0644 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0182 | 0.014 | 0.0181 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0523 | 0.0497 | 0.0603 |
Brugia malayi | dihydrofolate reductase family protein | 0.0496 | 0.0468 | 0.0607 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0461 | 0.0431 | 0.1174 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0461 | 0.0431 | 0.1174 |
Schistosoma mansoni | phosphoglucomutase | 0.0097 | 0.0052 | 0.0067 |
Brugia malayi | DNA polymerase family B containing protein | 0.0093 | 0.0047 | 0.0062 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0119 | 0.0074 | 0.0073 |
Trypanosoma brucei | ribonuclease H1 | 0.0097 | 0.0052 | 0.0044 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0213 | 0.0173 | 0.0197 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0097 | 0.0052 | 0.0044 |
Brugia malayi | thymidylate synthase | 0.7426 | 0.7716 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.0523 | 0.0497 | 0.0305 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.0093 | 0.0047 | 0.0039 |
Brugia malayi | thymidylate kinase | 0.0523 | 0.0497 | 0.0644 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0097 | 0.0052 | 0.001 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0496 | 0.0468 | 0.0275 |
Loa Loa (eye worm) | DNA polymerase epsilon catalytic subunit | 0.0052 | 0.0004 | 0.0005 |
Trypanosoma brucei | RNA helicase, putative | 0.1186 | 0.1191 | 0.1473 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.0093 | 0.0047 | 0.0039 |
Echinococcus multilocularis | hypothetical protein | 0.0075 | 0.0029 | 0.0037 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0113 | 0.0068 | 0.0176 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0093 | 0.0047 | 0.0119 |
Plasmodium falciparum | thymidylate kinase | 0.0523 | 0.0497 | 0.0617 |
Schistosoma mansoni | dihydrofolate reductase | 0.0496 | 0.0468 | 0.0607 |
Brugia malayi | Telomerase reverse transcriptase | 0.005 | 0.0002 | 0.0002 |
Echinococcus granulosus | ribonuclease H1 | 0.0097 | 0.0052 | 0.0067 |
Plasmodium falciparum | DNA polymerase alpha catalytic subunit A | 0.0061 | 0.0014 | 0.0012 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0119 | 0.0074 | 0.0073 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7689 | 0.7992 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0523 | 0.0497 | 1 |
Toxoplasma gondii | ribonuclease HI protein | 0.0097 | 0.0052 | 0.0032 |
Echinococcus granulosus | acetylcholinesterase | 0.0154 | 0.0111 | 0.0144 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0213 | 0.0173 | 0.0158 |
Schistosoma mansoni | phosphoglucomutase | 0.0097 | 0.0052 | 0.0067 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0154 | 0.0111 | 0.0144 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0496 | 0.0468 | 0.0398 |
Onchocerca volvulus | DNA polymerase epsilon catalytic subunit A homolog | 0.0093 | 0.0047 | 0.0005 |
Schistosoma mansoni | thymidylate kinase | 0.0523 | 0.0497 | 0.0644 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0169 | 0.0126 | 0.0138 |
Echinococcus multilocularis | DNA polymerase delta catalytic subunit | 0.0221 | 0.0181 | 0.0234 |
Loa Loa (eye worm) | thymidylate synthase | 0.7426 | 0.7716 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0029 | 0.0037 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0451 | 0.0421 | 0.0508 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.3533 | 0.3645 | 0.4549 |
Leishmania major | thymidine kinase, putative | 0.0461 | 0.0431 | 0.0483 |
Echinococcus granulosus | thymidylate kinase | 0.0523 | 0.0497 | 0.0644 |
Echinococcus multilocularis | dna polymerase epsilon catalytic subunit a | 0.0093 | 0.0047 | 0.0062 |
Giardia lamblia | Ribonuclease H | 0.0097 | 0.0052 | 0.009 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0523 | 0.0497 | 0.003 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.9609 | 1 | 1 |
Toxoplasma gondii | DNA polymerase | 0.0221 | 0.0181 | 0.0194 |
Echinococcus multilocularis | ribonuclease H1 | 0.0097 | 0.0052 | 0.0067 |
Plasmodium vivax | DNA polymerase delta catalytic subunit, putative | 0.0221 | 0.0181 | 0.0168 |
Loa Loa (eye worm) | carboxylesterase | 0.0154 | 0.0111 | 0.0144 |
Toxoplasma gondii | DNA polymerase family B protein | 0.0093 | 0.0047 | 0.0027 |
Onchocerca volvulus | DNA polymerase homolog | 0.0093 | 0.0047 | 0.0005 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0182 | 0.014 | 0.0181 |
Giardia lamblia | DNA polymerase delta, catalytic subunit | 0.0221 | 0.0181 | 0.2963 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0154 | 0.0111 | 0.0144 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.0205 | 0.0164 | 0.0186 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0154 | 0.0111 | 0.0144 |
Brugia malayi | Carboxylesterase family protein | 0.0154 | 0.0111 | 0.0144 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0159 | 0.0116 | 0.0086 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0523 | 0.0497 | 1 |
Trypanosoma brucei | unspecified product | 0.0119 | 0.0074 | 0.0073 |
Echinococcus granulosus | dihydrofolate reductase | 0.0496 | 0.0468 | 0.0607 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.7689 | 0.7992 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0496 | 0.0468 | 0.0607 |
Schistosoma mansoni | DNA polymerase gamma | 0.0075 | 0.0029 | 0.0037 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0496 | 0.0468 | 0.0607 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0523 | 0.0497 | 0.0427 |
Onchocerca volvulus | 0.7426 | 0.7716 | 1 | |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0119 | 0.0074 | 0.0073 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0113 | 0.0068 | 0.0176 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.7426 | 0.7716 | 0.77 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.7426 | 0.7716 | 0.7604 |
Trypanosoma brucei | DNA polymerase zeta catalytic subunit, putative | 0.0093 | 0.0047 | 0.0039 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0451 | 0.0421 | 0.0508 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0113 | 0.0068 | 0.0026 |
Toxoplasma gondii | thymidylate kinase | 0.0523 | 0.0497 | 0.0591 |
Entamoeba histolytica | thymidine kinase, putative | 0.0461 | 0.0431 | 0.865 |
Onchocerca volvulus | DNA polymerase delta catalytic subunit homolog | 0.0221 | 0.0181 | 0.0178 |
Echinococcus multilocularis | DNA polymerase zeta catalytic subunit | 0.0093 | 0.0047 | 0.0062 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7689 | 0.7992 | 1 |
Schistosoma mansoni | thymidylate kinase | 0.0523 | 0.0497 | 0.0644 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0221 | 0.0181 | 0.0206 |
Echinococcus granulosus | thymidylate synthase | 0.7426 | 0.7716 | 1 |
Entamoeba histolytica | DNA polymerase delta catalytic subunit, putative | 0.0221 | 0.0181 | 0.3455 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0451 | 0.0421 | 0.0508 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0237 | 0.0198 | 0.0126 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0523 | 0.0497 | 0.0603 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3533 | 0.3645 | 1 |
Brugia malayi | DNA polymerase delta catalytic subunit | 0.0221 | 0.0181 | 0.0234 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.013 | 0.0086 | 0.0851 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0496 | 0.0468 | 0.0607 |
Giardia lamblia | CDC8 | 0.0523 | 0.0497 | 1 |
Echinococcus multilocularis | thymidylate kinase | 0.0523 | 0.0497 | 0.0644 |
Schistosoma mansoni | hypothetical protein | 0.0523 | 0.0497 | 0.0644 |
Trypanosoma brucei | thymidine kinase | 0.0461 | 0.0431 | 0.0521 |
Echinococcus granulosus | dna polymerase epsilon catalytic subunit a | 0.0093 | 0.0047 | 0.0062 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7426 | 0.7716 | 1 |
Trichomonas vaginalis | DNA polymerase delta catalytic subunit, putative | 0.0093 | 0.0047 | 0.0119 |
Brugia malayi | DNA polymerase family B, exonuclease domain containing protein | 0.0093 | 0.0047 | 0.0062 |
Trypanosoma brucei | DNA polymerase epsilon catalytic subunit, putative | 0.0093 | 0.0047 | 0.0039 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0523 | 0.0497 | 0.0603 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0075 | 0.0029 | 0.0037 |
Leishmania major | hypothetical protein, conserved | 0.0205 | 0.0164 | 0.0147 |
Schistosoma mansoni | DNA polymerase delta catalytic subunit | 0.0221 | 0.0181 | 0.0234 |
Brugia malayi | RNase H family protein | 0.0097 | 0.0052 | 0.0067 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0523 | 0.0497 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0004 | 0.0005 |
Brugia malayi | RNase H family protein | 0.0097 | 0.0052 | 0.0067 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0097 | 0.0052 | 0.0044 |
Mycobacterium tuberculosis | Hypothetical protein | 0.3533 | 0.3645 | 0.3598 |
Echinococcus multilocularis | acetylcholinesterase | 0.0154 | 0.0111 | 0.0144 |
Echinococcus granulosus | carboxylesterase 5A | 0.0154 | 0.0111 | 0.0144 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0228 | 0.0188 | 0.0188 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.0205 | 0.0164 | 0.0186 |
Mycobacterium ulcerans | thymidylate synthase | 0.7426 | 0.7716 | 0.767 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7689 | 0.7992 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7689 | 0.7992 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7689 | 0.7992 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0077 | 0.0031 | 0.0018 |
Leishmania major | DNA polymerase delta catalytic subunit, putative | 0.0221 | 0.0181 | 0.0168 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0213 | 0.0173 | 0.0197 |
Giardia lamblia | Thymidine kinase | 0.0461 | 0.0431 | 0.8548 |
Echinococcus granulosus | DNA polymerase zeta catalytic subunit | 0.0093 | 0.0047 | 0.0062 |
Echinococcus multilocularis | thymidylate synthase | 0.7426 | 0.7716 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0188 | 0.0243 |
Loa Loa (eye worm) | DNA-directed DNA polymerase III | 0.0221 | 0.0181 | 0.0234 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0159 | 0.0116 | 0.0113 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0461 | 0.0431 | 0.0521 |
Echinococcus multilocularis | acetylcholinesterase | 0.0154 | 0.0111 | 0.0144 |
Brugia malayi | RNase H family protein | 0.0097 | 0.0052 | 0.0067 |
Schistosoma mansoni | DNA polymerase epsilon catalytic subunit | 0.0093 | 0.0047 | 0.0062 |
Schistosoma mansoni | hypothetical protein | 0.1186 | 0.1191 | 0.1543 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0113 | 0.0068 | 0.0065 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0523 | 0.0497 | 0.059 |
Brugia malayi | hypothetical protein | 0.3533 | 0.3645 | 0.4723 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0113 | 0.0068 | 0.0065 |
Leishmania major | ribonuclease H1, putative | 0.0097 | 0.0052 | 0.0005 |
Chlamydia trachomatis | thymidylate kinase | 0.0523 | 0.0497 | 1 |
Brugia malayi | DNA polymerase I family protein | 0.0075 | 0.0029 | 0.0037 |
Plasmodium vivax | thymidylate kinase, putative | 0.0523 | 0.0497 | 0.0565 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0451 | 0.0421 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0004 | 0.0005 |
Schistosoma mansoni | DNA polymerase zeta catalytic subunit | 0.0093 | 0.0047 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.0111 | 0.0144 |
Trypanosoma brucei | DNA polymerase delta catalytic subunit, putative | 0.0221 | 0.0181 | 0.0206 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.