TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.815 | Formula: C16H19ClN6O
H donors: 4 H acceptors: 3 LogP: 2.49 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)Nc1nc(cnc1C(=O)N)N[C@@H]1CCCNC1
InChi: 1S/C16H19ClN6O/c17-10-3-1-4-11(7-10)22-16-14(15(18)24)20-9-13(23-16)21-12-5-2-6-19-8-12/h1,3-4,7,9,12,19H,2,5-6,8H2,(H2,18,24)(H2,21,22,23)/t12-/m1/s1
InChiKey: KETVDYPMYWKUPE-GFCCVEGCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0004	0.0026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0021	0.0089
Giardia lamblia	Hypothetical protein	0.05	0.1634	0.1712
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0031	0.0031
Leishmania major	cathepsin L-like protease	0.0019	0.0021	0.0187
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Leishmania major	cathepsin L-like protease	0.0019	0.0021	0.0187
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0021	0.0131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Leishmania major	cathepsin L-like protease	0.0019	0.0021	0.0187
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0021	0.0131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.05	0.1634	0.6846
Echinococcus granulosus	dna polymerase eta	0.0022	0.0031	0.0031
Entamoeba histolytica	hypothetical protein	0.05	0.1634	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0072	0.0051
Echinococcus granulosus	inositol monophosphatase 1	0.0042	0.0099	0.0099
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Trypanosoma cruzi	thymidine kinase, putative	0.0287	0.0919	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0042	0.0099	0.5
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Loa Loa (eye worm)	inositol-1	0.0042	0.0099	0.0607
Trypanosoma brucei	thymidine kinase	0.0287	0.0919	1
Entamoeba histolytica	hypothetical protein	0.05	0.1634	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.1166	0.3866	0.4095
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0099	0.1038
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0021	0.0131
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0021	0.0131
Toxoplasma gondii	cathepsin CPC2	0.0445	0.1447	0.3709
Schistosoma mansoni	NADH-ubiquinone oxidoreductase	0.05	0.1634	0.1634
Schistosoma mansoni	DNA polymerase eta	0.0022	0.0031	0.0031
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0021	0.0245
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Entamoeba histolytica	hypothetical protein	0.05	0.1634	1
Leishmania major	cathepsin L-like protease	0.0073	0.0203	0.217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.05	0.1634	1
Entamoeba histolytica	hypothetical protein	0.05	0.1634	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0031	0.0191
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0203	0.217
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0031	0.0295
Onchocerca volvulus		0.0019	0.0021	0.0245
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0203	0.217
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0031	0.0295
Entamoeba histolytica	hypothetical protein	0.05	0.1634	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Echinococcus multilocularis	inositol monophosphatase 1	0.0042	0.0099	0.0078
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0021	0.0131
Loa Loa (eye worm)	fibroinase	0.0019	0.0021	0.0131
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0725	0.2387	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0021	0.0021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0072	0.0131
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0021	0.0131
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0021	0.0187
Giardia lamblia	Hypothetical protein	0.05	0.1634	0.1712
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.1166	0.3866	0.3866
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0099	0.1038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Giardia lamblia	Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative	0.05	0.1634	0.1712
Echinococcus granulosus	NADH ubiquinone oxidoreductase 42 kDa subunit	0.05	0.1634	0.1634
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0031	0.0191
Entamoeba histolytica	hypothetical protein	0.05	0.1634	1
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0038	0.0084	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0021	0.0089
Trichomonas vaginalis	set domain proteins, putative	0.0272	0.087	0.3644
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0031	0.0295
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0021	0.0021
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0072	0.0072
Brugia malayi	Deoxynucleoside kinase family protein	0.05	0.1634	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Onchocerca volvulus		0.0019	0.0021	0.0245
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0021	0.0089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Onchocerca volvulus		0.0019	0.0021	0.0245
Onchocerca volvulus		0.0034	0.0072	0.0826
Entamoeba histolytica	hypothetical protein	0.05	0.1634	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0072	0.0051
Leishmania major	cathepsin L-like protease	0.0019	0.0021	0.0187
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0072	0.0072
Entamoeba histolytica	hypothetical protein	0.05	0.1634	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0031	0.0295
Loa Loa (eye worm)	deoxynucleoside kinase	0.05	0.1634	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0072	0.0072
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Onchocerca volvulus		0.0272	0.087	1
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0031	0.0031
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0004	0.0026
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0031	0.0031
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0031	0.0191
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0031	0.2841
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0031	0.0295
Toxoplasma gondii	preprocathepsin c precursor, putative	0.1166	0.3866	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0021	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0031	0.001
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0445	0.1447	0.3709
Echinococcus multilocularis	thymidine kinase	0.2996	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0021	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.0131
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0021	0.0089
Trypanosoma brucei	unspecified product	0.0015	0.0008	0.0043
Echinococcus multilocularis	transfer RNA-Ile	0.2996	1	1
Giardia lamblia	Encystation-specific protease	0.0445	0.1447	0.1513
Schistosoma mansoni	thymidine kinase	0.2996	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0008	0.0043
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0031	0.0295
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0021	0.0021
Leishmania major	cysteine peptidase A (CPA)	0.0019	0.0021	0.0187
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0042	0.0099	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0099	0.0415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Trichomonas vaginalis	conserved hypothetical protein	0.05	0.1634	0.6846
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0203	0.217
Onchocerca volvulus		0.0019	0.0021	0.0245
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0021	0.0245
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0031	0.0031
Brugia malayi	Inositol-1	0.0042	0.0099	0.0607
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0072	0.044
Loa Loa (eye worm)	ctsf protein	0.0019	0.0021	0.0131
Trypanosoma brucei	unspecified product	0.0022	0.0031	0.0295
Leishmania major	cathepsin L-like protease	0.0073	0.0203	0.217
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0021	0.0089
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0042	0.0099	0.0415
Leishmania major	cathepsin L-like protease	0.0073	0.0203	0.217
Toxoplasma gondii	cathepsin CPC1	0.1166	0.3866	1
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.05	0.1634	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0445	0.1447	0.3709
Trypanosoma cruzi	thymidine kinase, putative	0.0287	0.0919	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Trichomonas vaginalis	conserved hypothetical protein	0.05	0.1634	0.6846
Trichomonas vaginalis	thymidine kinase, putative	0.0287	0.0919	0.3849
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0004	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Echinococcus multilocularis	thymidine kinase	0.2996	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0021	0.0089
Echinococcus multilocularis	NADH ubiquinone oxidoreductase 42 kDa subunit	0.05	0.1634	0.1616
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0239	0.0759	0.4644
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.1166	0.3866	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0042	0.0099	0.0415
Echinococcus granulosus	cathepsin l1	0.0019	0.0021	0.0021
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0021	0.0131
Entamoeba histolytica	hypothetical protein	0.05	0.1634	1
Echinococcus granulosus	thymidine kinase	0.2996	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0008	0.0043
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0067	0.0181	0.1937
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0021	0.0131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Trypanosoma brucei	unspecified product	0.0015	0.0008	0.0043
Leishmania major	cathepsin L-like protease	0.0019	0.0021	0.0187
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0099	0.1038
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0031	0.2841
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0068	0.0068
Plasmodium vivax	SET domain protein, putative	0.0034	0.0072	0.0131
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0031	0.0131
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0021	0.0131
Schistosoma mansoni	hypothetical protein	0.0059	0.0156	0.0156
Onchocerca volvulus		0.0019	0.0021	0.0245
Brugia malayi	Pre-SET motif family protein	0.0239	0.0759	0.4644
Loa Loa (eye worm)	cysteine protease	0.0019	0.0021	0.0131
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0021	0.0089
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Echinococcus multilocularis	dna polymerase eta	0.0022	0.0031	0.001
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0021	0.0021
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0021	0.0131
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.05	0.1634	1
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0021	0.0245
Brugia malayi	Pre-SET motif family protein	0.0034	0.0072	0.044
Trichomonas vaginalis	thymidine kinase, putative	0.0287	0.0919	0.3849
Giardia lamblia	Thymidine kinase	0.0287	0.0919	0.0948
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0021	0.0089
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.1166	0.3866	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0031	0.0191
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0445	0.1447	0.1513
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0072	0.0072
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0445	0.1447	0.1513
Schistosoma mansoni	inositol monophosphatase	0.0042	0.0099	0.0099
Giardia lamblia	Deoxynucleoside kinase	0.2815	0.9394	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0042	0.0099	0.1038
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0004	0.0026
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0042	0.0099	0.0202
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0021	0.0089
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0031	0.0131
Entamoeba histolytica	thymidine kinase, putative	0.0287	0.0919	0.5622
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0008	0.0043
Leishmania major	DNA polymerase eta, putative	0.0022	0.0031	0.0295
Onchocerca volvulus		0.0019	0.0021	0.0245
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0042	0.0099	0.0607
Onchocerca volvulus		0.0019	0.0021	0.0245
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.1166	0.3866	1
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0021	0.0131
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0031	0.0191
Trichomonas vaginalis	conserved hypothetical protein	0.05	0.1634	0.6846
Trichomonas vaginalis	thymidine kinase, putative	0.0287	0.0919	0.3849
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.1166	0.3866	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0203	0.217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0038	0.0084	1
Trichomonas vaginalis	conserved hypothetical protein	0.05	0.1634	0.6846
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0203	0.217
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.0004	0.0026
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0021	0.0131
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0031	0.001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0021	0.0089
Leishmania major	thymidine kinase, putative	0.0287	0.0919	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0031	0.0295
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.05	0.1634	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.015	0.1595
Echinococcus granulosus	Thymidine kinase 2 mitochondrial	0.2996	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3546380

Bibliographic References

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Detailed information for compound 2073201