Detailed information for compound 2073266

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 210.273 | Formula: C11H18N2O2
  • H donors: 1 H acceptors: 2 LogP: -0.04 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1C(=O)CC2(C1=O)CCCNC2
  • InChi: 1S/C11H18N2O2/c1-2-6-13-9(14)7-11(10(13)15)4-3-5-12-8-11/h12H,2-8H2,1H3
  • InChiKey: KIHMWEMULSIMIP-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0161 0.0391
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0138 0.0761
Trichomonas vaginalis ribokinase, putative 0.0056 0.0155 0.0348
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0158 0.0383
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.2738 1 1
Entamoeba histolytica hypothetical protein 0.0078 0.0236 0.0558
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0072 0.0062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0236 0.0584
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.2738 1 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1069 0.3873 0.3864
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0004 0.0001
Leishmania major tagatose-6-phosphate kinase-like protein 0.0056 0.0155 0.014
Echinococcus multilocularis tar DNA binding protein 0.0207 0.0706 0.1801
Brugia malayi isocitrate dehydrogenase 0.0018 0.0014 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0207 0.0706 0.0702
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0158 0.0358
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0056 0.0155 0.0134
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0068 0.0149
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0072 0.016
Echinococcus multilocularis transfer RNA-Lys 0.0034 0.0072 0.0161
Plasmodium vivax SET domain protein, putative 0.0034 0.0072 0.0058
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.2738 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1069 0.3873 1
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.2738 1 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0158 0.0158
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0236 0.0226
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.1069 0.3873 1
Giardia lamblia DINP protein human, muc B family 0.0021 0.0024 0.0226
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0138 0.0128
Onchocerca volvulus 0.0056 0.0155 0.0671
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0072 0.0062
Onchocerca volvulus 0.0034 0.0072 0.0123
Leishmania major adenosine kinase-like protein 0.0056 0.0155 0.014
Schistosoma mansoni lamin 0.0029 0.0054 0.0044
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0161 0.0391
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0013 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0154 0.0848
Echinococcus granulosus dna polymerase eta 0.0021 0.0024 0.0035
Brugia malayi RNA binding protein 0.0207 0.0706 0.0702
Trichomonas vaginalis ribokinase, putative 0.0056 0.0155 0.0348
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0035 0.002
Brugia malayi MH1 domain containing protein 0.0017 0.001 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0158 0.0148
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0158 0.0144
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0158 0.0144
Brugia malayi mbt repeat family protein 0.0051 0.0135 0.0131
Leishmania major tagatose-6-phosphate kinase-like protein 0.0056 0.0155 0.014
Echinococcus multilocularis ribokinase 0.0056 0.0155 0.0374
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0024 0.0009
Echinococcus multilocularis lamin dm0 0.0029 0.0054 0.0113
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0054 0.028
Schistosoma mansoni dihydroorotate dehydrogenase 0.2738 1 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0013 0.0007
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.1069 0.3873 1
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0135 0.0125
Loa Loa (eye worm) TAR-binding protein 0.0207 0.0706 0.3989
Onchocerca volvulus 0.0034 0.0072 0.0122
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.2738 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0138 0.0332
Brugia malayi bHLH-PAS transcription factor 0.0034 0.0072 0.0068
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0158 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0138 0.0332
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0035 0.002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0013 0.0009
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0437 0.1106
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0014 0.0011
Brugia malayi MH2 domain containing protein 0.0017 0.001 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0035 0.002
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0024 0.0013
Brugia malayi photoreceptor-specific nuclear receptor 0.0283 0.0987 0.0983
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0024 0.0009
Onchocerca volvulus 0.0051 0.0135 0.0543
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0056 0.0155 0.0374
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0014 0.0056
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0024 0.0024
Mycobacterium tuberculosis Adenosine kinase 0.0056 0.0155 0.014
Trypanosoma cruzi adenosine kinase, putative 0.0495 0.1763 0.1751
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0161 0.0151
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0024 0.0009
Brugia malayi Pre-SET motif family protein 0.0034 0.0072 0.0068
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.002 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.028
Echinococcus granulosus lamin 0.0029 0.0054 0.0113
Brugia malayi hypothetical protein 0.0078 0.0236 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0158 0.0358
Brugia malayi Smad1 0.0017 0.001 0.0006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0158 0.0144
Trypanosoma brucei ribokinase, putative 0.0056 0.0155 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0154 0.015
Schistosoma mansoni hypothetical protein 0.0354 0.1249 0.124
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0135 0.0744
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0054 0.028
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0054 0.005
Entamoeba histolytica hypothetical protein 0.0078 0.0236 0.0558
Loa Loa (eye worm) MBCTL1 0.0058 0.0161 0.0891
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1069 0.3873 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0437 0.0424
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0056 0.0155 0.0348
Brugia malayi PAS domain containing protein 0.0046 0.0116 0.0112
Trypanosoma cruzi adenosine kinase, putative 0.0056 0.0155 0.014
Mycobacterium tuberculosis Ribokinase RbsK 0.0056 0.0155 0.014
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0024 0.0035
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0158 0.0874
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0138 0.0128
Trypanosoma brucei protein kinase, putative 0.0057 0.0158 0.0158
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0205 0.0702 0.179
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1069 0.3873 1
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.0864 0.489
Onchocerca volvulus 0.0438 0.1556 1
Entamoeba histolytica kinase, PfkB family 0.0056 0.0155 0.0348
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0024 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0024 0.0024
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1069 0.3873 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0512 0.2886
Loa Loa (eye worm) hypothetical protein 0.0056 0.0155 0.0853
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2738 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0155 0.0853
Schistosoma mansoni aryl hydrocarbon receptor 0.0046 0.0116 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0035 0.002
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0135 0.0324
Echinococcus granulosus GPCR family 2 0.0018 0.0013 0.0007
Trypanosoma brucei adenosine kinase, putative 0.0495 0.1763 0.1763
Schistosoma mansoni ap endonuclease 0.002 0.002 0.001
Giardia lamblia Ribokinase 0.0056 0.0155 0.9731
Leishmania major adenosine kinase, putative 0.0495 0.1763 0.1751
Brugia malayi hypothetical protein 0.0056 0.0155 0.0151
Schistosoma mansoni hypothetical protein 0.0038 0.0088 0.0078
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.2738 1 1
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0056 0.0155 0.014
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0014 0.0011
Echinococcus granulosus tar DNA binding protein 0.0207 0.0706 0.1801
Toxoplasma gondii kinase, pfkB family protein 0.0056 0.0155 0.014
Brugia malayi MH2 domain containing protein 0.0017 0.001 0.0006
Trichomonas vaginalis set domain proteins, putative 0.0269 0.0935 0.2374
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0072 0.016
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0706 0.0697
Onchocerca volvulus Putative pyridoxal kinase 0.0056 0.0155 0.0671
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0024 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0014 0.0011
Echinococcus granulosus geminin 0.0354 0.1249 0.3207
Onchocerca volvulus 0.0269 0.0935 0.5865
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0437 0.0424
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0158 0.0144
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0158 0.0144
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0158 0.0383
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1069 0.3873 1
Brugia malayi Pre-SET motif family protein 0.0236 0.0815 0.0812
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0014 0.0011
Schistosoma mansoni ap endonuclease 0.002 0.002 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0072 0.0062
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0056 0.0155 0.0348
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0024 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0024 0.0003
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0024 0.0008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0024 0.0009
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0014 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0024 0.0009
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0158 0.0144
Brugia malayi hypothetical protein 0.0024 0.0035 0.0031
Schistosoma mansoni DNA polymerase eta 0.0021 0.0024 0.0013
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.2738 1 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0054 0.0044
Brugia malayi MH1 domain containing protein 0.0017 0.001 0.0006
Entamoeba histolytica fructokinase, putative 0.0056 0.0155 0.0348
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.002 0.0091
Onchocerca volvulus 0.0227 0.078 0.4832
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0014 0.0011
Echinococcus multilocularis adenosine kinase 0.0495 0.1763 0.4538
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.002 0.0006
Echinococcus granulosus dna polymerase kappa 0.0021 0.0024 0.0035
Schistosoma mansoni single-minded 0.0046 0.0116 0.0106
Echinococcus multilocularis musashi 0.0029 0.0054 0.0113
Leishmania major putative PfkB family sugar kinase 0.0056 0.0155 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0437 0.0418
Trypanosoma cruzi ribokinase, putative 0.0056 0.0155 0.014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0013 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0072 0.0062
Mycobacterium ulcerans putative regulatory protein 0.0034 0.0072 0.0052
Leishmania major DNA polymerase eta, putative 0.0021 0.0024 0.0009
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.002 0.0027
Trypanosoma cruzi adenosine kinase, putative 0.0056 0.0155 0.014
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.001 0.0032
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1069 0.3873 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0052 0.0269
Brugia malayi Pax transcription factor protein 2 0.0227 0.078 0.0776
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0138 0.0332
Echinococcus granulosus intermediate filament protein 0.0029 0.0054 0.0113
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0013 0.0007
Echinococcus multilocularis geminin 0.0354 0.1249 0.3207
Leishmania major adenosine kinase-like protein 0.0056 0.0155 0.014
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0135 0.0125
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0072 0.0058
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0013 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0158 0.0358
Loa Loa (eye worm) Smad1 0.0017 0.001 0.0032
Trypanosoma cruzi adenosine kinase, putative 0.0495 0.1763 0.1751
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.002 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0706 0.0697
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0478
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0024 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0155 0.0348
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0437 0.0418
Trypanosoma brucei unspecified product 0.0021 0.0024 0.0024
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1069 0.3873 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0013 0.0007
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0161 0.0157
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0135 0.0324
Brugia malayi Ribokinase 0.0056 0.0155 0.0151
Leishmania major hypothetical protein, conserved 0.0024 0.0035 0.002
Leishmania major ribokinase, putative 0.0056 0.0155 0.014
Loa Loa (eye worm) hypoxia-induced factor 1 0.0142 0.0468 0.2637
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1069 0.3873 1
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0135 0.0324
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0088 0.0085
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.002 0.0006
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0437 0.0428
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0024 0.0013
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0437 0.0424
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0236 0.0584
Brugia malayi TAR-binding protein 0.0207 0.0706 0.0702
Brugia malayi Adenosine kinase-like 0.0495 0.1763 0.176
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0706 0.0697
Loa Loa (eye worm) hypothetical protein 0.0283 0.0987 0.5587
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.0006
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0014 0.001
Leishmania major DNA polymerase kappa, putative 0.0021 0.0024 0.0009
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0024 0.0024
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0035 0.0035
Plasmodium falciparum dihydroorotate dehydrogenase 0.2738 1 1
Brugia malayi MH2 domain containing protein 0.025 0.0864 0.0861
Brugia malayi intermediate filament protein 0.0029 0.0054 0.005
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0158 0.0383
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0158 0.0144
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.002 0.0006
Onchocerca volvulus Ribokinase homolog 0.0056 0.0155 0.0671
Mycobacterium ulcerans fructokinase, PfkB 0.0056 0.0155 0.0134
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0437 0.1106
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.002 0.0027
Schistosoma mansoni adenosine kinase 0.0495 0.1763 0.1755
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0706 0.0697
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0135 0.0543
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.002 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0035 0.002
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0003
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.2738 1 1
Echinococcus granulosus single minded 2 0.0034 0.0072 0.0161
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0024 0.0009
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0056 0.0155 0.0374
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0024 0.0009
Echinococcus multilocularis dna polymerase eta 0.0021 0.0024 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0109
Trichomonas vaginalis ribokinase, putative 0.0056 0.0155 0.0348
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.002 0.0006
Schistosoma mansoni hypothetical protein 0.0354 0.1249 0.124
Entamoeba histolytica hypothetical protein 0.0078 0.0236 0.0558
Schistosoma mansoni ribokinase 0.0056 0.0155 0.0145
Brugia malayi MAP kinase sur-1 0.0057 0.0158 0.0154
Trypanosoma brucei adenosine kinase, putative 0.0495 0.1763 0.1763
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0048
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0384
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0172
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.0815 0.4609
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0024 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0138 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0437 0.0428
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0138 0.0134
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.001 0.0032
Toxoplasma gondii kinase, pfkB family protein 0.0495 0.1763 0.1751
Brugia malayi Zinc finger, C2H2 type family protein 0.1069 0.3873 0.387
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0072 0.016
Echinococcus granulosus adenosine kinase 0.0495 0.1763 0.4538
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0003
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0035 0.002
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2738 1 1
Schistosoma mansoni hypothetical protein 0.0078 0.0236 0.0226
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0207 0.0706 0.3989
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0158 0.0358
Brugia malayi hypoxia-induced factor 1 0.0142 0.0468 0.0464
Loa Loa (eye worm) hypothetical protein 0.0056 0.0154 0.0848
Brugia malayi mbt repeat family protein 0.0051 0.0135 0.0131
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.2738 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0014 0.0014
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0205 0.0702 0.179
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0135 0.0324
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0014 0.0011
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1069 0.3873 1
Brugia malayi hypothetical protein 0.0154 0.0512 0.0508
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0138 0.0332
Schistosoma mansoni adenosine kinase 0.0495 0.1763 0.1755
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0024 0.0035
Loa Loa (eye worm) hypothetical protein 0.0058 0.0161 0.0891
Entamoeba histolytica ribokinase, putative 0.0056 0.0155 0.0348
Loa Loa (eye worm) pax transcription factor protein 2 0.0227 0.078 0.4409
Schistosoma mansoni lamin 0.0029 0.0054 0.0044
Schistosoma mansoni hypothetical protein 0.0315 0.1103 0.1094
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0024 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0018 0.0013 0.0003
Echinococcus granulosus ribokinase 0.0056 0.0155 0.0374
Echinococcus multilocularis lamin 0.0029 0.0054 0.0113
Loa Loa (eye worm) hypothetical protein 0.0495 0.1763 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0437 0.0418
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0154 0.015
Schistosoma mansoni tar DNA-binding protein 0.0207 0.0706 0.0697
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Toxoplasma gondii exonuclease III APE 0.002 0.002 0.0006
Entamoeba histolytica hypothetical protein 0.0078 0.0236 0.0558
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0135 0.0125
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0024 0.002
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0161 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0024 0.0024
Loa Loa (eye worm) RNA binding protein 0.0207 0.0706 0.3989
Loa Loa (eye worm) hypothetical protein 0.0051 0.0135 0.0744
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0161 0.0391
Trypanosoma brucei ribokinase, putative 0.0056 0.0155 0.0155
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0024 0.0003
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0158 0.0383
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.0864 0.489
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0024 0.0109
Echinococcus granulosus lamin dm0 0.0029 0.0054 0.0113
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0013 0.0048
Leishmania major dihydroorotate dehydrogenase 0.2738 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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