Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | kinase, pfkB family protein | 0.0495 | 1 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0142 | 0.2613 | 0.2613 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0141 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0495 | 1 | 1 |
Giardia lamblia | Ribokinase | 0.0056 | 0.0824 | 0.5 |
Brugia malayi | hypothetical protein | 0.0056 | 0.0824 | 0.0824 |
Trypanosoma brucei | ribokinase, putative | 0.0056 | 0.0824 | 0.0802 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0056 | 0.0824 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0141 | 0.0117 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.7067 | 0.7067 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0034 | 0.0354 | 0.0354 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0056 | 0.0824 | 0.0802 |
Echinococcus granulosus | geminin | 0.0354 | 0.7067 | 0.7067 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.2863 | 0.2863 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.051 | 0.051 |
Onchocerca volvulus | 0.0438 | 0.882 | 1 | |
Trypanosoma cruzi | adenosine kinase, putative | 0.0056 | 0.0824 | 0.0802 |
Echinococcus granulosus | pseudouridine metabolizing bifunctional protein | 0.0056 | 0.0824 | 0.0824 |
Onchocerca volvulus | Ribokinase homolog | 0.0056 | 0.0824 | 0.0555 |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0056 | 0.0824 | 1 |
Echinococcus granulosus | ribokinase | 0.0056 | 0.0824 | 0.0824 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0024 | 0.0024 |
Schistosoma mansoni | adenosine kinase | 0.0495 | 1 | 1 |
Echinococcus granulosus | adenosine kinase | 0.0495 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0141 | 0.0117 |
Trypanosoma cruzi | ribokinase, putative | 0.0056 | 0.0824 | 0.0802 |
Trypanosoma brucei | ribokinase, putative | 0.0056 | 0.0824 | 0.0802 |
Leishmania major | tagatose-6-phosphate kinase-like protein | 0.0056 | 0.0824 | 0.0802 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0227 | 0.4391 | 0.4391 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0824 | 0.0824 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.0056 | 0.0824 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0824 | 0.0824 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.051 | 0.051 |
Entamoeba histolytica | fructokinase, putative | 0.0056 | 0.0824 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 0.7067 | 0.7067 |
Trichomonas vaginalis | ribokinase, putative | 0.0056 | 0.0824 | 0.5 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0056 | 0.0824 | 1 |
Echinococcus multilocularis | geminin | 0.0354 | 0.7067 | 0.7067 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.0824 | 0.5 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0142 | 0.2613 | 0.2613 |
Brugia malayi | Ribokinase | 0.0056 | 0.0824 | 0.0824 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0141 | 0.0117 |
Echinococcus multilocularis | pseudouridine metabolizing bifunctional protein | 0.0056 | 0.0824 | 0.0824 |
Echinococcus granulosus | single minded 2 | 0.0034 | 0.0354 | 0.0354 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.025 | 0.4874 | 0.4874 |
Entamoeba histolytica | ribokinase, putative | 0.0056 | 0.0824 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0056 | 0.0824 | 0.0802 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.0056 | 0.0824 | 1 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0056 | 0.0824 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0141 | 0.0117 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0024 | 0.0024 |
Brugia malayi | PAS domain containing protein | 0.0046 | 0.0603 | 0.0603 |
Brugia malayi | hypothetical protein | 0.0154 | 0.2863 | 0.2863 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0046 | 0.0603 | 0.0603 |
Leishmania major | adenosine kinase-like protein | 0.0056 | 0.0824 | 0.0802 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0024 | 0.0024 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0141 | 0.0117 |
Brugia malayi | bHLH-PAS transcription factor | 0.0034 | 0.0354 | 0.0354 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.051 | 0.051 |
Mycobacterium tuberculosis | Adenosine kinase | 0.0056 | 0.0824 | 1 |
Leishmania major | tagatose-6-phosphate kinase-like protein | 0.0056 | 0.0824 | 0.0802 |
Trypanosoma brucei | adenosine kinase, putative | 0.0495 | 1 | 1 |
Leishmania major | adenosine kinase-like protein | 0.0056 | 0.0824 | 0.0802 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0024 | 0.0024 |
Leishmania major | ribokinase, putative | 0.0056 | 0.0824 | 0.0802 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0024 | 0.0024 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0141 | 1 |
Leishmania major | adenosine kinase, putative | 0.0495 | 1 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0495 | 1 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0495 | 1 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.0495 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 1 | 1 |
Leishmania major | putative PfkB family sugar kinase | 0.0056 | 0.0824 | 0.0802 |
Brugia malayi | hypothetical protein | 0.0041 | 0.051 | 0.051 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0024 | 0.0024 |
Entamoeba histolytica | kinase, PfkB family | 0.0056 | 0.0824 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.025 | 0.4874 | 0.4874 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0141 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0024 | 0.0024 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0141 | 0.0141 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0024 | 0.0024 |
Onchocerca volvulus | 0.0056 | 0.0824 | 0.0555 | |
Onchocerca volvulus | 0.0227 | 0.4391 | 0.4768 | |
Trichomonas vaginalis | ribokinase, putative | 0.0056 | 0.0824 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0495 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0141 | 0.0141 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.051 | 0.051 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0056 | 0.0824 | 1 |
Brugia malayi | MH2 domain containing protein | 0.025 | 0.4874 | 0.4874 |
Echinococcus multilocularis | ribokinase | 0.0056 | 0.0824 | 0.0824 |
Trichomonas vaginalis | ribokinase, putative | 0.0056 | 0.0824 | 0.5 |
Brugia malayi | Pax transcription factor protein 2 | 0.0227 | 0.4391 | 0.4391 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0283 | 0.5572 | 0.5572 |
Schistosoma mansoni | ribokinase | 0.0056 | 0.0824 | 0.0824 |
Onchocerca volvulus | Putative pyridoxal kinase | 0.0056 | 0.0824 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.5572 | 0.5572 |
Schistosoma mansoni | single-minded | 0.0046 | 0.0603 | 0.0603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.