TDR Targets

Basic information

Technical information

TDR Targets ID: 2073485
Name: 1-[4-hydroxy-4-(1-methylimidazol-2-yl)piperid in-1-yl]-2-phenylethanone
MW: 299.368 | Formula: C17H21N3O2
H donors: 1 H acceptors: 3 LogP: 0.6 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CCC(CC1)(O)c1nccn1C)Cc1ccccc1
InChi: 1S/C17H21N3O2/c1-19-12-9-18-16(19)17(22)7-10-20(11-8-17)15(21)13-14-5-3-2-4-6-14/h2-6,9,12,22H,7-8,10-11,13H2,1H3
InChiKey: LYSXDGCYDCEXBG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[4-hydroxy-4-(1-methylimidazol-2-yl)-1-piperidyl]-2-phenyl-ethanone
1-[4-hydroxy-4-(1-methyl-2-imidazolyl)-1-piperidinyl]-2-phenylethanone
1-[4-hydroxy-4-(1-methylimidazol-2-yl)piperidin-1-yl]-2-phenyl-ethanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0042	0.024	0.024
Schistosoma mansoni	nAChR subunit	0.0078	0.0969	1
Loa Loa (eye worm)	ACC-1 protein	0.0078	0.0969	0.0969
Brugia malayi	Cation transporter family protein	0.0078	0.0969	0.0969
Entamoeba histolytica	hypothetical protein	0.0042	0.024	0.5
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.016	0.2626	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Onchocerca volvulus		0.0078	0.0969	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0078	0.0969	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Brugia malayi	RNA binding protein	0.0034	0.0081	0.0081
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0219	0.3815	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Brugia malayi	hypothetical protein	0.0036	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0078	0.0969	0.0969
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0078	0.0969	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0078	0.0969	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0042	0.024	0.024
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0036	0.0118	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0078	0.0969	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Loa Loa (eye worm)	RNA binding protein	0.0034	0.0081	0.0081
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0078	0.0969	0.0969
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.0081	0.083
Loa Loa (eye worm)	hypothetical protein	0.0142	0.2255	0.2255
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0036	0.0118	0.0118
Loa Loa (eye worm)	ACC-1 protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0078	0.0969	0.0969
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.0969	0.0969
Onchocerca volvulus		0.0078	0.0969	1
Trichomonas vaginalis	hypothetical protein	0.0219	0.3815	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0506	0.9629	0.9629
Onchocerca volvulus		0.0078	0.0969	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0036	0.0118	0.1215
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0078	0.0969	1
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0078	0.0969	0.3692
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0036	0.0118	0.0449
Onchocerca volvulus		0.0042	0.024	0.1437
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0078	0.0969	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Onchocerca volvulus		0.0078	0.0969	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0078	0.0969	0.0969
Echinococcus granulosus	nAChR subunit	0.0078	0.0969	0.3692
Schistosoma mansoni	acetylcholine receptor-related	0.0036	0.0118	0.1215
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.0969	0.0969
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0078	0.0969	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0078	0.0969	0.3692
Brugia malayi	hypothetical protein	0.0036	0.0118	0.0118
Onchocerca volvulus		0.0078	0.0969	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0036	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0042	0.024	0.024
Schistosoma mansoni	nAChR subunit	0.0078	0.0969	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0036	0.0118	0.0118
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.0969	0.0969
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0078	0.0969	0.3692
Loa Loa (eye worm)	MH2 domain-containing protein	0.0059	0.0579	0.0579
Schistosoma mansoni	nAChR subunit	0.0036	0.0118	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0036	0.0118	0.0118
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0078	0.0969	0.0969
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0219	0.3815	0.5
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0078	0.0969	0.0969
Echinococcus granulosus	glycine receptor subunit beta	0.0078	0.0969	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.024	0.024
Loa Loa (eye worm)	acetylcholine receptor protein	0.0036	0.0118	0.0118
Echinococcus multilocularis	glycine receptor subunit beta	0.0078	0.0969	0.3692
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.0081	0.083
Loa Loa (eye worm)	TAR-binding protein	0.0034	0.0081	0.0081
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0036	0.0118	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0078	0.0969	1
Schistosoma mansoni	nAChR subunit	0.0078	0.0969	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0078	0.0969	0.0969
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0078	0.0969	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0219	0.3815	0.5
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0219	0.3815	0.5
Schistosoma mansoni	nAChR subunit	0.0078	0.0969	1
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.0081	0.083
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0078	0.0969	0.3692
Brugia malayi	TAR-binding protein	0.0034	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Brugia malayi	RNA recognition motif domain containing protein	0.0034	0.0081	0.0081
Brugia malayi	hypothetical protein	0.0036	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.013	0.2014	0.2014
Onchocerca volvulus	Putative nachr subunit	0.0078	0.0969	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.0969	0.0969
Brugia malayi	Cation transporter family protein	0.0078	0.0969	0.0969
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0036	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0219	0.3815	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.024	0.024
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0078	0.0969	0.0969
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.016	0.2626	0.2626
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0078	0.0969	0.3692
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0036	0.0118	0.1215
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0042	0.024	0.024
Echinococcus granulosus	glycine receptor subunit beta	0.0078	0.0969	0.3692
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0078	0.0969	0.3692
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0219	0.3815	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0078	0.0969	1
Brugia malayi	Cation transporter family protein	0.0078	0.0969	0.0969
Onchocerca volvulus		0.0078	0.0969	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0042	0.024	0.2478
Schistosoma mansoni	nAChR subunit	0.0078	0.0969	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0078	0.0969	0.3692
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0078	0.0969	0.0969
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0078	0.0969	0.3692
Schistosoma mansoni	neurotransmitter gated ion channel	0.0042	0.024	0.2478
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0036	0.0118	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0042	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0042	0.024	0.024
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0078	0.0969	0.0969
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0078	0.0969	1
Brugia malayi	excitatory GABA receptor EXP-1A	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.003	0	0.5
Schistosoma mansoni	nAChR subunit	0.0036	0.0118	0.1215
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0036	0.0118	0.0118
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.003	0	0.5
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0078	0.0969	0.3692
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.003	0	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0078	0.0969	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0036	0.0118	0.0449
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0219	0.3815	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.016	0.2626	1
Echinococcus multilocularis	tar DNA binding protein	0.0034	0.0081	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0118	0.0118
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.003	0	0.5
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0219	0.3815	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Schistosoma mansoni	nAChR subunit	0.0078	0.0969	1
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0078	0.0969	0.3692
Echinococcus multilocularis	nAChR subunit	0.0078	0.0969	0.3692
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0034	0.0081	0.0081
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0078	0.0969	0.0969
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0078	0.0969	0.3692
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0042	0.024	0.024
Onchocerca volvulus		0.0042	0.024	0.1437
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0036	0.0118	0.0118
Loa Loa (eye worm)	transcription factor SMAD2	0.0059	0.0579	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0524	1	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0042	0.024	0.024
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0042	0.024	0.2478
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0078	0.0969	0.0969
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0078	0.0969	0.3692
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0042	0.024	0.024
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0078	0.0969	0.3692
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.0081	0.083
Loa Loa (eye worm)	hypothetical protein	0.0042	0.024	0.024
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0078	0.0969	0.3692
Schistosoma mansoni	neurotransmitter gated ion channel	0.0036	0.0118	0.1215
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.003	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0078	0.0969	0.0969
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0036	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0042	0.024	0.024
Brugia malayi	hypothetical protein	0.0036	0.0118	0.0118
Echinococcus multilocularis	nAChR subunit	0.0042	0.024	0.0915
Echinococcus granulosus	nAChR subunit	0.0042	0.024	0.0915
Loa Loa (eye worm)	GABA receptor subunit	0.0042	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0078	0.0969	0.3692
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0078	0.0969	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0969	0.0969
Echinococcus granulosus	tar DNA binding protein	0.0034	0.0081	0.0307
Schistosoma mansoni	nAChR subunit	0.0078	0.0969	1
Schistosoma mansoni	tar DNA-binding protein	0.0034	0.0081	0.083
Loa Loa (eye worm)	LGC-31 protein	0.0078	0.0969	0.0969
Brugia malayi	MH2 domain containing protein	0.0059	0.0579	0.0579
Brugia malayi	hypothetical protein	0.0036	0.0118	0.0118
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0078	0.0969	0.3692

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3547782

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2073485