Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.024 | 0.024 |
Schistosoma mansoni | nAChR subunit | 0.0078 | 0.0969 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | Cation transporter family protein | 0.0078 | 0.0969 | 0.0969 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.024 | 0.5 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.016 | 0.2626 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Onchocerca volvulus | 0.0078 | 0.0969 | 1 | |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | RNA binding protein | 0.0034 | 0.0081 | 0.0081 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0219 | 0.3815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0078 | 0.0969 | 0.0969 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.024 | 0.024 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0036 | 0.0118 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | RNA binding protein | 0.0034 | 0.0081 | 0.0081 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0078 | 0.0969 | 0.0969 |
Schistosoma mansoni | tar DNA-binding protein | 0.0034 | 0.0081 | 0.083 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.2255 | 0.2255 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | ACC-1 protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0078 | 0.0969 | 0.0969 |
Onchocerca volvulus | 0.0078 | 0.0969 | 1 | |
Trichomonas vaginalis | hypothetical protein | 0.0219 | 0.3815 | 1 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.9629 | 0.9629 |
Onchocerca volvulus | 0.0078 | 0.0969 | 1 | |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0036 | 0.0118 | 0.1215 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0078 | 0.0969 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0078 | 0.0969 | 0.3692 |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0036 | 0.0118 | 0.0449 |
Onchocerca volvulus | 0.0042 | 0.024 | 0.1437 | |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Onchocerca volvulus | 0.0078 | 0.0969 | 1 | |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0078 | 0.0969 | 0.0969 |
Echinococcus granulosus | nAChR subunit | 0.0078 | 0.0969 | 0.3692 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0036 | 0.0118 | 0.1215 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0078 | 0.0969 | 0.0969 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0078 | 0.0969 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0078 | 0.0969 | 0.3692 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Onchocerca volvulus | 0.0078 | 0.0969 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.024 | 0.024 |
Schistosoma mansoni | nAChR subunit | 0.0078 | 0.0969 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0036 | 0.0118 | 0.0118 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0078 | 0.0969 | 0.0969 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0059 | 0.0579 | 0.0579 |
Schistosoma mansoni | nAChR subunit | 0.0036 | 0.0118 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0036 | 0.0118 | 0.0118 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0078 | 0.0969 | 0.0969 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0219 | 0.3815 | 0.5 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0078 | 0.0969 | 0.0969 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0042 | 0.024 | 0.024 |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0036 | 0.0118 | 0.0118 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0078 | 0.0969 | 0.3692 |
Schistosoma mansoni | tar DNA-binding protein | 0.0034 | 0.0081 | 0.083 |
Loa Loa (eye worm) | TAR-binding protein | 0.0034 | 0.0081 | 0.0081 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0036 | 0.0118 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0078 | 0.0969 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0078 | 0.0969 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0078 | 0.0969 | 0.0969 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0219 | 0.3815 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0219 | 0.3815 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0078 | 0.0969 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0034 | 0.0081 | 0.083 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0078 | 0.0969 | 0.3692 |
Brugia malayi | TAR-binding protein | 0.0034 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0034 | 0.0081 | 0.0081 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.2014 | 0.2014 |
Onchocerca volvulus | Putative nachr subunit | 0.0078 | 0.0969 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | Cation transporter family protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0219 | 0.3815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.024 | 0.024 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.016 | 0.2626 | 0.2626 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0078 | 0.0969 | 0.3692 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0036 | 0.0118 | 0.1215 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0042 | 0.024 | 0.024 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0078 | 0.0969 | 0.3692 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0078 | 0.0969 | 0.3692 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0219 | 0.3815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0078 | 0.0969 | 1 |
Brugia malayi | Cation transporter family protein | 0.0078 | 0.0969 | 0.0969 |
Onchocerca volvulus | 0.0078 | 0.0969 | 1 | |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0042 | 0.024 | 0.2478 |
Schistosoma mansoni | nAChR subunit | 0.0078 | 0.0969 | 1 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0078 | 0.0969 | 0.3692 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0078 | 0.0969 | 0.0969 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0078 | 0.0969 | 0.3692 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0042 | 0.024 | 0.2478 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0036 | 0.0118 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.024 | 0.024 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0078 | 0.0969 | 0.0969 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0078 | 0.0969 | 1 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0036 | 0.0118 | 0.1215 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0036 | 0.0118 | 0.0118 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.003 | 0 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0078 | 0.0969 | 1 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0036 | 0.0118 | 0.0449 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0219 | 0.3815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.016 | 0.2626 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0034 | 0.0081 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.003 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0219 | 0.3815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Schistosoma mansoni | nAChR subunit | 0.0078 | 0.0969 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0078 | 0.0969 | 0.3692 |
Echinococcus multilocularis | nAChR subunit | 0.0078 | 0.0969 | 0.3692 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0034 | 0.0081 | 0.0081 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0078 | 0.0969 | 0.0969 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0078 | 0.0969 | 0.3692 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0042 | 0.024 | 0.024 |
Onchocerca volvulus | 0.0042 | 0.024 | 0.1437 | |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0059 | 0.0579 | 0.0579 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 1 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0042 | 0.024 | 0.024 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0042 | 0.024 | 0.2478 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0078 | 0.0969 | 0.0969 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0078 | 0.0969 | 0.3692 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.024 | 0.024 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0078 | 0.0969 | 0.3692 |
Schistosoma mansoni | tar DNA-binding protein | 0.0034 | 0.0081 | 0.083 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.024 | 0.024 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0078 | 0.0969 | 0.3692 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0036 | 0.0118 | 0.1215 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0036 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.024 | 0.024 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Echinococcus multilocularis | nAChR subunit | 0.0042 | 0.024 | 0.0915 |
Echinococcus granulosus | nAChR subunit | 0.0042 | 0.024 | 0.0915 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0042 | 0.024 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0078 | 0.0969 | 0.3692 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0078 | 0.0969 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0969 | 0.0969 |
Echinococcus granulosus | tar DNA binding protein | 0.0034 | 0.0081 | 0.0307 |
Schistosoma mansoni | nAChR subunit | 0.0078 | 0.0969 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0034 | 0.0081 | 0.083 |
Loa Loa (eye worm) | LGC-31 protein | 0.0078 | 0.0969 | 0.0969 |
Brugia malayi | MH2 domain containing protein | 0.0059 | 0.0579 | 0.0579 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0118 | 0.0118 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0078 | 0.0969 | 0.3692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.