Detailed information for compound 2073508

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 509.539 | Formula: C29H28F3N2O3+
  • H donors: 1 H acceptors: 1 LogP: 6.45 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNC(=O)[C@H]([n+]1ccc2c(c1CCc1ccc(cc1)C(F)(F)F)cc(c(c2)OC)OC)c1ccccc1
  • InChi: 1S/C29H27F3N2O3/c1-33-28(35)27(20-7-5-4-6-8-20)34-16-15-21-17-25(36-2)26(37-3)18-23(21)24(34)14-11-19-9-12-22(13-10-19)29(30,31)32/h4-10,12-13,15-18,27H,11,14H2,1-3H3/p+1/t27-/m1/s1
  • InChiKey: GXLLHVAGVUSWTO-HHHXNRCGSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi chromobox protein homolog 3 0.0047 0.0277 0.0788
Loa Loa (eye worm) hypothetical protein 0.0063 0.0409 0.1169
Echinococcus multilocularis X box binding protein 1 0.023 0.1803 0.1802
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0282 0.102
Echinococcus granulosus para nitrobenzyl esterase 0.007 0.0465 0.0463
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1239 0.6353
Trichomonas vaginalis ornithine decarboxylase, putative 0.0132 0.0988 0.5066
Leishmania major mitochondrial DNA polymerase beta 0.0344 0.2755 1
Echinococcus multilocularis dnaJ subfamily B 0.0327 0.2609 0.2608
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0085 0.0849
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0028 0.0097
Leishmania major ornithine decarboxylase, putative 0.0132 0.0988 0.3583
Schistosoma mansoni voltage-gated cation channel 0.011 0.0797 0.0797
Brugia malayi mbt repeat family protein 0.0054 0.0337 0.096
Echinococcus multilocularis snurportin 1 0.0351 0.281 0.2809
Trichomonas vaginalis ornithine decarboxylase, putative 0.0047 0.0278 0.142
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.04 0.0398
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Echinococcus granulosus dna polymerase kappa 0.0091 0.0641 0.064
Leishmania major DNA polymerase eta, putative 0.009 0.063 0.2284
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.011 0.0797 0.2276
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0213 0.1085
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0091 0.0641 0.3284
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0264 0.2083 0.2081
Echinococcus multilocularis RUN 0.003 0.0137 0.0135
Echinococcus granulosus RUN 0.003 0.0137 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0022 0.0103
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0075 0.0214
Giardia lamblia DNA damage repair protein 0.0019 0.004 0.0392
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.281 0.8035
Schistosoma mansoni chromobox protein 0.0084 0.0585 0.0585
Entamoeba histolytica hypothetical protein 0.0034 0.0163 0.1638
Echinococcus multilocularis ATP binding cassette sub family G 0.0031 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.007 0.0465 0.1329
Schistosoma mansoni chromobox protein 0.0084 0.0585 0.0585
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.011 0.0797 0.0796
Brugia malayi hypothetical protein 0.0075 0.0511 0.1458
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0163 0.0466
Brugia malayi Flap endonuclease-1 0.005 0.0305 0.0867
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0024 0.0088 0.0086
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.005 0.0305 0.1101
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0031 0.014 0.1404
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.0388 0.3919
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.004 0.014
Plasmodium falciparum LCCL domain-containing protein 0.003 0.0137 0.1373
Echinococcus multilocularis flap endonuclease 1 0.005 0.0305 0.0303
Toxoplasma gondii diaminopimelate decarboxylase 0.0132 0.0988 1
Loa Loa (eye worm) hypothetical protein 0.017 0.1298 0.3712
Onchocerca volvulus 0.007 0.0465 0.1945
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0094 0.0671 0.0669
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.0589 0.596
Loa Loa (eye worm) carboxylesterase 0.0413 0.3324 0.9504
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0042 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Brugia malayi Importin beta-1 subunit 0.0033 0.0158 0.0447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0103 0.0296
Echinococcus granulosus Polycystic kidney disease protein 0.003 0.0137 0.0135
Echinococcus multilocularis transcription factor btf3 0.0034 0.0163 0.0162
Brugia malayi CXXC zinc finger family protein 0.0023 0.0075 0.021
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0085 0.0849
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.011 0.0797 0.0796
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0004
Brugia malayi ABC transporter family protein 0.0026 0.0101 0.0285
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0296
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.04 0.0398
Schistosoma mansoni hypothetical protein 0.0079 0.0538 0.0538
Schistosoma mansoni rab6-interacting 0.003 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0296
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.011 0.0797 0.0797
Echinococcus granulosus lipoxygenase domain containing protein 0.003 0.0137 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1239 0.6353
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Echinococcus granulosus acetylcholinesterase 0.0413 0.3324 0.3323
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0213 0.2141
Brugia malayi Carboxylesterase family protein 0.007 0.0465 0.1325
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0082 0.0818
Trypanosoma brucei DNA polymerase eta, putative 0.009 0.063 0.2284
Schistosoma mansoni polycystin 1-related 0.003 0.0137 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0103 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.031 0.1583
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0337 0.0336
Trypanosoma cruzi DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0103 0.0296
Echinococcus granulosus lipoxygenase domain containing protein 0.003 0.0137 0.0135
Schistosoma mansoni rab6-interacting 0.003 0.0137 0.0137
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.007 0.0465 0.2379
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0028 0.0027
Schistosoma mansoni hypothetical protein 0.0298 0.2368 0.2368
Toxoplasma gondii hypothetical protein 0.0056 0.0347 0.3499
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0103 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0018 0.0087
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0103 0.0103
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0017 0.0028 0.0028
Trypanosoma brucei unspecified product 0.0042 0.0231 0.0835
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0067 0.0439 0.159
Echinococcus multilocularis dna polymerase kappa 0.0091 0.0641 0.064
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0103 0.0292
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0103 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0002 0.0002
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0024 0.0088 0.0874
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0277 0.1414
Echinococcus granulosus voltage dependent calcium channel 0.0023 0.0075 0.0073
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0213 0.2141
Schistosoma mansoni tyrosinase precursor 0.0299 0.2373 0.2373
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0296
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0163 0.0587
Echinococcus multilocularis para nitrobenzyl esterase 0.007 0.0465 0.0463
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0413 0.3324 0.9504
Giardia lamblia GTOR 0.0017 0.0028 0.027
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0031 0.014 0.014
Onchocerca volvulus 0.0299 0.2373 0.9972
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0103 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0163 0.083
Loa Loa (eye worm) ABC transporter 0.0026 0.0101 0.0289
Echinococcus granulosus carboxylesterase 5A 0.0413 0.3324 0.3323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0103 0.0292
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0299 0.2373 0.6785
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0103 0.0103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0082 0.0231
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0289 0.0289
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.004 0.014
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0028 0.0028
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.0028 0.0097
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0148
Mycobacterium ulcerans DNA polymerase IV 0.0091 0.0641 0.2136
Echinococcus multilocularis BC026374 protein (S09 family) 0.007 0.0465 0.0463
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0188 0.0188
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0094 0.0671 0.0671
Schistosoma mansoni hypothetical protein 0.0026 0.0098 0.0098
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0103 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Brugia malayi beta-NAC-like protein 0.0034 0.0163 0.0462
Echinococcus granulosus cpg binding protein 0.0024 0.0086 0.0084
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0017 0.0028 0.0097
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0103 0.0292
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0094 0.0671 0.0669
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Plasmodium vivax multidomain scavenger receptor, putative 0.003 0.0137 0.1373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0103 0.0292
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0465 0.0465
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Mycobacterium ulcerans DNA polymerase IV 0.0091 0.0641 0.2136
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0037 0.0188 0.0534
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0017 0.0028 0.027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0103 0.0292
Schistosoma mansoni hypothetical protein 0.0339 0.2707 0.2707
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0213 0.0767
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0314 0.2502 0.2501
Echinococcus granulosus BC026374 protein S09 family 0.007 0.0465 0.0463
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.011 0.0797 0.0796
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0103 0.0292
Onchocerca volvulus 0.007 0.0465 0.1945
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0031 0.014 0.0503
Trypanosoma cruzi target of rapamycin kinase 3 0.0017 0.0028 0.0097
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0103 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1239 0.6353
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0293 0.1058
Plasmodium vivax ABC transporter G family member 2, putative 0.0031 0.014 0.1404
Onchocerca volvulus 0.0023 0.0075 0.0304
Brugia malayi nuclear receptor NHR-88 0.0026 0.0103 0.0292
Onchocerca volvulus 0.0037 0.0192 0.0796
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0103 0.0102
Echinococcus granulosus neuropeptide s receptor 0.0443 0.3581 0.358
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.004 0.014
Loa Loa (eye worm) ShTK domain-containing protein 0.0299 0.2373 0.6785
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0106 0.0536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.04 0.1139
Schistosoma mansoni hypothetical protein 0.0351 0.281 0.281
Leishmania major basic transcription factor 3a, putative 0.0034 0.0163 0.0587
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0103 0.0292
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0207
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0028 0.0098
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0538 0.0537
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0163 0.0587
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0024 0.0088 0.0874
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0337 0.0336
Brugia malayi nuclear hormone receptor 0.0026 0.0103 0.0292
Loa Loa (eye worm) acetyltransferase 0.0314 0.2502 0.7155
Echinococcus granulosus chromobox protein 1 0.0084 0.0585 0.0584
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0042 0.0207
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0092 0.0654 0.661
Echinococcus granulosus neuropeptide receptor A26 0.0443 0.3581 0.358
Loa Loa (eye worm) hypothetical protein 0.011 0.0797 0.2279
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0103 0.0292
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0085 0.0084
Onchocerca volvulus 0.007 0.0465 0.1945
Onchocerca volvulus Phospholipase A2 homolog 0.0299 0.2379 1
Leishmania major DNA damage repair protein, putative 0.0019 0.004 0.014
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.04 0.0398
Schistosoma mansoni cpg binding protein 0.0024 0.0086 0.0086
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0103 0.0296
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.04 0.04
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0085 0.024
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0028 0.0097
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0085 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0337 0.0336
Loa Loa (eye worm) hypothetical protein 0.0299 0.2379 0.6804
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0213 0.0767
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0009 0.0026
Leishmania major GTP-binding protein, putative 0.0024 0.0085 0.0304
Schistosoma mansoni ap endonuclease 0.0039 0.0213 0.0213
Onchocerca volvulus Glucosylceramidase homolog 0.0162 0.1239 0.52
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0031 0.014 0.0355
Mycobacterium leprae cell division protein FtsZ 0.0356 0.2853 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0585 0.0584
Loa Loa (eye worm) hypothetical protein 0.0299 0.2373 0.6785
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0028 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0103 0.0296
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0024 0.0088 0.0874
Schistosoma mansoni hypothetical protein 0.0079 0.0538 0.0538
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0213 0.0767
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0094 0.0671 0.0669
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0068 0.0451 0.128
Leishmania major importin beta-1 subunit, putative 0.0027 0.0106 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0277 0.1414
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0344 0.2755 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0148
Brugia malayi ImpB/MucB/SamB family protein 0.009 0.063 0.1799
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.0589 0.596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Schistosoma mansoni ran 0.0024 0.0085 0.0085
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0024 0.0088 0.0313
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0001 0.0001
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0092 0.0654 0.661
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0054 0.0192
Trichomonas vaginalis flap endonuclease-1, putative 0.005 0.0305 0.1557
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0103 0.0102
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0068 0.0451 0.1632
Mycobacterium ulcerans diaminopimelate decarboxylase LysA 0.0132 0.0988 0.3369
Echinococcus granulosus ATP binding cassette sub family G 0.0031 0.014 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0155
Loa Loa (eye worm) hypothetical protein 0.007 0.0465 0.1329
Brugia malayi ShTK domain containing protein 0.0299 0.2373 0.6784
Mycobacterium tuberculosis Carboxylesterase LipT 0.007 0.0465 0.1331
Onchocerca volvulus 0.0132 0.0988 0.4146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0388 0.0388
Schistosoma mansoni gliotactin 0.007 0.0465 0.0465
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.1242 0.4507
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0307 0.128
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0282 0.2847
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0028 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0188 0.0187
Onchocerca volvulus 0.007 0.0465 0.1945
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0213 0.0211
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0024 0.0088 0.0443
Plasmodium vivax flap endonuclease 1, putative 0.005 0.0305 0.3073
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.004 0.014
Loa Loa (eye worm) hypothetical protein 0.003 0.0137 0.0392
Loa Loa (eye worm) calcium channel 0.011 0.0797 0.2279
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.011 0.0797 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0103 0.0292
Treponema pallidum cell division protein FtsZ 0.0356 0.2853 1
Schistosoma mansoni BC026374 protein (S09 family) 0.007 0.0465 0.0465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0188 0.0188
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0287 0.1038
Echinococcus granulosus GPCR family 2 0.0079 0.0538 0.0537
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0293 0.1058
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0067 0.0439 0.159
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0094 0.0671 0.0669
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0465 0.0465
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0017 0.0028 0.0097
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.011 0.0797 0.0796
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0031 0.014 0.0355
Echinococcus multilocularis acetylcholinesterase 0.0413 0.3324 0.3323
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1239 0.6353
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.0388 0.111
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.004 0.014
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0024 0.0088 0.0247
Schistosoma mansoni hypothetical protein 0.003 0.0137 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0103 0.0296
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0337 0.0964
Schistosoma mansoni ran 0.0024 0.0085 0.0085
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.005 0.0305 0.1101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Entamoeba histolytica hypothetical protein 0.0027 0.0106 0.1058
Toxoplasma gondii target of rapamycin (TOR), putative 0.0017 0.0028 0.027
Schistosoma mansoni hypothetical protein 0.0327 0.2609 0.2609
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0213 0.1085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0296
Entamoeba histolytica Ran family GTPase 0.0024 0.0085 0.0849
Schistosoma mansoni amyloid beta A4 protein related 0.0078 0.0537 0.0537
Onchocerca volvulus 0.0299 0.2373 0.9972
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.011 0.0797 0.0796
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0103 0.0103
Echinococcus granulosus chromobox protein 1 0.0084 0.0585 0.0584
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0028 0.0097
Echinococcus multilocularis dna polymerase eta 0.009 0.063 0.0629
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0085 0.0849
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0162 0.0824
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0337 0.0337
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.007 0.0465 0.0463
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0163 0.1242 0.4507
Entamoeba histolytica Flap nuclease, putative 0.005 0.0305 0.3073
Echinococcus granulosus voltage dependent calcium channel 0.011 0.0797 0.0796
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0028 0.0097
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0037 0.0188 0.0187
Trichomonas vaginalis ran, putative 0.0024 0.0085 0.043
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0213 0.0211
Toxoplasma gondii transporter, cation channel family protein 0.0023 0.0075 0.0743
Entamoeba histolytica ABC transporter, putative 0.0031 0.014 0.1404
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.007 0.0468 0.1333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Echinococcus granulosus ATP binding cassette sub family G 0.0031 0.014 0.0139
Echinococcus multilocularis ATP binding cassette sub family G 0.0031 0.014 0.0139
Onchocerca volvulus 0.0299 0.2373 0.9972
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0103 0.0296
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0103 0.0103
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0103 0.0425
Loa Loa (eye worm) hypothetical protein 0.007 0.0465 0.1329
Brugia malayi hypothetical protein 0.007 0.0465 0.1325
Toxoplasma gondii exonuclease III APE 0.0039 0.0213 0.2141
Schistosoma mansoni neuroligin 3 (S09 family) 0.007 0.0465 0.0465
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0299 0.2373 0.6784
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0248 0.1949 0.5572
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0165 0.1257 0.1255
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0299 0.2373 0.6784
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0017 0.0028 0.0097
Brugia malayi Phospholipase A2 family protein 0.0063 0.0409 0.1166
Leishmania major DNA polymerase kappa, putative 0.0068 0.0451 0.1632
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0103 0.0103
Leishmania major flap endonuclease-1 (FEN-1), putative 0.005 0.0305 0.1101
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0103 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0294 0.1063
Schistosoma mansoni hypothetical protein 0.0094 0.0671 0.0671
Loa Loa (eye worm) apoptosis regulator protein 0.0094 0.0671 0.1918
Loa Loa (eye worm) hypothetical protein 0.0047 0.0277 0.0791
Loa Loa (eye worm) hypothetical protein 0.0433 0.3497 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Schistosoma mansoni hypothetical protein 0.017 0.1298 0.1298
Loa Loa (eye worm) hypothetical protein 0.0094 0.0671 0.1918
Trypanosoma brucei ATP-binding cassette protein, putative 0.0031 0.014 0.0503
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0307 0.1567
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Schistosoma mansoni cpg binding protein 0.0023 0.0075 0.0075
Trypanosoma brucei ABC transporter, putative 0.0031 0.014 0.0503
Echinococcus granulosus amyloid beta A4 protein 0.0078 0.0537 0.0535
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0024 0.0088 0.0251
Schistosoma mansoni hypothetical protein 0.023 0.1803 0.1803
Echinococcus granulosus X box binding protein 1 0.023 0.1803 0.1802
Onchocerca volvulus 0.0299 0.2373 0.9972
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.0451 0.1632
Echinococcus multilocularis voltage dependent calcium channel 0.011 0.0797 0.0796
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Echinococcus granulosus transcription factor btf3 0.0034 0.0163 0.0162
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0103 0.0102
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.0388 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Trypanosoma cruzi DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Echinococcus multilocularis neuropeptide receptor A26 0.0443 0.3581 0.358
Brugia malayi polk-prov protein 0.0049 0.0293 0.0834
Schistosoma mansoni ABC transporter 0.0026 0.0101 0.0101
Trypanosoma brucei DNA polymerase IV, putative 0.0091 0.0641 0.2322
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0296
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0103 0.0102
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0165 0.1257 0.1255
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0163 0.1638
Leishmania major DNA polymerase kappa, putative 0.0019 0.004 0.014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0028 0.0076
Echinococcus multilocularis acetylcholinesterase 0.0413 0.3324 0.3323
Giardia lamblia ABC transporter 0.003 0.0137 0.1374
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.1953 0.5582
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0092 0.0654 0.3349
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0103 0.0102
Trichomonas vaginalis bromodomain-containing protein, putative 0.0092 0.0654 0.3349
Mycobacterium ulcerans cell division protein FtsZ 0.0356 0.2853 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0026 0.0103 0.1027
Loa Loa (eye worm) ShTK domain-containing protein 0.0299 0.2373 0.6785
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.0589 0.596
Echinococcus multilocularis neuropeptide s receptor 0.0443 0.3581 0.358
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.1953 0.5584
Schistosoma mansoni DNA polymerase eta 0.009 0.063 0.063
Brugia malayi Carboxylesterase family protein 0.0413 0.3324 0.9503
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0031 0.014 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0165 0.1257 0.3593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0092 0.0654 0.661
Brugia malayi hypothetical protein 0.003 0.0137 0.0388
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0028 0.0097
Brugia malayi mbt repeat family protein 0.0054 0.0337 0.096
Onchocerca volvulus 0.003 0.0137 0.0566
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0103 0.0102
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0344 0.2755 1
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.004 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1239 0.6353
Trichomonas vaginalis pyridoxal-dependent decarboxylase, putative 0.0132 0.0988 0.5066
Leishmania major DNA polymerase eta, putative 0.0048 0.0282 0.102
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.007 0.0465 0.1331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Trichomonas vaginalis spcc417.12 protein, putative 0.007 0.0465 0.2379
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0059 0.0376 0.1359
Echinococcus multilocularis voltage dependent calcium channel 0.011 0.0797 0.0796
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.0388 0.0387
Trypanosoma cruzi DNA polymerase eta, putative 0.009 0.063 0.2284
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.031 0.313
Echinococcus granulosus flap endonuclease 1 0.005 0.0305 0.0303
Brugia malayi Carboxylesterase family protein 0.007 0.0465 0.1325
Entamoeba histolytica hypothetical protein 0.0024 0.0082 0.0818
Plasmodium vivax importin-beta 2, putative 0.0033 0.0158 0.1583
Giardia lamblia Ornithine decarboxylase 0.0132 0.0988 1
Schistosoma mansoni microtubule-associated protein tau 0.1213 1 1
Brugia malayi Heterochromatin protein 1 0.0084 0.0585 0.167
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0024 0.0088 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0294 0.1063
Brugia malayi Carboxylesterase family protein 0.007 0.0465 0.1325
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0163 0.083
Loa Loa (eye worm) hypothetical protein 0.007 0.0465 0.1329
Echinococcus granulosus snurportin 1 0.0351 0.281 0.2809
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0103 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0103 0.0296
Trypanosoma cruzi DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.007 0.0465 0.1331
Loa Loa (eye worm) hypothetical protein 0.0075 0.0511 0.1461
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0344 0.2755 1
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0103 0.0103
Trypanosoma brucei ornithine decarboxylase 0.0132 0.0988 0.3583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Echinococcus multilocularis cpg binding protein 0.0024 0.0086 0.0084
Schistosoma mansoni loxhd1 0.003 0.0137 0.0137
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0082 0.0082
Brugia malayi Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein 0.0132 0.0988 0.2822
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0248 0.1949 0.557
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0163 0.1638
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0213 0.0767
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.011 0.0797 0.0797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Mycobacterium tuberculosis Cell division protein FtsZ 0.0356 0.2853 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0287 0.1038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0106 0.0536
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0538 0.0537
Loa Loa (eye worm) pyridoxal-dependent decarboxylase 0.0132 0.0988 0.2825
Brugia malayi Common central domain of tyrosinase family protein 0.0299 0.2373 0.6784
Loa Loa (eye worm) hypothetical protein 0.007 0.0465 0.1329
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0082 0.0293
Schistosoma mansoni hypothetical protein 0.0079 0.0538 0.0538
Brugia malayi RNA, U transporter 1 0.0093 0.0663 0.1893
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0024 0.0088 0.0874
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0287 0.1038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0207
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0222 0.1737 0.1736
Trichomonas vaginalis glucosylceramidase, putative 0.0248 0.1949 1
Brugia malayi ecdysteroid receptor 0.0026 0.0103 0.0292
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0082 0.0081
Loa Loa (eye worm) hypothetical protein 0.009 0.063 0.1802
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0538 0.1536
Loa Loa (eye worm) voltage-dependent calcium channel 0.0023 0.0075 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0163 0.083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0433 0.3497 1
Loa Loa (eye worm) doublecortin family protein 0.003 0.0137 0.0392
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0207
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.004 0.014
Giardia lamblia DINP protein human, muc B family 0.0068 0.0451 0.4555
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0388 0.1106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Schistosoma mansoni hypothetical protein 0.0094 0.0671 0.0671
Loa Loa (eye worm) tyrosinase 1 0.0299 0.2373 0.6785
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0017 0.0028 0.0097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0538 0.1536
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.011 0.0797 0.0796
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0207
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0022 0.0103
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0106 0.0536
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0163 0.1242 0.4507
Echinococcus multilocularis carboxylesterase 5A 0.0413 0.3324 0.3323
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0188 0.0187
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0103 0.0102
Echinococcus multilocularis Polycystic kidney disease protein 0.003 0.0137 0.0135
Onchocerca volvulus Phospholipase A2 homolog 0.0063 0.0409 0.171
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.1298 0.3709
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0158 0.0156
Loa Loa (eye worm) hypothetical protein 0.0079 0.0538 0.1539
Trichomonas vaginalis glucosylceramidase, putative 0.0248 0.1949 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0017 0.0028 0.027
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0037 0.0188 0.0538
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0024 0.0088 0.0088
Brugia malayi steroid hormone receptor 0.0026 0.0103 0.0292
Schistosoma mansoni hypothetical protein 0.0298 0.2368 0.2368
Giardia lamblia Flap structure-specific endonuclease 0.005 0.0305 0.3073
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.04 0.0398
Schistosoma mansoni importin beta-1 0.0033 0.0158 0.0158
Loa Loa (eye worm) X11 protein 0.0078 0.0537 0.1534
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0103 0.0102
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0165 0.1257 0.1257
Onchocerca volvulus 0.0054 0.0337 0.1407
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0103 0.0292
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0207
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0585 0.1673
Mycobacterium tuberculosis Conserved hypothetical protein 0.0181 0.1396 0.4711
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0094 0.0671 0.1915
Echinococcus multilocularis geminin 0.0298 0.2368 0.2367
Loa Loa (eye worm) hypothetical protein 0.0037 0.0192 0.0548
Echinococcus granulosus histone acetyltransferase KAT2B 0.0305 0.2429 0.2428
Mycobacterium ulcerans carboxylesterase, LipT 0.007 0.0465 0.151
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0165 0.1257 0.359
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0017 0.0028 0.0097
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0222 0.1737 0.1736
Loa Loa (eye worm) carboxylesterase 0.007 0.0465 0.1329
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0307 0.1567
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1311 0.6728
Loa Loa (eye worm) hypothetical protein 0.007 0.0465 0.1329
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.004 0.0392
Schistosoma mansoni hypothetical protein 0.0079 0.0538 0.0538
Plasmodium falciparum ABC transporter G family member 2 0.0031 0.014 0.1404
Echinococcus multilocularis ATP binding cassette sub family G 0.0031 0.014 0.0139
Plasmodium falciparum flap endonuclease 1 0.005 0.0305 0.3073
Echinococcus granulosus importin subunit beta 1 0.0033 0.0158 0.0156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0042 0.0207
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.004 0.014
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0132 0.0988 1
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0213 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0294 0.1063
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0085 0.0084
Onchocerca volvulus 0.007 0.0465 0.1945
Echinococcus multilocularis lipoxygenase domain containing protein 0.003 0.0137 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0103 0.0292
Loa Loa (eye worm) hypothetical protein 0.003 0.0137 0.0392
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0277 0.1154
Trypanosoma brucei unspecified product 0.0083 0.0578 0.2094
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0413 0.3324 0.3324
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0103 0.0102
Brugia malayi Carboxylesterase family protein 0.0413 0.3324 0.9503
Schistosoma mansoni apoptosis regulator bax 0.0094 0.0671 0.0671
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Brugia malayi Doublecortin family protein 0.003 0.0137 0.0388
Trichomonas vaginalis DNA polymerase eta, putative 0.0091 0.0641 0.3284
Loa Loa (eye worm) hypothetical protein 0.0413 0.3324 0.9504
Leishmania major phosphatidylinositol kinase related protein, putative 0.0017 0.0028 0.0098
Brugia malayi acetyltransferase, GNAT family protein 0.0314 0.2502 0.7153
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0158 0.0567
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0024 0.0088 0.0443
Trichomonas vaginalis glucosylceramidase, putative 0.0248 0.1949 1
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.004 0.014
Brugia malayi Carboxylesterase family protein 0.007 0.0465 0.1325
Echinococcus granulosus histone acetyltransferase KAT2B 0.0092 0.0654 0.0652
Trypanosoma cruzi ABC transporter, putative 0.0031 0.014 0.0503
Toxoplasma gondii hypothetical protein 0.002 0.0052 0.0509
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1239 0.6353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0103 0.0103
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0028 0.008
Loa Loa (eye worm) flap endonuclease-1 0.005 0.0305 0.0871
Loa Loa (eye worm) hypothetical protein 0.007 0.0465 0.1329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0162 0.0824
Echinococcus granulosus neuroligin 0.007 0.0465 0.0463
Mycobacterium ulcerans hypothetical protein 0.0181 0.1396 0.482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0337 0.0336
Echinococcus multilocularis sodium channel protein 0.0046 0.0271 0.027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0028 0.0076
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0085 0.0304
Echinococcus multilocularis neuroligin 0.007 0.0465 0.0463
Brugia malayi CHD4 protein 0.0015 0.0009 0.0022
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0465 0.0465
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0103 0.0102
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0213 0.2141
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0085 0.0849
Trypanosoma brucei DNA polymerase IV, putative 0.0091 0.0641 0.2322
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0314 0.2502 0.2502
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0024 0.0088 0.0313
Echinococcus granulosus family S9 non peptidase ue S09 family 0.007 0.0465 0.0463
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0103 0.0292
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.004 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0103 0.0292
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.005 0.0305 0.3073
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0163 0.0587
Loa Loa (eye worm) hypothetical protein 0.0049 0.0293 0.0838
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0132 0.0988 0.5066
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0024 0.0088 0.0247
Brugia malayi SET domain containing protein 0.0014 0.0002 0.0003
Echinococcus granulosus dnaJ subfamily B 0.0327 0.2609 0.2608
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0103 0.0292
Schistosoma mansoni flap endonuclease-1 0.0046 0.0264 0.0264
Schistosoma mansoni ap endonuclease 0.0039 0.0213 0.0213
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0337 0.0337
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0103 0.0292
Brugia malayi Cell division protein ftsZ 0.0171 0.1308 0.3739
Trichomonas vaginalis glucosylceramidase, putative 0.0248 0.1949 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0103 0.0103
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0287 0.1038
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0009 0.0008
Schistosoma mansoni coup transcription factor 0.0026 0.0103 0.0103
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0213 0.0613
Loa Loa (eye worm) hypothetical protein 0.0054 0.0337 0.0964
Schistosoma mansoni hypothetical protein 0.0094 0.0671 0.0671
Entamoeba histolytica ornithine decarboxylase, putative 0.0132 0.0988 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0585 0.0584
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0296
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0103 0.0102
Schistosoma mansoni tyrosinase precursor 0.0299 0.2373 0.2373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0538 0.1539
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0082 0.0081
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0106 0.0379
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0037 0.0188 0.0188
Loa Loa (eye worm) carboxylesterase 0.007 0.0465 0.1329
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0103 0.0102
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0085 0.0304
Schistosoma mansoni transcription factor btf3 0.0034 0.0163 0.0163
Trypanosoma brucei unspecified product 0.0042 0.0231 0.0835
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0024 0.0088 0.0313
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0337 0.1407
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0024 0.0088 0.0251
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0017 0.0028 0.0027
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0158 0.1583
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0001 0.0001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0103 0.0425
Schistosoma mansoni acetylcholinesterase 0.007 0.0465 0.0465
Plasmodium falciparum importin beta, putative 0.0033 0.0158 0.1583
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0585 0.2997
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0296
Trichomonas vaginalis ornithine decarboxylase, putative 0.0132 0.0988 0.5066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0356 0.2853 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0028 0.0027
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0337 0.0337
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0158 0.0567
Trichomonas vaginalis glucosylceramidase, putative 0.0248 0.1949 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0031 0.014 0.0355
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0031 0.014 0.0503
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0163 0.1638
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0214
Onchocerca volvulus 0.0026 0.0103 0.0425
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0103 0.0425
Brugia malayi hypothetical protein 0.003 0.0137 0.0388
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0213 0.0608
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0103 0.0102
Trypanosoma brucei DNA polymerase IV, putative 0.0083 0.0578 0.2094
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.1311 0.6728
Echinococcus multilocularis microtubule associated protein 2 0.1213 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0082 0.0293
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0037 0.0188 0.0187
Echinococcus granulosus geminin 0.0298 0.2368 0.2367
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0299 0.2373 0.6784
Schistosoma mansoni memapsin-2 (A01 family) 0.0242 0.1899 0.1899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0046 0.0271 0.027
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0213 0.2141
Loa Loa (eye worm) acetylcholinesterase 1 0.0413 0.3324 0.9504
Echinococcus multilocularis amyloid beta A4 protein 0.0078 0.0537 0.0535
Schistosoma mansoni cpg binding protein 0.0024 0.0086 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0162 0.1239 0.6353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0082 0.0414
Echinococcus multilocularis GPCR, family 2 0.0079 0.0538 0.0537
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.004 0.014
Mycobacterium tuberculosis Diaminopimelate decarboxylase LysA (DAP decarboxylase) 0.0132 0.0988 0.323
Brugia malayi Cell division protein ftsZ 0.0176 0.1349 0.3856
Echinococcus granulosus ATP binding cassette sub family G 0.0031 0.014 0.0139
Loa Loa (eye worm) MBCTL1 0.0062 0.04 0.1143
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0017 0.0028 0.0027
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0132 0.0988 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0009 0.0008
Echinococcus multilocularis lipoxygenase domain containing protein 0.003 0.0137 0.0135
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0103 0.0103
Trichomonas vaginalis glucosylceramidase, putative 0.0248 0.1949 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0388 0.1053
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0132 0.0988 0.5066
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0103 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0641 0.2322
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0299 0.2373 0.6784
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0028 0.0137
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0163 0.1638
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0213 0.0416
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0264 0.2083 0.2081
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0024 0.0088 0.0313
Echinococcus granulosus acetylcholinesterase 0.0413 0.3324 0.3323
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0085 0.0244
Loa Loa (eye worm) hypothetical protein 0.0033 0.0158 0.0451
Schistosoma mansoni lipoxygenase 0.003 0.0137 0.0137
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0585 0.2997
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0017 0.0028 0.0097
Loa Loa (eye worm) hypothetical protein 0.0062 0.04 0.1143
Echinococcus granulosus dna polymerase eta 0.009 0.063 0.0629
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.0388 0.0387
Onchocerca volvulus 0.003 0.0137 0.0566
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0017 0.0028 0.0097

Activities

Activity type Activity value Assay description Source Reference
Cmax (ADMET) = 80.4 ng/ml Cmax in healthy human treated with [14C]almorexant at 200 mg, po dosed as single dose ChEMBL. 23431113

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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