Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase | 0.0255 | 0.6051 | 0.6051 |
Plasmodium falciparum | lysophospholipase, putative | 0.0134 | 0.3063 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.009 | 0.1968 | 0.2877 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0134 | 0.3063 | 0.4786 |
Schistosoma mansoni | kinase | 0.0046 | 0.0899 | 0.1485 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0232 | 0.5489 | 0.5489 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0111 | 0.2505 | 0.2505 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0336 | 0.0825 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0134 | 0.3063 | 0.4786 |
Echinococcus multilocularis | citrate lyase subunit beta protein | 0.0023 | 0.032 | 0.032 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0336 | 0.0219 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0198 | 0.4655 | 0.459 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0358 | 0.0358 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0358 | 0.0241 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.009 | 0.1968 | 0.1871 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0358 | 0.0358 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0134 | 0.3063 | 0.4786 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0358 | 0.0358 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0.0336 | 0.0219 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0014 | 0.0091 | 0.0091 |
Mycobacterium ulcerans | glutaminase | 0.0255 | 0.6051 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0024 | 0.0358 | 0.0685 |
Mycobacterium tuberculosis | Conserved protein | 0.0024 | 0.0358 | 0.0685 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0358 | 0.0358 |
Brugia malayi | beta-lactamase family protein | 0.0024 | 0.0358 | 0.0358 |
Onchocerca volvulus | 0.0024 | 0.0358 | 0.1423 | |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0015 | 0.0119 | 0.0096 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0024 | 0.0358 | 0.0685 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0336 | 0.0336 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0119 | 0.0119 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0014 | 0.0091 | 0.0091 |
Trichomonas vaginalis | esterase, putative | 0.0024 | 0.0358 | 0.0067 |
Plasmodium vivax | hypothetical protein, conserved | 0.0024 | 0.0358 | 0.0899 |
Brugia malayi | glutaminase DH11.1 | 0.0255 | 0.6051 | 0.6051 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.009 | 0.1968 | 0.1968 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0.0358 | 0.0241 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0134 | 0.3063 | 0.4786 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0024 | 0.0358 | 0.0067 |
Brugia malayi | isocitrate dehydrogenase | 0.0015 | 0.0119 | 0.0119 |
Toxoplasma gondii | ABC1 family protein | 0.0024 | 0.0358 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0024 | 0.0358 | 0.0591 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0024 | 0.0358 | 0.0067 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0023 | 0.032 | 0.0203 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0134 | 0.3063 | 0.4786 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0358 | 0.0358 |
Brugia malayi | Isocitrate dehydrogenase | 0.0015 | 0.0119 | 0.0119 |
Mycobacterium ulcerans | beta-lactamase | 0.0024 | 0.0358 | 0.0067 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0016 | 0.0016 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0134 | 0.3063 | 0.2979 |
Trichomonas vaginalis | CAMK family protein kinase | 0.009 | 0.1968 | 0.2877 |
Schistosoma mansoni | lipoxygenase | 0.0057 | 0.1157 | 0.1913 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0358 | 0.0067 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0016 | 0.0026 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0134 | 0.3063 | 0.2979 |
Loa Loa (eye worm) | raf kinase | 0.0231 | 0.5461 | 0.5461 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0024 | 0.0358 | 0.0358 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0414 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0081 | 0.1761 | 0.1761 |
Brugia malayi | beta-lactamase | 0.0024 | 0.0358 | 0.0358 |
Trypanosoma cruzi | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0023 | 0.032 | 0.0203 |
Trichomonas vaginalis | glutaminase, putative | 0.0255 | 0.6051 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.009 | 0.1968 | 0.2877 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0015 | 0.0119 | 0.0197 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0414 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0023 | 0.0336 | 0.0825 |
Plasmodium falciparum | lysophospholipase, putative | 0.0134 | 0.3063 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0023 | 0.0336 | 0.0219 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0024 | 0.0358 | 0.0067 |
Giardia lamblia | Kinase, PLK | 0.009 | 0.1968 | 0.5 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0232 | 0.5489 | 0.5489 |
Schistosoma mansoni | rab6-interacting | 0.0014 | 0.0091 | 0.015 |
Leishmania major | hypothetical protein, conserved | 0.0198 | 0.4655 | 0.459 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.009 | 0.1968 | 0.1968 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0015 | 0.0119 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0091 | 0.0091 |
Trichomonas vaginalis | CAMK family protein kinase | 0.009 | 0.1968 | 0.2877 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.009 | 0.1968 | 0.1968 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0024 | 0.0358 | 0.0591 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0016 | 0.0016 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.009 | 0.1968 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0198 | 0.4655 | 0.459 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0024 | 0.0358 | 0.0067 |
Mycobacterium tuberculosis | Conserved protein | 0.0023 | 0.032 | 0.0575 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0336 | 0.0825 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0091 | 0.015 |
Leishmania major | monoglyceride lipase, putative | 0.0134 | 0.3063 | 0.2979 |
Echinococcus granulosus | RUN | 0.0014 | 0.0091 | 0.0091 |
Brugia malayi | hypothetical protein | 0.0015 | 0.013 | 0.013 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0023 | 0.0336 | 0.9081 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0024 | 0.0358 | 0.0358 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0134 | 0.3063 | 0.8446 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0414 | 1 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0134 | 0.3063 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.009 | 0.1968 | 0.2877 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0134 | 0.3063 | 0.2979 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0014 | 0.0091 | 0.0091 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0024 | 0.0358 | 0.0685 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0132 | 0.3006 | 0.3006 |
Loa Loa (eye worm) | beta-lactamase | 0.0024 | 0.0358 | 0.0358 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0414 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.009 | 0.1968 | 0.1871 |
Trypanosoma brucei | polo-like protein kinase | 0.009 | 0.1968 | 0.1871 |
Onchocerca volvulus | 0.0024 | 0.0358 | 0.1423 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0156 | 0.3604 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0024 | 0.0358 | 0.0067 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0134 | 0.3063 | 1 |
Plasmodium vivax | PST-A protein | 0.0134 | 0.3063 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0045 | 0.087 | 0.096 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0.0358 | 0.0241 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0198 | 0.4655 | 0.459 |
Leishmania major | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative | 0.0023 | 0.032 | 0.0203 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0024 | 0.0358 | 0.0685 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0015 | 0.0119 | 0.0119 |
Echinococcus multilocularis | RUN | 0.0014 | 0.0091 | 0.0091 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0014 | 0.0091 | 0.0091 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0024 | 0.0358 | 0.0067 |
Mycobacterium tuberculosis | Conserved protein | 0.0024 | 0.0358 | 0.0685 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0414 | 1 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0024 | 0.0358 | 0.0685 |
Trichomonas vaginalis | CAMK family protein kinase | 0.009 | 0.1968 | 0.2877 |
Brugia malayi | MH2 domain containing protein | 0.0111 | 0.2505 | 0.2505 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0024 | 0.0358 | 0.0685 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0091 | 0.0091 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0232 | 0.5489 | 0.9072 |
Schistosoma mansoni | loxhd1 | 0.0014 | 0.0091 | 0.015 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0414 | 1 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0134 | 0.3063 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0134 | 0.3063 | 0.4786 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0134 | 0.3063 | 0.4786 |
Mycobacterium ulcerans | lysophospholipase | 0.0134 | 0.3063 | 0.4786 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0024 | 0.0358 | 0.0067 |
Brugia malayi | Doublecortin family protein | 0.0014 | 0.0091 | 0.0091 |
Loa Loa (eye worm) | glutaminase 2 | 0.0255 | 0.6051 | 0.6051 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0134 | 0.3063 | 0.4786 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.009 | 0.1968 | 0.1968 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0045 | 0.087 | 0.096 |
Brugia malayi | Raf kinase | 0.0224 | 0.5289 | 0.5289 |
Loa Loa (eye worm) | doublecortin family protein | 0.0014 | 0.0091 | 0.0091 |
Schistosoma mansoni | rab6-interacting | 0.0014 | 0.0091 | 0.015 |
Brugia malayi | beta-lactamase family protein | 0.0024 | 0.0358 | 0.0358 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0414 | 1 | 1 |
Mycobacterium tuberculosis | Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) | 0.0023 | 0.032 | 0.0575 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0091 | 0.0091 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0134 | 0.3063 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0119 | 0.0119 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0024 | 0.0358 | 0.0685 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0015 | 0.0119 | 0.0096 |
Mycobacterium tuberculosis | Conserved protein | 0.0024 | 0.0358 | 0.0685 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0014 | 0.0091 | 0.0091 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0014 | 0.0091 | 0.0091 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0015 | 0.0119 | 0.0119 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0081 | 0.1761 | 0.1761 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.1761 | 0.291 |
Echinococcus granulosus | citrate lyase subunit beta protein | 0.0023 | 0.032 | 0.032 |
Plasmodium falciparum | esterase, putative | 0.0134 | 0.3063 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0134 | 0.3063 | 0.4786 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0414 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.009 | 0.1968 | 0.1871 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0024 | 0.0358 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0358 | 0.0358 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0414 | 1 | 1 |
Schistosoma mansoni | polycystin 1-related | 0.0014 | 0.0091 | 0.015 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0336 | 0.0219 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0111 | 0.2505 | 0.2505 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0024 | 0.0358 | 0.0358 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0414 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.009 | 0.1968 | 0.2877 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0414 | 1 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0024 | 0.0358 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0091 | 0.0091 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0015 | 0.0119 | 0.0119 |
Schistosoma mansoni | serine/threonine protein kinase | 0.009 | 0.1968 | 0.3253 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0.0358 | 0.0241 |
Onchocerca volvulus | 0.0024 | 0.0358 | 0.1423 | |
Schistosoma mansoni | glutaminase | 0.0255 | 0.6051 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0336 | 0.0336 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 35 % | Percent inhibition of estrone-stimulated uterotrophic effect in mice at 50 ug dose | ChEMBL. | 1404234 |
Inhibition (functional) | = 35 % | Percent inhibition of estrone-stimulated uterotrophic effect in mice at 50 ug dose | ChEMBL. | 1404234 |
Inhibition (functional) | = 39 % | Percent inhibition of estrone-stimulated uterotrophic effect in mice at 2 ug dose | ChEMBL. | 1404234 |
Inhibition (functional) | = 39 % | Percent inhibition of estrone-stimulated uterotrophic effect in mice at 2 ug dose | ChEMBL. | 1404234 |
Inhibition (functional) | = 41 % | Percent inhibition of estrone-stimulated uterotrophic effect in mice at 10 ug dose | ChEMBL. | 1404234 |
Inhibition (functional) | = 41 % | Percent inhibition of estrone-stimulated uterotrophic effect in mice at 10 ug dose | ChEMBL. | 1404234 |
Inhibition (functional) | = 65 % | Percent inhibition of estrone-stimulated uterotrophic effect in mice at 250 ug dose | ChEMBL. | 1404234 |
Inhibition (functional) | = 65 % | Percent inhibition of estrone-stimulated uterotrophic effect in mice at 250 ug dose | ChEMBL. | 1404234 |
RBA (binding) | = 0.5 | Relative binding affinity for calf uterine estrogen receptor compared to 17-beta-estradiol (E2) | ChEMBL. | 1404234 |
Relative uterus weight (functional) | = 16.9 | Anti-uterotrophic effect in mice as uterine weight(mg) relative to body weight(g) at 10 ug dose | ChEMBL. | 1404234 |
Relative uterus weight (functional) | = 17.1 | Uterotrophic effect in mice as uterine weight(mg) relative to body weight(g) at 10 ug dose | ChEMBL. | 1404234 |
Relative uterus weight (functional) | = 17.4 | Uterotrophic effect in mice as uterine weight(mg) relative to body weight(g) at 250 ug dose | ChEMBL. | 1404234 |
Relative uterus weight (functional) | = 20.4 | Uterotrophic effect in mice as uterine weight(mg) relative to body weight(g) at 2 ug dose | ChEMBL. | 1404234 |
Relative uterus weight (functional) | = 29.5 | Anti-uterotrophic effect in mice as uterine weight(mg) relative to body weight(g) at 250 ug dose | ChEMBL. | 1404234 |
Relative uterus weight (functional) | = 38.4 | Anti-uterotrophic effect in mice as uterine weight(mg) relative to body weight(g) at 10 ug dose | ChEMBL. | 1404234 |
Relative uterus weight (functional) | = 39.4 | Anti-uterotrophic effect in mice as uterine weight(mg) relative to body weight(g) at 2 ug dose | ChEMBL. | 1404234 |
Relative uterus weight (functional) | = 40.7 | Anti-uterotrophic effect in mice as uterine weight(mg) relative to body weight(g) at 50 ug dose | ChEMBL. | 1404234 |
T/C (functional) | = 0 % | Inhibition of hormone-sensitive MCF-7 mammary tumor cell proliferation at 5*10e-6 M | ChEMBL. | 1404234 |
T/C (functional) | = 0 % | Inhibition of hormone-sensitive MCF-7 mammary tumor cell proliferation at 1*10e-5 M | ChEMBL. | 1404234 |
T/C (functional) | = 0 % | Inhibition of hormone-sensitive MCF-7 mammary tumor cell proliferation at 5*10e-6 M | ChEMBL. | 1404234 |
T/C (functional) | = 0 % | Inhibition of hormone-sensitive MCF-7 mammary tumor cell proliferation at 1*10e-5 M | ChEMBL. | 1404234 |
T/C (functional) | = 1 % | Inhibition of hormone-sensitive MCF-7 mammary tumor cell proliferation at 1*10e-6 M | ChEMBL. | 1404234 |
T/C (functional) | = 1 % | Inhibition of hormone-sensitive MCF-7 mammary tumor cell proliferation at 1*10e-6 M | ChEMBL. | 1404234 |
T/C (functional) | = 14 % | Inhibition of hormone-independent MDA-MB 231 mammary tumor cell proliferation at 1*10e-5 M | ChEMBL. | 1404234 |
T/C (functional) | = 14 % | Inhibition of hormone-independent MDA-MB 231 mammary tumor cell proliferation at 1*10e-5 M | ChEMBL. | 1404234 |
T/C (functional) | = 15 % | Inhibition of hormone-independent MDA-MB 231 mammary tumor cell proliferation at 5*10e-6 M | ChEMBL. | 1404234 |
T/C (functional) | = 15 % | Inhibition of hormone-independent MDA-MB 231 mammary tumor cell proliferation at 5*10e-6 M | ChEMBL. | 1404234 |
T/C (functional) | = 31 % | Inhibition of hormone-independent MDA-MB 231 mammary tumor cell proliferation at 1*10e-6 M | ChEMBL. | 1404234 |
T/C (functional) | = 31 % | Inhibition of hormone-independent MDA-MB 231 mammary tumor cell proliferation at 1*10e-6 M | ChEMBL. | 1404234 |
T/C (functional) | = 71 % | Inhibition of hormone-sensitive MCF-7 mammary tumor cell proliferation at 1*10e-7 M | ChEMBL. | 1404234 |
T/C (functional) | = 71 % | Inhibition of hormone-sensitive MCF-7 mammary tumor cell proliferation at 1*10e-7 M | ChEMBL. | 1404234 |
T/C (functional) | = 100 % | Inhibition of hormone-independent MDA-MB 231 mammary tumor cell proliferation at 1*10e-7 M | ChEMBL. | 1404234 |
T/C (functional) | = 100 % | Inhibition of hormone-independent MDA-MB 231 mammary tumor cell proliferation at 1*10e-7 M | ChEMBL. | 1404234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.