Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Onchocerca volvulus | 0.0024 | 0.0039 | 0.0122 | |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0145 | 0.3094 | 0.3094 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0065 | 0.108 | 0.108 |
Onchocerca volvulus | 0.006 | 0.0942 | 0.298 | |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.021 | 0.4734 | 0.4734 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0138 | 0.2908 | 0.2908 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0259 | 0.0259 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0024 | 0.0039 | 0.0039 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0083 | 0.1534 | 0.1534 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.021 | 0.4734 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.3162 | 0.3162 |
Echinococcus multilocularis | solute carrier family 5 | 0.0046 | 0.0604 | 0.0604 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.021 | 0.4734 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0039 | 0.0039 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0046 | 0.0604 | 0.0604 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.9705 | 0.9705 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.021 | 0.4734 | 1 |
Echinococcus granulosus | RUN | 0.0024 | 0.0039 | 0.0039 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.021 | 0.4734 | 0.4734 |
Onchocerca volvulus | 0.0046 | 0.0604 | 0.1912 | |
Onchocerca volvulus | 0.0033 | 0.0259 | 0.0819 | |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.021 | 0.4734 | 0.4734 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0046 | 0.0604 | 0.0604 |
Schistosoma mansoni | lamin | 0.0033 | 0.0259 | 0.0259 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0039 | 0.0039 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.021 | 0.4734 | 0.4734 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0138 | 0.2908 | 0.2908 |
Brugia malayi | hypothetical protein | 0.0148 | 0.3162 | 0.3162 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0259 | 0.0259 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0039 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0039 | 0.0039 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.021 | 0.4734 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.0046 | 0.0604 | 0.0604 |
Echinococcus granulosus | geminin | 0.0205 | 0.4588 | 0.4588 |
Onchocerca volvulus | 0.0033 | 0.0259 | 0.0819 | |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.021 | 0.4734 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0024 | 0.0039 | 0.0039 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0138 | 0.2905 | 0.4996 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0942 | 0.0942 |
Schistosoma mansoni | inositol transporter | 0.0046 | 0.0604 | 0.0604 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.021 | 0.4734 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0259 | 0.0259 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.3162 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0083 | 0.1534 | 0.1534 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.021 | 0.4734 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0039 | 0.0039 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0073 | 0.1265 | 0.1265 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.021 | 0.4734 | 1 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0073 | 0.1268 | 0.5 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0073 | 0.1268 | 0.5 |
Schistosoma mansoni | high-affinity choline transporter | 0.042 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.3162 | 0.3162 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4588 | 0.4588 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0083 | 0.1534 | 0.1534 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.021 | 0.4734 | 0.4734 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0259 | 0.0259 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.2908 | 0.2908 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3067 | 0.3067 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.021 | 0.4734 | 0.4734 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0259 | 0.0259 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.021 | 0.4734 | 0.4734 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.021 | 0.4734 | 0.5 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.021 | 0.4734 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3067 | 0.3067 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0039 | 0.0039 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.0259 | 0.0259 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0259 | 0.0259 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0138 | 0.2908 | 0.2908 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.042 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0046 | 0.0604 | 0.0604 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0259 | 0.0259 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0046 | 0.0604 | 0.0604 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.021 | 0.4734 | 0.4734 |
Schistosoma mansoni | polycystin 1-related | 0.0024 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.042 | 1 | 1 |
Echinococcus multilocularis | RUN | 0.0024 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0145 | 0.3094 | 0.3094 |
Schistosoma mansoni | inositol transporter | 0.0046 | 0.0604 | 0.0604 |
Schistosoma mansoni | sodium/solute symporter | 0.0046 | 0.0604 | 0.0604 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0039 | 0.0039 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.042 | 1 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0024 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3067 | 0.3067 |
Schistosoma mansoni | lamin | 0.0033 | 0.0259 | 0.0259 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.021 | 0.4734 | 1 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.021 | 0.4734 | 1 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0046 | 0.0604 | 0.0604 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.021 | 0.4734 | 0.5 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0039 | 0.0039 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0138 | 0.2908 | 0.4737 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0604 | 0.0604 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.021 | 0.4734 | 1 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0046 | 0.0604 | 0.0604 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.3162 | 1 |
Brugia malayi | Doublecortin family protein | 0.0024 | 0.0039 | 0.0039 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4588 | 0.4588 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.9705 | 0.9705 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0244 | 0.0244 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.021 | 0.4734 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.0046 | 0.0604 | 0.0604 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.0039 | 0.0039 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0067 | 0.1117 | 0.1117 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.021 | 0.4734 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0138 | 0.2908 | 0.2908 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0259 | 0.0259 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0067 | 0.1117 | 0.1117 |
Onchocerca volvulus | 0.0024 | 0.0039 | 0.0122 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0942 | 0.0942 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0024 | 0.0039 | 0.0039 |
Schistosoma mansoni | lipoxygenase | 0.0067 | 0.1117 | 0.1117 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0138 | 0.2908 | 0.4737 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.021 | 0.4734 | 0.4734 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Brugia malayi | hypothetical protein | 0.0083 | 0.1534 | 0.1534 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0046 | 0.0604 | 0.0604 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.1534 | 0.1534 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0259 | 0.0259 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.021 | 0.4734 | 1 |
Schistosoma mansoni | loxhd1 | 0.0024 | 0.0039 | 0.0039 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0138 | 0.2905 | 0.4996 |
Echinococcus multilocularis | geminin | 0.0205 | 0.4588 | 0.4588 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.