Detailed information for compound 2073841

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.882 | Formula: C22H25ClO8
  • H donors: 5 H acceptors: 5 LogP: 0.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C(c1cc(ccc1Cl)[C@]12OC[C@@](O1)(CO)[C@H]([C@@H]([C@H]2O)O)O)O
  • InChi: 1S/C22H25ClO8/c1-2-29-14-6-3-12(4-7-14)17(25)15-9-13(5-8-16(15)23)22-20(28)18(26)19(27)21(10-24,31-22)11-30-22/h3-9,17-20,24-28H,2,10-11H2,1H3/t17?,18-,19-,20+,21-,22-/m0/s1
  • InChiKey: XLJINMDXOSTAIJ-BHPIROGQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0105 0.0245 0.1216
Trypanosoma brucei adenosine transporter 2, putative 0.0032 0.0053 0.1249
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0024 0.0104
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0018 0.0092
Echinococcus granulosus sex peptide receptor 0.078 0.2019 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Trypanosoma cruzi nucleoside transporter-like, putative 0.0032 0.0053 0.1249
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0002 0.001
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0008 0.0041
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0108 0.0252 0.6254
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0049 0.017
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.078 0.2019 0.7331
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0044 0.0153
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Schistosoma mansoni biogenic amine (5HT) receptor 0.078 0.2019 1
Onchocerca volvulus 0.083 0.2151 1
Loa Loa (eye worm) cysteine protease 0.0019 0.0018 0.006
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0018 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Schistosoma mansoni neuropeptide receptor 0.078 0.2019 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0057 0.0118 0.0422
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Brugia malayi sulfakinin receptor protein 0.078 0.2019 0.7331
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0158 0.0785
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0032 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.078 0.2019 1
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.0085
Brugia malayi Cytochrome P450 family protein 0.003 0.0049 0.017
Loa Loa (eye worm) ctsf protein 0.0019 0.0018 0.006
Echinococcus granulosus histone lysine methyltransferase setb 0.0105 0.0245 0.1216
Entamoeba histolytica acyl-coA synthetase, putative 0.0015 0.0008 0.0138
Brugia malayi G-protein coupled receptor 0.078 0.2019 0.7331
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0059 0.0264
Loa Loa (eye worm) hypothetical protein 0.0123 0.0293 0.1056
Echinococcus granulosus neuropeptides capa receptor 0.078 0.2019 1
Loa Loa (eye worm) runx1 0.0065 0.0139 0.0498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Schistosoma mansoni chromobox protein 0.0014 0.0005 0.0026
Onchocerca volvulus 0.006 0.0127 0.058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0122 0.0435
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0165 0.0402 1
Loa Loa (eye worm) neuropeptide F receptor 0.078 0.2019 0.7331
Brugia malayi follicle stimulating hormone receptor 0.106 0.2754 1
Brugia malayi chromobox protein homolog 3 0.0014 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0257 0.0644 0.2048
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0082 0.1932
Trichomonas vaginalis hypothetical protein 0.0014 0.0005 0.0015
Echinococcus multilocularis 6 phosphofructokinase 0.0127 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0046
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.003 0.0047 0.0208
Echinococcus granulosus tm gpcr rhodopsin 0.078 0.2019 1
Echinococcus granulosus dnaJ subfamily B 0.0459 0.1174 0.5814
Schistosoma mansoni opsin-like receptor 0.078 0.2019 1
Schistosoma mansoni biogenic amine receptor 0.078 0.2019 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0008 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.078 0.2019 1
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.0085
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0015 0.0046
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0082 0.0372
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.078 0.2019 0.2019
Leishmania major trypanothione reductase 0.0113 0.0265 0.6562
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0012 0.0046
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0059 0.1351
Echinococcus granulosus neuropeptide Y receptor 0.078 0.2019 1
Schistosoma mansoni cpg binding protein 0.0032 0.0053 0.0265
Loa Loa (eye worm) MH2 domain-containing protein 0.0145 0.035 0.1265
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0302 0.1396
Schistosoma mansoni peptide (allatostatin)-like receptor 0.078 0.2019 1
Echinococcus granulosus tm gpcr rhodopsin 0.078 0.2019 1
Trichomonas vaginalis glutathione reductase, putative 0.0039 0.0071 0.0323
Brugia malayi Pre-SET motif family protein 0.0105 0.0245 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Loa Loa (eye worm) helicase 0.0014 0.0005 0.0012
Echinococcus granulosus peptide allatostatin:somatostatin 0.078 0.2019 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.0082 0.0672
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0032 0.0053 0.0235
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Brugia malayi Dopamine receptor protein 1 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Leishmania major 4-coumarate:coa ligase-like protein 0.0015 0.0008 0.0141
Echinococcus multilocularis g protein coupled receptor 0.078 0.2019 0.2019
Brugia malayi hypothetical protein 0.0516 0.1326 0.4812
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0158 0.3887
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0139 0.3377
Brugia malayi larval opioid receptor 0.078 0.2019 0.7331
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0302 0.6686
Onchocerca volvulus 0.078 0.2019 0.9387
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0165 0.0402 1
Onchocerca volvulus 0.078 0.2019 0.9387
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0082 0.0082
Echinococcus granulosus orexin receptor type 2 0.078 0.2019 1
Echinococcus multilocularis fmrfamide receptor 0.078 0.2019 0.2019
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.1204 0.3133 1
Onchocerca volvulus 0.0119 0.0282 0.1302
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0039 0.0071 0.1667
Plasmodium vivax vivapain-2 0.0019 0.0018 0.0333
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0005 0.00000000027121
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0183 0.0451 0.2087
Onchocerca volvulus 0.078 0.2019 0.9387
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0005 0.0005
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0183 0.0451 0.2088
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0396
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0257 0.0644 0.2048
Echinococcus multilocularis lamin 0.003 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0257 0.0644 0.894
Onchocerca volvulus 0.078 0.2019 0.9387
Loa Loa (eye worm) hypothetical protein 0.003 0.0049 0.017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0018 0.0018
Trypanosoma cruzi nucleoside transporter 1, putative 0.0032 0.0053 0.1249
Echinococcus multilocularis neuropeptide receptor A26 0.078 0.2019 0.2019
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0005 0.001
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0012 0.0046
Echinococcus multilocularis Ankyrin 0.0018 0.0015 0.0015
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0165 0.0402 1
Echinococcus granulosus neuropeptide Y receptor 0.078 0.2019 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0076
Leishmania major nucleoside transporter 1, putative 0.0032 0.0053 0.1249
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.078 0.2019 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.078 0.2019 0.7331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Echinococcus multilocularis cysteine protease 0.0019 0.0018 0.0018
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0108 0.0253 0.1251
Schistosoma mansoni hypothetical protein 0.0206 0.051 0.2525
Trypanosoma cruzi nucleobase transporter, putative 0.0032 0.0053 0.1249
Echinococcus granulosus chromobox protein 1 0.0014 0.0005 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0055
Echinococcus multilocularis neuropeptides capa receptor 0.078 0.2019 0.2019
Schistosoma mansoni histamine h1 receptor 0.078 0.2019 1
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0114 0.0268 0.0966
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0008 0.0138
Entamoeba histolytica hypothetical protein 0.0014 0.0005 0.0071
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0108 0.0253 0.0911
Brugia malayi hypothetical protein 0.0382 0.0974 0.353
Schistosoma mansoni lozenge 0.0065 0.0139 0.0689
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0127 0.0302 0.0956
Echinococcus granulosus g protein coupled receptor 0.078 0.2019 1
Onchocerca volvulus 0.0084 0.0191 0.0877
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Leishmania major nucleoside transporter 1, putative 0.0032 0.0053 0.1249
Trypanosoma cruzi nucleobase transporter, putative 0.0032 0.0053 0.1249
Echinococcus granulosus G protein coupled receptor 139 0.078 0.2019 1
Echinococcus multilocularis neuropeptide Y receptor 0.078 0.2019 0.2019
Trypanosoma brucei adenosine transporter 2, putative 0.0032 0.0053 0.1249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.0276 0.0694 0.2513
Schistosoma mansoni hypothetical protein 0.0459 0.1174 0.5814
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0018 0.0076
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0032 0.0053 0.1249
Leishmania major nucleobase transporter 0.0032 0.0053 0.1249
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0108 0.0252 0.6254
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0014 0.0005 0.0015
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0302 0.1396
Onchocerca volvulus 0.0019 0.0018 0.0076
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0059 0.1351
Echinococcus multilocularis g protein coupled receptor 0.078 0.2019 0.2019
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0082 0.0588
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0084 0.0084
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.078 0.2019 1
Echinococcus granulosus death domain containing protein 0.0017 0.0015 0.0073
Schistosoma mansoni amine GPCR 0.078 0.2019 1
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0032 0.0053 0.1249
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0165 0.0402 1
Echinococcus granulosus Chromobox protein 3 0.0014 0.0005 0.0026
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0039 0.0071 0.1721
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.001 0.0029
Echinococcus granulosus chromobox protein 2 0.0014 0.0005 0.0026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0071 0.1721
Echinococcus multilocularis rhodopsin orphan GPCR 0.078 0.2019 0.2019
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.0778 0.2014 0.9971
Onchocerca volvulus 0.0015 0.0008 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Schistosoma mansoni opsin-like receptor 0.078 0.2019 1
Echinococcus granulosus biogenic amine 5HT receptor 0.078 0.2019 1
Echinococcus multilocularis dro:myosuppressin receptor 0.078 0.2019 0.2019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0165 0.0402 0.1991
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0005 0.0026
Schistosoma mansoni lamin 0.003 0.0049 0.0242
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Echinococcus multilocularis cysteine protease 0.0019 0.0018 0.0018
Schistosoma mansoni lamin 0.003 0.0049 0.0242
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0008 0.0141
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0032 0.0053 0.0235
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0084 0.0417
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0108 0.0253 0.0911
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0039 0.0071 0.0354
Onchocerca volvulus 0.078 0.2019 0.9387
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.006
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0165 0.0402 1
Brugia malayi hypothetical protein 0.0149 0.036 0.1301
Echinococcus granulosus neuropeptide FF receptor 2 0.078 0.2019 1
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0032 0.0053 0.1249
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0059 0.0264
Brugia malayi PAS domain containing protein 0.0114 0.0268 0.0968
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0005 0.0015
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0183 0.0451 0.2087
Plasmodium vivax glutathione reductase, putative 0.0113 0.0265 0.654
Trypanosoma brucei trypanothione reductase 0.0113 0.0265 0.6562
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0022
Echinococcus multilocularis g protein coupled receptor 0.078 0.2019 0.2019
Echinococcus multilocularis orexin receptor type 2 0.078 0.2019 0.2019
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0032 0.0053 0.1249
Schistosoma mansoni opsin-like receptor 0.078 0.2019 1
Giardia lamblia Hypothetical protein 0.0183 0.0451 1
Brugia malayi Protein kinase domain containing protein 0.0017 0.0015 0.0046
Onchocerca volvulus Neuropeptide F receptor homolog 0.078 0.2019 0.9387
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0396
Schistosoma mansoni biogenic amine (dopamine) receptor 0.078 0.2019 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0008 0.0022
Mycobacterium leprae Possible regulatory protein 0.003 0.0047 0.0541
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.078 0.2019 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0046
Brugia malayi Pre-SET motif family protein 0.0729 0.1886 0.6847
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.0063
Leishmania major ATP-dependent phosphofructokinase 0.0127 0.0302 0.7495
Schistosoma mansoni amine GPCR 0.078 0.2019 1
Schistosoma mansoni biogenic amine receptor 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Schistosoma mansoni biogenic amine (5HT) receptor 0.078 0.2019 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.078 0.2019 0.2019
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0005 0.0071
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0012 0.0035
Trypanosoma brucei nucleoside transporter 1, putative 0.0032 0.0053 0.1249
Echinococcus granulosus g-protein coupled receptor 0.078 0.2019 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0057 0.0118 0.0541
Schistosoma mansoni hypothetical protein 0.0206 0.051 0.2525
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0051 0.0103 0.2514
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0396
Plasmodium falciparum glutathione reductase 0.0113 0.0265 0.654
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.078 0.2019 0.2019
Onchocerca volvulus 0.0015 0.0008 0.0029
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0285 0.0719 1
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0165 0.0402 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.078 0.2019 1
Onchocerca volvulus 0.0056 0.0117 0.0533
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0015 0.0008 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0082 0.178
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0302 0.1496
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0032 0.0053 0.1249
Schistosoma mansoni rhodopsin-like orphan GPCR 0.078 0.2019 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0008 0.0017
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0039 0.0071 0.1721
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0165 0.0402 0.1862
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0084 0.0383
Onchocerca volvulus 0.078 0.2019 0.9387
Trichomonas vaginalis adenylate cyclase, putative 0.003 0.0047 0.0208
Echinococcus multilocularis microtubule associated protein 2 0.0778 0.2014 0.2014
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0008 0.0075
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0039 0.0071 0.1667
Echinococcus granulosus lamin dm0 0.003 0.0049 0.0242
Echinococcus granulosus cathepsin l1 0.0013 0.0002 0.001
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0165 0.0402 0.8917
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0024 0.0104
Brugia malayi hypothetical protein 0.0183 0.0451 0.163
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0024 0.0104
Schistosoma mansoni adenoreceptor 0.078 0.2019 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.078 0.2019 0.9387
Brugia malayi CXXC zinc finger family protein 0.0032 0.0053 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0119 0.0282 0.1396
Brugia malayi Death domain containing protein 0.0017 0.0015 0.0046
Trypanosoma cruzi nucleobase transporter, putative 0.0032 0.0053 0.1249
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0005 0.0005
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0012 0.0231
Echinococcus multilocularis neuropeptide Y receptor 0.078 0.2019 0.2019
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0165 0.0402 1
Onchocerca volvulus 0.0019 0.0018 0.0076
Leishmania major protein kinase, putative 0.003 0.0047 0.1103
Onchocerca volvulus 0.0019 0.0018 0.0076
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0051 0.0103 0.2514
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0032 0.0053 0.0235
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0008 0.0141
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0012
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0059 0.1351
Plasmodium vivax thioredoxin reductase, putative 0.0113 0.0265 0.654
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Echinococcus multilocularis cpg binding protein 0.0034 0.0058 0.0058
Onchocerca volvulus 0.078 0.2019 0.9387
Entamoeba histolytica acyl-CoA synthetase, putative 0.0015 0.0008 0.0138
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0008 0.0022
Schistosoma mansoni neuropeptide receptor 0.078 0.2019 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0008 0.0022
Onchocerca volvulus 0.0123 0.0292 0.135
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0071 0.1721
Brugia malayi Serotonin receptor 0.078 0.2019 0.7331
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0008 0.0017
Trypanosoma cruzi nucleoside transporter-like, putative 0.0032 0.0053 0.1249
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) RecQ helicase 0.0024 0.0032 0.0109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0005 0.0015
Loa Loa (eye worm) oxidoreductase 0.0015 0.0008 0.0022
Echinococcus granulosus bloom syndrome protein 0.0024 0.0032 0.0159
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0005 0.0071
Plasmodium vivax SET domain protein, putative 0.0105 0.0245 0.6053
Trypanosoma brucei adenosine transporter 2, putative 0.0032 0.0053 0.1249
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Brugia malayi putative neuropeptide receptor 0.078 0.2019 0.7331
Schistosoma mansoni ap endonuclease 0.0043 0.0082 0.0406
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.078 0.2019 0.7331
Echinococcus multilocularis alpha 1A adrenergic receptor 0.078 0.2019 0.2019
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0005 0.0015
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0165 0.0402 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0108 0.0252 0.4941
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0012 0.0231
Onchocerca volvulus 0.078 0.2019 0.9387
Brugia malayi 6-phosphofructokinase 0.0127 0.0302 0.109
Echinococcus multilocularis transfer RNA-Lys 0.0084 0.0191 0.0191
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0018 0.0366
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0071 0.1721
Echinococcus multilocularis neuropeptide receptor 0.078 0.2019 0.2019
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0008 0.0141
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0032 0.0053 0.1249
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.078 0.2019 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0082 0.0406
Onchocerca volvulus 0.0015 0.0008 0.0029
Schistosoma mansoni alpha glucosidase 0.0044 0.0084 0.0417
Echinococcus multilocularis rhodopsin orphan GPCR 0.078 0.2019 0.2019
Echinococcus granulosus tm gpcr rhodopsin 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Leishmania major cathepsin L-like protease 0.0019 0.0018 0.0396
Brugia malayi Glycosyl hydrolases family 31 protein 0.0198 0.0489 0.177
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0005 0.0015
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.003 0.0047 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0165 0.0402 0.1862
Echinococcus multilocularis chromobox protein 1 0.0014 0.0005 0.0005
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0007 0.0007
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0165 0.0402 0.1454
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0084 0.0383
Schistosoma mansoni biogenic amine receptor 0.078 0.2019 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.078 0.2019 1
Trypanosoma brucei glucosidase, putative 0.0044 0.0084 0.2044
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0183 0.0451 0.2232
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0165 0.0402 0.0402
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0165 0.0402 0.8917
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0057 0.0118 0.037
Brugia malayi AKH receptor 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0164
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0039 0.0071 0.1667
Echinococcus granulosus dro:myosuppressin receptor 0.078 0.2019 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.001 0.005
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0005 0.0026
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0165 0.0402 1
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0302 0.6686
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0183 0.0451 0.163
Leishmania major cathepsin L-like protease 0.0072 0.0158 0.3887
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0057 0.0118 0.155
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0059 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Echinococcus multilocularis neuropeptides capa receptor 0.078 0.2019 0.2019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0008 0.0017
Plasmodium falciparum glutathione reductase 0.0039 0.0071 0.1667
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0008 0.0017
Loa Loa (eye worm) TYRA-2 protein 0.078 0.2019 0.7331
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0008 0.0017
Echinococcus granulosus GPCR family 2 0.0018 0.0017 0.0085
Brugia malayi neuropeptide F receptor 0.078 0.2019 0.7331
Onchocerca volvulus Huntingtin homolog 0.0149 0.036 0.1666
Schistosoma mansoni equilibrative nucleoside transporter 0.0032 0.0053 0.026
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0165 0.0402 0.8917
Schistosoma mansoni hypothetical protein 0.078 0.2019 1
Schistosoma mansoni neuropeptide F-like receptor 0.078 0.2019 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0302 0.7495
Schistosoma mansoni hypothetical protein 0.078 0.2019 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0017 0.0055
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0017 0.0085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0071 0.1721
Schistosoma mansoni protein kinase 0.0032 0.0053 0.026
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.1204 0.3133 1
Schistosoma mansoni amine GPCR 0.078 0.2019 1
Echinococcus multilocularis somatostatin receptor 0.078 0.2019 0.2019
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0158 0.3887
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0149 0.036 0.1301
Mycobacterium ulcerans putative regulatory protein 0.0084 0.0191 0.0583
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0084 0.0383
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0059 0.1351
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0082 0.0253
Brugia malayi M-phase phosphoprotein, mpp8 0.0123 0.0292 0.1054
Loa Loa (eye worm) thioredoxin reductase 0.0113 0.0265 0.0955
Onchocerca volvulus 0.003 0.0049 0.0217
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0109 0.0256 0.1267
Schistosoma mansoni neuropeptide receptor 0.078 0.2019 1
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0005 0.0026
Plasmodium falciparum thioredoxin reductase 0.0113 0.0265 0.654
Echinococcus multilocularis geminin 0.0206 0.051 0.051
Brugia malayi Serotonin/octopamine receptor family protein 7 0.078 0.2019 0.7331
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0047 0.1103
Echinococcus granulosus biogenic amine 5HT receptor 0.078 0.2019 1
Schistosoma mansoni intermediate filament proteins 0.003 0.0049 0.0242
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0084 0.0383
Entamoeba histolytica hypothetical protein 0.0014 0.0005 0.0071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Echinococcus multilocularis serotonin receptor 0.078 0.2019 0.2019
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0018 0.0018
Schistosoma mansoni single-minded 0.0114 0.0268 0.1329
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0018 0.006
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.078 0.2019 0.2019
Onchocerca volvulus 0.0019 0.0018 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0084 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0047 0.0208
Onchocerca volvulus 0.0123 0.0292 0.135
Onchocerca volvulus 0.0032 0.0053 0.0239
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0039 0.0071 0.0202
Echinococcus granulosus equilibrative nucleoside transporter 0.0183 0.0451 0.2232
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.0085
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.006
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0082 0.0236
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0165 0.0402 0.876
Onchocerca volvulus 0.003 0.0047 0.0208
Schistosoma mansoni netrin receptor unc5 0.0017 0.0015 0.0073
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0039 0.0071 0.1721
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0005 0.0015
Mycobacterium ulcerans 6-phosphofructokinase 0.0127 0.0302 0.094
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0018 0.0333
Brugia malayi CHD4 protein 0.0016 0.001 0.0029
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0084 0.0383
Trypanosoma brucei unspecified product 0.0032 0.0053 0.1249
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.003 0.0047 0.0047
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0108 0.0253 0.1166
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0257 0.0644 0.2048
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0008 0.0141
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0015 0.0073
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0032 0.014
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0285 0.0719 0.2289
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Trypanosoma brucei adenosine transporter 2, putative 0.0032 0.0053 0.1249
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.078 0.2019 0.2019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0105 0.0245 0.0245
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0114 0.0268 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0005 0.0015
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0082 0.0372
Brugia malayi ORL1-like opioid receptor 0.078 0.2019 0.7331
Schistosoma mansoni chromobox protein 0.0014 0.0005 0.0026
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0071 0.1721
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.0085
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.036 0.1301
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0008 0.0141
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0018 0.0092
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0127 0.0302 0.7084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0076
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0005 0.0015
Toxoplasma gondii nucleoside transporter protein 0.0032 0.0053 0.1191
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Echinococcus granulosus neuropeptides capa receptor 0.078 0.2019 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0084 0.1833
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.0694 0.0694
Schistosoma mansoni rhodopsin-like orphan GPCR 0.078 0.2019 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0084 0.2044
Loa Loa (eye worm) hypothetical protein 0.0108 0.0253 0.0911
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0076
Schistosoma mansoni chromobox protein 0.0014 0.0005 0.0026
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.078 0.2019 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.003 0.0047 0.0208
Leishmania major 4-coumarate:coa ligase-like protein 0.0015 0.0008 0.0141
Loa Loa (eye worm) hypoxia-induced factor 1 0.0353 0.0896 0.3248
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.0256 0.1267
Leishmania major protein kinase, putative 0.003 0.0047 0.1103
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.078 0.2019 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0024 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.078 0.2019 1
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0059 0.0264
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.078 0.2019 0.2019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0071 0.1721
Echinococcus granulosus rhodopsin orphan GPCR 0.078 0.2019 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0039 0.0071 0.032
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.0008 0.0075
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0008 0.0017
Echinococcus multilocularis neuropeptide s receptor 0.078 0.2019 0.2019
Loa Loa (eye worm) melatonin receptor type 1A 0.078 0.2019 0.7331
Echinococcus granulosus microtubule associated protein 2 0.0778 0.2014 0.9971
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0018 0.0333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0076
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0008 0.0141
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0008 0.0141
Echinococcus granulosus serotonin receptor 0.078 0.2019 1
Schistosoma mansoni hypothetical protein 0.078 0.2019 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0019 0.0093
Schistosoma mansoni alpha-glucosidase 0.017 0.0417 0.2063
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0204 0.0204
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0059 0.0264
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0008 0.0022
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0108 0.0252 0.6254
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.0694 0.3435
Loa Loa (eye worm) hypothetical protein 0.0183 0.0451 0.163
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0039 0.0071 0.0695
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0302 0.109
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0012 0.0218
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0183 0.0451 0.2088
Brugia malayi SET domain containing protein 0.0018 0.0017 0.0055
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.078 0.2019 0.2019
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.078 0.2019 0.7331
Schistosoma mansoni chromobox protein 0.0014 0.0005 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0018 0.0396
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.078 0.2019 0.2019
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0008 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0008 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.078 0.2019 0.2019
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0018 0.0366
Echinococcus granulosus thioredoxin glutathione reductase 0.0113 0.0265 0.1311
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0044 0.0153
Brugia malayi hypothetical protein 0.0123 0.0293 0.1056
Echinococcus multilocularis fmrfamide receptor 0.078 0.2019 0.2019
Brugia malayi neuropeptide F receptor 0.078 0.2019 0.7331
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0039 0.0071 0.0202
Trypanosoma brucei adenosine transporter, putative 0.0032 0.0053 0.1249
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0022
Echinococcus granulosus intermediate filament protein 0.003 0.0049 0.0242
Brugia malayi bHLH-PAS transcription factor 0.0084 0.0191 0.0685
Schistosoma mansoni hypothetical protein 0.0014 0.0005 0.0026
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0108 0.0253 0.0253
Onchocerca volvulus 0.003 0.0049 0.0217
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.078 0.2019 1
Brugia malayi MH2 domain containing protein 0.0145 0.035 0.1265
Echinococcus granulosus rhodopsin orphan GPCR 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.037 0.0941 0.3413
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0165 0.0402 0.1991
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0198 0.0489 0.177
Brugia malayi Dopamine receptor protein 2 0.078 0.2019 0.7331
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.006
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0008 0.0041
Echinococcus granulosus g protein coupled receptor 0.078 0.2019 1
Echinococcus granulosus allatostatin A receptor 0.078 0.2019 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0032 0.0053 0.0235
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0071 0.1721
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Brugia malayi GnHR receptor homolog 0.078 0.2019 0.7331
Echinococcus granulosus neuropeptide receptor 0.078 0.2019 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.078 0.2019 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.078 0.2019 0.2019
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0165 0.0402 1
Schistosoma mansoni neuropeptide receptor 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.0382 0.0974 0.353
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0165 0.0402 0.1991
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0051 0.0103 0.2514
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0015 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0047 0.0208
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0082 0.1985
Mycobacterium tuberculosis Probable dehydrogenase 0.0257 0.0644 0.2048
Schistosoma mansoni neuropeptide F-like receptor 0.078 0.2019 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.006
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0047 0.1103
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0024 0.0104
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0015 0.0075
Onchocerca volvulus 0.078 0.2019 0.9387
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0105 0.0245 0.6053
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0005 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0105 0.0245 0.1216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0076
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0084 0.1833
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Echinococcus multilocularis lysosomal alpha glucosidase 0.0198 0.0489 0.0489
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0018 0.0092
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0012
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0051 0.0103 0.2514
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0183 0.0451 0.2088
Onchocerca volvulus 0.0015 0.0008 0.0029
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0204 0.101
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0071 0.1721
Onchocerca volvulus 0.078 0.2019 0.9387
Echinococcus granulosus cathepsin l1 0.0019 0.0018 0.0092
Brugia malayi hypothetical protein 0.0142 0.0342 0.1235
Brugia malayi RE15519p 0.078 0.2019 0.7331
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.003 0.0047 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Trypanosoma brucei purine nucleoside transporter 0.0032 0.0053 0.1249
Echinococcus granulosus fmrfamide receptor 0.078 0.2019 1
Echinococcus granulosus single minded 2 0.0084 0.0191 0.0943
Echinococcus granulosus thyrotropin releasing hormone receptor 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0127 0.0453
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0015 0.0046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0017 0.0017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0105 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0036
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0024 0.0482
Echinococcus multilocularis rhodopsin orphan GPCR 0.078 0.2019 0.2019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0285 0.0719 0.2289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0076
Schistosoma mansoni ap endonuclease 0.0043 0.0082 0.0406
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0024 0.0104
Trichomonas vaginalis guanylate cyclase, putative 0.003 0.0047 0.0208
Echinococcus multilocularis chromobox protein 1 0.0014 0.0005 0.0005
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0117 0.2874
Echinococcus granulosus hypothetical protein 0.078 0.2019 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0071 0.1721
Loa Loa (eye worm) phosphofructokinase 0.0127 0.0302 0.109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0105 0.0245 0.1216
Onchocerca volvulus 0.0114 0.027 0.1245
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0039 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Entamoeba histolytica hypothetical protein 0.0014 0.0005 0.0071
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0053 0.0187
Trypanosoma brucei purine nucleoside transporter 0.0032 0.0053 0.1249
Loa Loa (eye worm) neuropeptide F receptor 0.078 0.2019 0.7331
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0071 0.1721
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0008 0.0022
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0302 0.109
Loa Loa (eye worm) G-protein coupled receptor 0.078 0.2019 0.7331
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.0082 0.0318
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0084 0.1992
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0046
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0018 0.0076
Echinococcus multilocularis neuropeptide receptor 0.078 0.2019 0.2019
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0302 0.7495
Echinococcus granulosus cpg binding protein 0.0034 0.0058 0.0289
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.006
Loa Loa (eye worm) fibroinase 0.0019 0.0018 0.006
Entamoeba histolytica nucleoside transporter, putative 0.0032 0.0053 0.1125
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.003 0.0047 0.1103
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0059 0.0343
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0019
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0165 0.0402 1
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0005 0.0011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.078 0.2019 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0127 0.0628
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0039 0.0071 0.1721
Leishmania major cathepsin L-like protease 0.0072 0.0158 0.3887
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0051 0.0103 0.2514
Brugia malayi G protein-coupled receptor F59B2.13 0.078 0.2019 0.7331
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0141 0.3476
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0012 0.0035
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0302 0.1396
Brugia malayi Heterochromatin protein 1 0.0014 0.0005 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0082 0.1985
Schistosoma mansoni myosin xvIII 0.078 0.2019 1
Brugia malayi glutathione reductase 0.0113 0.0265 0.0955
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0008 0.0017
Echinococcus granulosus lamin 0.003 0.0049 0.0242
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.078 0.2019 0.7331
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.003 0.0047 0.0208
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0024 0.0104
Onchocerca volvulus 0.078 0.2019 0.9387
Loa Loa (eye worm) hypothetical protein 0.0123 0.0292 0.1054
Loa Loa (eye worm) hypothetical protein 0.0058 0.0122 0.0435
Schistosoma mansoni rhodopsin-like orphan GPCR 0.078 0.2019 1
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0165 0.0402 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0039 0.0071 0.0202
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0032 0.0032
Echinococcus multilocularis chromobox protein 2 0.0014 0.0005 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0039 0.0071 0.1667
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0165 0.0402 0.1991
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.0008 0.0075
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0012 0.016
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.003 0.0047 0.0208
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0084 0.0383
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0084 0.0383
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.078 0.2019 0.7331
Echinococcus granulosus tumor protein p63 0.041 0.1048 0.5189
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0165 0.0402 1
Brugia malayi Protein cec-1. 0.0014 0.0005 0.0012
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.003 0.0047 0.1103
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0003 0.0003
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0032 0.0053 0.1249
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0005 0.0071
Leishmania major nucleobase transporter 0.0032 0.0053 0.1249
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0008 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0084 0.0383
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0018 0.0333
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0302 0.1396
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Brugia malayi hypothetical protein 0.0276 0.0694 0.2513
Echinococcus multilocularis lamin dm0 0.003 0.0049 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Echinococcus granulosus aryl hydrocarbon receptor 0.003 0.0047 0.0231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.078 0.2019 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0008 0.0008
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0059 0.0343
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0049 0.017
Loa Loa (eye worm) follicle stimulating hormone receptor 0.106 0.2754 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0084 0.0299
Brugia malayi phosphofructokinase 0.0127 0.0302 0.109
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0014 0.0005 0.0015
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0084 0.2044
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0059 0.1351
Trichomonas vaginalis Heterochromatin protein, putative 0.0014 0.0005 0.0015
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0008 0.0075
Trypanosoma cruzi trypanothione reductase, putative 0.0113 0.0265 0.6562
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0165 0.0402 1
Echinococcus granulosus neuropeptide receptor 0.078 0.2019 1
Schistosoma mansoni survival motor neuron protein 0.0056 0.0117 0.0578
Trypanosoma brucei adenosine transporter 2, putative 0.0032 0.0053 0.1249
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0109 0.0256 0.0256
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0073
Toxoplasma gondii cathepsin CPL 0.0019 0.0018 0.0333
Onchocerca volvulus 0.078 0.2019 0.9387
Echinococcus multilocularis Protein lozenge 0.0065 0.0139 0.0139
Onchocerca volvulus 0.078 0.2019 0.9387
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Brugia malayi putative neuropeptide receptor NPR1 0.078 0.2019 0.7331
Loa Loa (eye worm) transcription factor SMAD2 0.0145 0.035 0.1265
Brugia malayi G protein-coupled receptor 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0183
Echinococcus granulosus 6 phosphofructokinase 0.0127 0.0302 0.1496
Trypanosoma brucei unspecified product 0.0032 0.0053 0.1249
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Leishmania major cathepsin L-like protease 0.0072 0.0158 0.3887
Onchocerca volvulus 0.078 0.2019 0.9387
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0017 0.0085
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0101 0.0234 0.1156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Echinococcus multilocularis aryl hydrocarbon receptor 0.003 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.078 0.2019 0.7331
Brugia malayi hypothetical protein 0.0032 0.0053 0.0183
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0008 0.0141
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0032 0.014
Schistosoma mansoni hypothetical protein 0.0056 0.0117 0.0578
Trypanosoma cruzi nucleoside transporter 1, putative 0.0032 0.0053 0.1249
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.078 0.2019 0.7331
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0017 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0015 0.0008 0.0138
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Schistosoma mansoni cpg binding protein 0.0034 0.0058 0.0289
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0016 0.0063
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0018 0.0076
Brugia malayi Dopamine receptor 0.078 0.2019 0.7331
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0165 0.0402 0.1991
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Loa Loa (eye worm) hypothetical protein 0.0516 0.1326 0.4812
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Toxoplasma gondii nucleoside transporter protein 0.0032 0.0053 0.1191
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0165 0.0402 0.1862
Echinococcus multilocularis rhodopsin orphan GPCR 0.078 0.2019 0.2019
Toxoplasma gondii exonuclease III APE 0.0043 0.0082 0.1932
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0008 0.0141
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0039 0.0071 0.0219
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.078 0.2019 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0047 0.1103
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0012 0.0231
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0012
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.078 0.2019 0.2019
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0108 0.0252 0.6254
Echinococcus granulosus rhodopsin orphan GPCR 0.078 0.2019 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0165 0.0402 0.1862
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0082 0.029
Trichomonas vaginalis guanylate cyclase, putative 0.003 0.0047 0.0208
Echinococcus multilocularis musashi 0.003 0.0049 0.0049
Schistosoma mansoni amine GPCR 0.078 0.2019 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0165 0.0402 0.0402
Echinococcus granulosus geminin 0.0206 0.051 0.2525
Trypanosoma brucei adenosine transporter 2 0.0032 0.0053 0.1249
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0018 0.0396
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0071 0.1721
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0049 0.017
Toxoplasma gondii NADPH-glutathione reductase 0.0039 0.0071 0.1667
Mycobacterium tuberculosis Probable oxidoreductase 0.0285 0.0719 0.2289
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0082 0.029
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0073 0.0259
Brugia malayi hypoxia-induced factor 1 0.0353 0.0896 0.3248
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0059 0.0264
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0005 0.0005
Echinococcus granulosus chromobox protein 1 0.0014 0.0005 0.0026
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0729 0.1886 0.6847
Schistosoma mansoni neuropeptide f receptor 76f 0.078 0.2019 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.001 0.001
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.003 0.0047 0.0162
Trichomonas vaginalis mercuric reductase, putative 0.0039 0.0071 0.0323
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0122 0.0435
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0008 0.0017
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.078 0.2019 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0018 0.006
Trichomonas vaginalis set domain proteins, putative 0.083 0.2151 1
Echinococcus multilocularis allatostatin A receptor 0.078 0.2019 0.2019
Brugia malayi Serotonin receptor 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Trypanosoma brucei nucleoside transporter 1, putative 0.0032 0.0053 0.1249
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0051 0.0103 0.0367
Echinococcus multilocularis lysosomal alpha glucosidase 0.0198 0.0489 0.0489
Schistosoma mansoni hypothetical protein 0.004 0.0073 0.0363
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0015 0.0073
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0302 0.6686
Echinococcus multilocularis G protein coupled receptor 139 0.078 0.2019 0.2019
Echinococcus granulosus alpha 1A adrenergic receptor 0.078 0.2019 1
Echinococcus granulosus neuropeptide receptor A26 0.078 0.2019 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0108 0.0253 0.1166
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0059 0.0264
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0008 0.0029
Echinococcus multilocularis Chromo domain 0.0014 0.0005 0.0005
Brugia malayi Uncoordinated protein 44 0.0017 0.0015 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0018 0.0076
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0183 0.0451 0.0451
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0039 0.0071 0.1667
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0165 0.0402 0.1862
Echinococcus multilocularis tachykinin peptides receptor 99D 0.078 0.2019 0.2019
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0127 0.0302 0.4132
Trypanosoma brucei adenosine transporter, putative 0.0032 0.0053 0.1249
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0012 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0005 0.0015
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0165 0.0402 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.001 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0015 0.0015
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0183 0.0451 0.2088
Echinococcus granulosus neuropeptide s receptor 0.078 0.2019 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0012 0.0231
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.078 0.2019 0.2019
Loa Loa (eye worm) hypothetical protein 0.003 0.0047 0.0162
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0257 0.0644 0.2048
Trypanosoma brucei adenosine transporter 2 0.0032 0.0053 0.1249
Echinococcus granulosus somatostatin receptor 0.078 0.2019 1
Onchocerca volvulus 0.0019 0.0018 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.078 0.2019 0.2019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0017 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0018 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Schistosoma mansoni growth hormone secretagogue receptor 0.078 0.2019 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.078 0.2019 0.2019
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0059 0.1351
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0113 0.0265 0.0837
Echinococcus granulosus rhodopsin orphan GPCR 0.078 0.2019 1
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0008 0.0022
Onchocerca volvulus 0.0516 0.1326 0.6162
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0016 0.0063
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0082 0.1932
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0183 0.0451 0.0451
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Schistosoma mansoni cpg binding protein 0.0034 0.0058 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0047 0.0208
Loa Loa (eye worm) intermediate filament protein 0.003 0.0049 0.017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0024 0.0104
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0039 0.0071 0.0354
Treponema pallidum NADH oxidase 0.0039 0.0071 0.0365
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0018 0.006
Echinococcus multilocularis neuropeptide FF receptor 2 0.078 0.2019 0.2019
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0003 0.0013
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0015 0.0015
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.006
Brugia malayi Nucleoside transporter family protein 0.0183 0.0451 0.163
Onchocerca volvulus 0.0015 0.0008 0.0029
Schistosoma mansoni aryl hydrocarbon receptor 0.0114 0.0268 0.1329
Loa Loa (eye worm) hypothetical protein 0.004 0.0073 0.0259
Loa Loa (eye worm) G-protein coupled receptor 0.078 0.2019 0.7331
Brugia malayi intermediate filament protein 0.003 0.0049 0.017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0122 0.0435
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.078 0.2019 0.2019
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0005 0.0012
Echinococcus granulosus Ankyrin 0.0018 0.0015 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0012 0.0036
Trichomonas vaginalis chromobox protein, putative 0.0014 0.0005 0.0015
Schistosoma mansoni alpha-1 adrenergic receptor 0.078 0.2019 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.078 0.2019 0.2019
Echinococcus multilocularis GPCR, family 2 0.0018 0.0017 0.0017
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0008 0.0017
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0018 0.0076
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0039 0.0071 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Onchocerca volvulus Huntingtin homolog 0.0149 0.036 0.1666
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0005 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0047 0.1103
Brugia malayi Melatonin receptor type 1A 0.078 0.2019 0.7331
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0032 0.0053 0.1249
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0165 0.0402 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0011 0.0147
Brugia malayi Cathepsin L-like precursor 0.0019 0.0018 0.006
Plasmodium falciparum thioredoxin reductase 0.0039 0.0071 0.1667
Echinococcus granulosus lysosomal alpha glucosidase 0.0198 0.0489 0.2422
Loa Loa (eye worm) hypothetical protein 0.0105 0.0245 0.0884
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0158 0.3887
Mycobacterium tuberculosis Probable reductase 0.0257 0.0644 0.2048
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0059 0.1266
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0071 0.1721
Echinococcus granulosus g protein coupled receptor 0.078 0.2019 1
Brugia malayi hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.078 0.2019 1
Brugia malayi Thioredoxin reductase 0.0113 0.0265 0.0955
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0032 0.0053 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Echinococcus multilocularis dnaJ subfamily B 0.0459 0.1174 0.1174
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Onchocerca volvulus 0.078 0.2019 0.9387
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0165 0.0402 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.078 0.2019 0.2019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0015 0.0073
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0165 0.0402 1
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0302 0.1496
Echinococcus multilocularis sex peptide receptor 0.078 0.2019 0.2019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.078 0.2019 0.7331
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0117 0.0417
Entamoeba histolytica nucleoside transporter, putative 0.0183 0.0451 1
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Toxoplasma gondii thioredoxin reductase 0.0113 0.0265 0.654
Plasmodium vivax vivapain-2 0.0019 0.0018 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0014 0.0005 0.00000000027121
Toxoplasma gondii nucleoside transporter protein 0.0032 0.0053 0.1191
Schistosoma mansoni biogenic amine (dopamine) receptor 0.078 0.2019 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0082 0.1985
Brugia malayi G-protein coupled receptor 0.078 0.2019 0.7331
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0165 0.0402 0.1991
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Loa Loa (eye worm) hypothetical protein 0.078 0.2019 0.7331
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0165 0.0402 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0084 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Loa Loa (eye worm) hypothetical protein 0.0183 0.0451 0.163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0158 0.3887
Loa Loa (eye worm) hypothetical protein 0.0516 0.1326 0.4812
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0005 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0014 0.0056
Echinococcus multilocularis tumor protein p63 0.041 0.1048 0.1048
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.0005 0.00000000027121
Entamoeba histolytica nucleoside transporter, putative 0.0032 0.0053 0.1125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.078 0.2019 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0014
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0017 0.0017
Echinococcus granulosus 7tm_1 domain containing protein 0.078 0.2019 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Schistosoma mansoni amine GPCR 0.078 0.2019 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0005 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.078 0.2019 1
Onchocerca volvulus 0.0019 0.0018 0.0076
Echinococcus multilocularis serotonin receptor 0.078 0.2019 0.2019
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0151 0.0367 0.0367
Onchocerca volvulus 0.078 0.2019 0.9387
Leishmania major 4-coumarate:coa ligase-like protein 0.0015 0.0008 0.0141
Echinococcus multilocularis g-protein coupled receptor 0.078 0.2019 0.2019
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0012 0.0046
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0082 0.1985
Onchocerca volvulus 0.0019 0.0018 0.0076
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0084 0.0299
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0158 0.3887
Echinococcus granulosus Chromo domain 0.0014 0.0005 0.0026
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0005 0.0026
Schistosoma mansoni hypothetical protein 0.078 0.2019 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0007 0.0037
Echinococcus multilocularis thioredoxin glutathione reductase 0.0113 0.0265 0.0265
Loa Loa (eye worm) glutathione reductase 0.0113 0.0265 0.0955
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0008 0.0022
Loa Loa (eye worm) heterochromatin protein 1 0.0014 0.0005 0.0012
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0046
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0047 0.1103
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0005 0.0012
Onchocerca volvulus 0.078 0.2019 0.9387
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0109 0.0256 0.1267
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0014
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0046
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0012 0.0046
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0165 0.0402 0.126
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0059 0.1351
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0008 0.0022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0071 0.1721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0076
Brugia malayi 6-phosphofructokinase 0.0127 0.0302 0.109
Trypanosoma cruzi nucleoside transporter 1, putative 0.0032 0.0053 0.1249
Echinococcus granulosus rhodopsin orphan GPCR 0.078 0.2019 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0018 0.0018
Schistosoma mansoni alpha-glucosidase 0.017 0.0417 0.2063
Echinococcus granulosus 7TM GPCR rhodopsin 0.078 0.2019 1

Activities

Activity type Activity value Assay description Source Reference
Drug excretion (ADMET) = 2.4 % Total drug excretion in healthy human treated with [14C]-ertugliflozin at 25 mg, po by HPLC-radiocardiogram analysis ChEMBL. 23169609

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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