TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 429.511 | Formula: C26H27N3O3
H donors: 3 H acceptors: 2 LogP: 3.64 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N[C@H](C(=O)Nc1ccc(cc1)[C@@H]1C[C@H]1N)Cc1ccccc1)OCc1ccccc1
InChi: 1S/C26H27N3O3/c27-23-16-22(23)20-11-13-21(14-12-20)28-25(30)24(15-18-7-3-1-4-8-18)29-26(31)32-17-19-9-5-2-6-10-19/h1-14,22-24H,15-17,27H2,(H,28,30)(H,29,31)/t22-,23+,24-/m0/s1
InChiKey: HDVDLEPVLVTECB-VXNXHJTFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.1878	0.9821	1
Brugia malayi	Protein kinase domain containing protein	0.0335	0.1563	0.1592
Schistosoma mansoni	serine/threonine protein kinase	0.0821	0.4163	0.4239
Brugia malayi	Protein kinase domain containing protein	0.0239	0.1047	0.1066
Loa Loa (eye worm)	multidrug resistance-associated protein	0.0115	0.0382	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0927	0.4732	0.4732
Brugia malayi	Ras association domain family 1 isoform A	0.0326	0.151	0.1538
Brugia malayi	p70 ribosomal S6 kinase beta	0.0195	0.0814	0.0829
Trichomonas vaginalis	AGC family protein kinase	0.0239	0.1047	1
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0195	0.0814	0.1673
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0053	0.0053	0.095
Entamoeba histolytica	protein kinase, putative	0.0053	0.0053	0.0234
Schistosoma mansoni	serine/threonine protein kinase	0.0326	0.151	0.1538
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0148	0.056	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0108	0.0346	0.0712
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0148	0.056	0.056
Trypanosoma cruzi	hypothetical protein	0.0114	0.0376	0.6714
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0107	0.0341	0.07
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0148	0.056	0.115
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0326	0.151	0.151
Onchocerca volvulus		0.0927	0.4732	0.4732
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0053	0.0053	1
Schistosoma mansoni	multidrug resistance protein	0.0148	0.056	0.057
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0927	0.4732	0.4732
Echinococcus granulosus	Diacylglycerol kinase theta	0.0326	0.151	0.3104
Loa Loa (eye worm)	hypothetical protein	0.1868	0.9767	0.9767
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.014	0.0142
Echinococcus multilocularis	multidrug resistance associated protein 4	0.0114	0.0376	0.0772
Brugia malayi	TAR-binding protein	0.007	0.014	0.0142
Entamoeba histolytica	protein kinase, putative	0.0053	0.0053	0.0234
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0053	0.0053	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0053	0.0053	0.095
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Entamoeba histolytica	hypothetical protein	0.0148	0.056	0.2462
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.014	0.014
Echinococcus granulosus	protein kinase c iota type	0.0521	0.2557	0.5255
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0195	0.0814	0.0814
Entamoeba histolytica	multidrug resistance protein, putative	0.0148	0.056	0.2462
Entamoeba histolytica	protein kinase, putative	0.0053	0.0053	0.0234
Entamoeba histolytica	ABC transporter, putative	0.0148	0.056	0.2462
Echinococcus granulosus	myotubularin protein 13	0.0369	0.1743	0.3582
Schistosoma mansoni	serine/threonine protein kinase	0.0195	0.0814	0.0829
Onchocerca volvulus		0.0927	0.4732	0.4732
Entamoeba histolytica	hypothetical protein	0.0053	0.0053	0.0234
Schistosoma mansoni	serine/threonine protein kinase	0.0195	0.0814	0.0829
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0326	0.151	0.3104
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0952	0.4866	0.4866
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0326	0.151	0.151
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0122	0.042	0.0864
Echinococcus multilocularis	myotubularin protein 13	0.0369	0.1743	0.3582
Loa Loa (eye worm)	hypothetical protein	0.0326	0.151	0.151
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.031	0.1427	0.1427
Trichomonas vaginalis	AGC family protein kinase	0.0239	0.1047	1
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0335	0.1563	0.3213
Loa Loa (eye worm)	hypothetical protein	0.0326	0.151	0.151
Loa Loa (eye worm)	hypothetical protein	0.0992	0.5079	0.5079
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0148	0.056	0.2462
Brugia malayi	Pleckstrin Homology Domain	0.0369	0.1743	0.1775
Echinococcus granulosus	raf serine:threonine protein kinase	0.0326	0.151	0.3104
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0053	0.0053	0.0303
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0148	0.056	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0122	0.042	0.0864
Trichomonas vaginalis	AGC family protein kinase	0.0239	0.1047	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0107	0.0341	0.0347
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0053	0.0053	0.095
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0195	0.0814	0.1673
Entamoeba histolytica	protein kinase, putative	0.0053	0.0053	0.0234
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Brugia malayi	RhoGAP domain containing protein	0.0326	0.151	0.1538
Echinococcus granulosus	serine/threonine protein kinase	0.0053	0.0053	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Schistosoma mansoni	atypical protein kinase C	0.0521	0.2557	0.2604
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0148	0.056	1
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0186	0.0761	0.7271
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0148	0.056	0.5347
Loa Loa (eye worm)	hypothetical protein	0.0342	0.1599	0.1599
Brugia malayi	TspO/MBR family protein	0.0927	0.4732	0.4818
Brugia malayi	C1-like domain containing protein	0.1878	0.9821	1
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0053	0.0053	0.0508
Brugia malayi	Variant SH3 domain containing protein	0.0326	0.151	0.1538
Loa Loa (eye worm)	raf kinase	0.0326	0.151	0.151
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0053	0.0053	0.0234
Onchocerca volvulus		0.0927	0.4732	0.4732
Echinococcus granulosus	multidrug resistance associated protein 1	0.0148	0.056	0.115
Leishmania major	ABC-thiol transporter	0.0148	0.056	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.056	0.056
Brugia malayi	Protein kinase domain containing protein	0.0195	0.0814	0.0829
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0053	0.0053	0.095
Loa Loa (eye worm)	hypothetical protein	0.0326	0.151	0.151
Schistosoma mansoni	vav2	0.0369	0.1743	0.1775
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0053	0.0053	0.095
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0342	0.1599	0.3286
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0148	0.056	0.2462
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0053	0.0053	0.0508
Leishmania major	protein kinase, putative	0.0053	0.0053	0.095
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0053	0.0053	0.0234
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0195	0.0814	0.1673
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0239	0.1047	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0053	0.0053	0.095
Giardia lamblia	ABC transporter, putative	0.0148	0.056	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0148	0.056	1
Brugia malayi	multidrug resistance related protein 1	0.0148	0.056	0.057
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0342	0.1599	0.3286
Schistosoma mansoni	unc-13 (munc13)	0.0342	0.1599	0.1628
Toxoplasma gondii	diacylglycerol kinase, putative	0.0326	0.151	0.8611
Schistosoma mansoni	serine/threonine-protein kinase	0.0053	0.0053	0.0054
Brugia malayi	protein kinase C II.	0.0952	0.4866	0.4955
Trypanosoma cruzi	Protein kinase B	0.0053	0.0053	0.095
Onchocerca volvulus		0.0927	0.4732	0.4732
Echinococcus granulosus	NDR protein kinase	0.0195	0.0814	0.1673
Echinococcus granulosus	serine:threonine protein kinase N2	0.0425	0.2041	0.4194
Entamoeba histolytica	protein kinase, putative	0.0239	0.1047	0.4604
Schistosoma mansoni	protein kinase C	0.0342	0.1599	0.1628
Brugia malayi	hypothetical protein	0.0374	0.1772	0.1804
Echinococcus multilocularis	serine:threonine protein kinase N2	0.061	0.3034	0.6236
Echinococcus granulosus	protein kinase C gamma type	0.0496	0.2421	0.4975
Loa Loa (eye worm)	hypothetical protein	0.0992	0.5079	0.5079
Brugia malayi	RhoGEF domain containing protein	0.0326	0.151	0.1538
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0195	0.0814	0.0814
Trypanosoma cruzi	NIMA-related kinase, putative	0.0053	0.0053	0.095
Trichomonas vaginalis	AGC family protein kinase	0.0239	0.1047	1
Echinococcus granulosus	protein kinase c epsilon type	0.0952	0.4866	1
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0053	0.0053	0.095
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0326	0.151	0.3104
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0195	0.0814	0.1673
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0335	0.1563	0.3213
Entamoeba histolytica	diacylglycerol kinase, putative	0.0326	0.151	0.6643
Echinococcus multilocularis	rac serine:threonine kinase	0.0053	0.0053	0.0109
Echinococcus multilocularis	unc 13 (munc13)	0.0342	0.1599	0.3286
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.1552	0.8078	0.8078
Loa Loa (eye worm)	hypothetical protein	0.0992	0.5079	0.5079
Loa Loa (eye worm)	hypothetical protein	0.0122	0.042	0.042
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0148	0.056	0.5347
Entamoeba histolytica	protein kinase, putative	0.0195	0.0814	0.3581
Echinococcus granulosus	serine:threonine protein kinase N2	0.0195	0.0814	0.1673
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0148	0.056	1
Schistosoma mansoni	unc-13 (munc13)	0.0342	0.1599	0.1628
Schistosoma mansoni	diacylglycerol kinase theta	0.0326	0.151	0.1538
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0148	0.056	0.2462
Trypanosoma brucei	p-glycoprotein	0.0148	0.056	0.5347
Loa Loa (eye worm)	hypothetical protein	0.1188	0.6126	0.6126
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0053	0.0053	0.095
Schistosoma mansoni	multidrug resistance protein	0.0148	0.056	0.057
Toxoplasma gondii	hypothetical protein	0.0371	0.1754	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0346	0.0346
Brugia malayi	RhoGAP domain containing protein	0.0326	0.151	0.1538
Brugia malayi	RNA binding protein	0.007	0.014	0.0142
Onchocerca volvulus		0.0342	0.1599	0.1599
Trichomonas vaginalis	AGC family protein kinase	0.0195	0.0814	0.7779
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0122	0.042	0.2396
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.006	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.1318	0.6822	0.6822
Loa Loa (eye worm)	hypothetical protein	0.0927	0.4732	0.4732
Leishmania major	protein kinase, putative	0.0053	0.0053	0.095
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0122	0.042	0.0864
Brugia malayi	amine oxidase, flavin-containing family protein	0.0049	0.003	0.0031
Entamoeba histolytica	diacylglycerol kinase, putative	0.0326	0.151	0.6643
Echinococcus granulosus	tar DNA binding protein	0.007	0.014	0.0287
Echinococcus multilocularis	N chimaerin	0.0326	0.151	0.3104
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0326	0.151	0.151
Loa Loa (eye worm)	hypothetical protein	0.0326	0.151	0.151
Brugia malayi	diacylglycerol kinase	0.0326	0.151	0.1538
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0148	0.056	0.3191
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0346	0.0346
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0468	0.2273	1
Schistosoma mansoni	tar DNA-binding protein	0.007	0.014	0.0142
Entamoeba histolytica	hypothetical protein	0.0053	0.0053	0.0234
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0148	0.056	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0108	0.0346	0.0353
Brugia malayi	diacylglycerol kinase	0.0326	0.151	0.1538
Schistosoma mansoni	tar DNA-binding protein	0.007	0.014	0.0142
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0195	0.0814	0.1673
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0053	0.0053	0.0234
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0053	0.0053	0.095
Leishmania major	p-glycoprotein e	0.0148	0.056	1
Schistosoma mansoni	serine/threonine protein kinase	0.0195	0.0814	0.0829
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0326	0.151	0.1538
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0195	0.0814	0.1673
Echinococcus granulosus	RNA directed DNA polymerase	0.0283	0.1285	0.2641
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0333	0.1552	0.5
Giardia lamblia	MRP-like ABC transporter	0.0148	0.056	1
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0053	0.0053	0.0508
Schistosoma mansoni	tar DNA-binding protein	0.007	0.014	0.0142
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0148	0.056	1
Entamoeba histolytica	protein kinase, putative	0.0053	0.0053	0.0234
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0053	0.0053	0.0234
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0195	0.0814	0.0814
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0108	0.0346	0.0712
Onchocerca volvulus		0.1542	0.8025	0.8025
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0107	0.0341	0.0341
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0053	0.0053	0.0508
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0195	0.0814	0.0814
Entamoeba histolytica	protein kinase, putative	0.0239	0.1047	0.4604
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0335	0.1563	0.1563
Trypanosoma brucei	multidrug resistance protein E	0.0148	0.056	0.5347
Schistosoma mansoni	serine/threonine kinase	0.0195	0.0814	0.0829
Echinococcus multilocularis	protein kinase c eta type	0.0326	0.151	0.3104
Brugia malayi	Protein kinase c protein 2	0.0636	0.317	0.3228
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0122	0.042	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0283	0.1285	0.1285
Echinococcus granulosus	unc 13 munc13	0.0342	0.1599	0.3286
Onchocerca volvulus		0.0115	0.0384	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0371	0.1754	0.1754
Schistosoma mansoni	rac gtpase activating protein	0.0326	0.151	0.1538
Schistosoma mansoni	serine/threonine protein kinase	0.0335	0.1563	0.1592
Echinococcus granulosus	Rac GTPase activating protein 1	0.0326	0.151	0.3104
Brugia malayi	ABC transporter transmembrane region family protein	0.0148	0.056	0.057
Schistosoma mansoni	diacylglycerol kinase theta	0.0326	0.151	0.1538
Loa Loa (eye worm)	hypothetical protein	0.0326	0.151	0.151
Schistosoma mansoni	serine/threonine-protein kinase	0.0053	0.0053	0.0054
Echinococcus multilocularis	tar DNA binding protein	0.007	0.014	0.0287
Echinococcus granulosus	translocator protein	0.0927	0.4732	0.9724
Brugia malayi	Hr1 repeat family protein	0.0195	0.0814	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0609	0.3028	0.3028
Brugia malayi	protein kinase C3,putative	0.0335	0.1563	0.1592
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0195	0.0814	0.0814
Trichomonas vaginalis	AGC family protein kinase	0.0239	0.1047	1
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0053	0.0053	0.0508
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0326	0.151	0.151
Schistosoma mansoni	serine/threonine protein kinase	0.0821	0.4163	0.4239
Schistosoma mansoni	multidrug resistance protein	0.0148	0.056	0.057
Trichomonas vaginalis	AGC family protein kinase	0.0195	0.0814	0.7779
Schistosoma mansoni	multidrug resistance protein	0.0148	0.056	0.057
Brugia malayi	SWIRM domain containing protein	0.0115	0.0384	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0927	0.4732	0.4732
Trypanosoma cruzi	NIMA-related kinase, putative	0.0053	0.0053	0.095
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.1878	0.9821	0.9821
Loa Loa (eye worm)	hypothetical protein	0.0369	0.1743	0.1743
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0326	0.151	0.1538
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0148	0.056	0.2462
Giardia lamblia	Multidrug resistance-associated protein 1	0.0147	0.0553	0.954
Trichomonas vaginalis	AGC family protein kinase	0.0239	0.1047	1
Echinococcus multilocularis	serine threonine protein kinase	0.0496	0.2421	0.4975
Leishmania major	folate/biopterin transporter, putative	0.0053	0.0053	0.095
Schistosoma mansoni	serine/threonine protein kinase	0.0195	0.0814	0.0829
Onchocerca volvulus		0.0992	0.5079	0.5079
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0326	0.151	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0371	0.1754	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0384	0.0384
Loa Loa (eye worm)	TAR-binding protein	0.007	0.014	0.014
Echinococcus granulosus	Protein kinase C brain isozyme	0.0821	0.4163	0.8556
Trypanosoma brucei	protein kinase, putative	0.0053	0.0053	0.0508
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0053	0.0053	0.095
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0122	0.042	0.0864
Schistosoma mansoni	tar DNA-binding protein	0.007	0.014	0.0142
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0283	0.1285	0.2641
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0148	0.056	0.115
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0195	0.0814	0.0814
Echinococcus multilocularis	protein kinase c epsilon type	0.0952	0.4866	1
Loa Loa (eye worm)	hypothetical protein	0.1542	0.8025	0.8025
Echinococcus multilocularis	protein kinase c iota type	0.0521	0.2557	0.5255
Leishmania major	serine/threonine-protein kinase a, putative	0.0053	0.0053	0.095
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0553	0.0553
Loa Loa (eye worm)	hypothetical protein	0.1542	0.8025	0.8025
Echinococcus multilocularis	RNA directed DNA polymerase	0.0283	0.1285	0.2641
Mycobacterium ulcerans	tryptophan-rich sensory protein	0.0927	0.4732	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.003	0.003
Schistosoma mansoni	protein kinase C mu	0.1878	0.9821	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.056	0.056
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0107	0.0341	0.07
Trichomonas vaginalis	AGC family protein kinase	0.0239	0.1047	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0053	0.0053	0.0303
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0053	0.0053	0.0234
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Echinococcus granulosus	protein kinase c eta type	0.0326	0.151	0.3104
Schistosoma mansoni	protein kinase C mu	0.0326	0.151	0.1538
Schistosoma mansoni	hypothetical protein	0.0326	0.151	0.1538
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0326	0.151	0.3104
Echinococcus multilocularis	translocator protein	0.0927	0.4732	0.9724
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0326	0.151	0.3104
Echinococcus granulosus	multidrug resistance associated protein 7	0.0148	0.056	0.115
Brugia malayi	Protein kinase domain containing protein	0.0195	0.0814	0.0829
Schistosoma mansoni	serine/threonine protein kinase	0.0335	0.1563	0.1592
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0195	0.0814	0.1673
Echinococcus granulosus	multidrug resistance associated protein 4	0.0114	0.0376	0.0772
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0195	0.0814	0.1673
Loa Loa (eye worm)	RNA binding protein	0.007	0.014	0.014
Giardia lamblia	Multidrug resistance-associated protein 1	0.0148	0.056	1
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0148	0.056	1
Loa Loa (eye worm)	hypothetical protein	0.0371	0.1754	0.1754
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0326	0.151	0.151
Onchocerca volvulus		0.1868	0.9767	0.9767
Toxoplasma gondii	AGC kinase	0.0195	0.0814	0.4642
Leishmania major	pentamidine resistance protein 1	0.0148	0.056	1
Entamoeba histolytica	hypothetical protein	0.0326	0.151	0.6643
Onchocerca volvulus		0.1911	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0952	0.4866	0.4955
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0821	0.4163	0.8556
Trichomonas vaginalis	AGC family protein kinase	0.0195	0.0814	0.7779
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0371	0.1754	0.1754
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0239	0.1047	0.1047
Entamoeba histolytica	protein kinase, putative	0.0195	0.0814	0.3581
Echinococcus granulosus	N chimaerin	0.0326	0.151	0.3104
Brugia malayi	Variant SH3 domain containing protein	0.006	0.0089	0.009
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0053	0.0053	0.095
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Schistosoma mansoni	tar DNA-binding protein	0.007	0.014	0.0142
Trichomonas vaginalis	AGC family protein kinase	0.0053	0.0053	0.0508
Trichomonas vaginalis	AGC family protein kinase	0.0239	0.1047	1
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0053	0.0053	0.0508
Entamoeba histolytica	p21-activated kinase	0.0053	0.0053	0.0234
Schistosoma mansoni	peripheral-type benzodiazepine receptor	0.0927	0.4732	0.4818

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3546915

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2074210