Detailed information for compound 2074214

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.511 | Formula: C26H27N3O3
  • H donors: 3 H acceptors: 2 LogP: 3.64 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@@H](C(=O)Nc1ccc(cc1)[C@@H]1C[C@H]1N)Cc1ccccc1)OCc1ccccc1
  • InChi: 1S/C26H27N3O3/c27-23-16-22(23)20-11-13-21(14-12-20)28-25(30)24(15-18-7-3-1-4-8-18)29-26(31)32-17-19-9-5-2-6-10-19/h1-14,22-24H,15-17,27H2,(H,28,30)(H,29,31)/t22-,23+,24+/m0/s1
  • InChiKey: HDVDLEPVLVTECB-RBZQAINGSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0053 0.0234
Brugia malayi multidrug resistance related protein 1 0.0148 0.056 0.057
Brugia malayi Variant SH3 domain containing protein 0.006 0.0089 0.009
Toxoplasma gondii diacylglycerol kinase, putative 0.0326 0.151 0.8611
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0195 0.0814 0.0814
Onchocerca volvulus 0.0927 0.4732 0.4732
Schistosoma mansoni tar DNA-binding protein 0.007 0.014 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Brugia malayi Protein kinase domain containing protein 0.0195 0.0814 0.0829
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0148 0.056 1
Trypanosoma cruzi NIMA-related kinase, putative 0.0053 0.0053 0.095
Echinococcus multilocularis serine threonine protein kinase 0.0496 0.2421 0.4975
Leishmania major folate/biopterin transporter, putative 0.0053 0.0053 0.095
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0107 0.0341 0.0341
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0107 0.0341 0.07
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Echinococcus multilocularis Rac GTPase activating protein 1 0.0326 0.151 0.3104
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0148 0.056 1
Schistosoma mansoni serine/threonine protein kinase 0.0326 0.151 0.1538
Trypanosoma cruzi multidrug resistance protein E, putative 0.0148 0.056 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.0148 0.056 0.115
Loa Loa (eye worm) CAMK/PKD protein kinase 0.1878 0.9821 0.9821
Schistosoma mansoni serine/threonine protein kinase 0.0335 0.1563 0.1592
Schistosoma mansoni multidrug resistance protein 0.0148 0.056 0.057
Echinococcus granulosus multidrug resistance associated protein 1 0.0148 0.056 0.115
Onchocerca volvulus 0.0992 0.5079 0.5079
Schistosoma mansoni serine/threonine-protein kinase 0.0053 0.0053 0.0054
Loa Loa (eye worm) hypothetical protein 0.1542 0.8025 0.8025
Loa Loa (eye worm) multidrug resistance-associated protein 0.0115 0.0382 0.0382
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0053 0.0053 0.095
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0122 0.042 0.2396
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0195 0.0814 0.1673
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0148 0.056 0.3191
Trichomonas vaginalis AGC family protein kinase 0.0239 0.1047 1
Schistosoma mansoni diacylglycerol kinase theta 0.0326 0.151 0.1538
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0326 0.151 0.1538
Loa Loa (eye worm) hypothetical protein 0.0326 0.151 0.151
Echinococcus multilocularis tar DNA binding protein 0.007 0.014 0.0287
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0195 0.0814 0.1673
Echinococcus granulosus myotubularin protein 13 0.0369 0.1743 0.3582
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0053 0.0053 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0195 0.0814 0.1673
Brugia malayi RhoGAP domain containing protein 0.0326 0.151 0.1538
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0122 0.042 0.0864
Trypanosoma cruzi hypothetical protein 0.0114 0.0376 0.6714
Schistosoma mansoni serine/threonine kinase 0.0195 0.0814 0.0829
Trichomonas vaginalis AGC family protein kinase 0.0239 0.1047 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0147 0.0553 0.954
Echinococcus multilocularis multidrug resistance associated protein 7 0.0148 0.056 0.115
Schistosoma mansoni serine/threonine protein kinase 0.0952 0.4866 0.4955
Leishmania major protein kinase, putative 0.0053 0.0053 0.095
Echinococcus granulosus Diacylglycerol kinase theta 0.0326 0.151 0.3104
Loa Loa (eye worm) hypothetical protein 0.0326 0.151 0.151
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.1878 0.9821 1
Onchocerca volvulus 0.0927 0.4732 0.4732
Loa Loa (eye worm) hypothetical protein 0.1318 0.6822 0.6822
Entamoeba histolytica ABC transporter, putative 0.0148 0.056 0.2462
Giardia lamblia ABC transporter, putative 0.0148 0.056 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0148 0.056 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0122 0.042 0.0864
Echinococcus multilocularis serine:threonine protein kinase 38 0.0195 0.0814 0.1673
Entamoeba histolytica diacylglycerol kinase, putative 0.0326 0.151 0.6643
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Echinococcus multilocularis myotubularin protein 13 0.0369 0.1743 0.3582
Echinococcus granulosus unc 13 munc13 0.0342 0.1599 0.3286
Trichomonas vaginalis AGC family protein kinase 0.0239 0.1047 1
Toxoplasma gondii protein kinase domain-containing protein 0.0053 0.0053 0.0303
Loa Loa (eye worm) hypothetical protein 0.0992 0.5079 0.5079
Onchocerca volvulus 0.1542 0.8025 0.8025
Loa Loa (eye worm) hypothetical protein 0.0326 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.0326 0.151 0.151
Entamoeba histolytica ATP-binding cassette protein, putative 0.0148 0.056 0.2462
Schistosoma mansoni protein kinase C mu 0.1878 0.9821 1
Entamoeba histolytica hypothetical protein 0.0326 0.151 0.6643
Entamoeba histolytica protein kinase, putative 0.0239 0.1047 0.4604
Trypanosoma brucei multidrug resistance protein E 0.0148 0.056 0.5347
Schistosoma mansoni rac gtpase activating protein 0.0326 0.151 0.1538
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0053 0.0053 0.095
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.014 0.014
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0053 0.0053 0.095
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0195 0.0814 0.1673
Entamoeba histolytica ATP-binding cassette protein, putative 0.0148 0.056 0.2462
Entamoeba histolytica p21-activated kinase 0.0053 0.0053 0.0234
Loa Loa (eye worm) hypothetical protein 0.0371 0.1754 0.1754
Echinococcus multilocularis translocator protein 0.0927 0.4732 0.9724
Echinococcus granulosus RNA directed DNA polymerase 0.0283 0.1285 0.2641
Echinococcus multilocularis protein kinase c eta type 0.0326 0.151 0.3104
Entamoeba histolytica PH domain containing protein kinase, putative 0.0468 0.2273 1
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0283 0.1285 0.2641
Loa Loa (eye worm) hypothetical protein 0.0326 0.151 0.151
Echinococcus multilocularis serine:threonine protein kinase N2 0.061 0.3034 0.6236
Echinococcus multilocularis unc 13 (munc13) 0.0342 0.1599 0.3286
Echinococcus multilocularis rac serine:threonine kinase 0.0053 0.0053 0.0109
Echinococcus granulosus NDR protein kinase 0.0195 0.0814 0.1673
Loa Loa (eye worm) hypothetical protein 0.0148 0.056 0.056
Echinococcus granulosus serine:threonine protein kinase N2 0.0425 0.2041 0.4194
Loa Loa (eye worm) AGC/PKN protein kinase 0.0195 0.0814 0.0814
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0342 0.1599 0.3286
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Trichomonas vaginalis AGC family protein kinase 0.0239 0.1047 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0148 0.056 0.115
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0195 0.0814 0.0814
Loa Loa (eye worm) hypothetical protein 0.1542 0.8025 0.8025
Schistosoma mansoni serine/threonine protein kinase 0.0821 0.4163 0.4239
Trichomonas vaginalis AGC family protein kinase 0.0239 0.1047 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0053 0.0234
Echinococcus granulosus Protein kinase C brain isozyme 0.0821 0.4163 0.8556
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0148 0.056 1
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0195 0.0814 0.0814
Entamoeba histolytica hypothetical protein 0.0148 0.056 0.2462
Loa Loa (eye worm) hypothetical protein 0.0108 0.0346 0.0346
Brugia malayi C1-like domain containing protein 0.1878 0.9821 1
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0195 0.0814 0.1673
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0335 0.1563 0.3213
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0053 0.0053 0.095
Brugia malayi TspO/MBR family protein 0.0927 0.4732 0.4818
Trypanosoma cruzi NIMA-related kinase, putative 0.0053 0.0053 0.095
Brugia malayi Protein kinase c protein 2 0.0636 0.317 0.3228
Trichomonas vaginalis AGC family protein kinase 0.0239 0.1047 1
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0371 0.1754 0.1754
Loa Loa (eye worm) hypothetical protein 0.0927 0.4732 0.4732
Brugia malayi protein kinase C3,putative 0.0335 0.1563 0.1592
Loa Loa (eye worm) hypothetical protein 0.0283 0.1285 0.1285
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0195 0.0814 0.0814
Brugia malayi diacylglycerol kinase 0.0326 0.151 0.1538
Toxoplasma gondii AGC kinase 0.0195 0.0814 0.4642
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Brugia malayi Hr1 repeat family protein 0.0195 0.0814 0.0829
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0148 0.056 0.056
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0814 0.0829
Echinococcus granulosus Rac GTPase activating protein 1 0.0326 0.151 0.3104
Brugia malayi protein kinase C II. 0.0952 0.4866 0.4955
Loa Loa (eye worm) hypothetical protein 0.0326 0.151 0.151
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0326 0.151 0.3104
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0122 0.042 0.0864
Loa Loa (eye worm) hypothetical protein 0.0122 0.042 0.042
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0148 0.056 1
Schistosoma mansoni atypical protein kinase C 0.0521 0.2557 0.2604
Brugia malayi TAR-binding protein 0.007 0.014 0.0142
Entamoeba histolytica protein kinase, putative 0.0195 0.0814 0.3581
Trichomonas vaginalis AGC family protein kinase 0.0239 0.1047 1
Brugia malayi Ras association domain family 1 isoform A 0.0326 0.151 0.1538
Schistosoma mansoni diacylglycerol kinase theta 0.0326 0.151 0.1538
Entamoeba histolytica diacylglycerol kinase, putative 0.0326 0.151 0.6643
Brugia malayi SWIRM domain containing protein 0.0115 0.0384 0.0391
Loa Loa (eye worm) hypothetical protein 0.0115 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.003
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0107 0.0341 0.07
Entamoeba histolytica protein kinase, putative 0.0053 0.0053 0.0234
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0148 0.056 1
Loa Loa (eye worm) hypothetical protein 0.0369 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0927 0.4732 0.4732
Entamoeba histolytica protein kinase, putative 0.0053 0.0053 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0195 0.0814 0.7779
Echinococcus granulosus raf serine:threonine protein kinase 0.0326 0.151 0.3104
Brugia malayi Protein kinase domain containing protein 0.0239 0.1047 0.1066
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Brugia malayi RhoGEF domain containing protein 0.0326 0.151 0.1538
Echinococcus granulosus multidrug resistance associated protein 4 0.0114 0.0376 0.0772
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.031 0.1427 0.1427
Toxoplasma gondii hypothetical protein 0.0371 0.1754 1
Loa Loa (eye worm) hypothetical protein 0.1188 0.6126 0.6126
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0107 0.0341 0.0347
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0053 0.0053 0.095
Schistosoma mansoni tar DNA-binding protein 0.007 0.014 0.0142
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0053 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Leishmania major protein kinase, putative 0.0053 0.0053 0.095
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0053 0.0053 0.0508
Echinococcus granulosus protein kinase C gamma type 0.0496 0.2421 0.4975
Schistosoma mansoni unc-13 (munc13) 0.0342 0.1599 0.1628
Onchocerca volvulus 0.0927 0.4732 0.4732
Loa Loa (eye worm) hypothetical protein 0.0342 0.1599 0.1599
Echinococcus multilocularis N chimaerin 0.0326 0.151 0.3104
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0326 0.151 0.1538
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0053 0.0053 0.0508
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.1552 0.5
Entamoeba histolytica hypothetical protein 0.0053 0.0053 0.0234
Schistosoma mansoni multidrug resistance protein 0.0148 0.056 0.057
Echinococcus multilocularis protein kinase c epsilon type 0.0952 0.4866 1
Leishmania major ABC-thiol transporter 0.0148 0.056 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0335 0.1563 0.3213
Trichomonas vaginalis AGC family protein kinase 0.0239 0.1047 1
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0814 0.0829
Schistosoma mansoni tar DNA-binding protein 0.007 0.014 0.0142
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0148 0.056 0.5347
Echinococcus multilocularis Diacylglycerol kinase theta 0.0326 0.151 0.3104
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0952 0.4866 0.4866
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0053 0.0053 0.095
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0195 0.0814 0.1673
Echinococcus multilocularis raf serine:threonine protein kinase 0.0326 0.151 0.3104
Loa Loa (eye worm) TAR-binding protein 0.007 0.014 0.014
Entamoeba histolytica ATP-binding cassette protein, putative 0.0148 0.056 0.2462
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0342 0.1599 0.3286
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Echinococcus granulosus translocator protein 0.0927 0.4732 0.9724
Echinococcus granulosus serine/threonine protein kinase 0.0053 0.0053 0.0109
Brugia malayi diacylglycerol kinase 0.0326 0.151 0.1538
Brugia malayi ABC transporter transmembrane region family protein 0.0148 0.056 0.057
Entamoeba histolytica ATP-binding cassette protein, putative 0.0148 0.056 0.2462
Loa Loa (eye worm) hypothetical protein 0.0609 0.3028 0.3028
Trichomonas vaginalis AGC family protein kinase 0.0195 0.0814 0.7779
Brugia malayi amine oxidase, flavin-containing family protein 0.0049 0.003 0.0031
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0122 0.042 0.0428
Brugia malayi Pleckstrin Homology Domain 0.0369 0.1743 0.1775
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0186 0.0761 0.7271
Loa Loa (eye worm) hypothetical protein 0.0108 0.0346 0.0346
Echinococcus granulosus protein kinase c epsilon type 0.0952 0.4866 1
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0814 0.0829
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0053 0.0234
Brugia malayi RNA binding protein 0.007 0.014 0.0142
Giardia lamblia Multidrug resistance-associated protein 1 0.0148 0.056 1
Schistosoma mansoni multidrug resistance protein 0.0148 0.056 0.057
Entamoeba histolytica protein kinase, putative 0.0239 0.1047 0.4604
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0053 0.0053 0.0508
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0326 0.151 0.151
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0195 0.0814 0.1673
Schistosoma mansoni multidrug resistance protein 0.0148 0.056 0.057
Echinococcus granulosus lysine specific histone demethylase 1A 0.0108 0.0346 0.0712
Entamoeba histolytica protein kinase, putative 0.0053 0.0053 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0821 0.4163 0.8556
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Loa Loa (eye worm) hypothetical protein 0.0371 0.1754 0.1754
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Trypanosoma brucei rac serine-threonine kinase, putative 0.0239 0.1047 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0108 0.0346 0.0712
Onchocerca volvulus 0.1911 1 1
Leishmania major serine/threonine-protein kinase a, putative 0.0053 0.0053 0.095
Echinococcus granulosus tar DNA binding protein 0.007 0.014 0.0287
Schistosoma mansoni protein kinase C mu 0.0326 0.151 0.1538
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0053 0.0053 0.095
Entamoeba histolytica hypothetical protein 0.0053 0.0053 0.0234
Loa Loa (eye worm) hypothetical protein 0.0992 0.5079 0.5079
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Onchocerca volvulus 0.0115 0.0384 0.0384
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0053 0.0053 0.0508
Brugia malayi hypothetical protein 0.0374 0.1772 0.1804
Loa Loa (eye worm) RasGEF domain-containing protein 0.0326 0.151 0.151
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0053 0.0053 0.0303
Trichomonas vaginalis AGC family protein kinase 0.0195 0.0814 0.7779
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0326 0.151 0.151
Trypanosoma brucei p-glycoprotein 0.0148 0.056 0.5347
Schistosoma mansoni protein kinase C 0.0342 0.1599 0.1628
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0326 0.151 0.3104
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Trypanosoma cruzi Protein kinase B 0.0053 0.0053 0.095
Leishmania major p-glycoprotein e 0.0148 0.056 1
Entamoeba histolytica protein kinase, putative 0.0053 0.0053 0.0234
Echinococcus granulosus protein kinase c eta type 0.0326 0.151 0.3104
Brugia malayi p70 ribosomal S6 kinase beta 0.0195 0.0814 0.0829
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Schistosoma mansoni unc-13 (munc13) 0.0342 0.1599 0.1628
Loa Loa (eye worm) raf kinase 0.0326 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.0927 0.4732 0.4732
Echinococcus multilocularis multidrug resistance associated protein 4 0.0114 0.0376 0.0772
Loa Loa (eye worm) AGC/AKT protein kinase 0.0239 0.1047 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Schistosoma mansoni tar DNA-binding protein 0.007 0.014 0.0142
Echinococcus granulosus protein kinase c iota type 0.0521 0.2557 0.5255
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0053 0.0053 0.095
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0108 0.0346 0.0353
Schistosoma mansoni vav2 0.0369 0.1743 0.1775
Brugia malayi Protein kinase domain containing protein 0.0195 0.0814 0.0829
Schistosoma mansoni hypothetical protein 0.0326 0.151 0.1538
Entamoeba histolytica protein kinase, putative 0.0053 0.0053 0.0234
Loa Loa (eye worm) hypothetical protein 0.0927 0.4732 0.4732
Loa Loa (eye worm) hypothetical protein 0.0148 0.056 0.056
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0335 0.1563 0.1563
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0927 0.4732 1
Schistosoma mansoni serine/threonine-protein kinase 0.0053 0.0053 0.0054
Leishmania major pentamidine resistance protein 1 0.0148 0.056 1
Schistosoma mansoni serine/threonine protein kinase 0.0335 0.1563 0.1592
Loa Loa (eye worm) CAMK/PKD protein kinase 0.1552 0.8078 0.8078
Entamoeba histolytica multidrug resistance protein, putative 0.0148 0.056 0.2462
Loa Loa (eye worm) AGC/NDR protein kinase 0.0195 0.0814 0.0814
Brugia malayi Protein kinase domain containing protein 0.0335 0.1563 0.1592
Brugia malayi Variant SH3 domain containing protein 0.0326 0.151 0.1538
Onchocerca volvulus 0.0342 0.1599 0.1599
Brugia malayi RhoGAP domain containing protein 0.0326 0.151 0.1538
Loa Loa (eye worm) hypothetical protein 0.1868 0.9767 0.9767
Schistosoma mansoni tar DNA-binding protein 0.007 0.014 0.0142
Onchocerca volvulus 0.0927 0.4732 0.4732
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0122 0.042 0.0864
Loa Loa (eye worm) hypothetical protein 0.0992 0.5079 0.5079
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0927 0.4732 0.4818
Echinococcus granulosus N chimaerin 0.0326 0.151 0.3104
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0148 0.056 1
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Plasmodium falciparum calcium-dependent protein kinase 7 0.0053 0.0053 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.006 0.0089 0.0089
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0053 0.0053 0.095
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0148 0.056 0.5347
Loa Loa (eye worm) hypothetical protein 0.0371 0.1754 0.1754
Loa Loa (eye worm) RNA binding protein 0.007 0.014 0.014
Giardia lamblia MRP-like ABC transporter 0.0148 0.056 1
Trypanosoma brucei protein kinase, putative 0.0053 0.0053 0.0508
Echinococcus multilocularis RNA directed DNA polymerase 0.0283 0.1285 0.2641
Schistosoma mansoni serine/threonine protein kinase 0.0821 0.4163 0.4239
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0814 0.0829
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0326 0.151 0.151
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0053 0.0053 0.0508
Echinococcus multilocularis protein kinase c iota type 0.0521 0.2557 0.5255
Echinococcus granulosus serine:threonine protein kinase N2 0.0195 0.0814 0.1673
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0053 0.0053 0.0508
Entamoeba histolytica PH domain containing protein kinase, putative 0.0053 0.0053 0.0234
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0053 0.0053 0.095
Brugia malayi RNA recognition motif domain containing protein 0.007 0.014 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0053 0.0053 0.0508
Entamoeba histolytica protein kinase, putative 0.0195 0.0814 0.3581
Loa Loa (eye worm) hypothetical protein 0.0147 0.0553 0.0553
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0053 0.0053 0.095
Onchocerca volvulus 0.1868 0.9767 0.9767

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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