Detailed information for compound 2074462

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.564 | Formula: C24H36N4O9
  • H donors: 4 H acceptors: 8 LogP: -5.67 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(CC(=O)O)(CC(=O)O)O.Cc1ccc(o1)CN(Cc1cncn1C)CCCN1CCOCC1
  • InChi: 1S/C18H28N4O2.C6H8O7/c1-16-4-5-18(24-16)14-22(13-17-12-19-15-20(17)2)7-3-6-21-8-10-23-11-9-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-5,12,15H,3,6-11,13-14H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
  • InChiKey: PNDOQRBVUCUVTA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0026 0.0026
Plasmodium vivax importin-beta 2, putative 0.0032 0.0043 0.5628
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0018 0.2388
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0016
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0076 1
Trichomonas vaginalis esterase, putative 0.0042 0.0061 0.8053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0046 0.0046
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0061 0.4963
Trichomonas vaginalis ABC transporter, putative 0.0012 0.0004 0.0564
Loa Loa (eye worm) steroid hormone receptor 0.0072 0.0118 0.0114
Onchocerca volvulus 0.0042 0.0061 0.0057
Brugia malayi RNA, U transporter 1 0.0092 0.0158 0.0158
Leishmania major importin beta-1 subunit, putative 0.0026 0.0031 0.2247
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0046 0.0046
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0053 0.0053
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0012 0.0004 0.0564
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0118 0.0118
Onchocerca volvulus 0.002 0.0018 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0061 0.8053
Onchocerca volvulus 0.0042 0.0061 0.0057
Entamoeba histolytica P-glycoprotein-2, putative 0.0012 0.0004 0.063
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0111 0.8997
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0061 0.116
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0124 1
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0061 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0076 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0018 0.2388
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0018 0.2388
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0072 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0018 0.2388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.0018 0.0014
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0018 0.2388
Brugia malayi ecdysone receptor 0.0034 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0046 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0268 0.0496 1
Plasmodium vivax vivapain-2 0.002 0.0018 0.2388
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0053 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0006 0.0848
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0018 0.2666
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0118 0.0118
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.0645 0.0641
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0072 0.0118 0.0118
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0076 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Brugia malayi Steroid receptor seven-up type 2 0.0072 0.0118 0.0118
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0061 0.5
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0118 0.0118
Schistosoma mansoni RAR-like nuclear receptor 0.0072 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Brugia malayi ecdysteroid receptor 0.0072 0.0118 0.0118
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0021 0.0021
Brugia malayi photoreceptor-specific nuclear receptor 0.0072 0.0118 0.0118
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012 0.0004 0.0564
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0076 1
Leishmania major GTP-binding protein, putative 0.0024 0.0026 0.1857
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0004 0.0004
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0031 0.4084
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.0018 0.0014
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0021 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Onchocerca volvulus 0.002 0.0018 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Brugia malayi Cathepsin L-like precursor 0.0013 0.0006 0.0006
Brugia malayi steroid hormone receptor 0.0072 0.0118 0.0118
Leishmania major cathepsin L-like protease 0.0074 0.0124 1
Schistosoma mansoni hypothetical protein 0.0388 0.0726 0.0726
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0021 0.269
Brugia malayi nuclear hormone receptor 0.0034 0.0046 0.0046
Echinococcus granulosus histone acetyltransferase KAT2B 0.0164 0.0297 0.0297
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0043 0.0043
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0021 0.0329
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0053 0.0053
Trichomonas vaginalis ABC transporter, putative 0.0012 0.0004 0.0564
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0061 0.8053
Loa Loa (eye worm) hypothetical protein 0.0038 0.0053 0.0049
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0072 0.0118 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0072 0.0118 0.0118
Brugia malayi cathepsin L-like precursor 0.0013 0.0006 0.0006
Loa Loa (eye worm) acetyltransferase 0.0169 0.0306 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0072 0.0118 0.0118
Brugia malayi beta-lactamase family protein 0.0042 0.0061 0.0061
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0046 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Echinococcus granulosus dna polymerase eta 0.0021 0.0021 0.0021
Brugia malayi nuclear receptor NHR-67 0.0034 0.0046 0.0046
Leishmania major DNA polymerase eta, putative 0.0021 0.0021 0.1357
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0072 0.0118 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0068 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0057
Trichomonas vaginalis abcb9, putative 0.0012 0.0004 0.0564
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012 0.0004 0.0564
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0046 0.0046
Echinococcus granulosus cathepsin l1 0.0013 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0026 0.214
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Trypanosoma brucei unspecified product 0.0021 0.0021 0.1658
Echinococcus multilocularis multidrug resistance protein 1 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0057
Brugia malayi beta-lactamase family protein 0.0042 0.0061 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0061 0.8053
Trichomonas vaginalis taga, putative 0.0012 0.0004 0.0564
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012 0.0004 0.0564
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0046 0.0046
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Mycobacterium ulcerans beta-lactamase 0.0042 0.0061 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012 0.0004 0.0564
Echinococcus multilocularis cysteine protease 0.002 0.0018 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0124 1
Brugia malayi Importin beta-1 subunit 0.0032 0.0043 0.0043
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0072 0.0118 0.0118
Schistosoma mansoni importin beta-1 0.0032 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0151 0.027 0.027
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0057
Loa Loa (eye worm) hypothetical protein 0.0072 0.0118 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.076
Schistosoma mansoni multidrug resistance protein 0.0012 0.0004 0.0004
Echinococcus multilocularis ATP binding cassette sub family B 0.0012 0.0004 0.0004
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0046 0.0046
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0018 0.0018
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0043 0.3468
Echinococcus multilocularis multidrug resistance protein 1 0.0012 0.0004 0.0004
Onchocerca volvulus 0.002 0.0018 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0018 0.2388
Echinococcus multilocularis sodium bile acid cotransporter 0.5211 1 1
Onchocerca volvulus 0.5211 1 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Brugia malayi hypothetical protein 0.0034 0.0046 0.0046
Onchocerca volvulus 0.0072 0.0118 0.0114
Leishmania major cathepsin L-like protease 0.002 0.0018 0.1164
Brugia malayi hypothetical protein 0.0034 0.0046 0.0046
Brugia malayi nuclear receptor NHR-88 0.0072 0.0118 0.0118
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0068 1
Toxoplasma gondii ABC1 family protein 0.0042 0.0061 0.7937
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012 0.0004 0.0564
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.0248 0.0244
Leishmania major cathepsin L-like protease 0.0074 0.0124 1
Mycobacterium ulcerans hypothetical protein 0.0042 0.0061 1
Echinococcus multilocularis dna polymerase eta 0.0021 0.0021 0.0021
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Brugia malayi hypothetical protein 0.0038 0.0053 0.0053
Onchocerca volvulus 0.002 0.0018 0.0014
Onchocerca volvulus 0.002 0.0018 0.0014
Mycobacterium tuberculosis Conserved protein 0.0042 0.0061 0.116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0072 0.0118 0.0114
Trichomonas vaginalis ABC transporter, putative 0.0012 0.0004 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0118 0.0118
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0658
Entamoeba histolytica cysteine protease, putative 0.002 0.0018 0.2666
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012 0.0004 0.0564
Entamoeba histolytica hypothetical protein 0.0026 0.0031 0.456
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012 0.0004 0.0564
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0021 0.1357
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0018 0.0018
Schistosoma mansoni multidrug resistance protein 0.0012 0.0004 0.0004
Trichomonas vaginalis ran, putative 0.0024 0.0026 0.3473
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0072 0.0118 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Echinococcus multilocularis sodium bile acid cotransporter 0.5211 1 1
Echinococcus granulosus FTZ F1 alpha 0.0072 0.0118 0.0118
Brugia malayi nuclear receptor RXR 0.0034 0.0046 0.0046
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0151 0.027 0.027
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0061 0.0057
Trichomonas vaginalis abcb9, putative 0.0012 0.0004 0.0564
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012 0.0004 0.0564
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012 0.0004 0.0564
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0658
Schistosoma mansoni ran 0.0024 0.0026 0.0026
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0124 1
Onchocerca volvulus 0.0034 0.0046 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0046 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.0072 0.0118 0.0118
Brugia malayi beta-lactamase 0.0042 0.0061 0.0061
Brugia malayi Cathepsin L-like precursor 0.002 0.0018 0.0018
Mycobacterium ulcerans lipase LipD 0.0042 0.0061 1
Brugia malayi tailless protein 0.0034 0.0046 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0046 0.0046
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0004 0.0004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Brugia malayi hypothetical protein 0.0038 0.0053 0.0053
Schistosoma mansoni sodium-bile acid cotransporter related 0.2113 0.4043 0.4043
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0026 0.3878
Entamoeba histolytica Ran family GTPase 0.0024 0.0026 0.3878
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0072 0.0118 0.0118
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Mycobacterium tuberculosis Conserved protein 0.0042 0.0061 0.116
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0018 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0072 0.0118 0.0118
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0076 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0118 0.0118
Loa Loa (eye worm) beta-lactamase 0.0042 0.0061 0.0057
Schistosoma mansoni sodium-bile acid cotransporter related 0.5211 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0046 0.0041
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0026 0.1248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0018 0.2388
Schistosoma mansoni hypothetical protein 0.0388 0.0726 0.0726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0004 0.0004
Schistosoma mansoni sodium-bile acid cotransporter 0.3098 0.5937 0.5937
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0072 0.0118 0.0114
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0061 0.8053
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0072 0.0118 0.0118
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0026 0.214
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0046 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0072 0.0118 0.0118
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0061 0.116
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0026 0.3082
Echinococcus granulosus snurportin 1 0.0346 0.0645 0.0645
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.0248 0.0244
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0118 0.0118
Onchocerca volvulus 0.002 0.0018 0.0014
Leishmania major cathepsin L-like protease 0.002 0.0018 0.1164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0072 0.0118 0.0114
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0072 0.0118 0.0118
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0018 0.2666
Toxoplasma gondii cathepsin CPL 0.002 0.0018 0.1933
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0046 0.0042
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0046 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0658
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0021 0.0021
Schistosoma mansoni nuclear receptor 0.0034 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Entamoeba histolytica P-glycoprotein-5 0.0012 0.0004 0.063
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0018 0.0018
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0046 0.0046
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0323 0.0602 0.0598
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0072 0.0118 0.0118
Schistosoma mansoni ran 0.0024 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0072 0.0118 0.0118
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0018 0.2666
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0046 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.1658
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0046 0.0046
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0061 0.116
Echinococcus granulosus cathepsin l1 0.002 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0042 0.0061 0.4781
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0061 1
Leishmania major cathepsin L-like protease 0.0074 0.0124 1
Brugia malayi nuclear receptor RXR 0.0038 0.0053 0.0053
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0061 0.116
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0151 0.027 0.027
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0018 0.0018
Plasmodium vivax multidrug resistance protein 1, putative 0.0012 0.0004 0.0564
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.0072 0.0118 0.0114
Entamoeba histolytica P-glycoprotein-2 0.0012 0.0004 0.063
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0006 0.076
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0021 0.3004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0046 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.0357 0.0667 0.0667
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0046 0.0042
Brugia malayi Cathepsin L-like precursor 0.002 0.0018 0.0018
Leishmania major DNA polymerase kappa, putative 0.0021 0.0021 0.1357
Echinococcus multilocularis thyroid hormone receptor alpha 0.0222 0.0408 0.0408
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0031 0.4084
Brugia malayi Nuclear hormone receptor-like 1 0.0323 0.0602 0.0602
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0018 0.2388
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0118 0.0118
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0072 0.0118 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0018 0.0018
Onchocerca volvulus 0.0034 0.0046 0.0041
Echinococcus multilocularis snurportin 1 0.0346 0.0645 0.0645
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0021 0.0021
Echinococcus granulosus importin subunit beta 1 0.0032 0.0043 0.0043
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0076 0.0076
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0018 0.2666
Entamoeba histolytica P-glyco protein 6, putative 0.0012 0.0004 0.063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Leishmania major cathepsin L-like protease 0.002 0.0018 0.1164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0018 0.2388
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012 0.0004 0.0564
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0072 0.0118 0.0118
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0012 0.0004 0.0564
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Brugia malayi multidrug resistance protein 3 0.0012 0.0004 0.0004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0072 0.0118 0.0118
Echinococcus granulosus dna polymerase kappa 0.0021 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012 0.0004 0.0564
Leishmania major cathepsin L-like protease 0.002 0.0018 0.1164
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0046 0.0046
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0021 0.0329
Mycobacterium leprae Probable lipase LipE 0.0042 0.0061 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Loa Loa (eye worm) hypothetical protein 0.0072 0.0118 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0046 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0072 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.091 0.1731 0.1731
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0018 0.2388
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0053 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0061 0.4963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0046 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.0072 0.0118 0.0114
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0012 0.0004 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0061 0.8053
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0008 0.0658
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0021 0.1658
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0072 0.0118 0.0114
Plasmodium falciparum multidrug resistance protein 1 0.0012 0.0004 0.063
Onchocerca volvulus Bile acid receptor homolog 0.0072 0.0118 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0118 0.0118
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0026 0.214
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0046 0.0046
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0046 0.0046
Onchocerca volvulus Cathepsin L homolog 0.002 0.0018 0.0014
Echinococcus granulosus sodium bile acid cotransporter 0.5211 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0004 0.0004
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0169 0.0306 0.0306
Loa Loa (eye worm) fibroinase 0.002 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0061 0.0057
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012 0.0004 0.0564
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0061 0.116
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0072 0.0118 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Echinococcus granulosus geminin 0.0388 0.0726 0.0726
Brugia malayi acetyltransferase, GNAT family protein 0.0169 0.0306 0.0306
Schistosoma mansoni DNA polymerase eta 0.0021 0.0021 0.0021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0072 0.0118 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.0323 0.0602 0.0602
Schistosoma mansoni nuclear receptor 0.0034 0.0046 0.0046
Entamoeba histolytica P-glycoprotein-1 0.0012 0.0004 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Schistosoma mansoni multidrug resistance protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0018 0.0014
Brugia malayi Cathepsin L-like precursor 0.002 0.0018 0.0018
Onchocerca volvulus 0.0013 0.0006 0.0001
Echinococcus granulosus multidrug resistance protein 1 0.0012 0.0004 0.0004
Brugia malayi nuclear receptor NHR-88 0.0034 0.0046 0.0046
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.1658
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0018 0.0018
Brugia malayi MH2 domain containing protein 0.0139 0.0248 0.0248
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0004 0.0004
Echinococcus multilocularis cysteine protease 0.002 0.0018 0.0018
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0021 0.1658
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012 0.0004 0.0564
Schistosoma mansoni smdr2 0.0012 0.0004 0.0004
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0004 0.0004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0072 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0072 0.0118 0.0114
Echinococcus multilocularis geminin 0.0388 0.0726 0.0726
Trypanosoma brucei unspecified product 0.0014 0.0008 0.0658
Loa Loa (eye worm) hypothetical protein 0.0038 0.0053 0.0049
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0093 0.7525
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0072 0.0118 0.0114
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0061 0.0061
Brugia malayi conserved hypotetical protein 0.0034 0.0046 0.0046
Echinococcus multilocularis sodium bile acid cotransporter 0.5211 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0004 0.0004
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0043 0.3468
Trichomonas vaginalis ABC transporter, putative 0.0012 0.0004 0.0564
Brugia malayi nuclear hormone receptor 0.0072 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0013 0.0006 0.0002
Onchocerca volvulus 0.002 0.0018 0.0014
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0012 0.0004 0.0564
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0061 0.8053
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0021 0.0021
Echinococcus granulosus sodium bile acid cotransporter 0.5211 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012 0.0004 0.0564
Plasmodium vivax vivapain-2 0.002 0.0018 0.2388
Loa Loa (eye worm) hypothetical protein 0.0072 0.0118 0.0114
Leishmania major cysteine peptidase A (CPA) 0.002 0.0018 0.1164
Schistosoma mansoni retinoic acid receptor RXR 0.0072 0.0118 0.0118
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0018 0.0018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0072 0.0118 0.0118
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0072 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0021 0.1658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0018 0.2388
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0031 0.2517
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0072 0.0118 0.0114
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0026 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0061 0.4963
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0061 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0169 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0038 0.0053 0.0049
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0021 0.269
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0012 0.0004 0.0004
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0018 0.2666
Loa Loa (eye worm) hypothetical protein 0.0072 0.0118 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0046 0.0046
Loa Loa (eye worm) cysteine protease 0.002 0.0018 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0031 0.4084
Plasmodium falciparum importin beta, putative 0.0032 0.0043 0.6285
Trichomonas vaginalis abcb9, putative 0.0012 0.0004 0.0564
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012 0.0004 0.0564
Schistosoma mansoni thyroid hormone receptor 0.0222 0.0408 0.0408
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0012 0.0004 0.0564
Brugia malayi ABC transporter family protein 0.0012 0.0004 0.0004
Loa Loa (eye worm) ctsf protein 0.002 0.0018 0.0014
Echinococcus granulosus ecdysone induced protein 78C 0.0072 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0072 0.0118 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0053 0.0049
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0018 0.1472
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0072 0.0118 0.0118
Schistosoma mansoni coup transcription factor 0.0072 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0046 0.0042
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0061 0.116
Brugia malayi Cathepsin L-like precursor 0.002 0.0018 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0124 1
Echinococcus granulosus sodium bile acid cotransporter 0.5211 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012 0.0004 0.0564
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0043 0.5367
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0046 0.0046
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0068 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0053 0.0049
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0021 0.1658
Loa Loa (eye worm) DR-78 0.0034 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.5211 1 1
Schistosoma mansoni thyroid hormone receptor 0.0222 0.0408 0.0408
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012 0.0004 0.0564
Entamoeba histolytica P-glycoprotein-2 0.0012 0.0004 0.063
Schistosoma mansoni hypothetical protein 0.0346 0.0645 0.0645
Leishmania major cathepsin L-like protease 0.002 0.0018 0.1164
Loa Loa (eye worm) hypothetical protein 0.0034 0.0046 0.0042
Entamoeba histolytica P-glycoprotein 5, putative 0.0012 0.0004 0.063
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0012 0.0004 0.0564
Loa Loa (eye worm) hypothetical protein 0.0072 0.0118 0.0114
Onchocerca volvulus 0.0042 0.0061 0.0057
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0072 0.0118 0.0118
Brugia malayi Cathepsin L-like precursor 0.002 0.0018 0.0018
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0012 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0124 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0018 0.2388
Onchocerca volvulus Cathepsin L homolog 0.002 0.0018 0.0014
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0061 0.0061
Schistosoma mansoni zinc finger protein 0.0034 0.0046 0.0046
Mycobacterium tuberculosis Conserved protein 0.0042 0.0061 0.116
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0072 0.0118 0.0118
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0026 0.3473
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0072 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0319 0.0594 0.0591
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0026 0.0022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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