TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 509.482 | Formula: C23H28FN3O9
H donors: 5 H acceptors: 10 LogP: -1.89 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(CC(=O)O)(CC(=O)O)O.COc1ccc(c(c1)CN1CCC(C1)c1cc(O)nc(n1)C)F
InChi: 1S/C17H20FN3O2.C6H8O7/c1-11-19-16(8-17(22)20-11)12-5-6-21(9-12)10-13-7-14(23-2)3-4-15(13)18;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-4,7-8,12H,5-6,9-10H2,1-2H3,(H,19,20,22);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChiKey: UAPAZQQAFFXMAD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear receptor NHR-88	0.0084	0.0136	0.0136
Brugia malayi	ecdysteroid receptor	0.0084	0.0136	0.0136
Leishmania major	hypothetical protein, conserved	0.0042	0.0056	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0044	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.002	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0056	0.0056
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0012	0.1762
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0056	0.4608
Schistosoma mansoni	retinoic acid receptor RXR	0.0084	0.0136	0.0136
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.0023	0.0023
Loa Loa (eye worm)	acetyltransferase	0.0169	0.03	0.03
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0023	0.0015
Schistosoma mansoni	coup transcription factor	0.0084	0.0136	0.0136
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.004	0.0051	0.0051
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0084	0.0136	0.0136
Schistosoma mansoni	nuclear receptor	0.004	0.0051	0.0051
Brugia malayi	nuclear receptor RXR	0.004	0.0051	0.0051
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0023	0.0015
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0044	0.006	0.006
Echinococcus granulosus	multidrug resistance protein 1	0.0017	0.0008	0.0008
Plasmodium falciparum	histone acetyltransferase GCN5	0.0046	0.0063	1
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0015	0.0015
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0012	0.0004
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0025	0.0023	0.1823
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0025	0.0023	0.5
Onchocerca volvulus		0.002	0.0012	0.0012
Echinococcus granulosus	Nuclear hormone receptor HR96	0.004	0.0051	0.0051
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0084	0.0136	0.0136
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0025	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0056	0.7893
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Onchocerca volvulus	Protein ultraspiracle homolog	0.0084	0.0136	0.0136
Onchocerca volvulus		0.0084	0.0136	0.0136
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0044	0.006	0.006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0084	0.0136	0.0128
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.0023	0.0023
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0025	0.3598
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.005	0.007	1
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0025	0.0023	0.3264
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0084	0.0136	0.0136
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0015	0.2356
Loa Loa (eye worm)	multidrug resistance protein 3	0.0025	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0136	0.0136
Entamoeba histolytica	Ran family GTPase	0.0024	0.0021	0.331
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0023	0.3264
Schistosoma mansoni	RAR-like nuclear receptor	0.0084	0.0136	0.0136
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0084	0.0136	0.0136
Onchocerca volvulus		0.002	0.0012	0.0012
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.004	0.0051	0.0051
Loa Loa (eye worm)	DR-78	0.004	0.0051	0.0051
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.0023	0.3264
Brugia malayi	ecdysone receptor	0.004	0.0051	0.0051
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0164	0.0291	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0037	0.0037
Echinococcus granulosus	geminin	0.0388	0.0721	0.0721
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0023	0.3264
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0056	0.7893
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Onchocerca volvulus		0.0042	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0136	0.0136
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0068	0.0106	0.8824
Trichomonas vaginalis	taga, putative	0.0025	0.0023	0.3264
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.005	0.007	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0015	0.2089
Entamoeba histolytica	P-glycoprotein-5	0.0025	0.0023	0.368
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0023	0.0015
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Onchocerca volvulus		0.002	0.0012	0.0012
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0015	0.0219
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0015	0.0219
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Schistosoma mansoni	nuclear hormone receptor	0.0084	0.0136	0.0136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.004	0.0051	0.0051
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0084	0.0136	0.0136
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0015	0.0015
Echinococcus granulosus	nuclear receptor nhr 48	0.004	0.0051	0.0051
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0056	0.0859
Onchocerca volvulus		0.002	0.0012	0.0012
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0268	0.0491	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0023	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Echinococcus granulosus	snurportin 1	0.0346	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0136	0.0136
Trichomonas vaginalis	bromodomain-containing protein, putative	0.005	0.007	1
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0015	0.0219
Onchocerca volvulus		0.002	0.0012	0.0012
Schistosoma mansoni	ran	0.0024	0.0021	0.0021
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0056	0.4093
Echinococcus granulosus	histone acetyltransferase KAT2B	0.005	0.007	0.007
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0023	0.3264
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0015	0.0006
Toxoplasma gondii	HEAT repeat-containing protein	0.0032	0.0037	0.4257
Echinococcus multilocularis	ATP binding cassette sub family B	0.0025	0.0022	0.0014
Brugia malayi	hypothetical protein	0.0044	0.006	0.006
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0056	0.0047
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.004	0.0051	0.0042
Brugia malayi	Cathepsin L-like precursor	0.002	0.0012	0.0012
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0015	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0056	0.0056
Brugia malayi	photoreceptor-specific nuclear receptor	0.0084	0.0136	0.0136
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0056	0.0056
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0051	0.0051
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0026	0.0025	0.1226
Brugia malayi	RNA, U transporter 1	0.0092	0.0152	0.0152
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0084	0.0136	0.0136
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0012	0.0012
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0056	0.0859
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0056	0.0859
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0012	0.1762
Brugia malayi	multidrug resistance protein 3	0.0025	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0056	0.0056
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.004	0.0051	0.0051
Plasmodium vivax	multidrug resistance protein 1, putative	0.0025	0.0023	0.1823
Brugia malayi	tailless protein	0.004	0.0051	0.0051
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0023	0.3264
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0015	0.107
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0056	0.0056
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0118	1
Trichomonas vaginalis	abcb9, putative	0.0025	0.0023	0.3264
Brugia malayi	ABC transporter family protein	0.0025	0.0023	0.0023
Schistosoma mansoni	sodium-bile acid cotransporter related	0.2113	0.404	0.404
Leishmania major	cathepsin L-like protease	0.0074	0.0118	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0024	0.0021	0.1425
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0056	0.0056
Leishmania major	p-glycoprotein	0.0025	0.0023	0.1003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0056	0.0859
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.005	0.007	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0084	0.0136	0.0136
Loa Loa (eye worm)	cysteine protease	0.002	0.0012	0.0012
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0012	0.0004
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0023	0.3264
Entamoeba histolytica	hypothetical protein	0.0026	0.0025	0.4056
Brugia malayi	Cathepsin L-like precursor	0.002	0.0012	0.0012
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0015	0.0219
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0084	0.0136	0.0136
Echinococcus multilocularis	multidrug resistance protein 1	0.0025	0.0023	0.0015
Echinococcus granulosus	sodium bile acid cotransporter	0.5211	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0084	0.0136	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.0023	0.0023
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0012	0.1762
Echinococcus granulosus	cathepsin l1	0.002	0.0012	0.0012
Brugia malayi	beta-lactamase family protein	0.0042	0.0056	0.0056
Schistosoma mansoni	multidrug resistance protein	0.0025	0.0023	0.0023
Onchocerca volvulus		0.002	0.0012	0.0012
Loa Loa (eye worm)	fibroinase	0.002	0.0012	0.0012
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0151	0.0265	0.0265
Brugia malayi	hypothetical protein	0.004	0.0051	0.0051
Loa Loa (eye worm)	nuclear receptor NHR-67	0.004	0.0051	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0084	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0023	0.0023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0025	0.0023	0.0174
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0084	0.0136	0.0128
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0056	0.0859
Brugia malayi	Nuclear hormone receptor E75	0.004	0.0051	0.0051
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0012	0.0012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0012	0.1762
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0136	0.0136
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0044	0.006	0.006
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0012	0.0004
Loa Loa (eye worm)	nuclear hormone receptor	0.004	0.0051	0.0051
Echinococcus multilocularis	sodium bile acid cotransporter	0.5211	1	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.0021	0.0012
Leishmania major	DNA polymerase eta, putative	0.0021	0.0015	0.0219
Echinococcus multilocularis	importin subunit beta 1	0.0032	0.0037	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.0021	0.1425
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0084	0.0136	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0136	0.0136
Brugia malayi	nuclear receptor NHR-67	0.004	0.0051	0.0051
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0015	0.0006
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0056	0.0859
Loa Loa (eye worm)	hypothetical protein	0.5211	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0084	0.0136	0.0136
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0015	0.0015
Loa Loa (eye worm)	transcription factor SMAD2	0.0139	0.0243	0.0243
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0084	0.0136	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Giardia lamblia	Histone acetyltransferase GCN5	0.0046	0.0063	1
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0056	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0056	0.0056
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Schistosoma mansoni	multidrug resistance protein	0.0025	0.0023	0.0023
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0056	0.7893
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0056	0.0056
Brugia malayi	nuclear hormone receptor	0.0084	0.0136	0.0136
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0021	0.0784
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0056	0.0056
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0012	0.1762
Onchocerca volvulus		0.0025	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0023	0.0023
Onchocerca volvulus		0.0042	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0044	0.006	0.006
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.004	0.0051	0.0051
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0056	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0012	0.0012
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0021	0.0784
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.004	0.0051	0.0042
Onchocerca volvulus		0.0042	0.0056	0.0056
Entamoeba histolytica	P-glycoprotein-2	0.0025	0.0023	0.368
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0012	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0084	0.0136	0.0136
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0037	0.3008
Brugia malayi	Steroid receptor seven-up type 2	0.0084	0.0136	0.0136
Brugia malayi	Importin beta-1 subunit	0.0032	0.0037	0.0037
Schistosoma mansoni	hypothetical protein	0.0151	0.0265	0.0265
Plasmodium falciparum	importin beta, putative	0.0032	0.0037	0.4934
Leishmania major	cathepsin L-like protease	0.0074	0.0118	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0012	0.1987
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.0021	0.0021
Entamoeba histolytica	P-glycoprotein-2	0.0025	0.0023	0.368
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0084	0.0136	0.0136
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.0023	0.0023
Toxoplasma gondii	ABC1 family protein	0.0042	0.0056	0.7442
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0022	0.0022
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0051	0.0042
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0015	0.0015
Echinococcus granulosus	dna polymerase eta	0.0021	0.0015	0.0015
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.091	0.1726	0.1719
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0056	0.0859
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0015	0.107
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0056	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Loa Loa (eye worm)	ctsf protein	0.002	0.0012	0.0012
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0025	0.0023	0.1823
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0084	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0044	0.006	0.006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0012	0.1762
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0084	0.0136	0.0128
Echinococcus multilocularis	cysteine protease	0.002	0.0012	0.0004
Onchocerca volvulus	Bile acid receptor homolog	0.0084	0.0136	0.0136
Onchocerca volvulus		0.004	0.0051	0.0051
Brugia malayi	Nuclear hormone receptor-like 1	0.0369	0.0685	0.0685
Echinococcus multilocularis	multidrug resistance protein 1	0.0025	0.0023	0.0015
Echinococcus granulosus	Nuclear hormone receptor HR96	0.004	0.0051	0.0051
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0012	0.0012
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0025	0.3598
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0235	0.0426	0.0418
Entamoeba histolytica	P-glycoprotein 5, putative	0.0025	0.0023	0.368
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0023	0.3264
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0012	0.1762
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0084	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0084	0.0136	0.0136
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.033	0.0609	0.0609
Echinococcus multilocularis	nuclear receptor nhr 48	0.004	0.0051	0.0042
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0023	0.3264
Brugia malayi	hypothetical protein	0.004	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0044	0.006	0.006
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.005	0.007	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0037	0.3008
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0023	0.3264
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0346	0.064	0.064
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0023	0.3264
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.004	0.0051	0.0051
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0015	0.0015
Echinococcus granulosus	FTZ F1 alpha	0.0084	0.0136	0.0136
Echinococcus multilocularis	cysteine protease	0.002	0.0012	0.0004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0012	0.1762
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0015	0.0219
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0051	0.0051
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.0021	0.0021
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Schistosoma mansoni	nuclear receptor nhr-48	0.004	0.0051	0.0051
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.0023	0.3264
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Onchocerca volvulus		0.004	0.0051	0.0051
Schistosoma mansoni	ran	0.0024	0.0021	0.0021
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0023	0.3264
Loa Loa (eye worm)	steroid hormone receptor	0.0084	0.0136	0.0136
Brugia malayi	Nuclear hormone receptor-like 1	0.033	0.0609	0.0609
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0056	0.7893
Leishmania major	GTP-binding protein, putative	0.0024	0.0021	0.0784
Brugia malayi	nuclear hormone receptor	0.004	0.0051	0.0051
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.0023	0.3264
Trichomonas vaginalis	ran, putative	0.0024	0.0021	0.2936
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0084	0.0136	0.0136
Schistosoma mansoni	zinc finger protein	0.004	0.0051	0.0051
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0056	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0056	0.4093
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0056	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0084	0.0136	0.0136
Brugia malayi	beta-lactamase	0.0042	0.0056	0.0056
Brugia malayi	Cathepsin L-like precursor	0.002	0.0012	0.0012
Brugia malayi	Nuclear hormone receptor E75	0.004	0.0051	0.0051
Entamoeba histolytica	P-glycoprotein-2, putative	0.0025	0.0023	0.368
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0151	0.0265	0.0257
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0015	0.107
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Schistosoma mansoni	sodium-bile acid cotransporter related	0.5211	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0084	0.0136	0.0136
Schistosoma mansoni	hypothetical protein	0.0388	0.0721	0.0721
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0044	0.006	0.006
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0084	0.0136	0.0128
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0023	0.3264
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0084	0.0136	0.0136
Schistosoma mansoni	sodium-bile acid cotransporter	0.3098	0.5935	0.5935
Brugia malayi	nuclear receptor NHR-88	0.004	0.0051	0.0051
Echinococcus multilocularis	snurportin 1	0.0346	0.064	0.0632
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0023	0.3264
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0056	0.0056
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0015	0.0015
Trypanosoma brucei	unspecified product	0.0021	0.0015	0.107
Brugia malayi	MH2 domain containing protein	0.0139	0.0243	0.0243
Echinococcus granulosus	ecdysone induced protein 78C	0.0084	0.0136	0.0136
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Entamoeba histolytica	P-glycoprotein-1	0.0025	0.0023	0.368
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0012	0.1762
Schistosoma mansoni	thyroid hormone receptor	0.0235	0.0426	0.0426
Echinococcus granulosus	sodium bile acid cotransporter	0.5211	1	1
Schistosoma mansoni	nuclear receptor	0.004	0.0051	0.0051
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0025	0.0023	0.3264
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Schistosoma mansoni	hypothetical protein	0.0346	0.064	0.064
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0056	0.7893
Brugia malayi	Cathepsin L-like precursor	0.002	0.0012	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0084	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0084	0.0136	0.0136
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0023	0.3264
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0084	0.0136	0.0136
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0015	0.0015
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0024	0.0021	0.1248
Schistosoma mansoni	smdr2	0.0025	0.0023	0.0023
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0056	0.0859
Echinococcus granulosus	thyroid hormone receptor alpha	0.004	0.0051	0.0051
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0084	0.0136	0.0136
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0056	0.0859
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.0023	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0325	0.06	0.06
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0084	0.0136	0.0136
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0023	0.0015
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0056	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0136	0.0136
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0169	0.03	0.0292
Brugia malayi	orphan nuclear receptor NR2E1	0.004	0.0051	0.0051
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0084	0.0136	0.0136
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0015	0.107
Schistosoma mansoni	thyroid hormone receptor	0.0235	0.0426	0.0426
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0012	0.0012
Echinococcus granulosus	importin subunit beta 1	0.0032	0.0037	0.0037
Trichomonas vaginalis	importin beta-1, putative	0.0026	0.0025	0.3598
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0023	0.3264
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0118	1
Trichomonas vaginalis	abcb9, putative	0.0025	0.0023	0.3264
Echinococcus granulosus	multidrug resistance protein 1	0.0017	0.0008	0.0008
Entamoeba histolytica	cysteine protease, putative	0.002	0.0012	0.1987
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0136	0.0136
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0056	0.7442
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0118	1
Brugia malayi	steroid hormone receptor	0.0084	0.0136	0.0136
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0084	0.0136	0.0136
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.004	0.0051	0.0042
Brugia malayi	beta-lactamase family protein	0.0042	0.0056	0.0056
Plasmodium falciparum	multidrug resistance protein 1	0.0025	0.0023	0.2113
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0084	0.0136	0.0136
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0012	0.0004
Echinococcus granulosus	sodium bile acid cotransporter	0.5211	1	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0056	0.0056
Entamoeba histolytica	acetyltransferase, GNAT family	0.0046	0.0063	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0051	0.0051
Plasmodium vivax	importin-beta 2, putative	0.0032	0.0037	0.4257
Onchocerca volvulus		0.002	0.0012	0.0012
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0023	0.3264
Echinococcus multilocularis	geminin	0.0388	0.0721	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0056	0.0056
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0087	0.7098
Trypanosoma cruzi	cruzipain precursor, putative	0.0074	0.0118	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0084	0.0136	0.0128
Brugia malayi	conserved hypotetical protein	0.004	0.0051	0.0051
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0056	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0084	0.0136	0.0128
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0136	0.0136
Echinococcus multilocularis	sodium bile acid cotransporter	0.5211	1	1
Schistosoma mansoni	importin beta-1	0.0032	0.0037	0.0037
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0012	0.0012
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0023	0.3264
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0044	0.006	0.0052
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0015	0.0219
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0015	0.2089
Echinococcus multilocularis	FTZ F1 alpha	0.0084	0.0136	0.0128
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.0023	0.3264
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0084	0.0136	0.0136
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0024	0.0021	0.1586
Echinococcus multilocularis	sodium bile acid cotransporter	0.5211	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0012	0.1987
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0084	0.0136	0.0136
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0084	0.0136	0.0136
Leishmania major	importin beta-1 subunit, putative	0.0026	0.0025	0.1226
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0015	0.107
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0023	0.3264
Mycobacterium ulcerans	lipase LipD	0.0042	0.0056	1
Brugia malayi	nuclear receptor RXR	0.0044	0.006	0.006
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0025	0.0023	0.0023
Leishmania major	cathepsin L-like protease	0.0074	0.0118	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0015	0.0219
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Brugia malayi	nuclear hormone receptor family member odr-7	0.004	0.0051	0.0051
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0023	0.3264
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.004	0.0051	0.0042
Brugia malayi	hypothetical protein	0.0044	0.006	0.006
Brugia malayi	acetyltransferase, GNAT family protein	0.0169	0.03	0.03
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0025	0.0023	0.1003
Onchocerca volvulus		0.5211	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0017	0.0008	0.1201
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0084	0.0136	0.0136
Trichomonas vaginalis	esterase, putative	0.0042	0.0056	0.7893
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0012	0.0012
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.004	0.0051	0.0051
Brugia malayi	Nuclear hormone receptor-like 1	0.033	0.0609	0.0609
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0084	0.0136	0.0136
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0023	0.3264
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0169	0.03	0.03
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0084	0.0136	0.0136
Schistosoma mansoni	hypothetical protein	0.0388	0.0721	0.0721
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Trichomonas vaginalis	abcb9, putative	0.0025	0.0023	0.3264
Brugia malayi	nuclear hormone receptor family member nhr-6	0.004	0.0051	0.0051
Entamoeba histolytica	P-glyco protein 6, putative	0.0025	0.0023	0.368
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0012	0.1762
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.0021	0.1651
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.0021	0.0021
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.0023	0.0023
Brugia malayi	Cathepsin L-like precursor	0.002	0.0012	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0012	0.1762
Schistosoma mansoni	multidrug resistance protein	0.0025	0.0023	0.0023
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0023	0.3264
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0012	0.1762
Loa Loa (eye worm)	MH2 domain-containing protein	0.0139	0.0243	0.0243

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3504788

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2074463