Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3289 | 0.3289 |
Brugia malayi | hypothetical protein | 0.003 | 0.091 | 0.091 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.091 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.091 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.091 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0019 | 0.0002 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1767 | 0.1767 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.091 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4591 | 0.4591 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.091 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0019 | 0.0002 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3289 | 0.3289 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4591 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4591 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1767 | 0.3848 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3289 | 0.3289 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.091 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0005 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4591 | 0.4591 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3289 | 0.3289 |
Brugia malayi | hypothetical protein | 0.002 | 0.0048 | 0.0048 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4591 | 0.4591 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.091 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0.0002 | 0.0002 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.091 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.091 | 0.091 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1767 | 0.1767 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.