Detailed information for compound 2074694

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 467.645 | Formula: C22H33N3O4S2
  • H donors: 2 H acceptors: 2 LogP: 2.16 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: SC[C@@H](/C=C/CN1C[C@@H](C[C@H]1C(=O)N[C@H](C(=O)OC)CCSC)Oc1ccccc1)N
  • InChi: 1S/C22H33N3O4S2/c1-28-22(27)19(10-12-31-2)24-21(26)20-13-18(29-17-8-4-3-5-9-17)14-25(20)11-6-7-16(23)15-30/h3-9,16,18-20,30H,10-15,23H2,1-2H3,(H,24,26)/b7-6+/t16-,18-,19+,20+/m1/s1
  • InChiKey: DAKLZKDSHKWINM-UMESMWHJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.0412 0.0412
Trichomonas vaginalis CAMK family protein kinase 0.0027 0.0424 0.1085
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0674 0.0674
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0021 0.0258 0.0462
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0545 0.0828
Brugia malayi serine/threonine-protein kinase plk-2 0.0055 0.1156 0.1156
Echinococcus granulosus carboxylesterase 5A 0.0392 1 1
Onchocerca volvulus 0.0035 0.0617 0.3019
Echinococcus multilocularis muscleblind protein 1 0.0087 0.1999 0.1999
Trichomonas vaginalis CAMK family protein kinase 0.0027 0.0424 0.1085
Onchocerca volvulus 0.0066 0.1445 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0058 0.0058
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0066 0.1445 0.1445
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0185 0.0185
Toxoplasma gondii ABC1 family protein 0.0021 0.0258 0.0575
Trichomonas vaginalis spcc417.12 protein, putative 0.0066 0.1445 0.3703
Schistosoma mansoni glutaminase 0.016 0.3902 0.3902
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.1156 0.2962
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.321 0.9915
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.1156 0.2962
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0055 0.1156 0.1921
Trichomonas vaginalis glutaminase, putative 0.016 0.3902 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1445 0.1445
Echinococcus multilocularis BC026374 protein (S09 family) 0.0066 0.1445 0.1445
Echinococcus multilocularis integrin alpha ps 0.0096 0.2232 0.2232
Echinococcus granulosus citrate lyase subunit beta protein 0.0014 0.0082 0.0082
Trypanosoma brucei polo-like protein kinase 0.0055 0.1156 0.177
Loa Loa (eye worm) PHD-finger family protein 0.0012 0.0022 0.0022
Echinococcus multilocularis beta adrenergic receptor kinase 0.0011 0.0005 0.0005
Schistosoma mansoni acetylcholinesterase 0.0066 0.1445 0.1445
Loa Loa (eye worm) hypothetical protein 0.0066 0.1445 0.1445
Loa Loa (eye worm) hypothetical protein 0.0066 0.1445 0.1445
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0185 0.0473
Plasmodium falciparum thioredoxin reductase 0.0053 0.1088 1
Schistosoma mansoni cpg binding protein 0.0038 0.0698 0.0698
Echinococcus granulosus acetylcholinesterase 0.0392 1 1
Echinococcus multilocularis integrin alpha 3 0.0164 0.4026 0.4026
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0021 0.0258 0.0258
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1445 0.1445
Echinococcus multilocularis cpg binding protein 0.0038 0.0698 0.0698
Schistosoma mansoni bromodomain containing protein 0.0039 0.0729 0.0729
Brugia malayi beta-lactamase family protein 0.0021 0.0258 0.0258
Schistosoma mansoni hypothetical protein 0.0203 0.504 0.504
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0021 0.0257 0.0257
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.2858 0.88
Leishmania major trypanothione reductase 0.0053 0.1088 0.18
Mycobacterium tuberculosis Probable lipase LipE 0.0021 0.0258 0.056
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.1468 1
Echinococcus multilocularis acetylcholinesterase 0.0392 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0021 0.0258 0.0662
Mycobacterium tuberculosis Conserved protein 0.0021 0.0258 0.056
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0227 0.5671 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0185 0.0185
Brugia malayi glutathione reductase 0.0053 0.1088 0.1088
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.1156 0.1156
Loa Loa (eye worm) hypothetical protein 0.0021 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0066 0.1445 0.1445
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0185 0.0473
Echinococcus granulosus expressed protein 0.0218 0.5436 0.5436
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0185 0.0184
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.1156 0.2962
Leishmania major hypothetical protein, conserved 0.0021 0.0258 0.0316
Loa Loa (eye worm) carboxylesterase 0.0392 1 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0185 0.0184
Mycobacterium tuberculosis Probable lipase LipD 0.0021 0.0258 0.056
Brugia malayi Integrin alpha pat-2 precursor 0.0215 0.5341 0.5341
Brugia malayi glutaminase DH11.1 0.016 0.3902 0.3902
Trypanosoma cruzi polo-like protein kinase, putative 0.0055 0.1156 0.1921
Loa Loa (eye worm) hypothetical protein 0.0066 0.1445 0.1445
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.1156 0.2962
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0005 0.0005
Trichomonas vaginalis esterase, putative 0.0021 0.0258 0.0662
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0185 0.0184
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0617 0.0617
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0185 0.0184
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0066 0.1445 0.3703
Loa Loa (eye worm) MH2 domain-containing protein 0.007 0.1538 0.1538
Echinococcus granulosus muscleblind protein 0.0087 0.1999 0.1999
Trypanosoma brucei RNA helicase, putative 0.0054 0.1126 0.1716
Echinococcus granulosus integrin alpha 3 0.0164 0.4026 0.4026
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0185 0.0269
Mycobacterium tuberculosis Conserved protein 0.0021 0.0258 0.056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0331 0.0331
Echinococcus granulosus fetal alzheimer antigen falz 0.0015 0.0104 0.0104
Entamoeba histolytica hypothetical protein 0.0021 0.0258 0.2232
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0032 0.0545 0.0656
Loa Loa (eye worm) glutaminase 2 0.016 0.3902 0.3902
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0055 0.1156 0.1156
Schistosoma mansoni hypothetical protein 0.0046 0.0917 0.0917
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0185 0.0185
Echinococcus granulosus BC026374 protein S09 family 0.0066 0.1445 0.1445
Echinococcus multilocularis acetylcholinesterase 0.0392 1 1
Onchocerca volvulus 0.0066 0.1445 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0021 0.0258 0.056
Loa Loa (eye worm) beta-lactamase 0.0021 0.0258 0.0258
Echinococcus granulosus integrin alpha ps 0.0096 0.2232 0.2232
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0168 0.413 0.413
Toxoplasma gondii hypothetical protein 0.0037 0.0668 0.3766
Loa Loa (eye worm) hypothetical protein 0.0021 0.0258 0.0258
Giardia lamblia Kinase, PLK 0.0055 0.1156 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.2858 0.88
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0185 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0021 0.0258 0.0258
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.2858 0.88
Toxoplasma gondii thioredoxin reductase 0.0053 0.1088 0.7037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0066 0.1445 0.1445
Leishmania major mitochondrial DNA polymerase beta 0.0227 0.5671 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0185 0.0184
Loa Loa (eye worm) glutathione reductase 0.0053 0.1088 0.1088
Schistosoma mansoni zinc finger protein 0.0013 0.0058 0.0058
Echinococcus granulosus neuroligin 0.0066 0.1445 0.1445
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0674 0.0674
Entamoeba histolytica hypothetical protein 0.0021 0.0258 0.2232
Loa Loa (eye worm) hypothetical protein 0.0392 1 1
Schistosoma mansoni integrin alpha 0.0215 0.5341 0.5341
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0107 0.2529 0.4273
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0014 0.0082 0.021
Echinococcus granulosus beta-adrenergic receptor kinase 0.0011 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.0038 0.0698 0.0698
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.1088 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.2858 0.88
Mycobacterium ulcerans esterase/lipase LipP 0.0021 0.0258 0.0462
Trichomonas vaginalis penicillin-binding protein, putative 0.0021 0.0258 0.0662
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0134 0.3237 1
Onchocerca volvulus 0.0066 0.1445 1
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.2971 0.517
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0185 0.0269
Plasmodium vivax glutathione reductase, putative 0.0053 0.1088 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0185 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0258 0.0316
Mycobacterium tuberculosis Carboxylesterase LipT 0.0066 0.1445 0.4321
Brugia malayi Carboxylesterase family protein 0.0066 0.1445 0.1445
Loa Loa (eye worm) hypothetical protein 0.005 0.1021 0.1021
Schistosoma mansoni gliotactin 0.0066 0.1445 0.1445
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.1088 0.1088
Schistosoma mansoni kinase 0.0028 0.0443 0.0443
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0032 0.0545 0.0828
Brugia malayi Muscleblind-like protein 0.0087 0.1999 0.1999
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0185 0.0184
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0011 0.0005 0.0005
Echinococcus granulosus cpg binding protein 0.0038 0.0698 0.0698
Mycobacterium ulcerans hypothetical protein 0.012 0.2848 0.7241
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0011 0.0005 0.0005
Loa Loa (eye worm) glutaminase 0.016 0.3902 0.3902
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.1156 0.2962
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0185 0.5
Loa Loa (eye worm) hypothetical protein 0.0087 0.1999 0.1999
Leishmania major hypothetical protein, conserved 0.0124 0.2971 0.517
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0185 0.0269
Brugia malayi hypothetical protein 0.0066 0.1445 0.1445
Echinococcus multilocularis neuroligin 0.0066 0.1445 0.1445
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0185 0.0185
Schistosoma mansoni BC026374 protein (S09 family) 0.0066 0.1445 0.1445
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0021 0.0257 0.0257
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0392 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0021 0.0258 0.0258
Brugia malayi CXXC zinc finger family protein 0.0035 0.0617 0.0617
Schistosoma mansoni hypothetical protein 0.0012 0.0022 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0227 0.5671 1
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0124 0.2971 0.517
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1638 0.1638
Treponema pallidum NADH oxidase 0.0018 0.0185 0.5
Echinococcus granulosus integrin alpha ps 0.0046 0.0917 0.0917
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.2529 0.4378
Brugia malayi Carboxylesterase family protein 0.0066 0.1445 0.1445
Trichomonas vaginalis D-aminoacylase, putative 0.0021 0.0258 0.0662
Trypanosoma brucei hypothetical protein, conserved 0.0021 0.0258 0.0135
Trypanosoma brucei hypothetical protein, conserved 0.0124 0.2971 0.5079
Loa Loa (eye worm) hypothetical protein 0.0392 1 1
Mycobacterium ulcerans lipase LipD 0.0021 0.0258 0.0462
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0039 0.0728 0.1156
Echinococcus granulosus acetylcholinesterase 0.0392 1 1
Echinococcus multilocularis expressed protein 0.0218 0.5436 0.5436
Trypanosoma cruzi polo-like protein kinase, putative 0.0055 0.1156 0.1921
Plasmodium falciparum glutathione reductase 0.0053 0.1088 1
Brugia malayi PHD-finger family protein 0.0017 0.014 0.014
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0096 0.2225 0.2225
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0185 0.0184
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0015 0.0104 0.0104
Schistosoma mansoni cpg binding protein 0.0035 0.0617 0.0617
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0185 0.0184
Mycobacterium ulcerans glutaminase 0.016 0.3902 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0258 0.0258
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0021 0.0258 0.056
Loa Loa (eye worm) hypothetical protein 0.0066 0.1445 0.1445
Schistosoma mansoni transcription factor LCR-F1 0.0021 0.0258 0.0258
Echinococcus granulosus geminin 0.0203 0.504 0.504
Mycobacterium ulcerans beta-lactamase 0.0021 0.0258 0.0462
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.2529 0.4378
Brugia malayi beta-lactamase family protein 0.0021 0.0258 0.0258
Onchocerca volvulus 0.0066 0.1445 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0185 0.0184
Schistosoma mansoni integrin alpha-ps 0.005 0.1021 0.1021
Loa Loa (eye worm) carboxylesterase 0.0066 0.1445 0.1445
Entamoeba histolytica serine/threonine protein kinase, putative 0.0055 0.1156 1
Brugia malayi beta-lactamase 0.0021 0.0258 0.0258
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.2848 0.8767
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.321 1
Brugia malayi hypothetical protein 0.0021 0.0258 0.0258
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.1156 0.2962
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.321 0.9915
Brugia malayi Bromodomain containing protein 0.0022 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0041 0.0791 0.0791
Loa Loa (eye worm) hypothetical protein 0.0021 0.0258 0.0258
Echinococcus multilocularis citrate lyase subunit beta protein 0.0014 0.0082 0.0082
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.1088 0.3188
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0055 0.1156 0.1156
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0021 0.0258 0.056
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0021 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0096 0.2225 0.2225
Entamoeba histolytica hypothetical protein 0.0021 0.0258 0.2232
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0185 0.0184
Schistosoma mansoni hypothetical protein 0.0054 0.1126 0.1126
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.1096 0.1096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0066 0.1445 0.1445
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0066 0.1445 0.1445
Brugia malayi MH2 domain containing protein 0.007 0.1538 0.1538
Brugia malayi Thioredoxin reductase 0.0053 0.1088 0.1088
Loa Loa (eye worm) integrin alpha pat-2 0.0264 0.6649 0.6649
Mycobacterium ulcerans hypothetical protein 0.0021 0.0258 0.0462
Brugia malayi Carboxylesterase family protein 0.0066 0.1445 0.1445
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0055 0.1156 0.1156
Echinococcus multilocularis geminin 0.0203 0.504 0.504
Loa Loa (eye worm) transcription factor SMAD2 0.007 0.1538 0.1538
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.321 0.9915
Schistosoma mansoni hypothetical protein 0.0203 0.504 0.504
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0021 0.0258 0.0258
Entamoeba histolytica hypothetical protein 0.0021 0.0258 0.2232
Schistosoma mansoni hypothetical protein 0.0021 0.0258 0.0258
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0185 0.5
Echinococcus multilocularis integrin alpha ps 0.0046 0.0917 0.0917
Echinococcus granulosus zinc finger protein 0.0013 0.0058 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0258 0.0316
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.1088 0.18
Mycobacterium tuberculosis Probable hydrolase 0.0021 0.0258 0.056
Echinococcus multilocularis muscleblind protein 0.0087 0.1999 0.1999
Mycobacterium tuberculosis Probable reductase 0.012 0.2858 0.88
Schistosoma mansoni neuroligin 3 (S09 family) 0.0066 0.1445 0.1445
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0227 0.5671 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0185 0.0326
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0066 0.1445 0.4321
Mycobacterium tuberculosis Conserved protein 0.0021 0.0258 0.056
Trichomonas vaginalis penicillin-binding protein, putative 0.0021 0.0258 0.0662
Loa Loa (eye worm) acetylcholinesterase 1 0.0392 1 1
Schistosoma mansoni integrin alpha-ps 0.0096 0.2232 0.2232
Echinococcus granulosus para nitrobenzyl esterase 0.0066 0.1445 0.1445
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0005 0.0005
Onchocerca volvulus Serine\/threonine kinase homolog 0.0055 0.1156 0.7562
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0032 0.0545 0.0828
Echinococcus multilocularis integrin alpha ps 0.0096 0.2232 0.2232
Loa Loa (eye worm) hypothetical protein 0.0118 0.2815 0.2815
Loa Loa (eye worm) carboxylesterase 0.0066 0.1445 0.1445
Trichomonas vaginalis D-aminoacylase, putative 0.0021 0.0258 0.0662
Trypanosoma brucei trypanothione reductase 0.0053 0.1088 0.1646
Echinococcus multilocularis para nitrobenzyl esterase 0.0066 0.1445 0.1445
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0258 0.0817
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.1156 0.2962
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0066 0.1445 0.4321
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0013 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0185 0.0184
Brugia malayi Carboxylesterase family protein 0.0066 0.1445 0.1445
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0021 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0046 0.0917 0.0917
Brugia malayi Bromodomain containing protein 0.0046 0.0909 0.0909
Echinococcus multilocularis carboxylesterase 5A 0.0392 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1445 0.1445
Mycobacterium tuberculosis Probable esterase LipL 0.0021 0.0258 0.056
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0011 0.0005 0.0005
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.1096 0.1096
Echinococcus multilocularis beta LACTamase domain containing family member 0.0021 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0021 0.0258 0.0258
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0185 0.0184
Loa Loa (eye worm) hypothetical protein 0.0087 0.1999 0.1999
Echinococcus granulosus beta LACTamase domain containing family member 0.0021 0.0258 0.0258
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.2858 0.8808
Onchocerca volvulus 0.0066 0.1445 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0066 0.1445 0.3569
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.2858 0.88
Brugia malayi Carboxylesterase family protein 0.0392 1 1
Echinococcus multilocularis zinc finger protein 0.0013 0.0058 0.0058
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0015 0.0104 0.0104

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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