Detailed information for compound 20747

Basic information

Technical information
  • TDR Targets ID: 20747
  • Name: 2-[2-(4-chlorophenyl)-5-furan-3-yl-1,3-oxazol -4-yl]acetic acid
  • MW: 303.697 | Formula: C15H10ClNO4
  • H donors: 1 H acceptors: 3 LogP: 2.85 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)Cc1nc(oc1c1cocc1)c1ccc(cc1)Cl
  • InChi: 1S/C15H10ClNO4/c16-11-3-1-9(2-4-11)15-17-12(7-13(18)19)14(21-15)10-5-6-20-8-10/h1-6,8H,7H2,(H,18,19)
  • InChiKey: VTJUUVAPCCJCNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(4-chlorophenyl)-5-(3-furyl)oxazol-4-yl]acetic acid
  • 2-[2-(4-chlorophenyl)-5-(3-furyl)-4-oxazolyl]acetic acid
  • 2-[2-(4-chlorophenyl)-5-furan-3-yl-1,3-oxazol-4-yl]ethanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0076 0.0559 0.0543
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0158 0.0154
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0594 0.5098 0.5086
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0195
Giardia lamblia Cysteine protease 0.0213 0.1756 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1153 1 1
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0307 0.0303
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0195 0.0744
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0213 0.1756 0.1704
Echinococcus granulosus cathepsin l1 0.1153 1 1
Plasmodium vivax vivapain-3 0.0594 0.5098 0.5067
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0213 0.1756 0.1736
Schistosoma mansoni biogenic amine (5HT) receptor 0.0129 0.1018 0.0997
Giardia lamblia Cysteine protease 0.0213 0.1756 1
Entamoeba histolytica cysteine protease, putative 0.0213 0.1756 0.1704
Brugia malayi Cathepsin L-like precursor 0.1153 1 1
Schistosoma mansoni cathepsin s 0.0381 0.3232 0.3216
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0039 0.0015
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.1727 0.1727
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0213 0.1756 0.1704
Entamoeba histolytica cysteine protease, putative 0.0213 0.1756 0.1704
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Trypanosoma cruzi cysteine proteinase, putative 0.0594 0.5098 0.5086
Loa Loa (eye worm) hypothetical protein 0.0129 0.1018 0.1018
Mycobacterium ulcerans hypothetical protein 0.0035 0.0195 1
Giardia lamblia Hypothetical protein 0.0213 0.1756 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0195
Giardia lamblia Encystation-specific protease 0.0213 0.1756 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.1153 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0127 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.1756 0.1704
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0195
Brugia malayi Papain family cysteine protease containing protein 0.0594 0.5098 0.509
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0594 0.5098 0.5067
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.1756 0.1704
Brugia malayi Cathepsin L-like precursor 0.0772 0.6658 0.6652
Brugia malayi cathepsin F-like cysteine proteinase 0.0213 0.1756 0.1742
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0426 0.0422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Giardia lamblia Cathepsin L precursor 0.0213 0.1756 1
Echinococcus granulosus cathepsin L 0.0213 0.1756 0.1752
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0063 0.0063
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0204 0.02
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0426 0.0422
Brugia malayi Papain family cysteine protease containing protein 0.0213 0.1756 0.1742
Echinococcus granulosus geminin 0.0333 0.2806 0.2803
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0213 0.1756 0.1742
Echinococcus multilocularis cathepsin L cysteine protease 0.1153 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.0133
Schistosoma mansoni cathepsin F (C01 family) 0.1153 1 1
Giardia lamblia Cathepsin B precursor 0.0213 0.1756 1
Plasmodium falciparum serine repeat antigen 2 0.0213 0.1756 0.1704
Echinococcus granulosus biogenic amine 5HT receptor 0.0383 0.3248 0.3245
Onchocerca volvulus 0.1153 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0139 0.0139
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1153 1 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.0744
Brugia malayi Cathepsin L-like precursor 0.0772 0.6658 0.6652
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0307 0.0303
Schistosoma mansoni cathepsin B (C01 family) 0.0213 0.1756 0.1736
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0127 0.0127
Giardia lamblia Cathepsin L-like protease 0.0213 0.1756 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0381 0.3232 0.3216
Loa Loa (eye worm) hypothetical protein 0.0213 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.1153 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1153 1 1
Entamoeba histolytica cysteine protease, putative 0.0213 0.1756 0.1704
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.0109
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0017 0.0017
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Brugia malayi Papain family cysteine protease containing protein 0.0594 0.5098 0.509
Trypanosoma brucei cysteine peptidase C (CPC) 0.0213 0.1756 0.1736
Echinococcus granulosus cathepsin L cysteine proteinase 0.1153 1 1
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0039
Loa Loa (eye worm) hypothetical protein 0.0381 0.3232 0.3232
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0213 0.1756 0.1736
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0213 0.1756 0.1736
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0322 0.0306
Plasmodium vivax serine-repeat antigen (SERA) 0.0213 0.1756 0.1704
Brugia malayi Cathepsin L-like precursor 0.1153 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0195 0.0172
Echinococcus multilocularis cathepsin L 0.0213 0.1756 0.1752
Entamoeba histolytica cysteine protease, putative 0.0213 0.1756 0.1704
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0689 0.0689
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0213 0.1756 0.1704
Brugia malayi cathepsin L-like precursor 0.0772 0.6658 0.6652
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0204 0.02
Echinococcus granulosus intermediate filament protein 0.0027 0.0127 0.0123
Toxoplasma gondii cathepsin CPL 0.1153 1 1
Entamoeba histolytica hypothetical protein 0.0213 0.1756 0.1704
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0213 0.1756 0.1736
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0195 0.0133
Echinococcus granulosus cathepsin l cysteine peptidase 0.1153 1 1
Giardia lamblia Cathepsin B precursor 0.0213 0.1756 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0277 0.0277
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0594 0.5098 0.5086
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0213 0.1756 0.1704
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Schistosoma mansoni intermediate filament proteins 0.0027 0.0127 0.0104
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0109 0.0046
Leishmania major cathepsin L-like protease 0.1153 1 1
Toxoplasma gondii cathepsin B 0.0213 0.1756 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Brugia malayi intermediate filament protein 0.0027 0.0127 0.011
Trichomonas vaginalis set domain proteins, putative 0.0239 0.1981 0.193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0027 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0594 0.5098 0.5086
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0213 0.1756 0.1704
Echinococcus granulosus cathepsin l1 0.0772 0.6658 0.6656
Echinococcus multilocularis serotonin receptor 0.0129 0.1018 0.1014
Entamoeba histolytica cysteine proteinase 2 0.0594 0.5098 0.5067
Onchocerca volvulus 0.0772 0.6658 0.6615
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0195 0.0744
Giardia lamblia Cathepsin B precursor 0.0213 0.1756 1
Brugia malayi Papain family cysteine protease containing protein 0.0213 0.1756 0.1742
Echinococcus multilocularis lamin dm0 0.0027 0.0127 0.0123
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0195 0.0744
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0594 0.5098 0.5086
Schistosoma mansoni lamin 0.0027 0.0127 0.0104
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0213 0.1756 0.1736
Loa Loa (eye worm) hypothetical protein 0.0213 0.1756 0.1756
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0063 0.5
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0101 0.0097
Plasmodium falciparum serine repeat antigen 9 0.0213 0.1756 0.1704
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0307 0.0284
Trypanosoma cruzi cruzipain precursor, putative 0.1153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0772 0.6658 0.6637
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0689 0.0674
Echinococcus granulosus dnaJ subfamily B 0.0405 0.3439 0.3436
Schistosoma mansoni biogenic amine (5HT) receptor 0.0383 0.3248 0.3232
Onchocerca volvulus 0.0213 0.1756 0.1649
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0213 0.1756 0.1704
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0127 0.0127
Brugia malayi CXXC zinc finger family protein 0.0028 0.0139 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0213 0.1756 0.1704
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0213 0.1756 0.1736
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0213 0.1756 0.1736
Giardia lamblia Cathepsin L precursor 0.0213 0.1756 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0195 0.0195
Giardia lamblia Cathepsin B precursor 0.0213 0.1756 1
Leishmania major cysteine peptidase A (CPA) 0.1153 1 1
Loa Loa (eye worm) hypothetical protein 0.0772 0.6658 0.6658
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0195 0.0744
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0195 0.0744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0213 0.1756 0.1704
Schistosoma mansoni cathepsin F (C01 family) 0.1153 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1153 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1153 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0213 0.1756 0.1736
Echinococcus multilocularis cpg binding protein 0.0032 0.017 0.0166
Brugia malayi cathepsin Z-like cysteine proteinase 0.0213 0.1756 0.1742
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0143 0.0139
Entamoeba histolytica cysteine proteinase, putative 0.0594 0.5098 0.5067
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0213 0.1756 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Echinococcus granulosus cathepsin L cysteine protease 0.0594 0.5098 0.5096
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0213 0.1756 0.1736
Echinococcus multilocularis GPCR, family 2 0.0016 0.0027 0.0022
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0101 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0772 0.6658 0.665
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0158 0.0135
Plasmodium falciparum serine repeat antigen 4 0.0213 0.1756 0.1704
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0213 0.1756 0.1736
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1153 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0063 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0689 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Giardia lamblia Cathepsin L precursor 0.0213 0.1756 1
Brugia malayi Bromodomain containing protein 0.0038 0.0225 0.0208
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1153 1 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0195 0.0195
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.0744
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0392 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.1756 0.1704
Plasmodium falciparum serine repeat antigen 3 0.0213 0.1756 0.1704
Giardia lamblia Cathepsin L precursor 0.0213 0.1756 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0689 0.0685
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.3439 0.3436
Schistosoma mansoni hypothetical protein 0.0034 0.0185 0.0162
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0213 0.1756 0.1704
Brugia malayi cathepsin L precursor 0.0213 0.1756 0.1742
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.0172
Onchocerca volvulus 0.1153 1 1
Schistosoma mansoni cpg binding protein 0.0032 0.017 0.0147
Entamoeba histolytica cysteine proteinase, putative 0.1153 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0003
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Loa Loa (eye worm) cathepsin B 0.0213 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.0213 0.1756 0.1756
Toxoplasma gondii preprocathepsin c precursor, putative 0.0213 0.1756 0.1704
Leishmania major cathepsin L-like protease 0.1153 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0246 0.0246
Giardia lamblia Hypothetical protein 0.0213 0.1756 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0195 0.0744
Plasmodium vivax vivapain-2 0.1153 1 1
Echinococcus multilocularis musashi 0.0027 0.0127 0.0123
Schistosoma mansoni lamin 0.0027 0.0127 0.0104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0063 0.0039
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0063 0.0039
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0178
Brugia malayi beta-lactamase 0.0035 0.0195 0.0178
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0195 0.0172
Echinococcus granulosus GPCR family 2 0.0016 0.0027 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0213 0.1756 0.1704
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.1756 0.1704
Plasmodium vivax vivapain-2 0.1153 1 1
Onchocerca volvulus 0.1153 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0594 0.5098 0.5086
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.1756 0.1704
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0101 0.0078
Plasmodium falciparum serine repeat antigen 7 0.0213 0.1756 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0213 0.1756 0.1704
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.5965 0.5963
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0213 0.1756 0.1704
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Schistosoma mansoni hypothetical protein 0.0021 0.007 0.0047
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0213 0.1756 0.1736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Echinococcus multilocularis serotonin receptor 0.0129 0.1018 0.1014
Giardia lamblia Cathepsin B precursor 0.0213 0.1756 1
Echinococcus multilocularis cysteine protease 0.1153 1 1
Loa Loa (eye worm) hypothetical protein 0.0213 0.1756 0.1756
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Trypanosoma cruzi major cysteine proteinase, putative 0.0213 0.1756 0.1736
Giardia lamblia Cathepsin B precursor 0.0213 0.1756 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0689 0.0667
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0185 0.0169
Mycobacterium ulcerans beta-lactamase 0.0035 0.0195 1
Plasmodium vivax unspecified product 0.0213 0.1756 0.1704
Brugia malayi beta-lactamase family protein 0.0035 0.0195 0.0178
Leishmania major hypothetical protein, conserved 0.0025 0.0109 0.0085
Echinococcus granulosus cpg binding protein 0.0032 0.017 0.0166
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1153 1 1
Onchocerca volvulus Cathepsin L homolog 0.0213 0.1756 0.1649
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.5965 0.5955
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0594 0.5098 0.5086
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0039 0.0034
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0127 0.011
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Brugia malayi Papain family cysteine protease containing protein 0.1153 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0322 0.0322
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0213 0.1756 0.1704
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0213 0.1756 1
Giardia lamblia Cathepsin L precursor 0.0213 0.1756 1
Brugia malayi hypothetical protein 0.0025 0.0109 0.0092
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0109 0.0046
Schistosoma mansoni cathepsin S (C01 family) 0.0213 0.1756 0.1736
Echinococcus multilocularis geminin 0.0333 0.2806 0.2803
Trypanosoma cruzi cysteine protease, putative 0.0594 0.5098 0.5086
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0109 0.0046
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0213 0.1756 0.1704
Onchocerca volvulus 0.0035 0.0195 0.0068
Onchocerca volvulus Cathepsin F homolog 0.1153 1 1
Plasmodium falciparum serine repeat antigen 6 0.0213 0.1756 0.1704
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0195 0.5
Echinococcus granulosus cysteine protease 0.0594 0.5098 0.5096
Loa Loa (eye worm) hypothetical protein 0.0213 0.1756 0.1756
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.0133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0213 0.1756 0.1704
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0213 0.1756 0.1704
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0027 0.0027
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0027 0.0022
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0213 0.1756 0.1736
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0213 0.1756 0.1736
Plasmodium falciparum serine repeat antigen 8 0.0213 0.1756 0.1704
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1838 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0063 0.0058
Brugia malayi Cathepsin L-like precursor 0.1153 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0594 0.5098 0.5067
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0213 0.1756 0.1756
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0381 0.3232 0.3221
Toxoplasma gondii cathepsin CPC1 0.0213 0.1756 0.1704
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0213 0.1756 0.1756
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0195 0.0133
Loa Loa (eye worm) hypothetical protein 0.0213 0.1756 0.1756
Onchocerca volvulus 0.0035 0.0195 0.0068
Schistosoma mansoni hypothetical protein 0.0333 0.2806 0.2789
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0027 0.001
Onchocerca volvulus Cathepsin L homolog 0.1153 1 1
Entamoeba histolytica cysteine protease, putative 0.0213 0.1756 0.1704
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0027 0.0022
Loa Loa (eye worm) fibroinase 0.1153 1 1
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Onchocerca volvulus 0.0239 0.1981 0.1877
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0689 0.0685
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0027 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0195 0.0133
Echinococcus granulosus zinc finger protein 0.0021 0.0075 0.0071
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0109 0.0046
Brugia malayi Cathepsin L-like cysteine proteinase 0.0772 0.6658 0.6652
Leishmania major cathepsin L-like protease 0.1153 1 1
Schistosoma mansoni bromodomain containing protein 0.0065 0.0457 0.0435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0307 0.0284
Brugia malayi cathepsin L-like cysteine proteinase 0.0213 0.1756 0.1742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Plasmodium vivax vivapain-1 0.0594 0.5098 0.5067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1153 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0158 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0213 0.1756 0.1704
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0213 0.1756 0.1704
Echinococcus granulosus microtubule associated protein 2 0.0693 0.5965 0.5963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Plasmodium falciparum serine repeat antigen 5 0.0213 0.1756 0.1704
Loa Loa (eye worm) hypothetical protein 0.0049 0.0322 0.0322
Echinococcus multilocularis cathepsin L 0.0594 0.5098 0.5096
Plasmodium vivax unspecified product 0.0594 0.5098 0.5067
Brugia malayi fibroinase precursor 0.0213 0.1756 0.1742
Entamoeba histolytica cysteine proteinase, putative 0.0594 0.5098 0.5067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1153 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1153 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1153 1 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0213 0.1756 0.1704
Echinococcus granulosus lamin dm0 0.0027 0.0127 0.0123
Schistosoma mansoni zinc finger protein 0.0021 0.0075 0.0052
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0123
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0213 0.1756 0.1704
Leishmania major cathepsin L-like protease 0.1153 1 1
Echinococcus granulosus cathepsin L 0.0594 0.5098 0.5096
Loa Loa (eye worm) hypothetical protein 0.0772 0.6658 0.6658
Echinococcus granulosus biogenic amine 5HT receptor 0.0129 0.1018 0.1014
Schistosoma mansoni cathepsin C 0.0213 0.1756 0.1736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0594 0.5098 0.5067
Loa Loa (eye worm) hypothetical protein 0.0381 0.3232 0.3232
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0109 0.0085
Leishmania major cathepsin L-like protease 0.1153 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0213 0.1756 0.1756
Brugia malayi cathepsin F-like cysteine proteinase 0.0381 0.3232 0.3221
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0109 0.0085
Loa Loa (eye worm) ctsf protein 0.1153 1 1
Brugia malayi Cathepsin L-like precursor 0.1153 1 1
Schistosoma mansoni cpg binding protein 0.0028 0.0139 0.0116
Entamoeba histolytica cysteine protease, putative 0.1153 1 1
Giardia lamblia Cathepsin L precursor 0.0213 0.1756 1
Plasmodium vivax unspecified product 0.0381 0.3232 0.319
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0027 0.0022
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0195 0.0133
Trypanosoma cruzi cysteine peptidase, putative 0.0594 0.5098 0.5086
Echinococcus multilocularis cathepsin b 0.0213 0.1756 0.1752
Leishmania major cathepsin L-like protease 0.1153 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.1153 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.1756 0.1704
Echinococcus multilocularis cathepsin b 0.0213 0.1756 0.1752
Entamoeba histolytica cysteine proteinase, putative 0.1153 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1153 1 1
Brugia malayi Pre-SET motif family protein 0.021 0.1727 0.1713
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0195 1
Echinococcus granulosus cathepsin b 0.0213 0.1756 0.1752
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0213 0.1756 0.1704
Schistosoma mansoni cathepsin F (C01 family) 0.0772 0.6658 0.665
Echinococcus granulosus cathepsin b 0.0213 0.1756 0.1752
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0158 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0213 0.1756 0.1704
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1153 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.1756 0.1704
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Brugia malayi Cathepsin L-like precursor 0.1153 1 1
Onchocerca volvulus 0.0035 0.0195 0.0068
Trypanosoma cruzi major cysteine proteinase, putative 0.0213 0.1756 0.1736
Echinococcus multilocularis lamin 0.0027 0.0127 0.0123
Loa Loa (eye worm) hypothetical protein 0.0213 0.1756 0.1756
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0003
Brugia malayi Pre-SET motif family protein 0.0031 0.0158 0.0141
Schistosoma mansoni hypothetical protein 0.0405 0.3439 0.3424
Loa Loa (eye worm) hypothetical protein 0.0772 0.6658 0.6658
Echinococcus multilocularis cysteine protease 0.1153 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0689 0.0667
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0195 0.0744
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Leishmania major cathepsin L-like protease 0.1153 1 1
Entamoeba histolytica cysteine protease, putative 0.0213 0.1756 0.1704
Onchocerca volvulus 0.1153 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0689 0.0685
Schistosoma mansoni hypothetical protein 0.0333 0.2806 0.2789
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0063 0.0039
Echinococcus multilocularis zinc finger protein 0.0021 0.0075 0.0071
Brugia malayi cathepsin Z-like cysteine proteinase 0.0213 0.1756 0.1742
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0039 0.0034
Loa Loa (eye worm) hypothetical protein 0.0381 0.3232 0.3232
Leishmania major hypothetical protein, conserved 0.0035 0.0195 0.0172
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0213 0.1756 0.1704
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0213 0.1756 0.1704
Loa Loa (eye worm) hypothetical protein 0.0034 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0129 0.1018 0.1018
Onchocerca volvulus 0.1153 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0063 0.0058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0689 0.0685
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0195 0.019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0195 0.0133
Trypanosoma cruzi cysteine proteinase, putative 0.0594 0.5098 0.5086
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0213 0.1756 0.1736
Brugia malayi PHD-finger family protein 0.0026 0.0122 0.0105
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0213 0.1756 0.1736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0772 0.6658 0.6637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1153 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0195 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0213 0.1756 0.1736
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Giardia lamblia Cathepsin L-like protease 0.0213 0.1756 1
Plasmodium falciparum serine repeat antigen 1 0.0213 0.1756 0.1704
Loa Loa (eye worm) hypothetical protein 0.0035 0.0195 0.0195
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0213 0.1756 1
Onchocerca volvulus 0.0028 0.0139 0.0012
Onchocerca volvulus 0.0031 0.0158 0.0031
Trichomonas vaginalis esterase, putative 0.0035 0.0195 0.0133
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0004
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0383 0.3248 0.3245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Giardia lamblia Cathepsin B precursor 0.0213 0.1756 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0428 0.0406
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0213 0.1756 0.1704
Trypanosoma cruzi cysteine peptidase, putative 0.1153 1 1
Leishmania major cathepsin L-like protease 0.1153 1 1
Onchocerca volvulus Cathepsin L homolog 0.1153 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0195 0.0178
Giardia lamblia Cysteine protease 0.0213 0.1756 1
Plasmodium vivax SET domain protein, putative 0.0031 0.0158 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0225 0.0225
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1153 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0213 0.1756 0.1742
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0322 0.0306
Trypanosoma cruzi cruzipain precursor, putative 0.0381 0.3232 0.3216
Plasmodium falciparum cysteine proteinase falcipain 1 0.0594 0.5098 0.5067
Loa Loa (eye worm) cysteine protease 0.1153 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0213 0.1756 0.1736
Loa Loa (eye worm) hypothetical protein 0.0048 0.0307 0.0307
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0063 0.5
Giardia lamblia Cathepsin B precursor 0.0213 0.1756 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0213 0.1756 0.1704
Onchocerca volvulus 0.1153 1 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0195 0.0744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1153 1 1
Schistosoma mansoni ap endonuclease 0.002 0.0063 0.0039
Entamoeba histolytica cysteine proteinase, putative 0.0772 0.6658 0.6637
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0213 0.1756 0.1704
Entamoeba histolytica cysteine proteinase 1, putative 0.0594 0.5098 0.5067
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0195 1
Entamoeba histolytica cysteine proteinase, putative 0.0594 0.5098 0.5067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0027
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0213 0.1756 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0195 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0109 0.0085
Brugia malayi Papain family cysteine protease containing protein 0.0213 0.1756 0.1742
Schistosoma mansoni cpg binding protein 0.0032 0.017 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1153 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0213 0.1756 1
Brugia malayi Cathepsin L-like precursor 0.0381 0.3232 0.3221
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0195 0.019
Brugia malayi hypothetical protein 0.0016 0.0031 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.1153 1 1
Echinococcus granulosus lamin 0.0027 0.0127 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1153 1 1
Mycobacterium leprae Probable lipase LipE 0.0035 0.0195 0.5
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0213 0.1756 0.1704
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0039 0.0015
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0003
Echinococcus multilocularis cathepsin L cysteine protease 0.1153 1 1
Entamoeba histolytica cysteine protease, putative 0.0594 0.5098 0.5067
Onchocerca volvulus 0.1153 1 1
Toxoplasma gondii cathepsin CPC2 0.0213 0.1756 0.1704
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0381 0.3232 0.3232
Loa Loa (eye worm) hypothetical protein 0.0071 0.0508 0.0508
Giardia lamblia Cysteine protease 0.0213 0.1756 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) 0 % Ability of the compound to inhibit collagen -induced platelet aggregation in male SD rats; Inhibition >= aspirin (34-96%) ChEMBL. 3373489
Reduction (functional) = 23 % Hypolipidemic activity of the compound was expressed as percent decrease in serum cholesterol in Sprague-Dawley rats ChEMBL. 3373489
Reduction (functional) = 42 % Hypolipidemic activity of the compound was expressed as percent decrease in triglycerides in Sprague-Dawley rats ChEMBL. 3373489

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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