Detailed information for compound 2074751

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 447.377 | Formula: C19H19F6N5O
  • H donors: 1 H acceptors: 3 LogP: 1.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CC[C@@H]2[C@H](C1)Cc1n2c(nn1)C(F)(F)F
  • InChi: 1S/C19H19F6N5O/c20-12-7-14(22)13(21)4-9(12)3-11(26)6-17(31)29-2-1-15-10(8-29)5-16-27-28-18(30(15)16)19(23,24)25/h4,7,10-11,15H,1-3,5-6,8,26H2/t10-,11+,15+/m0/s1
  • InChiKey: JQIYEBPQYRFTMS-FIXISWKDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0299 0.0289 0.2037
Brugia malayi beta-lactamase 0.0111 0.0087 0.0613
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0136 0.0114 0.163
Echinococcus granulosus L aminoadipate semialdehyde 0.0213 0.0197 0.2316
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0051 0.0022 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0593 0.0604 0.5063
Chlamydia trachomatis transglycolase/transpeptidase 0.0333 0.0325 0.793
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0041 0.0011 0.0987
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0102 0.0862
Schistosoma mansoni lamin 0.0177 0.0157 0.1321
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0087 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0026 0.03
Brugia malayi beta-NAC-like protein 0.0057 0.0029 0.0201
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0101 0.0076 0.0899
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0054 0.0026 0.03
Schistosoma mansoni kinase 0.004 0.0011 0.0091
Schistosoma mansoni transcription factor btf3 0.0057 0.0029 0.024
Echinococcus granulosus dna polymerase eta 0.0065 0.0038 0.0445
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0136 0.0114 0.1886
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0053 0.041
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0038 0.0527
Treponema pallidum fructose-bisphosphate aldolase 0.0593 0.0604 0.7542
Schistosoma mansoni hypothetical protein 0.0101 0.0076 0.0642
Schistosoma mansoni hypothetical protein 0.082 0.0848 0.7131
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0079 0.0053 0.062
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.049 0.0494 0.0474
Loa Loa (eye worm) hypothetical protein 0.0256 0.0243 0.1706
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0087 0.1236
Mycobacterium tuberculosis Conserved hypothetical protein 0.0357 0.0351 0.0345
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.006 0.0032 0.281
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0053 0.041
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0299 0.0289 0.3403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0022 0.0188
Echinococcus multilocularis lysine specific demethylase 6a 0.008 0.0053 0.0627
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0054 0.0026 0.03
Treponema pallidum cysteinyl-tRNA synthetase 0.0136 0.0114 0.141
Brugia malayi polk-prov protein 0.0036 0.0007 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0033 0.0464
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0087 0.1024
Giardia lamblia Sgs1 DNA helicase, putative 0.0061 0.0034 0.0491
Brugia malayi hypothetical protein 0.0053 0.0025 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0102 0.1696
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0136 0.0114 0.1344
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0004 0.036
Brugia malayi serine/threonine-protein kinase plk-2 0.0079 0.0053 0.0371
Echinococcus granulosus cysteinyl tRNA synthetase 0.0136 0.0114 0.1343
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0145 0.0123 0.0102
Trichomonas vaginalis ap endonuclease, putative 0.0136 0.0114 0.0927
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0033 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0033 0.0464
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0004 0.036
Giardia lamblia Fructose-bisphosphate aldolase 0.0593 0.0604 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0005 0.0053
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.008 0.0053 0.075
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.006 0.0032 0.0032
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0136 0.0114 0.1343
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0104 0.0079 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0033 0.0464
Loa Loa (eye worm) hypothetical protein 0.0061 0.0034 0.0228
Echinococcus multilocularis lysine specific demethylase 5A 0.0299 0.0289 0.3403
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.0134 0.1582
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0102 0.1696
Toxoplasma gondii aldehyde dehydrogenase 0.0051 0.0022 0.1958
Schistosoma mansoni blooms syndrome DNA helicase 0.0031 0.0001 0.0011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0087 0.0081
Mycobacterium ulcerans 6-phosphofructokinase 0.0126 0.0102 0.0102
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0061 0.0034 0.0466
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0136 0.0114 0.0804
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0033 0.046
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0068 0.004 0.0473
Brugia malayi 6-phosphofructokinase 0.0126 0.0102 0.0723
Trypanosoma brucei hypothetical protein, conserved 0.006 0.0032 0.0448
Brugia malayi hypothetical protein 0.0256 0.0243 0.1713
Echinococcus multilocularis ubiquitin specific protease 41 0.0035 0.0005 0.0057
Brugia malayi hypoxia-induced factor 1 0.0126 0.0103 0.0728
Loa Loa (eye worm) hypothetical protein 0.0111 0.0087 0.0605
Entamoeba histolytica recQ family DNA helicase 0.0031 0.0001 0.0021
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0004 0.036
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0026 0.018
Onchocerca volvulus 0.0053 0.0025 0.0173
Toxoplasma gondii hypothetical protein 0.0109 0.0085 0.7448
Brugia malayi jmjC domain containing protein 0.008 0.0053 0.0375
Loa Loa (eye worm) hypothetical protein 0.0111 0.0087 0.0605
Schistosoma mansoni ap endonuclease 0.0136 0.0114 0.0959
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0022 0.0022
Leishmania major cathepsin L-like protease 0.0064 0.0036 0.0453
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0079 0.0053 0.0363
Loa Loa (eye worm) runx1 0.0169 0.0149 0.1047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0005 0.004
Echinococcus multilocularis phd:f box containing protein 0.008 0.0053 0.0627
Brugia malayi PAS domain containing protein 0.0041 0.0011 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.001 0.0048
Plasmodium vivax JmjC domain containing protein 0.008 0.0053 0.4672
Schistosoma mansoni RAR-like nuclear receptor 0.0054 0.0026 0.0215
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.006 0.0032 0.281
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0013 0.0173
Echinococcus multilocularis dna polymerase eta 0.0065 0.0038 0.0445
Onchocerca volvulus 0.0136 0.0114 0.0804
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0001 0.0112
Toxoplasma gondii ABC1 family protein 0.0111 0.0087 0.7626
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0036 0.0006 0.0073
Onchocerca volvulus 0.0111 0.0087 0.0613
Mycobacterium ulcerans hypothetical protein 0.0357 0.0351 0.0351
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.006 0.0032 0.2542
Brugia malayi jmjC domain containing protein 0.008 0.0053 0.0375
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0102 0.083
Schistosoma mansoni steroid hormone receptor ad4bp 0.0054 0.0026 0.0215
Entamoeba histolytica transcription factor BTF3, putative 0.0057 0.0029 0.0472
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.9349 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0035 0.0005 0.0034
Echinococcus granulosus JmjC domain containing protein 4 0.008 0.0053 0.0627
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0026 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0029 0.0206
Onchocerca volvulus 0.0043 0.0014 0.0096
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0061 0.0034 0.0395
Trichomonas vaginalis DNA helicase recq, putative 0.0061 0.0034 0.0249
Loa Loa (eye worm) hypothetical protein 0.0085 0.0059 0.0409
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0026 0.03
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0035 0.0005 0.0042
Leishmania major DNA polymerase eta, putative 0.0041 0.0011 0.0091
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0054 0.0026 0.03
Plasmodium vivax basic transcription factor 3b, putative 0.0057 0.0029 0.2503
Echinococcus multilocularis tumor protein p63 0.0293 0.0282 0.3327
Schistosoma mansoni lamin 0.0177 0.0157 0.1321
Schistosoma mansoni 6-phosphofructokinase 0.0126 0.0102 0.0862
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0054 0.0026 0.018
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0102 0.0715
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0136 0.0114 0.1626
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0079 0.0053 0.062
Schistosoma mansoni hypothetical protein 0.0055 0.0027 0.0224
Treponema pallidum penicillin-binding protein (pbp-2) 0.0494 0.0497 0.6205
Brugia malayi phosphofructokinase 0.0126 0.0102 0.0723
Mycobacterium leprae Probable lipase LipE 0.0111 0.0087 0.0066
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0061 0.0034 0.2682
Onchocerca volvulus 0.0111 0.0087 0.0613
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0126 0.0102 0.0082
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0054 0.0026 0.03
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0054 0.0026 0.018
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.001 0.0048
Loa Loa (eye worm) hypothetical protein 0.0054 0.0026 0.0172
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.008 0.0053 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0494 0.0497 0.4161
Schistosoma mansoni retinoic acid receptor RXR 0.0054 0.0026 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0026 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Echinococcus multilocularis FTZ F1 alpha 0.0054 0.0026 0.03
Brugia malayi Intermediate filament tail domain containing protein 0.0177 0.0157 0.1109
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0053 0.041
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0005 0.0053
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0005 0.0054
Loa Loa (eye worm) hypothetical protein 0.0065 0.0038 0.0258
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0061 0.0034 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0029 0.0206
Schistosoma mansoni lozenge 0.0169 0.0149 0.1256
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0054 0.0026 0.0215
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0012 0.0078
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0005 0.0054
Loa Loa (eye worm) intermediate filament protein 0.0177 0.0157 0.1101
Leishmania major hypothetical protein, conserved 0.008 0.0053 0.0701
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0054 0.0026 0.0215
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0087 0.0081
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0061 0.0034 0.047
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0061 0.0034 0.0395
Loa Loa (eye worm) glutaminase 0.1138 0.1189 0.8395
Mycobacterium ulcerans beta-lactamase 0.0111 0.0087 0.0087
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0013 0.0116
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.029 0.0279 0.0258
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.06 0.0612 0.0612
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0367
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0593 0.0604 0.5063
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0038 0.0532
Treponema pallidum penicillin-binding protein (pbp-3) 0.0776 0.0801 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0087 0.0731
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0087 0.0731
Plasmodium falciparum basic transcription factor 3b, putative 0.0057 0.0029 0.2223
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0026 0.0215
Onchocerca volvulus Bile acid receptor homolog 0.0054 0.0026 0.018
Brugia malayi nuclear hormone receptor 0.0054 0.0026 0.018
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0299 0.0289 0.3403
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0087 0.0081
Onchocerca volvulus 0.0054 0.0026 0.018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0095 0.007 0.099
Leishmania major DNA polymerase eta, putative 0.0065 0.0038 0.0477
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0087 0.0699
Plasmodium vivax cysteine--tRNA ligase, putative 0.0136 0.0114 0.9996
Schistosoma mansoni protein phosphatase 2C 0.008 0.0053 0.0448
Loa Loa (eye worm) hypothetical protein 0.0213 0.0197 0.138
Mycobacterium tuberculosis Conserved protein 0.0111 0.0087 0.0081
Brugia malayi Steroid receptor seven-up type 2 0.0054 0.0026 0.018
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0061 0.0034 0.0228
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0087 0.0699
Brugia malayi photoreceptor-specific nuclear receptor 0.0054 0.0026 0.018
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0068 0.004 0.0473
Loa Loa (eye worm) hypothetical protein 0.0111 0.0087 0.0605
Trichomonas vaginalis esterase, putative 0.0111 0.0087 0.0699
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0054 0.0026 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0102 0.083
Brugia malayi jmjC domain containing protein 0.0299 0.0289 0.2037
Brugia malayi nuclear receptor NHR-88 0.0054 0.0026 0.018
Brugia malayi bZIP transcription factor family protein 0.0068 0.004 0.0283
Trichomonas vaginalis set domain proteins, putative 0.0274 0.0261 0.2171
Mycobacterium ulcerans glutaminase 0.1138 0.1189 0.1189
Schistosoma mansoni jumonji/arid domain-containing protein 0.0299 0.0289 0.2427
Loa Loa (eye worm) hypothetical protein 0.0034 0.0005 0.0024
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0036 0.0006 0.0035
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0145 0.0123 0.0117
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0035 0.0005 0.0014
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0005 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0033 0.046
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.049 0.0494 0.0494
Schistosoma mansoni hypothetical protein 0.0294 0.0284 0.2384
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0004 0.036
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.008 0.0053 0.0627
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0677 0.0695 1
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0102 0.083
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0102 0.1464
Echinococcus granulosus intermediate filament protein 0.0177 0.0157 0.1852
Onchocerca volvulus Protein ultraspiracle homolog 0.0054 0.0026 0.018
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0004 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0033 0.0464
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0005 0.0413
Leishmania major mitochondrial DNA polymerase beta 0.0677 0.0695 1
Mycobacterium ulcerans lipoprotein LpqF 0.005 0.0021 0.0021
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0035 0.0005 0.0082
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0054 0.0026 0.0215
Trichomonas vaginalis glutaminase, putative 0.1138 0.1189 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.008 0.0053 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0026 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0593 0.0604 0.5063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.0226 0.1586
Plasmodium falciparum cysteine--tRNA ligase 0.0136 0.0114 0.9996
Loa Loa (eye worm) RecQ helicase 0.0061 0.0034 0.0228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0321 0.0312 0.448
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0026 0.03
Schistosoma mansoni jumonji/arid domain-containing protein 0.0299 0.0289 0.2427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0036 0.0504
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0026 0.018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0051 0.0022 0.0252
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0104 0.0079 0.0073
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0033 0.0464
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0033 0.046
Echinococcus multilocularis L aminoadipate semialdehyde 0.0213 0.0197 0.2316
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0054 0.0026 0.018
Brugia malayi Pre-SET motif family protein 0.0034 0.0005 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0593 0.0604 0.5063
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0412 0.0409 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0126 0.0102 0.0715
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0087 0.124
Loa Loa (eye worm) hypothetical protein 0.0082 0.0056 0.0384
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0054 0.0026 0.03
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0004 0.036
Brugia malayi glutaminase DH11.1 0.1138 0.1189 0.8396
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0003 0.0038
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0136 0.0114 0.0796
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0087 0.1024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0116 0.0092 0.1312
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0145 0.0123 0.0123
Leishmania major DNA polymerase kappa, putative 0.0042 0.0013 0.0116
Echinococcus granulosus jun protein 0.0068 0.004 0.0473
Schistosoma mansoni ap endonuclease 0.0136 0.0114 0.0959
Entamoeba histolytica hypothetical protein 0.0057 0.0029 0.0472
Leishmania major cytochrome p450-like protein 0.0042 0.0012 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0033 0.0464
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.0088
Schistosoma mansoni glutaminase 0.1138 0.1189 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0026 0.0172
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0054 0.0026 0.03
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0095 0.007 0.099
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0136 0.0114 0.0114
Echinococcus multilocularis lamin dm0 0.0177 0.0157 0.1852
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0126 0.0102 0.0096
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.006 0.0032 0.0026
Echinococcus granulosus geminin 0.082 0.0848 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0005 0.0054
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0136 0.0114 0.1344
Loa Loa (eye worm) hypothetical protein 0.0054 0.0026 0.0172
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0136 0.0114 0.0797
Brugia malayi jmjC domain containing protein 0.008 0.0053 0.0375
Schistosoma mansoni aryl hydrocarbon receptor 0.0041 0.0011 0.0096
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0005 0.0057
Onchocerca volvulus 0.0052 0.0024 0.0167
Trypanosoma brucei polo-like protein kinase 0.0079 0.0053 0.0745
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0051 0.0022 0.0262
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0005 0.0007
Onchocerca volvulus 0.0274 0.0261 0.1845
Onchocerca volvulus 0.0034 0.0005 0.0033
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0061 0.0034 0.0395
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0061 0.0034 0.2682
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0036 0.0006 0.0073
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0677 0.0695 1
Schistosoma mansoni hypothetical protein 0.082 0.0848 0.7131
Onchocerca volvulus 0.0213 0.0197 0.1387
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0136 0.0114 0.1582
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0593 0.0604 0.5063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Loa Loa (eye worm) hypothetical protein 0.0054 0.0026 0.0172
Loa Loa (eye worm) hypothetical protein 0.135 0.1417 1
Echinococcus granulosus lysine specific demethylase 6a 0.008 0.0053 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0007 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0054 0.0026 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0054 0.0026 0.0172
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0494 0.0497 0.0497
Leishmania major cathepsin L-like protease 0.0064 0.0036 0.0453
Schistosoma mansoni hypothetical protein 0.0052 0.0024 0.02
Trypanosoma brucei beta lactamase 0.005 0.0021 0.0289
Echinococcus granulosus FTZ F1 alpha 0.0054 0.0026 0.03
Schistosoma mansoni DNA polymerase eta 0.0065 0.0038 0.0318
Brugia malayi Bloom's syndrome protein homolog 0.0061 0.0034 0.0237
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0054 0.0026 0.0215
Toxoplasma gondii histone lysine demethylase JMJD6a 0.008 0.0053 0.4672
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0001 0.0112
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0038 0.0267
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.003 0.0418
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0145 0.0123 0.0102
Brugia malayi exodeoxyribonuclease III family protein 0.0136 0.0114 0.0804
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0367
Giardia lamblia Kinase, PLK 0.0079 0.0053 0.0809
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0051 0.0022 0.0262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0054 0.0026 0.0172
Chlamydia trachomatis cysteine--tRNA ligase 0.0136 0.0114 0.2712
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0054 0.0026 0.0172
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0136 0.0114 0.0958
Trichomonas vaginalis DNA helicase recq, putative 0.0061 0.0034 0.0249
Onchocerca volvulus 0.0177 0.0157 0.1109
Mycobacterium ulcerans lipase LipD 0.0111 0.0087 0.0087
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0087 0.0087
Trypanosoma cruzi polo-like protein kinase, putative 0.0079 0.0053 0.0741
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0177 0.0157 0.1101
Plasmodium falciparum cysteine--tRNA ligase 0.0136 0.0114 0.9996
Brugia malayi intermediate filament protein 0.0177 0.0157 0.1109
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.006 0.0032 0.069
Loa Loa (eye worm) hypothetical protein 0.0177 0.0157 0.1101
Onchocerca volvulus 0.0111 0.0087 0.0613
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0126 0.0102 0.146
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0213 0.0197 0.1387
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0035 0.0005 0.0057
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.008 0.0053 0.0448
Loa Loa (eye worm) ICD-1 protein 0.0057 0.0029 0.0193
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0087 0.0605
Schistosoma mansoni cellular tumor antigen P53 0.0043 0.0014 0.0115
Loa Loa (eye worm) hypothetical protein 0.0066 0.0038 0.0261
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0005 0.004
Loa Loa (eye worm) steroid hormone receptor 0.0054 0.0026 0.0172
Brugia malayi steroid hormone receptor 0.0054 0.0026 0.018
Plasmodium falciparum JmjC domain-containing protein, putative 0.008 0.0053 0.4473
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0022 0.0022
Trypanosoma brucei cytochrome P450, putative 0.0042 0.0012 0.0164
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0035 0.0005 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0036 0.0006 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0022 0.0022
Trypanosoma brucei transcription factor BTF3, putative 0.0057 0.0029 0.0398
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0033 0.0033
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0136 0.0114 0.0927
Brugia malayi ImpB/MucB/SamB family protein 0.0036 0.0006 0.0044
Schistosoma mansoni phosphatidylserine receptor 0.008 0.0053 0.0448
Echinococcus granulosus transcription factor btf3 0.0057 0.0029 0.0336
Treponema pallidum penicillin-binding protein (pbp-1) 0.0412 0.0409 0.5104
Mycobacterium tuberculosis Possible penicillin-binding protein 0.071 0.073 0.0724
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0294 0.0284 0.1994
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0029 0.0206
Brugia malayi 6-phosphofructokinase 0.0126 0.0102 0.0723
Loa Loa (eye worm) jmjC domain-containing protein 0.0299 0.0289 0.203
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0087 0.0081
Toxoplasma gondii NAC domain-containing protein 0.0057 0.0029 0.2503
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0024 0.0167
Echinococcus granulosus lamin dm0 0.0177 0.0157 0.1852
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0026 0.018
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0136 0.0114 0.1832
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0095 0.0069 0.048
Echinococcus multilocularis JmjC domain containing protein 4 0.008 0.0053 0.0627
Loa Loa (eye worm) jmjC domain-containing protein 0.008 0.0053 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0054 0.0026 0.018
Giardia lamblia DINP protein human, muc B family 0.0042 0.0013 0.0147
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0136 0.0114 0.1626
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0054 0.0026 0.018
Loa Loa (eye worm) jmjC domain-containing protein 0.008 0.0053 0.0367
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.049 0.0494 0.0488
Echinococcus granulosus dna polymerase kappa 0.0061 0.0033 0.039
Trypanosoma cruzi transcription factor btf3, putative 0.0057 0.0029 0.0393
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0087 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0053 0.041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0136 0.0114 0.0114
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0136 0.0114 0.2173
Brugia malayi hypothetical protein 0.0137 0.0115 0.0808
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0145 0.0123 0.0123
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0136 0.0114 0.1626
Echinococcus granulosus jumonji domain containing 1A 0.008 0.0053 0.0627
Loa Loa (eye worm) glutaminase 2 0.1138 0.1189 0.8395
Leishmania major ATP-dependent phosphofructokinase 0.0126 0.0102 0.1414
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0022 0.0292
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0033 0.046
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0042 0.0012 0.0012
Trypanosoma cruzi polo-like protein kinase, putative 0.0079 0.0053 0.0741
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0026 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0033 0.0464
Brugia malayi Pre-SET motif family protein 0.0241 0.0226 0.1593
Echinococcus granulosus ecdysone induced protein 78C 0.0054 0.0026 0.03
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0012 0.0159
Echinococcus multilocularis musashi 0.0177 0.0157 0.1852
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0054 0.0026 0.03
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.008 0.0053 0.4672
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0593 0.0604 0.5063
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0095 0.007 0.0994
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.029 0.0279 0.0279
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0053 0.041
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0213 0.0197 0.1652
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0176 0.0157 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0087 0.0699
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0321 0.0312 0.4448
Leishmania major cysteinyl-tRNA synthetase, putative 0.0136 0.0114 0.1581
Loa Loa (eye worm) hypothetical protein 0.135 0.1417 1
Onchocerca volvulus 0.135 0.1417 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0033 0.0464
Echinococcus multilocularis ecdysone induced protein 78C 0.0054 0.0026 0.03
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0087 0.0066
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0136 0.0114 0.9996
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0035 0.0005 0.0042
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0033 0.0464
Trichomonas vaginalis DNA helicase recq1, putative 0.0061 0.0034 0.0249
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.006 0.0032 0.281
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0136 0.0114 0.2172
Brugia malayi follicle stimulating hormone receptor 0.0435 0.0435 0.3069
Loa Loa (eye worm) hypothetical protein 0.0035 0.0005 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0054 0.0026 0.0172
Echinococcus granulosus leucyl tRNA synthetase 0.0136 0.0114 0.1343
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0005 0.004
Echinococcus granulosus tumor protein p63 0.0293 0.0282 0.3327
Loa Loa (eye worm) hypothetical protein 0.0036 0.0007 0.0037
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0061 0.0034 0.2946
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0087 0.7626
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0136 0.0114 1
Toxoplasma gondii exonuclease III APE 0.0136 0.0114 1
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0053 0.0443
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0035 0.0005 0.0057
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0085 0.0059 0.0696
Loa Loa (eye worm) hypothetical protein 0.0054 0.0026 0.0172
Loa Loa (eye worm) hypothetical protein 0.0082 0.0056 0.0384
Schistosoma mansoni intermediate filament proteins 0.0177 0.0157 0.1321
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0435 0.0435 0.3063
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0085 0.0059 0.0696
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0036 0.0006 0.0053
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0054 0.0026 0.03
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0136 0.0114 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0054 0.0026 0.0172
Entamoeba histolytica phosphofructokinase, putative 0.0126 0.0102 0.1696
Brugia malayi jmjC domain containing protein 0.008 0.0053 0.0375
Schistosoma mansoni DNA helicase recq5 0.0061 0.0034 0.0282
Mycobacterium tuberculosis Conserved protein 0.0111 0.0087 0.0081
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0004 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0087 0.0699
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0145 0.0123 0.0117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0026 0.03
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0176 0.0157 0.0151
Treponema pallidum exodeoxyribonuclease (exoA) 0.0136 0.0114 0.141
Treponema pallidum 4'-phosphopantetheinyl transferase 0.006 0.0032 0.0385
Loa Loa (eye worm) hypothetical protein 0.0173 0.0154 0.1077
Echinococcus multilocularis 6 phosphofructokinase 0.0126 0.0102 0.1208
Loa Loa (eye worm) phosphofructokinase 0.0126 0.0102 0.0715
Entamoeba histolytica recQ family helicase, putative 0.0061 0.0034 0.0556
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0134 0.1129
Schistosoma mansoni survival motor neuron protein 0.0052 0.0024 0.02
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.006 0.0032 0.0032
Onchocerca volvulus 0.0177 0.0157 0.1109
Entamoeba histolytica hypothetical protein 0.006 0.0032 0.053
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0053 0.041
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0079 0.0053 0.0692
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0176 0.0157 0.0136
Trypanosoma brucei DNA polymerase IV, putative 0.0055 0.0026 0.0368
Trypanosoma brucei unspecified product 0.0055 0.0026 0.0368
Echinococcus multilocularis dna polymerase kappa 0.0061 0.0033 0.039
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0036 0.0504
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0061 0.0034 0.0395
Schistosoma mansoni terminal deoxycytidyl transferase 0.0036 0.0006 0.0053
Giardia lamblia Cysteinyl-tRNA synthetase 0.0136 0.0114 0.1831
Onchocerca volvulus Serine\/threonine kinase homolog 0.0079 0.0053 0.0371
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0677 0.0695 1
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0087 0.0081
Trypanosoma cruzi cytochrome P450, putative 0.0042 0.0012 0.0159
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0593 0.0604 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0013 0.0007
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.0033 0.0245
Leishmania major phosphopantetheinyl transferase-like protein 0.006 0.0032 0.0393
Loa Loa (eye worm) hypothetical protein 0.0111 0.0087 0.0605
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.0033 0.0245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0001 0.00000000019202
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0494 0.0497 0.0477
Trichomonas vaginalis phosphofructokinase, putative 0.0126 0.0102 0.083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0005 0.004
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0136 0.0114 0.1629
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0136 0.0114 0.0958
Schistosoma mansoni DNA helicase recq1 0.0061 0.0034 0.0282
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0126 0.0102 0.1266
Brugia malayi beta-lactamase family protein 0.0111 0.0087 0.0613
Echinococcus multilocularis snurportin 1 0.0294 0.0284 0.3342
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0061 0.0034 0.0237
Loa Loa (eye worm) hypothetical protein 0.0111 0.0087 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0005 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0087 0.1236
Loa Loa (eye worm) hypothetical protein 0.008 0.0053 0.0367
Trichomonas vaginalis ap endonuclease, putative 0.0136 0.0114 0.0927
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0189 0.017 0.015
Brugia malayi Cytochrome P450 family protein 0.0042 0.0012 0.0086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0054 0.0026 0.0215
Loa Loa (eye worm) hypothetical protein 0.0054 0.0026 0.0172
Echinococcus multilocularis geminin 0.082 0.0848 1
Loa Loa (eye worm) jmjC domain-containing protein 0.008 0.0053 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0033 0.0464
Brugia malayi hypothetical protein 0.135 0.1417 1
Mycobacterium ulcerans hypothetical protein 0.0111 0.0087 0.0087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Loa Loa (eye worm) hypothetical protein 0.0137 0.0115 0.08
Echinococcus granulosus bloom syndrome protein 0.0061 0.0034 0.0395
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0136 0.0114 0.1887
Brugia malayi ecdysteroid receptor 0.0054 0.0026 0.018
Mycobacterium tuberculosis Conserved protein 0.0111 0.0087 0.0081
Loa Loa (eye worm) hypothetical protein 0.0054 0.0026 0.0172
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0593 0.0604 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0079 0.0053 0.0871
Brugia malayi beta-lactamase family protein 0.0111 0.0087 0.0613
Echinococcus granulosus lamin 0.0177 0.0157 0.1852
Loa Loa (eye worm) CYP4Cod1 0.0042 0.0012 0.0078
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.008 0.0053 0.0754
Loa Loa (eye worm) hypoxia-induced factor 1 0.0126 0.0103 0.072
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0087 0.0613
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0061 0.0034 0.2946
Schistosoma mansoni single-minded 0.0041 0.0011 0.0096
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0022 0.0188
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0035 0.0005 0.0057
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0134 0.1129
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0054 0.0026 0.03
Echinococcus multilocularis transcription factor btf3 0.0057 0.0029 0.0336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0593 0.0604 0.5063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0026 0.018
Echinococcus multilocularis jumonji domain containing 1A 0.008 0.0053 0.0627
Brugia malayi cytoplasmic intermediate filament protein 0.0095 0.0069 0.0488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0036 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0054 0.0026 0.018
Schistosoma mansoni phd/f-box containing protein 0.008 0.0053 0.0448
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.005 0.0021 0.0015
Echinococcus granulosus 6 phosphofructokinase 0.0126 0.0102 0.1208
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0136 0.0114 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0054 0.0026 0.0172
Loa Loa (eye worm) hypothetical protein 0.0111 0.0087 0.0605
Chlamydia trachomatis transglycolase/transpeptidase 0.0412 0.0409 1
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0036 0.0504
Schistosoma mansoni jumonji domain containing protein 0.0299 0.0289 0.2427
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.029 0.0279 0.0273
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0061 0.0034 0.0415
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0321 0.0312 0.4477
Trypanosoma cruzi DNA polymerase eta, putative 0.0041 0.0011 0.0144
Leishmania major basic transcription factor 3a, putative 0.0057 0.0029 0.0342
Echinococcus granulosus snurportin 1 0.0294 0.0284 0.3342
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0095 0.007 0.099
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0007 0.0081
Echinococcus multilocularis jun protein 0.0068 0.004 0.0473
Echinococcus multilocularis Protein lozenge 0.0169 0.0149 0.1761
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0179 0.016 0.0154
Loa Loa (eye worm) hypothetical protein 0.0136 0.0114 0.0796
Treponema pallidum hypothetical protein 0.0176 0.0157 0.1942
Echinococcus granulosus phd:f box containing protein 0.008 0.0053 0.0627
Echinococcus multilocularis bloom syndrome protein 0.0061 0.0034 0.0395
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.0243 0.2862
Echinococcus multilocularis lamin 0.0177 0.0157 0.1852
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0189 0.017 0.0164
Plasmodium vivax SET domain protein, putative 0.0034 0.0005 0.0413
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.9349 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.0057 0.0029 0.0393
Schistosoma mansoni coup transcription factor 0.0054 0.0026 0.0215
Loa Loa (eye worm) beta-lactamase 0.0111 0.0087 0.0605
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0593 0.0604 0.5063
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.0243 0.2862
Echinococcus granulosus lysine specific demethylase 5A 0.0299 0.0289 0.3403
Brugia malayi RNA, U transporter 1 0.0078 0.0052 0.0365
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0136 0.0114 0.1626
Schistosoma mansoni jun-related protein 0.0055 0.0027 0.0224
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0087 0.0081
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0012 0.0078
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0033 0.0033
Leishmania major hypothetical protein, conserved 0.0111 0.0087 0.1189
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0101 0.0076 0.0899
Loa Loa (eye worm) hypothetical protein 0.0054 0.0026 0.0172
Schistosoma mansoni jumonji domain containing protein 0.008 0.0053 0.0448
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0036 0.0504
Echinococcus granulosus ubiquitin specific protease 41 0.0035 0.0005 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0087 0.0699
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0054 0.0026 0.018
Leishmania major cathepsin L-like protease 0.0064 0.0036 0.0453
Brugia malayi Cytochrome P450 family protein 0.0042 0.0012 0.0086
Mycobacterium leprae conserved hypothetical protein 0.006 0.0032 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0079 0.0053 0.041

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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