TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 473.455 | Formula: C23H25F6N3O
H donors: 1 H acceptors: 1 LogP: 4.56 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@H](c1ccccc1)N1CCNCC1)N(CCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C
InChi: 1S/C23H25F6N3O/c1-31(10-7-16-13-18(22(24,25)26)15-19(14-16)23(27,28)29)21(33)20(17-5-3-2-4-6-17)32-11-8-30-9-12-32/h2-6,13-15,20,30H,7-12H2,1H3/t20-/m0/s1
InChiKey: CCIZGCFBHMZVTA-FQEVSTJZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0403	0.0403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0099	0.2895	0.2895
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0533	0.0533
Brugia malayi	Cytochrome P450 family protein	0.0023	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0533	0.0533
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0099	0.2895	0.2895
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0163	0.5222	0.5222
Loa Loa (eye worm)	hypothetical protein	0.003	0.0403	0.0403
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0056	0.1332	0.1332
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0099	0.2895	0.2895
Echinococcus multilocularis	follistatin	0.0023	0.0145	0.0145
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0219	0.7261	0.7261
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0042	0.0822	0.0822
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0163	0.5222	0.5222
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.4544	0.4544
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0403	0.0403
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0294	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0062	0.1563	0.2153
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0403	0.0403
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0163	0.5222	0.5222
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0042	0.0822	0.0822
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0022	0.0124	0.0124
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0403	0.0403
Brugia malayi	nuclear hormone receptor	0.003	0.0403	0.0403
Trichomonas vaginalis	fk506 binding protein, putative	0.0022	0.0124	0.0124
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0022	0.0124	0.0171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.5082	0.5082
Brugia malayi	hypothetical protein	0.0034	0.0533	0.0533
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.5074	0.5074
Toxoplasma gondii	transporter, major facilitator family protein	0.0034	0.0533	0.0733
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0219	0.7261	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.7813	0.7813
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13	0.0022	0.0124	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.5074	0.5074
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0034	0.0533	0.0533
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0124	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0294	1	1
Leishmania major	eukaryotic translation initiation factor-like	0.0042	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0145	0.0145
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0164	0.5273	0.5273
Brugia malayi	SPARC precursor	0.0023	0.0145	0.0145
Brugia malayi	steroid hormone receptor	0.003	0.0403	0.0403
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0099	0.2895	0.2895
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0642	0.0642
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.016	0.016
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0403	0.0403
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0163	0.5222	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0294	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0198	0.6481	0.6481
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0403	0.0403
Echinococcus multilocularis	agrin	0.0023	0.0145	0.0145
Mycobacterium tuberculosis	Probable trigger factor (TF) protein Tig	0.0022	0.0124	1
Onchocerca volvulus		0.0034	0.0533	1
Schistosoma mansoni	immunophilin	0.0142	0.446	0.446
Schistosoma mansoni	organic anion transporter	0.0034	0.0533	0.0533
Trichomonas vaginalis	fk506-binding protein, putative	0.0163	0.5222	0.5222
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0023	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0145	0.0145
Brugia malayi	nuclear receptor NHR-88	0.003	0.0403	0.0403
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0163	0.5222	1
Schistosoma mansoni	programmed cell death protein	0.0072	0.1933	0.1933
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0219	0.7261	0.7261
Leishmania major	peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative	0.0022	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.003	0.0403	0.0403
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0294	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0099	0.2895	0.2895
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0403	0.0403
Loa Loa (eye worm)	hypothetical protein	0.003	0.0403	0.0403
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0403	0.0403
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0023	0.0145	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0403	0.0403
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.0042	0.0822	0.0822
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0022	0.0124	0.0124
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0294	1	1
Schistosoma mansoni	hypothetical protein	0.0043	0.0873	0.0873
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0022	0.0124	0.0124
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0403	0.0403
Loa Loa (eye worm)	hypothetical protein	0.003	0.0403	0.0403
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0403	0.0403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0174	0.5634	0.5634
Entamoeba histolytica	hypothetical protein	0.0056	0.1332	0.1332
Echinococcus multilocularis		0.0022	0.0124	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0403	0.0403
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0099	0.2895	0.2895
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0873	0.0873
Schistosoma mansoni	immunophilin	0.0164	0.5273	0.5273
Brugia malayi	Cytochrome P450 family protein	0.0023	0.016	0.016
Giardia lamblia	Hypothetical protein	0.0022	0.0124	0.0124
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0294	1	1
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0163	0.5222	0.5222
Onchocerca volvulus		0.003	0.0403	0.756
Echinococcus granulosus	serine protein kinase ATM	0.0056	0.1332	0.1332
Loa Loa (eye worm)	hypothetical protein	0.006	0.1489	0.1489
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0403	0.0403
Plasmodium vivax	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0124	0.0237
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0145	0.0199
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0403	0.0403
Brugia malayi	ecdysteroid receptor	0.003	0.0403	0.0403
Brugia malayi	sodium-independent organic anion transporter family protein	0.0034	0.0533	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0145	0.0145
Trypanosoma brucei	macrophage infectivity potentiator, precursor, putative	0.0022	0.0124	0.0124
Schistosoma mansoni	coup transcription factor	0.003	0.0403	0.0403
Toxoplasma gondii	protease inhibitor PI2	0.0023	0.0145	0.0199
Schistosoma mansoni	follistatin	0.0023	0.0145	0.0145
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0191	0.625	0.625
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0163	0.5222	0.5222
Toxoplasma gondii	FATC domain-containing protein	0.0056	0.1332	0.1835
Brugia malayi	sodium-independent organic anion transporter family protein	0.0034	0.0533	0.0533
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.5082	0.5082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.5082	0.5082
Echinococcus multilocularis	FK506 binding protein 8, 38 kDa	0.0024	0.0175	0.0175
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-13	0.0022	0.0124	0.0124
Brugia malayi	MH2 domain containing protein	0.0144	0.4544	0.4544
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.5082	0.5082
Onchocerca volvulus	Putative organic anion transporter	0.0034	0.0533	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0234	0.7822	0.7822
Mycobacterium leprae	PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG	0.0022	0.0124	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0056	0.1332	0.1332
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0145	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0533	0.0533
Trypanosoma brucei	hypothetical protein, conserved	0.0022	0.0124	0.0124
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0403	0.0403
Leishmania major	cytochrome p450-like protein	0.0023	0.016	0.016
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.016	0.007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0219	0.7261	0.7261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0099	0.2895	0.2895
Echinococcus multilocularis	fk506 binding protein	0.0163	0.5222	0.5222
Trichomonas vaginalis	immunophilin, putative	0.0163	0.5222	0.5222
Loa Loa (eye worm)	FKBP5 protein	0.0163	0.5222	0.5222
Loa Loa (eye worm)	hypothetical protein	0.003	0.0403	0.0403
Toxoplasma gondii	MA3 domain-containing protein	0.0072	0.1933	0.2662
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0022	0.0124	0.0124
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0042	0.0822	0.1132
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0164	0.5273	0.5273
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0034	0.0533	0.0533
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0145	0.0199
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0022	0.0124	0.0171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0219	0.7261	0.7261
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0403	0.0403
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0034	0.0533	0.0533
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0163	0.5222	0.5222
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0403	0.0403
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0022	0.0124	0.5
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0124	0.0124
Trichomonas vaginalis	fk506-binding protein, putative	0.0022	0.0124	0.0124
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0099	0.2895	0.2895
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0234	0.7822	0.7822
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0037	0.0642	0.0642
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0403	0.0403
Onchocerca volvulus		0.0034	0.0533	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0403	0.0403
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0163	0.5222	0.5222
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0533	0.0533
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.0042	0.0822	0.0822
Loa Loa (eye worm)	hypothetical protein	0.014	0.4409	0.4409
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0145	0.0145
Echinococcus multilocularis	serine protein kinase ATM	0.0056	0.1332	0.1332
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-30	0.0022	0.0124	0.0124
Loa Loa (eye worm)	agrin synaptic family protein	0.0023	0.0145	0.0145
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0403	0.0403
Trichomonas vaginalis	fk506-binding protein, putative	0.0022	0.0124	0.0124
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0163	0.5222	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-33	0.0022	0.0124	0.0124
Brugia malayi	Cytochrome P450 family protein	0.0059	0.1448	0.1448
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0403	0.0403
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0023	0.0145	0.0199
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0403	0.0403
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.016	0.016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0294	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0403	0.0403
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0043	0.0873	0.0873
Echinococcus granulosus	agrin	0.0023	0.0145	0.0145
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0022	0.0124	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0403	0.0403
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0056	0.1332	0.1332
Onchocerca volvulus	Bile acid receptor homolog	0.003	0.0403	0.756
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.7813	0.7813
Schistosoma mansoni	fk506 binding protein	0.0022	0.0124	0.0124
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0124	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0145	0.0145
Echinococcus multilocularis	expressed protein	0.0023	0.0145	0.0145
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0176	0.5698	0.5698
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.0042	0.0822	0.0822
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0139	0.4366	0.4366
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0403	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0533	0.0533
Trypanosoma cruzi	target of rapamycin kinase 3	0.0234	0.7822	0.7822
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0163	0.5222	1
Trypanosoma brucei	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0022	0.0124	0.0124
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0164	0.5273	0.5273
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0163	0.5222	0.5222
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0142	0.446	0.446
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.1332	0.1332
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0124	0.0124
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0056	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0079	0.2178	0.2178
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0403	0.0403
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0124	0.0124
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0403	0.0403
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0023	0.0145	0.0145
Schistosoma mansoni	agrin	0.0023	0.0145	0.0145
Brugia malayi	secreted modular calcium-binding protein 1	0.0023	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.003	0.0403	0.0403
Brugia malayi	FAT domain containing protein	0.0043	0.0873	0.0873
Trypanosoma cruzi	macrophage infectivity potentiator, precursor, putative	0.0022	0.0124	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0176	0.5698	0.5698
Echinococcus granulosus	follistatin	0.0023	0.0145	0.0145
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0056	0.1332	0.1332
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0294	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0159	0.5074	0.5074
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0042	0.0822	0.0822
Onchocerca volvulus	Putative organic anion transporter	0.0034	0.0533	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0533	0.0533
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0042	0.0822	0.0822
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0403	0.0403
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0163	0.5222	0.5222
Loa Loa (eye worm)	hypothetical protein	0.003	0.0403	0.0403
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.016	0.016
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0163	0.5222	0.5222
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0642	0.0642
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0056	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0176	0.5698	0.5698
Brugia malayi	hypothetical protein	0.0034	0.0533	0.0533
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.0042	0.0822	0.0822
Loa Loa (eye worm)	phosphatidylinositol 3	0.0294	1	1
Schistosoma mansoni	hypothetical protein	0.0022	0.0124	0.0124
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0042	0.0822	0.0822
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0124	0.0124
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0163	0.5222	0.5222
Toxoplasma gondii	peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein	0.0022	0.0124	0.0171
Brugia malayi	sodium-independent organic anion transporter family protein	0.0034	0.0533	0.0533
Loa Loa (eye worm)	cytochrome P450 family protein	0.0059	0.1448	0.1448
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0642	0.0642
Brugia malayi	translation initiation factor 4E	0.0042	0.0822	0.0822
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0403	0.0403
Loa Loa (eye worm)	phosphatidylinositol 3	0.0099	0.2895	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.7813	0.7813
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0043	0.0873	0.0873
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.4544	0.4544
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0403	0.0403
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0403	0.0403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0219	0.7261	0.7261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.1332	0.1332
Leishmania major	fk506-binding protein 1-like protein	0.0163	0.5222	0.5222
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0034	0.0533	0.0533
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0219	0.7261	0.7261
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0163	0.5222	0.5222
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0174	0.5634	0.5634
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1332	0.1332
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0122	0.375	0.375
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0403	0.0403
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0124	0.0237
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0403	0.0403
Onchocerca volvulus		0.0034	0.0533	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0403	0.0403
Onchocerca volvulus	Putative organic anion transporter	0.0034	0.0533	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0164	0.5273	0.5273
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0099	0.2895	0.2895
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0403	0.0403
Loa Loa (eye worm)	hypothetical protein	0.003	0.0403	0.0403
Echinococcus granulosus	programmed cell death protein 4	0.0072	0.1933	0.1933
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0056	0.1332	0.1332
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0022	0.0124	0.5
Echinococcus multilocularis	programmed cell death protein 4	0.0072	0.1933	0.1933
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0403	0.0403
Onchocerca volvulus		0.0022	0.0124	0.2326
Onchocerca volvulus		0.0022	0.0124	0.2326
Echinococcus granulosus	FK506 binding protein 8 38 kDa	0.0022	0.0124	0.0124
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0142	0.446	0.446
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0403	0.0403
Schistosoma mansoni	immunophilin	0.0164	0.5273	0.5273
Onchocerca volvulus		0.0023	0.0145	0.2719
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0294	1	1
Trypanosoma cruzi	MFS transporter, putative	0.0034	0.0533	0.0533
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.1563	0.1563
Onchocerca volvulus		0.0034	0.0533	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0403	0.0403
Loa Loa (eye worm)	translation initiation factor 4E	0.0042	0.0822	0.0822
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0099	0.2895	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0219	0.7261	0.7261
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0403	0.0403
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.016	0.016
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0403	0.0403
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0124	0.0124
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0042	0.0822	0.0822
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0403	0.0403
Onchocerca volvulus		0.0034	0.0533	1
Echinococcus granulosus	FK506 binding protein 2	0.0022	0.0124	0.0124
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0403	0.0403
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0072	0.1933	0.3701
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1563	0.1563
Leishmania major	peptidylprolyl isomerase-like protein	0.0163	0.5222	0.5222
Leishmania major	eukaryotic translation initiation factor-like protein	0.0042	0.0822	0.0822
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.0042	0.0822	0.0822
Trypanosoma cruzi	FKBP-type peptidylprolyl cis-trans isomerase, putative	0.0022	0.0124	0.0124
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0023	0.0145	0.0145
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33	0.0022	0.0124	0.0124
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0403	0.0403
Leishmania major	FKBP-type peptidyl-prolyl cis-trans isomerase, putative	0.0022	0.0124	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0294	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0403	0.0403
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0403	0.0403
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0403	0.0403
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0163	0.5222	0.5222
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0034	0.0533	0.0533
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0403	0.0403
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0022	0.0124	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0251	0.8437	0.8437
Schistosoma mansoni	hypothetical protein	0.0062	0.1577	0.1577
Entamoeba histolytica	protein kinase rad3, putative	0.0056	0.1332	0.1332
Brugia malayi	prostaglandin transporter	0.0034	0.0533	0.0533
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0042	0.0822	0.0822
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.003	0.0403	0.756
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0294	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.7813	0.7813
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0042	0.0822	0.0822
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0403	0.0403
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0403	0.0403
Onchocerca volvulus	Protein ultraspiracle homolog	0.003	0.0403	0.756
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0873	0.0873
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0403	0.0403
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0403	0.0403
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0403	0.0403
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0056	0.1332	0.1332
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0099	0.2895	0.2895
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0294	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0099	0.2895	0.2895
Schistosoma mansoni	programmed cell death protein	0.0072	0.1933	0.1933
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0234	0.7813	0.7813
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.016	0.016
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0533	0.0533
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0056	0.1332	0.1332
Echinococcus multilocularis	thyroid hormone receptor alpha	0.003	0.0403	0.0403
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0099	0.2895	0.2895
Giardia lamblia	GTOR	0.0294	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.1332	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0099	0.2895	0.2895
Schistosoma mansoni	organic anion transporter	0.0034	0.0533	0.0533
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0163	0.5222	0.5222
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.016	0.016
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.1933	0.3701
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30	0.0022	0.0124	0.0124
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0294	1	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0294	1	1
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0403	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0124	0.0124
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0099	0.2895	0.2895
Toxoplasma gondii	peptidyl-prolyl isomerase FKBP12, putative	0.0022	0.0124	0.0171
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0163	0.5222	0.5222
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0056	0.1332	0.1332

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3542412

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2074941