Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0388 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0332 | 0.8095 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0306 | 0.0344 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0355 | 0.889 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0103 | 0.0306 | 0.0344 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | ecdysteroid receptor | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0178 | 0.2853 | 0.321 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2853 | 0.321 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0103 | 0.0306 | 0.0306 |
Schistosoma mansoni | coup transcription factor | 0.0178 | 0.2853 | 0.2853 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0178 | 0.2853 | 0.321 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0178 | 0.2853 | 0.321 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0178 | 0.2853 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0178 | 0.2853 | 0.321 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0178 | 0.2853 | 0.321 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0178 | 0.2853 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0178 | 0.2853 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0332 | 0.8095 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0178 | 0.2853 | 0.321 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0103 | 0.0306 | 0.0344 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0178 | 0.2853 | 0.321 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0178 | 0.2853 | 0.321 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0355 | 0.889 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0178 | 0.2853 | 0.2853 |
Onchocerca volvulus | 0.0178 | 0.2853 | 0.5 | |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.7294 | 0.8205 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0178 | 0.2853 | 0.321 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0355 | 0.889 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0178 | 0.2853 | 0.2853 |
Brugia malayi | nuclear hormone receptor | 0.0178 | 0.2853 | 0.321 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0178 | 0.2853 | 0.2853 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0178 | 0.2853 | 0.2853 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0178 | 0.2853 | 0.321 |
Schistosoma mansoni | thyroid hormone receptor | 0.0178 | 0.2853 | 0.2853 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0103 | 0.0306 | 0.0344 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2853 | 0.321 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0178 | 0.2853 | 0.2853 |
Echinococcus granulosus | FTZ F1 alpha | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | steroid hormone receptor | 0.0178 | 0.2853 | 0.321 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0178 | 0.2853 | 0.321 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0178 | 0.2853 | 0.2853 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0178 | 0.2853 | 0.321 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0178 | 0.2853 | 0.321 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2853 | 0.321 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0178 | 0.2853 | 0.2853 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0178 | 0.2853 | 0.2853 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0178 | 0.2853 | 0.321 |
Echinococcus granulosus | voltage gated potassium channel | 0.0103 | 0.0306 | 0.0344 |
Schistosoma mansoni | thyroid hormone receptor | 0.0178 | 0.2853 | 0.2853 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0178 | 0.2853 | 0.321 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0103 | 0.0306 | 0.0306 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0355 | 0.889 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0178 | 0.2853 | 0.321 |
Schistosoma mansoni | nuclear hormone receptor | 0.0178 | 0.2853 | 0.2853 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0103 | 0.0306 | 0.0344 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2853 | 0.321 |
Brugia malayi | nuclear receptor NHR-88 | 0.0178 | 0.2853 | 0.321 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0178 | 0.2853 | 0.321 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0178 | 0.2853 | 0.2853 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0178 | 0.2853 | 0.321 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.2853 | 0.321 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0178 | 0.2853 | 0.321 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T1/2 (ADMET) | = 1.47 hr | Half life in human multiple myeloma patient with normal renal function treated with carfilzomib at 15 mg/m'2, iv on days 1, 2, 8, 9, 15 and 16 of 28-day cycle over 2 to 10 mins by LC-MS/MS analysis | ChEMBL. | 23118326 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.