Detailed information for compound 2075226

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2349.06 | Formula: C92H110N27O34P5Si2
  • H donors: 15 H acceptors: 23 LogP: -0.91 Rotable bonds: 42
    Rule of 5 violations (Lipinski): 4
  • SMILES: Nc1[nH]c(=O)c2c(n1)n(cn2)[C@H]1C[C@@H]([C@H](O1)COP(=O)(O[C@H]1C[C@@H](O[C@@H]1COP(=O)(O[C@H]1C[C@@H](O[C@@H]1CO[Si](C(C)(C)C)(c1ccccc1)c1ccccc1)n1cc(C)c(=O)[nH]c1=O)O)n1cnc2c1nc(N)[nH]c2=O)O)OP(=O)(OC[C@H]1O[C@H](CC1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1OP(=O)(OC[C@H]1O[C@H](C[C@@H]1O[Si](C(C)(C)C)(c1ccccc1)c1ccccc1)n1cnc2c1nc(N)[nH]c2=O)O)n1cnc2c1ncnc2N)O)n1cnc2c1nc(N)[nH]c2=O)O
  • InChi: 1S/C92H110N27O34P5Si2/c1-47-34-114(90(125)113-81(47)120)64-28-56(63(147-64)40-141-159(91(2,3)4,48-20-12-8-13-21-48)49-22-14-9-15-23-49)152-157(132,133)139-38-61-55(32-68(145-61)118-45-103-73-79(118)107-88(96)111-84(73)123)151-156(130,131)138-37-60-54(31-67(144-60)117-44-102-72-78(117)106-87(95)110-83(72)122)150-155(128,129)137-36-59-53(30-66(143-59)116-43-101-71-77(116)105-86(94)109-82(71)121)149-154(126,127)136-35-58-52(29-65(142-58)115-42-100-70-75(93)98-41-99-76(70)115)148-158(134,135)140-39-62-57(33-69(146-62)119-46-104-74-80(119)108-89(97)112-85(74)124)153-160(92(5,6)7,50-24-16-10-17-25-50)51-26-18-11-19-27-51/h8-27,34,41-46,52-69H,28-33,35-40H2,1-7H3,(H,126,127)(H,128,129)(H,130,131)(H,132,133)(H,134,135)(H2,93,98,99)(H,113,120,125)(H3,94,105,109,121)(H3,95,106,110,122)(H3,96,107,111,123)(H3,97,108,112,124)/t52-,53?,54-,55-,56-,57-,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,68+,69+/m0/s1
  • InChiKey: JZJSQYJVSHMRPU-ALPNEYHISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0134 0.1471
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0306 0.0296
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0306 0.0614
Entamoeba histolytica Arginase, putative 0.0121 0.3244 1
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0508 0.0508
Brugia malayi Carboxylesterase family protein 0.0058 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0058 0.1342 0.1342
Schistosoma mansoni acetylcholinesterase 0.0058 0.1342 0.1333
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0111 0.2937 1
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.0121 0.3244 0.3237
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0306 0.0085
Echinococcus granulosus multidrug resistance associated protein 7 0.0024 0.0306 0.0296
Loa Loa (eye worm) hypothetical protein 0.0058 0.1342 0.1342
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0024 0.0306 0.2206
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0306 0.0296
Brugia malayi Carboxylesterase family protein 0.0343 1 1
Loa Loa (eye worm) carboxylesterase 0.0058 0.1342 0.1342
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.001
Schistosoma mansoni multidrug resistance protein 0.0024 0.0306 0.0296
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0076 0.1899 0.5421
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0709 0.1273
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0046 0.0499
Loa Loa (eye worm) hypothetical protein 0.0058 0.1342 0.1342
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0079 0.197 0.6549
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0709 0.7757
Schistosoma mansoni neuroligin 3 (S09 family) 0.0058 0.1342 0.1333
Schistosoma mansoni inositol monophosphatase 0.0037 0.0709 0.0699
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0709 0.1444
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0024 0.0306 0.2206
Plasmodium falciparum arginase 0.0121 0.3244 1
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0306 0.0085
Loa Loa (eye worm) hypothetical protein 0.0023 0.0281 0.0281
Brugia malayi Latrophilin receptor protein 2 0.0014 0.001 0.001
Trichomonas vaginalis abcb9, putative 0.0076 0.1899 0.3911
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.1899 0.1891
Loa Loa (eye worm) hypothetical protein 0.0058 0.1342 0.1342
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0709 0.737
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.1342 0.6224
Trypanosoma cruzi multidrug resistance protein E, putative 0.0024 0.0306 0.2206
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.3226 0.3226
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.1342 0.1333
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0058 0.1342 0.1333
Schistosoma mansoni gliotactin 0.0058 0.1342 0.1333
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0134 0.1471
Trichomonas vaginalis ABC transporter, putative 0.0076 0.1899 0.3911
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.1899 0.3911
Loa Loa (eye worm) hypothetical protein 0.0023 0.0281 0.0281
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.1899 0.3911
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.1899 0.3911
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0134 0.1471
Trichomonas vaginalis taga, putative 0.0076 0.1899 0.3911
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0079 0.197 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0058 0.1342 0.1333
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0024 0.0306 0.0614
Loa Loa (eye worm) hypothetical protein 0.0058 0.1342 0.1342
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0306 0.0296
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0709 0.2527
Loa Loa (eye worm) hypothetical protein 0.0076 0.1874 0.1874
Trypanosoma cruzi arginase, putative 0.0044 0.0914 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0709 0.737
Loa Loa (eye worm) hypothetical protein 0.0343 1 1
Echinococcus granulosus neuroligin 0.0058 0.1342 0.1333
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.1899 0.3911
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0709 0.1273
Trypanosoma cruzi agmatinase, putative 0.0044 0.0914 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0134 0.1471
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0709 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0591 0.171
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.1899 0.1891
Entamoeba histolytica ABC transporter, putative 0.0024 0.0306 0.0085
Echinococcus granulosus acetylcholinesterase 0.0343 1 1
Echinococcus granulosus BC026374 protein S09 family 0.0058 0.1342 0.1333
Schistosoma mansoni hypothetical protein 0.0031 0.0508 0.0499
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0076 0.1899 0.1891
Loa Loa (eye worm) ABC transporter 0.0024 0.0306 0.0306
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0167 0.4647 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0591 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0938 0.0938
Loa Loa (eye worm) hypothetical protein 0.0031 0.0508 0.0508
Echinococcus multilocularis multidrug resistance protein 1 0.0076 0.1899 0.1891
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.3226 0.3226
Echinococcus multilocularis carboxylesterase 5A 0.0343 1 1
Schistosoma mansoni arginase 0.0121 0.3244 0.3237
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0978 0.0978
Giardia lamblia MRP-like ABC transporter 0.0024 0.0306 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0938 0.0938
Echinococcus granulosus multidrug resistance protein 1 0.0053 0.1199 0.119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0306 0.0306
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0134 0.1471
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0076 0.1899 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.1899 0.3911
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.1342 0.6224
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0076 0.1899 0.3911
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0709 0.0699
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0938 0.0938
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0134 0.1471
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0024 0.0306 0.0306
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0056 0.1291 0.5923
Echinococcus multilocularis ATP binding cassette sub family B 0.0076 0.1874 0.1865
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0709 0.0699
Echinococcus multilocularis multidrug resistance associated protein 7 0.0024 0.0306 0.0296
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0306 0.0381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0978 0.0968
Leishmania major p-glycoprotein 0.0076 0.1899 0.5421
Trichomonas vaginalis ABC transporter, putative 0.0076 0.1899 0.3911
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.1899 0.3911
Entamoeba histolytica P-glyco protein 6, putative 0.0076 0.1899 0.546
Entamoeba histolytica multidrug resistance protein, putative 0.0024 0.0306 0.0085
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0058 0.1342 0.1333
Brugia malayi P-glycoprotein-like protein 0.0024 0.0306 0.0306
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.1899 0.3911
Loa Loa (eye worm) hypothetical protein 0.0024 0.0306 0.0306
Loa Loa (eye worm) carboxylesterase 0.0343 1 1
Entamoeba histolytica hypothetical protein 0.0024 0.0306 0.0085
Trichomonas vaginalis ABC transporter, putative 0.0076 0.1899 0.3911
Echinococcus multilocularis multidrug resistance protein 1 0.0076 0.1899 0.1891
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0306 0.0085
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.1899 0.3911
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0076 0.1899 0.5
Loa Loa (eye worm) ABC transporter 0.0024 0.0306 0.0306
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.1899 0.3911
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0024 0.0306 0.2206
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0134 0.1471
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0076 0.1899 0.1891
Mycobacterium ulcerans carboxylesterase, LipT 0.0058 0.1342 0.4308
Brugia malayi MH2 domain containing protein 0.012 0.3226 0.3226
Brugia malayi multidrug resistance related protein 1 0.0024 0.0306 0.0306
Brugia malayi hypothetical protein 0.0058 0.1342 0.1342
Echinococcus granulosus multidrug resistance protein 1 0.0076 0.1899 0.1891
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0306 0.0614
Schistosoma mansoni multidrug resistance protein 0.0076 0.1899 0.1891
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0024 0.0306 0.0306
Brugia malayi ABC transporter 0.0023 0.0281 0.0281
Echinococcus multilocularis arginase 2, mitochondrial 0.0121 0.3244 0.3237
Leishmania major agmatinase-like protein 0.0044 0.0914 0.2068
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0709 0.1273
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.1899 0.1891
Echinococcus granulosus carboxylesterase 5A 0.0343 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.1899 0.3911
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0306 0.0296
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0978 0.0968
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.1899 0.3911
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0306 0.0085
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0076 0.1899 0.1891
Echinococcus granulosus multidrug resistance protein 1 0.0053 0.1199 0.119
Loa Loa (eye worm) hypothetical protein 0.0045 0.0938 0.0938
Echinococcus multilocularis dna polymerase kappa 0.0018 0.0134 0.0124
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0306 0.0614
Echinococcus granulosus arginase 2 mitochondrial 0.0121 0.3244 0.3237
Echinococcus multilocularis acetylcholinesterase 0.0343 1 1
Schistosoma mansoni multidrug resistance protein 0.0023 0.0281 0.0271
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.1899 0.3911
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.1899 0.3911
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0281 0.0325
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0024 0.0306 0.3353
Trypanosoma cruzi arginase, putative 0.0044 0.0914 1
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0167 0.4647 1
Plasmodium falciparum multidrug resistance protein 1 0.0076 0.1899 0.5421
Brugia malayi Inositol-1 0.0037 0.0709 0.0709
Loa Loa (eye worm) carboxylesterase 0.0058 0.1342 0.1342
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0053 0.1199 0.236
Echinococcus granulosus multidrug resistance associated protein 1 0.0024 0.0306 0.0296
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0281 0.0325
Giardia lamblia Multidrug resistance-associated protein 1 0.0024 0.0306 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0978 0.0968
Onchocerca volvulus 0.0076 0.1899 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0709 0.137
Brugia malayi ABC transporter family protein 0.0024 0.0306 0.0306
Trichomonas vaginalis abcb9, putative 0.0076 0.1899 0.3911
Brugia malayi Carboxylesterase family protein 0.0058 0.1342 0.1342
Echinococcus multilocularis BC026374 protein (S09 family) 0.0058 0.1342 0.1333
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0076 0.1899 0.1891
Schistosoma mansoni multidrug resistance protein 0.0024 0.0306 0.0296
Loa Loa (eye worm) hypothetical protein 0.0058 0.1342 0.1342
Plasmodium vivax multidrug resistance protein 1, putative 0.0076 0.1899 0.5421
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0306 0.0085
Trypanosoma brucei unspecified product 0.0015 0.0046 0.0499
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.1899 0.1891
Trichomonas vaginalis abcb9, putative 0.0076 0.1899 0.3911
Trypanosoma brucei p-glycoprotein 0.0024 0.0306 0.3353
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.1899 0.3911
Mycobacterium tuberculosis Carboxylesterase LipT 0.0058 0.1342 0.6224
Loa Loa (eye worm) hypothetical protein 0.0058 0.1342 0.1342
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0024 0.0306 0.0296
Treponema pallidum hypothetical protein 0.0027 0.0405 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0058 0.1342 0.2675
Echinococcus multilocularis multidrug resistance protein 1 0.0053 0.1199 0.119
Brugia malayi ABC transporter family protein 0.0024 0.0306 0.0306
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0056 0.1291 0.4129
Echinococcus granulosus para nitrobenzyl esterase 0.0058 0.1342 0.1333
Entamoeba histolytica P-glycoprotein-2 0.0076 0.1899 0.546
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0281 0.0325
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0024 0.0306 0.3353
Loa Loa (eye worm) hypothetical protein 0.0343 1 1
Trichomonas vaginalis Arginase, putative 0.0121 0.3244 0.6892
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0343 1 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.0405 0.0964
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.1899 0.3911
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0978 0.0968
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0306 0.0296
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0978 0.0968
Schistosoma mansoni multidrug resistance protein 0.0024 0.0306 0.0296
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0076 0.1899 0.1899
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0076 0.1899 0.9577
Entamoeba histolytica P-glycoprotein 5, putative 0.0076 0.1899 0.546
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0134 0.1471
Leishmania major arginase 0.0121 0.3244 1
Trypanosoma brucei agmatinase, putative 0.0044 0.0914 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0134 0.1471
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.1899 0.3911
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0076 0.1899 0.3911
Brugia malayi ABC transporter 0.0024 0.0306 0.0306
Trypanosoma brucei multidrug resistance protein E 0.0024 0.0306 0.3353
Echinococcus granulosus multidrug resistance protein 1 0.0076 0.1899 0.1891
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0049 0.1083 0.3384
Brugia malayi multidrug resistance protein 3 0.0076 0.1899 0.1899
Schistosoma mansoni multidrug resistance protein 0.0024 0.0306 0.0296
Treponema pallidum quinoline 2-oxidoreductase 0.0027 0.0386 0.8682
Plasmodium vivax arginase, putative 0.0121 0.3244 1
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0079 0.197 0.6549
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0032 0.0548 0.1455
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0548 0.1477
Trypanosoma cruzi agmatinase, putative 0.0044 0.0914 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0024 0.0306 0.2206
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0023 0.0281 0.0271
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0306 0.0306
Echinococcus granulosus dna polymerase kappa 0.0018 0.0134 0.0124
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.1899 0.3911
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.1342 0.1333
Brugia malayi ABC transporter family protein 0.0024 0.0306 0.0306
Echinococcus multilocularis neuroligin 0.0058 0.1342 0.1333
Loa Loa (eye worm) ABC transporter 0.0024 0.0306 0.0306
Schistosoma mansoni smdr2 0.0076 0.1899 0.1891
Trichomonas vaginalis spcc417.12 protein, putative 0.0058 0.1342 0.2675
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0306 0.0296
Brugia malayi ABC transporter family protein 0.0076 0.1899 0.1899
Entamoeba histolytica P-glycoprotein-2, putative 0.0076 0.1899 0.546
Entamoeba histolytica P-glycoprotein-5 0.0076 0.1899 0.546
Schistosoma mansoni inositol monophosphatase 0.0037 0.0709 0.0699
Brugia malayi Carboxylesterase family protein 0.0058 0.1342 0.1342
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0134 0.1471
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.1899 0.3911
Echinococcus multilocularis acetylcholinesterase 0.0343 1 1
Entamoeba histolytica P-glycoprotein-2 0.0076 0.1899 0.546
Echinococcus granulosus ATP binding cassette sub family B 0.0023 0.0281 0.0271
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0281 0.0325
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0306 0.0085
Brugia malayi hypothetical protein 0.0024 0.0306 0.0306
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0076 0.1899 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.1899 0.1891
Loa Loa (eye worm) hypothetical protein 0.0076 0.1899 0.1899
Giardia lamblia ABC transporter, putative 0.0024 0.0306 1
Schistosoma mansoni multidrug resistance protein 0.0076 0.1899 0.1891
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0056 0.1291 0.4129
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.0134 0.1471
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0548 0.1477
Loa Loa (eye worm) inositol-1 0.0037 0.0709 0.0709
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.001 0.001
Echinococcus multilocularis multidrug resistance associated protein 1 0.0024 0.0306 0.0296
Trichomonas vaginalis ABC transporter, putative 0.0076 0.1899 0.3911
Echinococcus granulosus acetylcholinesterase 0.0343 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0978 0.0968
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0024 0.0306 0.0306
Brugia malayi ABC transporter transmembrane region family protein 0.0023 0.0281 0.0281
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0024 0.0306 0.3353
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0978 0.0968
Giardia lamblia Multidrug resistance-associated protein 1 0.0024 0.0306 1
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0306 0.0306
Echinococcus multilocularis 0.0121 0.3244 0.3237
Entamoeba histolytica P-glycoprotein-1 0.0076 0.1899 0.546
Loa Loa (eye worm) hypothetical protein 0.0076 0.1899 0.1899
Echinococcus multilocularis 0.0024 0.0306 0.0296
Trichomonas vaginalis aldehyde oxidase, putative 0.0167 0.4647 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.1342 0.1333
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.3244 0.6892
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.001 0.001
Brugia malayi Carboxylesterase family protein 0.0058 0.1342 0.1342
Schistosoma mansoni multidrug resistance protein 0.0076 0.1899 0.1891
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.1899 0.3911
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0024 0.0306 0.0614
Loa Loa (eye worm) acetylcholinesterase 1 0.0343 1 1
Schistosoma mansoni multidrug resistance protein 0.0024 0.0306 0.0296
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0076 0.1874 0.1865
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.1899 0.3911
Schistosoma mansoni smdr1 0.0024 0.0306 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.3244 0.6892
Echinococcus granulosus multidrug resistance protein 1 0.0076 0.1899 0.1891
Loa Loa (eye worm) multidrug resistance protein 3 0.0076 0.1899 0.1899
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0709 0.205
Schistosoma mansoni BC026374 protein (S09 family) 0.0058 0.1342 0.1333
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0024 0.0306 0.3353

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.