Detailed information for compound 2075281

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 243.308 | Formula: C13H17N5
  • H donors: 2 H acceptors: 3 LogP: 1.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc2nc(ccc2c(n1)N)C1CCCCN1
  • InChi: 1S/C13H17N5/c1-8-16-12(14)9-5-6-11(18-13(9)17-8)10-4-2-3-7-15-10/h5-6,10,15H,2-4,7H2,1H3,(H2,14,16,17,18)
  • InChiKey: ZYGFQLMTQQGZGR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0399 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.002 0.0149 0.0149
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0008 0.0003 0.0003
Onchocerca volvulus 0.0107 0.1178 0.1178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0528 0.0528
Loa Loa (eye worm) AGC/PKN protein kinase 0.002 0.0149 0.0149
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0399 0.0399
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0022 0.017 0.017
Chlamydia trachomatis glycogen phosphorylase 0.0853 1 0.5
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0166 0.9795
Echinococcus multilocularis unc 13 (munc13) 0.0008 0.0003 0.0003
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.005 0.005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0399 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0001 0.0001
Mycobacterium ulcerans hypothetical protein 0.0007 0.0001 0.0003
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0094 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.005 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0721 0.0721
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.005 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.005 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0001 0.0001
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Echinococcus multilocularis protein tyrosine kinase 0.0262 0.3006 0.3006
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0149 0.0149
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Schistosoma mansoni unc-13 (munc13) 0.0008 0.0003 0.0003
Entamoeba histolytica protein kinase, putative 0.0043 0.0425 0.0425
Trypanosoma cruzi aldo/keto reductase, putative 0.0026 0.0216 0.5404
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.005 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0528 0.0528
Loa Loa (eye worm) oxidoreductase 0.0026 0.0216 0.0216
Brugia malayi Pleckstrin Homology Domain 0.0008 0.0013 0.0013
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0094 0.0094
Onchocerca volvulus 0.0026 0.0216 0.0216
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.002 0.0149 0.0149
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0041 0.0396 0.0396
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0094 0.2366
Loa Loa (eye worm) hypothetical protein 0.0242 0.2775 0.2775
Echinococcus multilocularis voltage gated potassium channel subunit 0.0007 0.0001 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0166 0.4163
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.002 0.0149 0.0149
Giardia lamblia Aldose reductase 0.0026 0.0216 0.0216
Echinococcus granulosus lysosomal alpha glucosidase 0.0185 0.21 0.21
Echinococcus multilocularis myotubularin protein 13 0.0008 0.0013 0.0013
Trypanosoma brucei aldo-keto reductase, putative 0.0026 0.0216 0.5073
Echinococcus granulosus NDR protein kinase 0.002 0.0149 0.0149
Trichomonas vaginalis aldo/keto reductase, putative 0.0026 0.0216 0.0216
Schistosoma mansoni nuclear hormone receptor 0.0012 0.005 0.005
Echinococcus multilocularis RNA directed DNA polymerase 0.0041 0.0396 0.0396
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0399 0.0399
Entamoeba histolytica glycogen phosphorylase, putative 0.0369 0.4275 0.4275
Echinococcus multilocularis Glycosyl transferase, family 35 0.0853 1 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0007 0.0001 0.0027
Echinococcus multilocularis serine:threonine protein kinase N2 0.002 0.0149 0.0149
Brugia malayi Protein kinase domain containing protein 0.0059 0.0607 0.0607
Echinococcus granulosus Protein kinase C brain isozyme 0.0068 0.0721 0.0721
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0094 0.2366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.005 0.005
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0024 0.0195 0.488
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0399 1
Onchocerca volvulus Glycogen phosphorylase homolog 0.0853 1 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0026 0.0216 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Schistosoma mansoni vav2 0.0008 0.0013 0.0013
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0166 0.0388
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0003
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0399 0.0399
Trichomonas vaginalis aldo-keto reductase, putative 0.0007 0.0001 0.0001
Brugia malayi Protein kinase domain containing protein 0.002 0.0149 0.0149
Mycobacterium leprae Possible oxidoreductase 0.0007 0.0001 0.005
Mycobacterium ulcerans oxidoreductase 0.0026 0.0216 0.0504
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.017 0.425
Mycobacterium ulcerans epoxide hydrolase EphA 0.0266 0.3059 0.7157
Entamoeba histolytica protein kinase, putative 0.002 0.0149 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.005 0.005
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.005 0.005
Echinococcus multilocularis aldo keto reductase 0.0026 0.0216 0.0216
Schistosoma mansoni serine/threonine kinase 0.002 0.0149 0.0149
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.005 0.005
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0092 0.0996 0.0996
Trypanosoma cruzi Protein kinase B 0.0024 0.0195 0.488
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0166 0.0166
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0721 0.0721
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.005
Trypanosoma cruzi aldo/keto reductase, putative 0.0007 0.0001 0.0027
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0026 0.0216 0.0216
Echinococcus granulosus RNA directed DNA polymerase 0.0041 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.005
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.002 0.0149 0.0149
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0026 0.0216 0.0216
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0425 0.0425
Giardia lamblia Glycogen phosphorylase 0.0853 1 1
Mycobacterium tuberculosis Conserved protein 0.0007 0.0001 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0528 0.0528
Trichomonas vaginalis AGC family protein kinase 0.0022 0.0174 0.0174
Trypanosoma cruzi aldo-keto reductase 0.0026 0.0216 0.5404
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.002 0.0149 0.0149
Loa Loa (eye worm) TK/FAK protein kinase 0.0265 0.3043 0.3043
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0026 0.0216 0.0216
Echinococcus granulosus voltage gated potassium channel subunit 0.0007 0.0001 0.0001
Brugia malayi nuclear receptor NHR-88 0.0012 0.005 0.005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0166 0.9795
Echinococcus multilocularis serine:threonine protein kinase N2 0.002 0.0149 0.0149
Brugia malayi nuclear hormone receptor 0.0248 0.284 0.284
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0026 0.0216 0.0216
Brugia malayi protein kinase C II. 0.0027 0.0238 0.0238
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.005 0.005
Echinococcus granulosus protein kinase c epsilon type 0.0027 0.0238 0.0238
Echinococcus granulosus serine:threonine protein kinase N2 0.002 0.0149 0.0149
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0094 0.0094
Onchocerca volvulus 0.0008 0.0013 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0528 0.0528
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0007 0.0001 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0425 0.0425
Echinococcus granulosus aldo keto reductase 0.0026 0.0216 0.0216
Toxoplasma gondii aldo-keto reductase 0.0007 0.0001 0.0027
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0007 0.0001 0.0027
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0094 0.2366
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0369 0.4275 1
Onchocerca volvulus 0.0026 0.0216 0.0216
Entamoeba histolytica aldose reductase, putative 0.0026 0.0216 0.0216
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0399 0.0399
Schistosoma mansoni tyrosine kinase 0.0262 0.3006 0.3006
Onchocerca volvulus 0.0026 0.0216 0.0216
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0094 0.0094
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.005 0.005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0166 0.0166
Entamoeba histolytica protein kinase 2, putative 0.0022 0.017 0.017
Onchocerca volvulus 0.0026 0.0216 0.0216
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0094 0.0094
Schistosoma mansoni ap endonuclease 0.0021 0.0166 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0399 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.005 0.005
Trypanosoma brucei prostaglandin f synthase 0.0026 0.0216 0.5073
Echinococcus granulosus aldo keto reductase 0.0026 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0015 0.0094 0.0094
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0369 0.4275 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.005 0.005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0166 0.0166
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.005 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0166 0.0166
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.002 0.0149 0.0149
Entamoeba histolytica glycogen phosphorylase, putative 0.0853 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Echinococcus multilocularis rac serine:threonine kinase 0.0024 0.0195 0.0195
Schistosoma mansoni protein kinase C 0.0008 0.0003 0.0003
Trichomonas vaginalis aldo-keto reductase, putative 0.0007 0.0001 0.0001
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0425 0.0425
Schistosoma mansoni aldo-keto reductase 0.0026 0.0216 0.0216
Brugia malayi Protein kinase domain containing protein 0.0265 0.3043 0.3043
Echinococcus multilocularis glycogen phosphorylase 0.0853 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0166 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0299 0.3442 0.3442
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0026 0.0216 0.0216
Onchocerca volvulus 0.0007 0.0001 0.0001
Echinococcus multilocularis glycogen phosphorylase 0.0853 1 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0043 0.0425 1
Schistosoma mansoni ap endonuclease 0.0021 0.0166 0.0166
Leishmania major prostaglandin f synthase, putative 0.0026 0.0216 0.5404
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0068 0.0721 0.0721
Schistosoma mansoni serine/threonine-protein kinase 0.0024 0.0195 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.005 0.005
Echinococcus granulosus glycogen phosphorylase 0.0853 1 1
Leishmania major aldo-keto reductase-like protein 0.0026 0.0216 0.5404
Plasmodium falciparum aldo-keto reductase, putative 0.0007 0.0001 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.005 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0094 0.0094
Trypanosoma brucei glucosidase, putative 0.0041 0.0399 0.9387
Echinococcus multilocularis protein kinase c epsilon type 0.0027 0.0238 0.0238
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0399 0.0399
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.005 0.005
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0026 0.0216 0.0216
Trichomonas vaginalis AGC family protein kinase 0.002 0.0149 0.0149
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.005
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.002 0.0149 0.0149
Schistosoma mansoni coup transcription factor 0.0012 0.005 0.005
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.21 0.21
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0026 0.0216 0.0216
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0248 0.284 0.284
Toxoplasma gondii exonuclease III APE 0.0021 0.0166 0.4153
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0399 0.9976
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0166 0.0388
Echinococcus granulosus raf serine:threonine protein kinase 0.0007 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.005 0.005
Echinococcus granulosus protein tyrosine kinase 0.0262 0.3006 0.3006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.005 0.005
Onchocerca volvulus 0.0026 0.0216 0.0216
Echinococcus multilocularis aldo keto reductase 0.0026 0.0216 0.0216
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0026 0.0216 0.0216
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0019 0.0144 0.0144
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0149
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0528 0.0528
Schistosoma mansoni alpha glucosidase 0.0041 0.0399 0.0399
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0094 0.0094
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Echinococcus granulosus hypothetical protein 0.0026 0.0216 0.0216
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0026 0.0216 0.0216
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0007 0.0001 0.0027
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0026 0.0216 0.0216
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0026 0.0216 0.5404
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0425 0.0425
Echinococcus granulosus myotubularin protein 13 0.0008 0.0013 0.0013
Trichomonas vaginalis aldo/keto reductase, putative 0.0026 0.0216 0.0216
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.005 0.005
Onchocerca volvulus 0.0026 0.0216 0.0216
Loa Loa (eye worm) glycogen phosphorylase 0.0853 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0026 0.0216 0.0216
Trypanosoma brucei aldo/keto reductase, putative 0.0007 0.0001 0.0026
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0399 0.0399
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0166 0.0166
Echinococcus multilocularis nervana 2 0.0021 0.0164 0.0164
Schistosoma mansoni unc-13 (munc13) 0.0008 0.0003 0.0003
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0399 0.0399
Entamoeba histolytica protein kinase, putative 0.0043 0.0425 0.0425
Brugia malayi Fibroblast growth factor family protein 0.0092 0.0996 0.0996
Loa Loa (eye worm) hypothetical protein 0.0047 0.047 0.047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0166 0.4163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.005 0.005
Schistosoma mansoni glycogen phosphorylase 0.0853 1 1
Brugia malayi Fibroblast growth factor family protein 0.0092 0.0996 0.0996
Schistosoma mansoni potassium channel beta 0.0007 0.0001 0.0001
Loa Loa (eye worm) AGC/NDR protein kinase 0.002 0.0149 0.0149
Brugia malayi Protein kinase domain containing protein 0.002 0.0149 0.0149
Schistosoma mansoni serine/threonine-protein kinase 0.0024 0.0195 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.005 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0399 0.0399
Trichomonas vaginalis glycogen phosphorylase, putative 0.0853 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.005 0.005
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.005 0.005
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0094 0.2221
Toxoplasma gondii aldose reductase, putative 0.0026 0.0216 0.5391
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.005 0.005
Schistosoma mansoni atypical protein kinase C 0.0026 0.0223 0.0223
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0094 0.0094
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.005 0.005
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0164 0.0164
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0041 0.04 0.04
Echinococcus multilocularis protein kinase c iota type 0.0026 0.0223 0.0223
Echinococcus granulosus serine threonine protein kinase nrc 0.0022 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0041 0.0396 0.0396
Onchocerca volvulus 0.0008 0.0003 0.0003
Echinococcus granulosus aldehyde reductase 0.0018 0.0128 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0399 0.0399
Brugia malayi steroid hormone receptor 0.0012 0.005 0.005
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0027 0.0238 0.0238
Trichomonas vaginalis AGC family protein kinase 0.002 0.0149 0.0149
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0026 0.0216 0.0216
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0094 0.0094
Brugia malayi Protein kinase domain containing protein 0.0043 0.0425 0.0425
Echinococcus multilocularis serine threonine protein kinase 0.0062 0.0647 0.0647
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0528 0.0528
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.005 0.005
Entamoeba histolytica alcohol dehydrogenase, putative 0.0007 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.005 0.005
Entamoeba histolytica protein kinase, putative 0.0041 0.04 0.04
Echinococcus granulosus serine/threonine protein kinase 0.0024 0.0195 0.0195
Schistosoma mansoni glycogen phosphorylase 0.0853 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0528 0.0528
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0166 0.0166
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0092 0.0996 0.0996
Brugia malayi Protein kinase c protein 2 0.0049 0.0491 0.0491
Echinococcus granulosus unc 13 munc13 0.0008 0.0003 0.0003
Schistosoma mansoni pol-related 0.0026 0.0216 0.0216
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0195 0.0195
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.005
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0425 0.0425
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0166 0.3908
Schistosoma mansoni glycogen phosphorylase 0.0369 0.4275 0.4275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.005 0.005
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.005 0.005
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0164 0.0164
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0299 0.3442 0.3442
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0007 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0022 0.017 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.005
Echinococcus multilocularis serine:threonine protein kinase 38 0.002 0.0149 0.0149
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Trichomonas vaginalis AGC family protein kinase 0.002 0.0149 0.0149
Trichomonas vaginalis aldo-keto reductase, putative 0.0007 0.0001 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.005 0.005
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0166 0.0166
Plasmodium falciparum aldehyde reductase, putative 0.0007 0.0001 0.0064
Trichomonas vaginalis glycogen phosphorylase, putative 0.0853 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0026 0.0216 0.0216
Mycobacterium tuberculosis Probable oxidoreductase 0.0026 0.0216 0.0504
Entamoeba histolytica glycogen phosphorylase, putative 0.0369 0.4275 0.4275
Echinococcus multilocularis aldo keto reductase 0.0026 0.0216 0.0216
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0094 0.0094
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0399 0.0399
Brugia malayi nuclear hormone receptor 0.0012 0.005 0.005
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.005
Echinococcus multilocularis lysosomal alpha glucosidase 0.0185 0.21 0.21
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0425 0.0425
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.005 0.005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0399 0.0399
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0164 0.0164
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0094 0.0094
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.005 0.005
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0043 0.0417 0.0417
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.005 0.005
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0399 0.0399
Onchocerca volvulus 0.0012 0.005 0.005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.005
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0026 0.0216 0.0216
Entamoeba histolytica aldose reductase, putative 0.0026 0.0216 0.0216
Loa Loa (eye worm) oxidoreductase 0.0026 0.0216 0.0216
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.005 0.005
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.005 0.005
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0166 0.5
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0008 0.0003 0.0003
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0022 0.017 0.017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0528 0.0528
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0026 0.0216 0.0216
Echinococcus granulosus nervana 2 0.0021 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0008 0.0013 0.0013
Echinococcus granulosus aldo keto reductase 0.0026 0.0216 0.0216
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0166 0.0166
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.005 0.005
Loa Loa (eye worm) oxidoreductase 0.0026 0.0216 0.0216
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0185 0.21 0.21
Schistosoma mansoni aldo-keto reductase 0.0026 0.0216 0.0216
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.002 0.0149 0.0149
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.005
Brugia malayi NADH-dependent xylose reductase 0.0007 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0238 0.0238
Plasmodium vivax aldehyde reductase, putative 0.0007 0.0001 0.0064
Giardia lamblia Hypothetical protein 0.0092 0.0996 0.0996
Echinococcus multilocularis nervana 2 0.0021 0.0164 0.0164
Echinococcus multilocularis aldo keto reductase 0.0026 0.0216 0.0216
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0166 0.4163
Schistosoma mansoni thyroid hormone receptor 0.0012 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.005 0.005
Brugia malayi Glycosyl hydrolases family 31 protein 0.0185 0.21 0.21
Entamoeba histolytica aldose reductase, putative 0.0026 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.005 0.005
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0164 0.0164
Toxoplasma gondii AGC kinase 0.0041 0.04 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.005 0.005
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0026 0.0216 0.0216
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0266 0.3059 0.7157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.005 0.005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0399 0.0399
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0007 0.0001 0.0001
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.002 0.0149 0.0149
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0022 0.017 1
Echinococcus granulosus protein kinase C gamma type 0.0062 0.0647 0.0647
Loa Loa (eye worm) oxidoreductase 0.0026 0.0216 0.0216
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.005 0.005
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.005 0.005
Loa Loa (eye worm) oxidoreductase 0.0026 0.0216 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0149 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0149 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0149 0.0149
Echinococcus granulosus FTZ F1 alpha 0.0012 0.005 0.005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0254 0.2912 0.2912
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0026 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.005 0.005
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0026 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.005 0.005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.005 0.005
Entamoeba histolytica alcohol dehydrogenase, putative 0.0007 0.0001 0.0001
Giardia lamblia Kinase, AGC PKA 0.0022 0.017 0.017
Entamoeba histolytica glycogen phosphorylase, putative 0.0853 1 1
Entamoeba histolytica glycogenphosphorylase, putative 0.0369 0.4275 0.4275
Echinococcus granulosus glycogen phosphorylase 0.0853 1 1
Schistosoma mansoni alpha-glucosidase 0.0159 0.1796 0.1796
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0026 0.0216 0.5404
Giardia lamblia Aldose reductase 0.0026 0.0216 0.0216
Entamoeba histolytica PH domain containing protein kinase, putative 0.0024 0.0195 0.0195
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Echinococcus granulosus protein kinase c iota type 0.0026 0.0223 0.0223
Brugia malayi Hr1 repeat family protein 0.002 0.0149 0.0149
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0528 0.0528
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0128 0.5943
Echinococcus granulosus Glycosyl transferase family 35 0.0853 1 1
Echinococcus multilocularis aldehyde reductase 0.0018 0.0128 0.0128
Trichomonas vaginalis aldo-keto reductase, putative 0.0026 0.0216 0.0216
Echinococcus multilocularis raf serine:threonine protein kinase 0.0007 0.0001 0.0001
Schistosoma mansoni alpha-glucosidase 0.0159 0.1796 0.1796
Trichomonas vaginalis aldo/keto reductase, putative 0.0026 0.0216 0.0216
Brugia malayi ecdysteroid receptor 0.0012 0.005 0.005
Echinococcus granulosus nervana 2 0.0021 0.0164 0.0164
Loa Loa (eye worm) AGC/AKT protein kinase 0.0043 0.0425 0.0425
Brugia malayi p70 ribosomal S6 kinase beta 0.0041 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0058 0.0602 0.0602
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.005 0.005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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