Detailed information for compound 2075302

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 381.389 | Formula: C20H22F3NO3
  • H donors: 2 H acceptors: 1 LogP: 3.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2[C@@H](NCCc2cc1OC)CC(c1ccc(cc1)C(F)(F)F)O
  • InChi: 1S/C20H22F3NO3/c1-26-18-9-13-7-8-24-16(15(13)10-19(18)27-2)11-17(25)12-3-5-14(6-4-12)20(21,22)23/h3-6,9-10,16-17,24-25H,7-8,11H2,1-2H3/t16-,17?/m0/s1
  • InChiKey: CJZHQFCDBGCSGH-BHWOMJMDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Smad4 0.0015 0.0092 0.0092
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0092 0.0756
Entamoeba histolytica hypothetical protein 0.0029 0.067 0.0583
Schistosoma mansoni multidrug resistance protein 0.0024 0.0466 0.0466
Giardia lamblia Multidrug resistance-associated protein 1 0.0024 0.0466 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0433 0.0549
Trichomonas vaginalis abcb9, putative 0.0077 0.2542 0.2528
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0024 0.0466 0.0448
Trichomonas vaginalis ABC transporter, putative 0.0077 0.2542 0.2528
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0991 0.0991
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.2542 0.2542
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0466 0.0378
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.2542 0.2542
Leishmania major p-glycoprotein 0.0077 0.2542 0.2528
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0057 0.175 0.4468
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0466 0.0466
Loa Loa (eye worm) MH2 domain-containing protein 0.0213 0.7894 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.2542 0.2528
Echinococcus multilocularis transcription factor btf3 0.0029 0.067 0.067
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0024 0.0466 0.1155
Brugia malayi MH1 domain containing protein 0.0015 0.0092 0.0116
Toxoplasma gondii thioredoxin reductase 0.0037 0.0956 0.3717
Schistosoma mansoni multidrug resistance protein 0.0024 0.0466 0.0466
Trypanosoma cruzi arginase, putative 0.0097 0.3334 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0092 0.0234
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0024 0.0466 0.135
Brugia malayi N-terminal motif family protein 0.0139 0.5 0.6334
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.2542 0.2528
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.2542 0.2528
Echinococcus multilocularis multidrug resistance protein 1 0.0077 0.2542 0.2542
Giardia lamblia ABC transporter, putative 0.0024 0.0466 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.0024 0.0466 0.0466
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.6122 0.6115
Plasmodium vivax ABC transporter B family member 7, putative 0.0024 0.0466 0.0448
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0092 0.0117
Giardia lamblia Multidrug resistance-associated protein 1 0.0024 0.0466 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.2542 0.2528
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0991 0.3853
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0466 0.1774
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0466 0.1155
Echinococcus multilocularis smad 0.0015 0.0092 0.0092
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0024 0.0466 0.135
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0023 0.0433 0.0415
Schistosoma mansoni hypothetical protein 0.0142 0.5087 0.5087
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1341 0.1699
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0466 0.0466
Echinococcus granulosus Smad4 0.0015 0.0092 0.0092
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.2542 0.2528
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0139 0.5 1
Schistosoma mansoni multidrug resistance protein 0.0024 0.0466 0.0466
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0466 0.0591
Giardia lamblia MRP-like ABC transporter 0.0024 0.0466 1
Brugia malayi MH1 domain containing protein 0.0015 0.0092 0.0116
Treponema pallidum hypothetical protein 0.0022 0.0405 0.6711
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0024 0.0466 0.4605
Plasmodium falciparum thioredoxin reductase 0.0037 0.0956 0.0939
Trypanosoma cruzi transcription factor btf3, putative 0.0029 0.067 0.1964
Plasmodium falciparum basic transcription factor 3b, putative 0.0029 0.067 0.0652
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0077 0.2542 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.2795 0.8837
Brugia malayi ABC transporter family protein 0.0024 0.0466 0.0591
Echinococcus multilocularis mothers against decapentaplegic 5 0.0015 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0023 0.0433 0.0549
Brugia malayi ABC transporter family protein 0.0024 0.0466 0.0591
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.2542 0.2528
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0092 0.0222
Entamoeba histolytica transcription factor BTF3, putative 0.0029 0.067 0.0583
Brugia malayi MH2 domain containing protein 0.0015 0.0092 0.0116
Plasmodium vivax ABC transporter B family member 3, putative 0.0024 0.0466 0.0448
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0991 0.0974
Schistosoma mansoni arginase 0.0267 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.1034 0.131
Schistosoma mansoni smdr1 0.0024 0.0466 0.0466
Echinococcus granulosus multidrug resistance protein 1 0.0077 0.2542 0.2542
Entamoeba histolytica P-glyco protein 6, putative 0.0077 0.2542 0.2472
Brugia malayi hypothetical protein 0.0024 0.0466 0.0591
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0024 0.0466 0.0591
Plasmodium vivax arginase, putative 0.0267 1 1
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0024 0.0466 0.0448
Brugia malayi ABC transporter family protein 0.0077 0.2542 0.322
Trichomonas vaginalis aldehyde oxidase, putative 0.0168 0.6122 0.6115
Echinococcus granulosus multidrug resistance protein 1 0.0054 0.163 0.163
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0057 0.175 0.4468
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0092 0.0074
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.005 0.1478 0.3766
Schistosoma mansoni transcription factor btf3 0.0029 0.067 0.067
Schistosoma mansoni hypothetical protein 0.0142 0.5087 0.5087
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0024 0.0466 0.0448
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.2795 0.8837
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0077 0.2542 0.2528
Echinococcus granulosus geminin 0.0142 0.5087 0.5087
Entamoeba histolytica P-glycoprotein-2 0.0077 0.2542 0.2472
Echinococcus multilocularis multidrug resistance associated protein 7 0.0024 0.0466 0.0466
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0837 0.2604
Echinococcus granulosus ATP binding cassette sub family B 0.0023 0.0433 0.0433
Brugia malayi ABC transporter 0.0024 0.0466 0.0591
Trypanosoma cruzi agmatinase, putative 0.0097 0.3334 1
Echinococcus granulosus arginase 2 mitochondrial 0.0267 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0956 0.0956
Schistosoma mansoni multidrug resistance protein 0.0024 0.0466 0.0466
Brugia malayi multidrug resistance related protein 1 0.0024 0.0466 0.0591
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0077 0.2542 0.2528
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.067 0.0652
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0111 0.3893 1
Schistosoma mansoni multidrug resistance protein 0.0077 0.2542 0.2542
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0024 0.0466 0.135
Trichomonas vaginalis ABC transporter, putative 0.0077 0.2542 0.2528
Brugia malayi MH2 domain containing protein 0.0015 0.0092 0.0116
Entamoeba histolytica P-glycoprotein-5 0.0077 0.2542 0.2472
Schistosoma mansoni Smad4 0.0015 0.0092 0.0092
Schistosoma mansoni ap endonuclease 0.0015 0.0092 0.0092
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0024 0.0466 0.135
Trypanosoma brucei multidrug resistance protein E 0.0024 0.0466 0.135
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0092 0.0074
Leishmania major agmatinase-like protein 0.0097 0.3334 0.3321
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0076 0.2509 0.2509
Schistosoma mansoni smad1 5 8 and 0.0015 0.0092 0.0092
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.2542 0.2528
Trypanosoma cruzi arginase, putative 0.0097 0.3334 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0466 0.0378
Mycobacterium ulcerans hypothetical protein 0.0027 0.0594 0.1486
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.2542 0.2542
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0466 0.1774
Trichomonas vaginalis conserved hypothetical protein 0.0267 1 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0466 0.0466
Plasmodium falciparum ABC transporter B family member 4, putative 0.0024 0.0466 0.0448
Brugia malayi ABC transporter family protein 0.0024 0.0466 0.0591
Treponema pallidum hypothetical protein 0.0027 0.0594 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.1034 0.131
Schistosoma mansoni hypothetical protein 0.0026 0.0556 0.0556
Entamoeba histolytica P-glycoprotein-2, putative 0.0077 0.2542 0.2472
Echinococcus multilocularis ATP binding cassette sub family B 0.0076 0.2509 0.2509
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0015 0.0092 0.0092
Entamoeba histolytica P-glycoprotein-2 0.0077 0.2542 0.2472
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0956 0.1211
Echinococcus granulosus smad 0.0015 0.0092 0.0092
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0077 0.2542 0.322
Entamoeba histolytica P-glycoprotein 5, putative 0.0077 0.2542 0.2472
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0024 0.0466 0.135
Plasmodium falciparum arginase 0.0267 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.2542 0.2528
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0019 0.0019
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0433 0.0415
Brugia malayi Inositol-1 0.0037 0.0991 0.1255
Plasmodium falciparum multidrug resistance protein 1 0.0077 0.2542 0.2528
Trypanosoma brucei transcription factor BTF3, putative 0.0029 0.067 0.1964
Loa Loa (eye worm) transcription factor SMAD2 0.0213 0.7894 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1341 0.1341
Entamoeba histolytica P-glycoprotein 5, putative 0.0023 0.0433 0.0344
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.2542 0.2528
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0991 0.0974
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0077 0.2542 0.2528
Trypanosoma cruzi multidrug resistance protein E, putative 0.0024 0.0466 0.135
Schistosoma mansoni multidrug resistance protein 0.0023 0.0433 0.0433
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0024 0.0466 0.0448
Schistosoma mansoni multidrug resistance protein 0.0077 0.2542 0.2542
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0991 0.2932
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0991 0.2509
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0024 0.0466 0.0466
Schistosoma mansoni smad 0.0015 0.0092 0.0092
Trichomonas vaginalis Arginase, putative 0.0267 1 1
Schistosoma mansoni smad1 5 8 and 0.0015 0.0092 0.0092
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0077 0.2542 0.8031
Echinococcus granulosus multidrug resistance protein 1 0.0077 0.2542 0.2542
Loa Loa (eye worm) hypothetical protein 0.0077 0.2542 0.322
Trichomonas vaginalis taga, putative 0.0077 0.2542 0.2528
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0956 0.2985
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.2542 0.2542
Loa Loa (eye worm) hypothetical protein 0.0139 0.5 0.6334
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0024 0.0466 0.0591
Trichomonas vaginalis abcb9, putative 0.0077 0.2542 0.2528
Brugia malayi MH2 domain containing protein 0.0213 0.7894 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0023 0.0433 0.9264
Trypanosoma brucei agmatinase, putative 0.0097 0.3334 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.2542 0.2528
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0024 0.0466 0.0448
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0019 0.0019
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0024 0.0466 0.1774
Loa Loa (eye worm) ABC transporter 0.0024 0.0466 0.0591
Entamoeba histolytica Arginase, putative 0.0267 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0991 0.0991
Echinococcus multilocularis 0.0024 0.0466 0.0466
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.316 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0092 0.0116
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0092 0.0092
Echinococcus granulosus mothers against decapentaplegic 5 0.0015 0.0092 0.0092
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.2795 0.8837
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0024 0.0466 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0433 0.0415
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0092 0.0116
Schistosoma mansoni ap endonuclease 0.0015 0.0092 0.0092
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0092 0.1276
Plasmodium vivax ABC transporter B family member 6, putative 0.0024 0.0466 0.0448
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.316 1
Echinococcus multilocularis multidrug resistance protein 1 0.0077 0.2542 0.2542
Brugia malayi glutathione reductase 0.0037 0.0956 0.1211
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0015 0.0092 0.0092
Loa Loa (eye worm) multidrug resistance protein 3 0.0077 0.2542 0.322
Brugia malayi P-glycoprotein-like protein 0.0024 0.0466 0.0591
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0466 0.0466
Trichomonas vaginalis ABC transporter, putative 0.0077 0.2542 0.2528
Trypanosoma cruzi transcription factor btf3, putative 0.0029 0.067 0.1964
Loa Loa (eye worm) inositol-1 0.0037 0.0991 0.1255
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0556 0.0704
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0077 0.2542 0.322
Echinococcus multilocularis multidrug resistance protein 1 0.0054 0.163 0.163
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0466 0.1774
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0024 0.0466 0.135
Entamoeba histolytica P-glycoprotein 6, putative 0.0024 0.0466 0.0378
Plasmodium vivax multidrug resistance protein 2, putative 0.0024 0.0466 0.0448
Toxoplasma gondii ABC transporter, putative 0.0024 0.0466 0.1774
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0466 0.0378
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.2542 0.2528
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.1034 0.131
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0991 0.0907
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.2542 0.2528
Schistosoma mansoni inositol monophosphatase 0.0037 0.0991 0.0991
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1341 0.1341
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.2542 0.2528
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0092 0.0074
Echinococcus granulosus multidrug resistance protein 1 0.0077 0.2542 0.2542
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.2542 0.2528
Echinococcus granulosus multidrug resistance associated protein 7 0.0024 0.0466 0.0466
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0837 0.1375
Loa Loa (eye worm) ABC transporter 0.0024 0.0466 0.0591
Brugia malayi ABC transporter transmembrane region family protein 0.0024 0.0466 0.0591
Loa Loa (eye worm) ABC transporter 0.0024 0.0466 0.0591
Mycobacterium tuberculosis Probable reductase 0.0083 0.2795 0.8837
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.2542 0.2542
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0466 0.1774
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.316 1
Plasmodium falciparum multidrug resistance-associated protein 1 0.0024 0.0466 0.0448
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0168 0.6122 0.6115
Brugia malayi ABC transporter transmembrane region family protein 0.0023 0.0433 0.0549
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0092 0.1641
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1341 0.1341
Plasmodium falciparum ABC transporter B family member 6, putative 0.0024 0.0466 0.0448
Leishmania major ABC-thiol transporter 0.0024 0.0466 0.0448
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0092 0.0074
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0092 0.0074
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0077 0.2542 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0024 0.0466 0.0466
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.2542 0.2528
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0466 0.1155
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0019 0.0019
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0019 0.0024
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0079 0.2633 0.8323
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0956 0.0939
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1341 0.1341
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.0023 0.0433 0.9264
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0032 0.0781 0.2429
Echinococcus granulosus ATP binding cassette sub family B 0.0024 0.0466 0.0466
Loa Loa (eye worm) Smad1 0.0015 0.0092 0.0116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1341 0.1341
Trypanosoma cruzi agmatinase, putative 0.0097 0.3334 1
Entamoeba histolytica multidrug resistance protein, putative 0.0024 0.0466 0.0378
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0092 0.0222
Treponema pallidum quinoline 2-oxidoreductase 0.0027 0.0569 0.9567
Trichomonas vaginalis abcb9, putative 0.0077 0.2542 0.2528
Echinococcus granulosus multidrug resistance protein 1 0.0054 0.163 0.163
Echinococcus multilocularis geminin 0.0142 0.5087 0.5087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1341 0.1341
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0092 0.0092
Brugia malayi multidrug resistance protein 3 0.0077 0.2542 0.322
Loa Loa (eye worm) hypothetical protein 0.0076 0.2509 0.3178
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0466 0.1774
Leishmania major trypanothione reductase 0.0037 0.0956 0.0939
Loa Loa (eye worm) hypothetical protein 0.0024 0.0466 0.0591
Plasmodium vivax multidrug resistance protein 1, putative 0.0077 0.2542 0.2528
Plasmodium vivax basic transcription factor 3b, putative 0.0029 0.067 0.0652
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0024 0.0466 0.1155
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0077 0.2542 0.2528
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.067 0.0652
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0024 0.0466 0.135
Leishmania major pentamidine resistance protein 1 0.0024 0.0466 0.0448
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1341 0.1699
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0023 0.0433 0.0433
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0991 0.0974
Brugia malayi Thioredoxin reductase 0.0037 0.0956 0.1211
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0781 0.1969
Leishmania major p-glycoprotein e 0.0024 0.0466 0.0448
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.2795 0.8837
Toxoplasma gondii NAC domain-containing protein 0.0029 0.067 0.2581
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0466 0.1774
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0024 0.0466 0.0448
Trichomonas vaginalis ABC transporter, putative 0.0077 0.2542 0.2528
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0023 0.0433 0.0415
Plasmodium vivax ABC transporter B family member 5, putative 0.0024 0.0466 0.0448
Loa Loa (eye worm) hypothetical protein 0.0024 0.0466 0.0591
Plasmodium vivax glutathione reductase, putative 0.0037 0.0956 0.0939
Toxoplasma gondii ABC transporter family protein 0.0024 0.0466 0.1774
Entamoeba histolytica ABC transporter, putative 0.0024 0.0466 0.0378
Entamoeba histolytica P-glycoprotein-2, putative 0.0023 0.0433 0.0344
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0057 0.175 0.5511
Plasmodium falciparum glutathione reductase 0.0037 0.0956 0.0939
Toxoplasma gondii exonuclease III APE 0.0015 0.0092 0.0291
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0956 0.0956
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0054 0.163 0.1614
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1341 0.1341
Leishmania major basic transcription factor 3a, putative 0.0029 0.067 0.0652
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0024 0.0466 0.0448
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0024 0.0466 0.0448
Echinococcus multilocularis 0.0267 1 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.2542 0.2542
Plasmodium falciparum multidrug resistance protein 2 0.0024 0.0466 0.0448
Entamoeba histolytica hypothetical protein 0.0024 0.0466 0.0378
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0077 0.2542 0.2542
Trypanosoma brucei p-glycoprotein 0.0024 0.0466 0.135
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0024 0.0466 0.135
Schistosoma mansoni multidrug resistance protein 0.0077 0.2542 0.2542
Plasmodium vivax ABC transporter B family member 4, putative 0.0024 0.0466 0.0448
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0092 0.0222
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.2542 0.2528
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0991 0.0974
Entamoeba histolytica P-glycoprotein-1 0.0077 0.2542 0.2472
Plasmodium falciparum ABC transporter B family member 5, putative 0.0024 0.0466 0.0448
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.2542 0.2528
Echinococcus multilocularis arginase 2, mitochondrial 0.0267 1 1
Giardia lamblia Hypothetical protein 0.0023 0.0433 0.9264
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.316 1
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0024 0.0466 0.4605
Schistosoma mansoni multidrug resistance protein 0.0024 0.0466 0.0466
Loa Loa (eye worm) ICD-1 protein 0.0029 0.067 0.0848
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0024 0.0466 0.1425
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0092 0.0117
Leishmania major arginase 0.0267 1 1
Brugia malayi Smad1 0.0015 0.0092 0.0116
Schistosoma mansoni inositol monophosphatase 0.0037 0.0991 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.0267 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.2542 0.2528
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0077 0.2542 1
Plasmodium falciparum ABC transporter B family member 3, putative 0.0024 0.0466 0.0448
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0991 0.2932
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.2542 0.2528
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0024 0.0466 0.1155
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0991 1
Loa Loa (eye worm) glutathione reductase 0.0037 0.0956 0.1211
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0466 0.0378
Echinococcus granulosus transcription factor btf3 0.0029 0.067 0.067
Brugia malayi beta-NAC-like protein 0.0029 0.067 0.0848
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0092 0.019
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.2542 0.2542
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0466 0.0448
Schistosoma mansoni smdr2 0.0077 0.2542 0.2542
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.2795 0.8644
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0079 0.2633 0.6748
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.067 0.0652
Loa Loa (eye worm) hypothetical protein 0.0039 0.1034 0.131
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0781 0.1969
Loa Loa (eye worm) hypothetical protein 0.0024 0.0466 0.0591
Echinococcus granulosus TGF beta signal transducer SmadC 0.0015 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0556 0.0704
Entamoeba histolytica ATP-binding cassette protein, putative 0.0024 0.0466 0.0378
Brugia malayi ABC transporter 0.0023 0.0433 0.0549
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0991 0.2932
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0956 0.2829
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0024 0.0466 0.1425
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0079 0.2633 0.6748
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0077 0.2542 0.2542
Plasmodium falciparum ABC transporter B family member 7, putative 0.0024 0.0466 0.0448
Plasmodium falciparum multidrug resistance-associated protein 2 0.0024 0.0466 0.0448
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.2795 0.8837
Trypanosoma brucei trypanothione reductase 0.0037 0.0956 0.2829
Schistosoma mansoni smad1 5 8 and 0.0015 0.0092 0.0092

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.