Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0018 | 0.1047 | 0.2437 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0017 | 0.1029 | 0.2393 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.4299 | 0.4299 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4299 | 0.5 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0017 | 0.1029 | 0.1029 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.1047 | 1 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0017 | 0.1029 | 0.2393 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.1029 | 0.2393 |
Echinococcus multilocularis | Ankyrin | 0.0018 | 0.1047 | 0.1047 |
Echinococcus granulosus | Ankyrin | 0.0018 | 0.1047 | 0.1047 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0017 | 0.1029 | 0.1029 |
Brugia malayi | Death domain containing protein | 0.0017 | 0.1029 | 0.2393 |
Brugia malayi | hypothetical protein | 0.0043 | 0.4299 | 1 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0017 | 0.1029 | 0.1029 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4299 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.4299 | 1 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0017 | 0.1029 | 0.1029 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4299 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.4299 | 0.4299 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.4299 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 1 | 1 |
Brugia malayi | Uncoordinated protein 44 | 0.0017 | 0.1029 | 0.2393 |
Schistosoma mansoni | netrin receptor unc5 | 0.0017 | 0.1029 | 0.2393 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0017 | 0.1029 | 0.9823 |
Onchocerca volvulus | Netrin receptor homolog | 0.0017 | 0.1029 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4299 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.1029 | 0.9823 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.1029 | 0.2393 |
Echinococcus granulosus | death domain containing protein | 0.0017 | 0.1029 | 0.1029 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug metabolism (ADMET) | < 5 % | Drug level in human liver microsomes treated with Rp,Sp-dinulceotide-2 at 10 uM incubated up to 8 hrs by LC/MS analysis | ChEMBL. | 22328581 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.