Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3198 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0395 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0395 | 0.3198 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0209 | 0.0342 | 0.0342 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0395 | 0.3198 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0395 | 0.3198 | 0.3198 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0395 | 0.3198 | 0.3198 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0395 | 0.3198 | 0.3198 |
Echinococcus granulosus | expressed protein | 0.0454 | 0.4098 | 0.4098 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3198 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0395 | 0.3198 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0395 | 0.3198 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0395 | 0.3198 | 0.3198 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0209 | 0.0342 | 0.0342 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0395 | 0.3198 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0395 | 0.3198 | 0.3198 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0395 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3198 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0395 | 0.3198 | 0.3198 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0395 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0395 | 0.3198 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0395 | 0.3198 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0395 | 0.3198 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0395 | 0.3198 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0395 | 0.3198 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0209 | 0.0342 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0209 | 0.0342 | 0.1071 |
Echinococcus granulosus | FTZ F1 alpha | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | steroid hormone receptor | 0.0395 | 0.3198 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0395 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0342 | 0.1071 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0395 | 0.3198 | 0.3198 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0395 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0395 | 0.3198 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0395 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3198 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0395 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0395 | 0.3198 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0395 | 0.3198 | 1 |
Onchocerca volvulus | 0.0395 | 0.3198 | 1 | |
Brugia malayi | nuclear hormone receptor | 0.0395 | 0.3198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3198 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0395 | 0.3198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0342 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0342 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0395 | 0.3198 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0395 | 0.3198 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0395 | 0.3198 | 0.3198 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0839 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0395 | 0.3198 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0395 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0395 | 0.3198 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0395 | 0.3198 | 1 |
Brugia malayi | hypothetical protein | 0.0209 | 0.0342 | 0.1071 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0395 | 0.3198 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0395 | 0.3198 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0395 | 0.3198 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0839 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0209 | 0.0342 | 0.0342 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0209 | 0.0342 | 0.1071 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0395 | 0.3198 | 0.3198 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0395 | 0.3198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3198 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | hypothetical protein | 0.0209 | 0.0342 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0395 | 0.3198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 0.3198 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0395 | 0.3198 | 0.3198 |
Schistosoma mansoni | thyroid hormone receptor | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0395 | 0.3198 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | ecdysteroid receptor | 0.0395 | 0.3198 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0395 | 0.3198 | 0.3198 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0395 | 0.3198 | 0.3198 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0342 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.0342 | 0.1071 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0395 | 0.3198 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0395 | 0.3198 | 0.3198 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0209 | 0.0342 | 0.0342 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0395 | 0.3198 | 1 |
Echinococcus multilocularis | expressed protein | 0.0454 | 0.4098 | 0.4098 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0395 | 0.3198 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0395 | 0.3198 | 0.3198 |
Brugia malayi | nuclear receptor RXR | 0.0209 | 0.0342 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
PPB (ADMET) | Covalent binding affinity to human CYP2D6 with P450 reductase assessed per nmol of enzyme after 10 mins by SDS-PAGE with Western blotting and autoradiography analysis in presence of NADPH | ChEMBL. | 21422192 | |
PPB (ADMET) | Covalent binding affinity to human CYP2D6 with P450 reductase assessed per nmol of enzyme after 10 mins by SDS-PAGE with Western blotting and autoradiography analysis in absence of NADPH | ChEMBL. | 21422192 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.