Detailed information for compound 2075511

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 518.451 | Formula: C20H28F6N4O5
  • H donors: 2 H acceptors: 5 LogP: -2.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: O1CCC(CC1)N1CCn2c(C1)nc(c2)CN1CCCC1.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F
  • InChi: 1S/C16H26N4O.2C2HF3O2/c1-2-6-18(5-1)11-14-12-20-8-7-19(13-16(20)17-14)15-3-9-21-10-4-15;2*3-2(4,5)1(6)7/h12,15H,1-11,13H2;2*(H,6,7)
  • InChiKey: YXYKDPBKVVVWRV-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0045 0.0134
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0045 0.2253
Schistosoma mansoni cpg binding protein 0.0035 0.0201 0.0594
Brugia malayi ecdysteroid receptor 0.0012 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Brugia malayi ImpB/MucB/SamB family protein 0.0031 0.0175 0.2806
Trypanosoma brucei unspecified product 0.0031 0.0175 0.511
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Schistosoma mansoni DNA helicase recq1 0.0024 0.0127 0.0374
Schistosoma mansoni hypothetical protein 0.0136 0.0903 0.2662
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0052 0.0846
Echinococcus multilocularis cpg binding protein 0.0037 0.0215 0.0635
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0045 0.0134
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0001 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0052 0.0846
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0052 0.0025
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0127 0.5555
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0045 0.0625
Brugia malayi Animal haem peroxidase family protein 0.0018 0.0082 0.1321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0045 0.0727
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0027 0.0098
Brugia malayi MH2 domain containing protein 0.0096 0.0624 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Mycobacterium tuberculosis Probable reductase 0.0086 0.056 0.0714
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0052 0.0185
Echinococcus multilocularis geminin 0.0136 0.0903 0.2662
Brugia malayi Smad1 0.0007 0.0006 0.0094
Trichomonas vaginalis pc-MYB2, putative 0.0034 0.0195 0.9938
Trypanosoma brucei DNA polymerase IV, putative 0.0031 0.0175 0.511
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0045 0.0134
Plasmodium vivax glutathione reductase, putative 0.0038 0.0224 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0052 0.0846
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0006 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Echinococcus granulosus dnaJ subfamily B 0.0494 0.339 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0627 0.0808
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0727
Echinococcus granulosus dna polymerase kappa 0.0031 0.0175 0.0517
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0727
Trypanosoma brucei DNA polymerase IV, putative 0.0031 0.0175 0.511
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0034 0.0195 1
Loa Loa (eye worm) blistered cuticle protein 3 0.0018 0.0082 0.1321
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Echinococcus multilocularis peroxidasin 0.0018 0.0082 0.0243
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0007 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0726
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0052 0.0846
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0727
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.281
Brugia malayi hypothetical protein 0.0006 0.0001 0.001
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0127 0.0374
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0005 0.0016
Loa Loa (eye worm) Smad1 0.0007 0.0006 0.0094
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0034 0.0195 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0042 0.0124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0015 0.0000000037959
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0034 0.0195 1
Brugia malayi Animal haem peroxidase family protein 0.0018 0.0082 0.1321
Schistosoma mansoni nuclear hormone receptor 0.0006 0.0001 0.0002
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0127 0.3439
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0127 0.2031
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0052 0.0846
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0408 0.2791 0.3375
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0045 0.0134
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0001 0.0031
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0224 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0045 0.0727
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1446 1 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0007 0.0006 0.0017
Loa Loa (eye worm) MH2 domain-containing protein 0.0096 0.0624 1
Onchocerca volvulus 0.0018 0.0082 0.4093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0006 0.0001 0.0002
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0006 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0726
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0127 0.5074
Plasmodium falciparum thioredoxin reductase 0.0013 0.0052 0.1248
Echinococcus multilocularis dna polymerase eta 0.0051 0.0317 0.0935
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0127 0.0454
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0087
Trichomonas vaginalis MYB, putative 0.0034 0.0196 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0052 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0045 0.0727
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0045 0.0134
Loa Loa (eye worm) nuclear hormone receptor 0.0006 0.0001 0.001
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0052 0.2644
Trichomonas vaginalis MYB72, putative 0.0034 0.0195 0.9938
Onchocerca volvulus 0.0006 0.0001 0.0031
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.0317 1
Toxoplasma gondii thioredoxin reductase 0.0038 0.0224 0.0801
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0034 0.0195 0.9938
Brugia malayi Animal haem peroxidase family protein 0.0018 0.0082 0.1321
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0169 0.0605
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0224 0.0659
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.002 0.006
Echinococcus multilocularis Smad4 0.0007 0.0006 0.0017
Mycobacterium tuberculosis Conserved hypothetical protein 0.0031 0.0175 0.0173
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0045 0.0134
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1038 0.717 1
Schistosoma mansoni hypothetical protein 0.0494 0.339 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0052 0.1248
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0052 0.2024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0015 0.0000000037959
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0045 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0045 0.0727
Trichomonas vaginalis C-MYB, putative 0.0034 0.0195 0.9938
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Echinococcus multilocularis smad 0.0007 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0045 0.0134
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0052 0.2024
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0006 0.0001 0.0002
Trypanosoma brucei unspecified product 0.0021 0.0109 0.281
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0045 0.0134
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0006 0.0094
Onchocerca volvulus 0.0035 0.0201 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0045 0.2253
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0471 0.1391
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Brugia malayi nuclear hormone receptor family member nhr-6 0.0006 0.0001 0.001
Loa Loa (eye worm) glutathione reductase 0.0038 0.0224 0.358
Brugia malayi MH2 domain containing protein 0.0007 0.0006 0.0094
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0087
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0031 0.0175 0.2806
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0034 0.0195 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0006 0.0001 0.001
Schistosoma mansoni hypothetical protein 0.0136 0.0903 0.2662
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0034 0.0195 0.9938
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Brugia malayi nuclear receptor RXR 0.0006 0.0001 0.001
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0052 0.0185
Plasmodium falciparum glutathione reductase 0.0013 0.0052 0.1248
Schistosoma mansoni cpg binding protein 0.0037 0.0215 0.0635
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0417 0.1494
Brugia malayi nuclear receptor NHR-67 0.0006 0.0001 0.001
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0034 0.0195 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0006 0.0001 0.0002
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.056 0.0714
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0006 0.0001 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0045 0.0134
Brugia malayi MH1 domain containing protein 0.0007 0.0006 0.0094
Plasmodium falciparum glutathione reductase 0.0038 0.0224 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0045 0.0727
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0127 0.0374
Echinococcus granulosus nuclear receptor nhr 48 0.0006 0.0001 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0052 0.0846
Onchocerca volvulus Dual oxidase homolog 0.0018 0.0082 0.4093
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0127 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.281
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0127 0.3439
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0045 0.0727
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0031 0.0175 0.0173
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0034 0.0195 0.9938
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0045 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0045 0.0727
Trypanosoma brucei trypanothione reductase 0.0038 0.0224 0.6778
Schistosoma mansoni peroxidasin 0.0018 0.0082 0.0243
Mycobacterium ulcerans DNA polymerase IV 0.0031 0.0175 0.0148
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0052 0.0153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0045 0.0134
Echinococcus granulosus dna polymerase eta 0.0051 0.0317 0.0935
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0052 0.0846
Brugia malayi nuclear hormone receptor family member odr-7 0.0006 0.0001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0045 0.0727
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0045 0.0134
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0127 0.2031
Brugia malayi hypothetical protein 0.0006 0.0005 0.0087
Brugia malayi Animal haem peroxidase family protein 0.0018 0.0082 0.1321
Schistosoma mansoni DNA helicase recq5 0.0024 0.0127 0.0374
Leishmania major DNA polymerase kappa, putative 0.0031 0.0175 0.511
Brugia malayi ecdysone receptor 0.0006 0.0001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0052 0.0846
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0052 0.0846
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0408 0.2791 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0408 0.2791 0.2771
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Echinococcus granulosus Smad4 0.0007 0.0006 0.0017
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.056 0.0714
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Echinococcus granulosus TGF beta signal transducer SmadC 0.0007 0.0006 0.0017
Plasmodium falciparum thioredoxin reductase 0.0038 0.0224 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0045 0.0727
Echinococcus granulosus peroxidasin 0.0018 0.0082 0.0243
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0015 0.0000000037959
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0045 0.0134
Brugia malayi hypothetical protein 0.0018 0.0082 0.1321
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0028 0.0441
Trichomonas vaginalis pc-MYB2, putative 0.0034 0.0195 0.9938
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0127 0.6481
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0127 0.0374
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0727
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0127 0.3439
Trichomonas vaginalis MYB3r3, putative 0.0034 0.0195 0.9938
Echinococcus multilocularis mothers against decapentaplegic 5 0.0007 0.0006 0.0017
Loa Loa (eye worm) DR-78 0.0006 0.0001 0.001
Brugia malayi nuclear receptor NHR-88 0.0006 0.0001 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0127 0.0374
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0052 0.1248
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0001 0.0002
Schistosoma mansoni nuclear receptor 0.0006 0.0001 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0045 0.0727
Treponema pallidum NADH oxidase 0.0013 0.0052 0.0006
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0001 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0045 0.0134
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0127 0.5074
Trichomonas vaginalis DNA polymerase eta, putative 0.0031 0.0175 0.8864
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0045 0.0134
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0052 0.0846
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0127 0.2031
Onchocerca volvulus Peroxidasin homolog 0.0018 0.0082 0.4093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Schistosoma mansoni nuclear receptor 0.0006 0.0001 0.0002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0006 0.0001 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0015 0.0000000037959
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Leishmania major trypanothione reductase 0.0038 0.0224 0.6778
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0045 0.0134
Loa Loa (eye worm) animal heme peroxidase 0.0018 0.0082 0.1321
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0006 0.0094
Schistosoma mansoni peroxidasin 0.0018 0.0082 0.0243
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0052 0.1248
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0052 0.0025
Schistosoma mansoni terminal deoxycytidyl transferase 0.0031 0.0175 0.0517
Loa Loa (eye worm) hypothetical protein 0.0051 0.0317 0.5075
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0052 0.0846
Trypanosoma cruzi DNA polymerase kappa, putative 0.0031 0.0175 0.511
Brugia malayi MH1 domain containing protein 0.0007 0.0006 0.0094
Brugia malayi Peroxidasin 0.0018 0.0082 0.1321
Brugia malayi hypothetical protein 0.0006 0.0001 0.001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0031 0.0175 0.0517
Echinococcus granulosus thyroid hormone receptor alpha 0.0006 0.0001 0.0002
Onchocerca volvulus 0.0018 0.0082 0.4093
Brugia malayi nuclear hormone receptor 0.0012 0.0045 0.0727
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0045 0.0923
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0224 0.0659
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0045 0.0134
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0627 0.0808
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Brugia malayi nuclear receptor NHR-88 0.0012 0.0045 0.0727
Echinococcus granulosus mothers against decapentaplegic 5 0.0007 0.0006 0.0017
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0034 0.0196 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0727
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0127 0.6183
Brugia malayi nuclear hormone receptor 0.0006 0.0001 0.001
Leishmania major DNA polymerase eta, putative 0.0051 0.0317 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0045 0.0727
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.002 0.006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0005 0.0087
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0052 0.0153
Brugia malayi conserved hypotetical protein 0.0006 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0045 0.0727
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0034 0.0548
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0127 0.6183
Brugia malayi steroid hormone receptor 0.0012 0.0045 0.0727
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0224 0.0241
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Brugia malayi MH2 domain containing protein 0.0007 0.0006 0.0094
Onchocerca volvulus 0.0006 0.0001 0.0031
Schistosoma mansoni zinc finger protein 0.0006 0.0001 0.0002
Schistosoma mansoni smad 0.0007 0.0006 0.0017
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0127 0.2031
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0045 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0015 0.0000000037959
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0034 0.0195 0.9938
Echinococcus granulosus bloom syndrome protein 0.0024 0.0127 0.0374
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0052 0.0846
Brugia malayi Thioredoxin reductase 0.0038 0.0224 0.358
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0045 0.0134
Schistosoma mansoni smad1 5 8 and 0.0007 0.0006 0.0017
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0034 0.0195 0.9938
Giardia lamblia DNA damage repair protein 0.001 0.0027 0.1392
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0045 0.0134
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.056 0.0714
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.056 0.0714
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.002 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0015 0.0000000037959
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0436
Loa Loa (eye worm) RecQ helicase 0.0024 0.0127 0.2031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0045 0.0134
Brugia malayi hypothetical protein 0.0006 0.0005 0.0087
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0005 0.0016
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0006 0.0001 0.0002
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0012 0.0042 0.0758
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0045 0.0134
Brugia malayi Blistered cuticle protein 3 0.0018 0.0082 0.1321
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0727
Onchocerca volvulus Peroxidase homolog 0.0018 0.0082 0.4093
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0408 0.2791 0.2753
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0031 0.0175 0.0517
Trypanosoma cruzi DNA polymerase kappa, putative 0.0031 0.0175 0.511
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.001 0.0027 0.0098
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0627 0.0101
Echinococcus multilocularis dna polymerase kappa 0.0031 0.0175 0.0517
Brugia malayi tailless protein 0.0006 0.0001 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0045 0.0727
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0028 0.0441
Onchocerca volvulus Peroxidasin homolog 0.0018 0.0082 0.4093
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0045 0.0727
Giardia lamblia DINP protein human, muc B family 0.0031 0.0175 0.8954
Leishmania major DNA polymerase eta, putative 0.003 0.0169 0.489
Loa Loa (eye worm) animal heme peroxidase 0.0018 0.0082 0.1321
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.339 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0052 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0031 0.0175 0.511
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0015 0.0000000037959
Loa Loa (eye worm) animal heme peroxidase 0.0018 0.0082 0.1321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0045 0.0727
Brugia malayi nuclear receptor RXR 0.0006 0.0005 0.0087
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.002 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0045 0.0727
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0006 0.0001 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0104
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0031 0.0175 0.0517
Loa Loa (eye worm) transcription factor SMAD2 0.0096 0.0624 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1038 0.717 1
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0034 0.0196 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0627 0.0808
Schistosoma mansoni smad1 5 8 and 0.0007 0.0006 0.0017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.1321
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0034 0.0195 0.9938
Trypanosoma cruzi DNA polymerase kappa, putative 0.0031 0.0175 0.511
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0052 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0045 0.0727
Onchocerca volvulus 0.0012 0.0045 0.2253
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0224 0.6778
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0127 0.0454
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0127 0.6183
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0052 0.0153
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0052 0.0846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0045 0.0727
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0045 0.0727
Brugia malayi glutathione reductase 0.0038 0.0224 0.358
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0104
Schistosoma mansoni smad1 5 8 and 0.0007 0.0006 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0045 0.0134
Onchocerca volvulus Peroxidase homolog 0.0018 0.0082 0.4093
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0052 0.0846
Brugia malayi CXXC zinc finger family protein 0.0035 0.0201 0.3227
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.281
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.056 0.0714
Giardia lamblia Myb 1-like protein 0.0034 0.0196 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0045 0.0625
Schistosoma mansoni Smad4 0.0007 0.0006 0.0017
Brugia malayi Animal haem peroxidase family protein 0.0018 0.0082 0.1321
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0045 0.0727
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0001 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0045 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0045 0.0727
Mycobacterium ulcerans DNA polymerase IV 0.0031 0.0175 0.0148
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0052 0.0829
Trichomonas vaginalis C-MYB, putative 0.0034 0.0195 0.9938
Echinococcus granulosus smad 0.0007 0.0006 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0045 0.0134
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1446 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0015 0.0000000037959
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0045 0.2253
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.0317 0.5075
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0052 0.0846
Entamoeba histolytica deoxycytidyl transferase, putative 0.0031 0.0175 0.8728
Onchocerca volvulus 0.0018 0.0082 0.4093
Echinococcus granulosus Nuclear hormone receptor HR96 0.0006 0.0001 0.0002
Schistosoma mansoni nuclear receptor nhr-48 0.0006 0.0001 0.0002
Echinococcus granulosus geminin 0.0136 0.0903 0.2662
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0035 0.0563
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0045 0.0727
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0052 0.1248
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0317 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0042 0.0151
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0045 0.0134
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0045 0.0134
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0031 0.0175 0.511
Brugia malayi orphan nuclear receptor NR2E1 0.0006 0.0001 0.001
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1446 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0006 0.0001 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Brugia malayi polk-prov protein 0.001 0.0027 0.0436
Loa Loa (eye worm) nuclear receptor NHR-67 0.0006 0.0001 0.001
Echinococcus granulosus cpg binding protein 0.0037 0.0215 0.0635
Loa Loa (eye worm) animal heme peroxidase 0.0018 0.0082 0.1321
Schistosoma mansoni cpg binding protein 0.0037 0.0215 0.0635
Schistosoma mansoni DNA polymerase IV / kappa 0.001 0.0027 0.008
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0031 0.0175 0.8864
Trypanosoma cruzi DNA polymerase kappa, putative 0.0031 0.0175 0.511
Onchocerca volvulus Chorion peroxidase homolog 0.0018 0.0082 0.4093
Schistosoma mansoni DNA polymerase eta 0.0051 0.0317 0.0935
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0175 0.511
Loa Loa (eye worm) hypothetical protein 0.0006 0.0001 0.001
Schistosoma mansoni coup transcription factor 0.0012 0.0045 0.0134
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0169 0.489
Loa Loa (eye worm) hypothetical protein 0.0024 0.0127 0.2031
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0201 0.3227
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0006 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0727
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0016
Brugia malayi Nuclear hormone receptor E75 0.0006 0.0001 0.001
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0224 0.358
Trypanosoma brucei unspecified product 0.0021 0.0109 0.281
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0034 0.0196 0.0701

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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