Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | thioredoxin reductase, putative | 0.004 | 0.0142 | 0.5 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0036 | 0.0113 | 0.9455 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0033 | 0.0094 | 0.3199 |
Trichomonas vaginalis | pc-MYB2, putative | 0.0036 | 0.0113 | 0.9455 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0033 | 0.0094 | 0.1712 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0055 | 0.0236 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0103 | 0.0549 | 0.0646 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0236 | 0.4325 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0019 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.043 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0036 | 0.0113 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.004 | 0.0142 | 0.3694 |
Brugia malayi | Thioredoxin reductase | 0.004 | 0.0142 | 0.2603 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0033 | 0.0094 | 0.1712 |
Mycobacterium leprae | PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA | 0.111 | 0.7146 | 1 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0036 | 0.0113 | 0.9455 |
Brugia malayi | glutathione reductase | 0.004 | 0.0142 | 0.2603 |
Onchocerca volvulus | Peroxidase homolog | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | pc-MYB2, putative | 0.0036 | 0.0113 | 0.9455 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0103 | 0.0549 | 0.0646 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0092 | 0.0482 | 0.055 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Trichomonas vaginalis | C-MYB, putative | 0.0036 | 0.0113 | 0.9455 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0036 | 0.0113 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.004 | 0.0142 | 0.5 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0036 | 0.0113 | 1 |
Trichomonas vaginalis | C-MYB, putative | 0.0036 | 0.0113 | 0.9455 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus multilocularis | dna polymerase eta | 0.0055 | 0.0236 | 0.2858 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Loa Loa (eye worm) | thioredoxin reductase | 0.004 | 0.0142 | 0.2603 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0036 | 0.0113 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0827 | 1 |
Giardia lamblia | Myb 1-like protein | 0.0036 | 0.0114 | 1 |
Entamoeba histolytica | myb-like DNA-binding domain containing protein | 0.0036 | 0.0113 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.004 | 0.0142 | 0.0069 |
Brugia malayi | MH2 domain containing protein | 0.0102 | 0.0546 | 1 |
Echinococcus granulosus | geminin | 0.0145 | 0.0827 | 1 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0036 | 0.0113 | 0.9455 |
Mycobacterium ulcerans | 3-phosphoshikimate 1-carboxyvinyltransferase | 0.0436 | 0.2731 | 0.2662 |
Trichomonas vaginalis | MYB3r3, putative | 0.0036 | 0.0113 | 0.9455 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0033 | 0.0094 | 0.1131 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0102 | 0.0546 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA | 0.111 | 0.7146 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0033 | 0.0094 | 0.1131 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0033 | 0.0094 | 0.1131 |
Leishmania major | DNA polymerase eta, putative | 0.0055 | 0.0236 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0092 | 0.0482 | 0.055 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0033 | 0.0094 | 0.3199 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.004 | 0.0142 | 0.172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0036 | 0.0114 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0092 | 0.0482 | 0.055 |
Toxoplasma gondii | shikimate dehydrogenase substrate binding domain-containing protein | 0.0436 | 0.2731 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Toxoplasma gondii | thioredoxin reductase | 0.004 | 0.0142 | 0.0208 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0055 | 0.0236 | 1 |
Wolbachia endosymbiont of Brugia malayi | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1545 | 1 | 0.5 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0036 | 0.0113 | 0.9455 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Onchocerca volvulus | Dual oxidase homolog | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0055 | 0.0236 | 0.2858 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.043 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0033 | 0.0094 | 0.3199 |
Toxoplasma gondii | Myb family DNA-binding domain-containing protein | 0.0036 | 0.0114 | 0.0102 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0019 | 0 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0055 | 0.0236 | 0.4325 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0092 | 0.0482 | 0.055 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0033 | 0.0094 | 0.1131 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0036 | 0.0113 | 0.9455 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.043 |
Onchocerca volvulus | Peroxidasin homolog | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0102 | 0.0546 | 1 |
Trichomonas vaginalis | MYB72, putative | 0.0036 | 0.0113 | 0.9455 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0103 | 0.0549 | 0.0646 |
Plasmodium vivax | glutathione reductase, putative | 0.004 | 0.0142 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0055 | 0.0236 | 0.2858 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0092 | 0.0482 | 0.055 |
Onchocerca volvulus | Peroxidasin homolog | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0827 | 1 |
Leishmania major | trypanothione reductase | 0.004 | 0.0142 | 0.3694 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0036 | 0.0114 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0033 | 0.0094 | 0.1131 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0103 | 0.0549 | 0.0101 |
Echinococcus multilocularis | geminin | 0.0145 | 0.0827 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0033 | 0.0094 | 0.1131 |
Leishmania major | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.043 |
Loa Loa (eye worm) | glutathione reductase | 0.004 | 0.0142 | 0.2603 |
Plasmodium falciparum | glutathione reductase | 0.004 | 0.0142 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0092 | 0.0482 | 0.055 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.0036 | 0.0113 | 0.9455 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.004 | 0.0142 | 0.172 |
Trypanosoma brucei | trypanothione reductase | 0.004 | 0.0142 | 0.5518 |
Mycobacterium ulcerans | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1545 | 1 | 1 |
Mycobacterium leprae | probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS | 0.0436 | 0.2731 | 0.3375 |
Trypanosoma brucei | unspecified product | 0.0033 | 0.0094 | 0.3199 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0033 | 0.0094 | 0.3199 |
Treponema pallidum | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | 0.1545 | 1 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0033 | 0.0094 | 0.043 |
Trichomonas vaginalis | MYB, putative | 0.0036 | 0.0114 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.