TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 466.454 | Formula: C22H25F3N4O4
H donors: 1 H acceptors: 5 LogP: 2.71 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.O=C(N1CCn2c(C1C)ncc2COc1cccnc1)C1=CCCCC1
InChi: 1S/C20H24N4O2.C2HF3O2/c1-15-19-22-12-17(14-26-18-8-5-9-21-13-18)24(19)11-10-23(15)20(25)16-6-3-2-4-7-16;3-2(4,5)1(6)7/h5-6,8-9,12-13,15H,2-4,7,10-11,14H2,1H3;(H,6,7)
InChiKey: AJERLXSZKGSNAU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0525	1
Onchocerca volvulus	Peroxidase homolog	0.0551	0.6529	1
Schistosoma mansoni	notch	0.0071	0.0643	0.0643
Giardia lamblia	High cysteine protein	0.0071	0.0643	1
Leishmania major	hypothetical protein, conserved	0.003	0.0144	0.2676
Onchocerca volvulus		0.0551	0.6529	1
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0026	0.0085	1
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0525	0.0525
Echinococcus granulosus	L aminoadipate semialdehyde	0.0091	0.0889	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0124	0.019
Loa Loa (eye worm)	animal heme peroxidase	0.0551	0.6529	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0071	0.0643	0.0643
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0525	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0026	0.0085	0.1259
Brugia malayi	GCC2 and GCC3 family protein	0.0071	0.0643	0.0985
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0525	1
Entamoeba histolytica	hypothetical protein	0.0083	0.0788	1
Schistosoma mansoni	ap endonuclease	0.0023	0.0049	0.0049
Schistosoma mansoni	slit	0.0071	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0026	0.0085	0.5199
Brugia malayi	EGF-like domain containing protein	0.0071	0.0643	0.0985
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0091	0.0889	0.0889
Loa Loa (eye worm)	hypothetical protein	0.002	0.0018	0.0027
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0085	0.5773
Toxoplasma gondii	EGF family domain-containing protein	0.0071	0.0643	1
Schistosoma mansoni	microtubule-associated protein tau	0.0833	1	1
Brugia malayi	hypothetical protein	0.003	0.0144	0.022
Brugia malayi	EGF-like domain containing protein	0.0071	0.0643	0.0985
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0525	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0049	0.0856
Schistosoma mansoni	notch	0.0071	0.0643	0.0643
Brugia malayi	Blistered cuticle protein 3	0.0551	0.6529	1
Brugia malayi	hypothetical protein	0.0551	0.6529	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0028	0.0118	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0525	0.8153
Echinococcus granulosus	protein jagged 2	0.0071	0.0643	0.0643
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0071	0.0643	0.0643
Onchocerca volvulus		0.0166	0.1804	0.212
Brugia malayi	Peroxidasin	0.0551	0.6529	1
Echinococcus multilocularis	protein jagged 2	0.0071	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Loa Loa (eye worm)	CYP4Cod1	0.0028	0.0118	0.018
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0026	0.0085	0.5
Brugia malayi	hypothetical protein	0.002	0.0011	0.0017
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0026	0.0085	1
Brugia malayi	MAP kinase sur-1	0.0062	0.0525	0.0805
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0085	0.5773
Echinococcus granulosus	protein jagged 1	0.0071	0.0643	0.0643
Loa Loa (eye worm)	intermediate filament protein	0.0062	0.0533	0.0816
Brugia malayi	Calcium binding EGF domain containing protein	0.0071	0.0643	0.0985
Schistosoma mansoni	hypothetical protein	0.0083	0.0788	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Echinococcus granulosus	slit 2 protein	0.0071	0.0643	0.0643
Onchocerca volvulus		0.0071	0.0643	0.0185
Brugia malayi	EGF-like domain containing protein	0.0071	0.0643	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Brugia malayi	intermediate filament protein	0.0062	0.0533	0.0816
Echinococcus granulosus	protein jagged 2	0.0071	0.0643	0.0643
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0525	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0049	0.0075
Brugia malayi	Muscle positioning protein 4	0.0071	0.0643	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Echinococcus granulosus	geminin	0.0205	0.2282	0.2282
Brugia malayi	hypothetical protein	0.0083	0.0788	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Brugia malayi	Animal haem peroxidase family protein	0.0551	0.6529	1
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0026	0.0085	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0049	0.0049
Onchocerca volvulus		0.0091	0.0889	0.0594
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0525	1
Echinococcus granulosus	delta-like protein 1	0.0071	0.0643	0.0643
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0525	0.0525
Echinococcus multilocularis	neurogenic locus notch protein	0.0071	0.0643	0.0643
Entamoeba histolytica	hypothetical protein	0.0083	0.0788	1
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0144	1
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Mycobacterium leprae	conserved hypothetical protein	0.0026	0.0085	0.5
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0049	0.3197
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.0004	0.0004
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0049	0.0856
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0071	0.0643	0.0643
Echinococcus granulosus	peroxidasin	0.0551	0.6529	0.6529
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0004	0.0004
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0049	0.0049
Schistosoma mansoni	cell polarity protein	0.0071	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.003	0.0144	0.022
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Onchocerca volvulus	Chorion peroxidase homolog	0.0551	0.6529	1
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0144	0.2676
Loa Loa (eye worm)	transcription factor SMAD2	0.0275	0.3147	0.4819
Onchocerca volvulus		0.0071	0.0643	0.0185
Schistosoma mansoni	notch	0.0071	0.0643	0.0643
Brugia malayi	Intermediate filament tail domain containing protein	0.0062	0.0533	0.0816
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.0004	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Schistosoma mansoni	transcription factor LCR-F1	0.0083	0.0788	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0525	0.0525
Echinococcus multilocularis	neural cadherin	0.0071	0.0643	0.0643
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0118	0.018
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.0004	0.0006
Entamoeba histolytica	hypothetical protein	0.0083	0.0788	1
Echinococcus granulosus	neurogenic locus notch protein	0.0071	0.0643	0.0643
Onchocerca volvulus	Putative cubilin	0.0071	0.0643	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Onchocerca volvulus	Neurogenic locus notch homolog	0.0071	0.0643	0.0185
Brugia malayi	Animal haem peroxidase family protein	0.0551	0.6529	1
Schistosoma mansoni	notch	0.0071	0.0643	0.0643
Brugia malayi	hypothetical protein	0.0166	0.1804	0.2763
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.0004	0.0004
Brugia malayi	notch-like transmembrane receptor	0.0071	0.0643	0.0985
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.0004	0.0004
Leishmania major	cytochrome p450-like protein	0.0028	0.0118	0.2181
Schistosoma mansoni	intermediate filament proteins	0.0062	0.0533	0.0533
Echinococcus granulosus	neurogenic locus notch protein 4	0.0071	0.0643	0.0643
Loa Loa (eye worm)	animal heme peroxidase	0.0551	0.6529	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0525	0.0525
Onchocerca volvulus		0.0551	0.6529	1
Echinococcus granulosus	notch	0.0071	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Schistosoma mansoni	hypothetical protein	0.0071	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0525	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0049	0.0856
Brugia malayi	MH2 domain containing protein	0.0275	0.3147	0.4819
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0062	0.0533	0.0816
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0071	0.0643	0.0185
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0091	0.0889	0.1362
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0118	0.018
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0033	0.0179	0.0273
Schistosoma mansoni	peroxidasin	0.0551	0.6529	0.6529
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Schistosoma mansoni	hypothetical protein	0.0071	0.0643	0.0643
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0144	0.2181
Loa Loa (eye worm)	hypothetical protein	0.003	0.0138	0.0211
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0144	0.2676
Brugia malayi	EGF-like domain containing protein	0.0071	0.0643	0.0985
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0144	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0144	1
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0118	0.018
Schistosoma mansoni	laminin gamma-3 chain	0.0071	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Onchocerca volvulus		0.0071	0.0643	0.0185
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0071	0.0643	0.0643
Echinococcus multilocularis	microtubule associated protein 2	0.0833	1	1
Echinococcus granulosus	lamin dm0	0.0062	0.0533	0.0533
Echinococcus multilocularis	peroxidasin	0.0551	0.6529	0.6529
Brugia malayi	Cadherin domain containing protein	0.0071	0.0643	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Echinococcus multilocularis	slit 2 protein	0.0071	0.0643	0.0643
Onchocerca volvulus		0.0071	0.0643	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0519	0.0794
Onchocerca volvulus		0.0071	0.0643	0.0185
Echinococcus granulosus	intermediate filament protein	0.0062	0.0533	0.0533
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0091	0.0889	0.0889
Loa Loa (eye worm)	Notch2	0.0071	0.0643	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Brugia malayi	isocitrate dehydrogenase	0.0019	0.0004	0.0006
Brugia malayi	Animal haem peroxidase family protein	0.0551	0.6529	1
Loa Loa (eye worm)	animal heme peroxidase	0.0551	0.6529	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0071	0.0643	0.0985
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0083	0.0788	0.0788
Echinococcus granulosus	protein jagged 1	0.0071	0.0643	0.0643
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0085	0.1545
Entamoeba histolytica	hypothetical protein	0.0026	0.0085	0.0486
Schistosoma mansoni	hypothetical protein	0.0205	0.2282	0.2282
Echinococcus granulosus	lamin	0.0062	0.0533	0.0533
Schistosoma mansoni	peroxidasin	0.0551	0.6529	0.6529
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0144	0.2676
Echinococcus multilocularis	lamin	0.0062	0.0533	0.0533
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0071	0.0643	0.0985
Loa Loa (eye worm)	blistered cuticle protein 3	0.0551	0.6529	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Schistosoma mansoni	ap endonuclease	0.0023	0.0049	0.0049
Brugia malayi	cytoplasmic intermediate filament protein	0.0033	0.0179	0.0273
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0004	0.0004
Schistosoma mansoni	lamin	0.0062	0.0533	0.0533
Schistosoma mansoni	notch	0.0071	0.0643	0.0643
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0026	0.0085	0.1259
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Echinococcus multilocularis	neurogenic locus protein delta	0.0071	0.0643	0.0643
Schistosoma mansoni	hypothetical protein	0.0071	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Entamoeba histolytica	hypothetical protein	0.0083	0.0788	1
Leishmania major	phosphopantetheinyl transferase-like protein	0.0026	0.0085	0.1545
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0118	0.2181
Toxoplasma gondii	exonuclease III APE	0.0023	0.0049	0.0697
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.003	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0525	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.003	0.0138	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Schistosoma mansoni	septate junction protein	0.0071	0.0643	0.0643
Echinococcus multilocularis	protein jagged 1	0.0071	0.0643	0.0643
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0525	0.0805
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0525	1
Schistosoma mansoni	hypothetical protein	0.0071	0.0643	0.0643
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0533	0.0816
Echinococcus multilocularis	protein jagged 1	0.0071	0.0643	0.0643
Loa Loa (eye worm)	notch protein	0.0071	0.0643	0.0985
Brugia malayi	Animal haem peroxidase family protein	0.0551	0.6529	1
Echinococcus granulosus	neurogenic locus notch protein	0.0071	0.0643	0.0643
Brugia malayi	Delta serrate ligand family protein	0.0071	0.0643	0.0985
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0049	0.3197
Loa Loa (eye worm)	animal heme peroxidase	0.0551	0.6529	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0049	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Echinococcus granulosus	fibropellin Ia	0.0071	0.0643	0.0643
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Echinococcus multilocularis	musashi	0.0062	0.0533	0.0533
Brugia malayi	EGF-like domain containing protein	0.0071	0.0643	0.0985
Onchocerca volvulus	Peroxidasin homolog	0.0551	0.6529	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.1804	0.2763
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0118	0.018
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0118	0.2181
Loa Loa (eye worm)	MH2 domain-containing protein	0.0275	0.3147	0.4819
Echinococcus multilocularis	lamin dm0	0.0062	0.0533	0.0533
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0049	0.5538
Schistosoma mansoni	lamin	0.0062	0.0533	0.0533
Trypanosoma brucei	cytochrome P450, putative	0.0028	0.0118	0.2181
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0124	0.019
Onchocerca volvulus	Slit protein homolog	0.0071	0.0643	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Brugia malayi	Cadherin domain containing protein	0.0071	0.0643	0.0985
Onchocerca volvulus	Peroxidasin homolog	0.0551	0.6529	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0889	0.1362
Echinococcus granulosus	neurogenic locus protein delta	0.0071	0.0643	0.0643
Schistosoma mansoni	hypothetical protein	0.0071	0.0643	0.0643
Echinococcus multilocularis	geminin	0.0205	0.2282	0.2282
Onchocerca volvulus	Peroxidase homolog	0.0551	0.6529	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Echinococcus multilocularis	fibropellin Ia	0.0071	0.0643	0.0643
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.0004	0.0004
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0049	0.0856
Schistosoma mansoni	hypothetical protein	0.0071	0.0643	0.0643
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0525	1
Onchocerca volvulus		0.0551	0.6529	1
Echinococcus multilocularis	notch	0.0071	0.0643	0.0643
Brugia malayi	Calcium binding EGF domain containing protein	0.0071	0.0643	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0643	0.0985
Loa Loa (eye worm)	hypothetical protein	0.0551	0.6529	1
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0026	0.0085	0.5199
Brugia malayi	EGF-like domain containing protein	0.0071	0.0643	0.0985
Trypanosoma brucei	protein kinase, putative	0.0062	0.0525	1
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0525	0.0525
Schistosoma mansoni	hypothetical protein	0.0205	0.2282	0.2282
Schistosoma mansoni	notch	0.0071	0.0643	0.0643
Echinococcus multilocularis	neurogenic locus notch protein	0.0071	0.0643	0.0643
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0525	0.8014
Echinococcus granulosus	neural cadherin	0.0071	0.0643	0.0643
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0525	1
Brugia malayi	Animal haem peroxidase family protein	0.0551	0.6529	1
Onchocerca volvulus	Dual oxidase homolog	0.0551	0.6529	1
Brugia malayi	EGF-like domain containing protein	0.0071	0.0643	0.0985
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0083	0.0788	0.0788
Schistosoma mansoni	hypothetical protein	0.0071	0.0643	0.0643

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3500528

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2075641