TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 565.462 | Formula: C24H25F6N3O6
H donors: 2 H acceptors: 6 LogP: 1.31 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.O=C1COC2(CN1c1ccccc1)CCN(CC2)Cc1ccncc1
InChi: 1S/C20H23N3O2.2C2HF3O2/c24-19-15-25-20(16-23(19)18-4-2-1-3-5-18)8-12-22(13-9-20)14-17-6-10-21-11-7-17;2*3-2(4,5)1(6)7/h1-7,10-11H,8-9,12-16H2;2*(H,6,7)
InChiKey: XBJZASLUUMVYGQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0031	0.0109	0.2149
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Plasmodium vivax	vivapain-1	0.0031	0.0109	0.2757
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0048	0.0231	0.0231
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0045	0.0209	0.6451
Schistosoma mansoni	inositol monophosphatase	0.0045	0.0209	0.0202
Trypanosoma cruzi	cysteine peptidase, putative	0.0228	0.1539	0.1539
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0045	0.0209	0.0202
Trichomonas vaginalis	conserved hypothetical protein	0.0268	0.183	0.3807
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0029	0.0029
Echinococcus multilocularis	cysteine protease	0.006	0.0319	0.0312
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0121	0.0114
Schistosoma mansoni	rab6-interacting	0.0023	0.0051	0.0044
Toxoplasma gondii	cathepsin CPL	0.006	0.0319	0.903
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.1154	0.1148
Brugia malayi	Cathepsin L-like precursor	0.004	0.0176	0.0169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0109	0.0102
Entamoeba histolytica	cysteine protease, putative	0.006	0.0319	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Echinococcus multilocularis	dna polymerase kappa	0.0048	0.0231	0.0224
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Echinococcus multilocularis	protein patched	0.0268	0.183	0.1824
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0064	0.035	0.0343
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.006	0.0319	0.0312
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0331	0.0324
Trypanosoma brucei	DNA polymerase kappa, putative	0.0024	0.0063	0.0056
Schistosoma mansoni	lamin	0.0033	0.0121	0.0114
Brugia malayi	PAS domain containing protein	0.0059	0.0311	0.0304
Echinococcus granulosus	single minded 2	0.0043	0.02	0.0193
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0655	0.463	1
Brugia malayi	Inositol-1	0.0045	0.0209	0.0202
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0258	0.0331
Echinococcus multilocularis	Niemann Pick C1 protein	0.0268	0.183	0.1824
Echinococcus granulosus	hydroxymethylglutaryl coenzyme A reductase	0.1395	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0176	0.0148
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0051	0.0044
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0331	0.0492
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Leishmania major	cysteine peptidase A (CPA)	0.006	0.0319	0.0319
Onchocerca volvulus		0.0033	0.0121	0.2612
Brugia malayi	hypothetical protein	0.0023	0.0051	0.0044
Plasmodium vivax	vivapain-2	0.006	0.0319	1
Loa Loa (eye worm)	cysteine protease	0.006	0.0319	0.0312
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0045	0.0209	0.0209
Onchocerca volvulus		0.0033	0.0121	0.2612
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0319	0.0466
Leishmania major	cathepsin L-like protease	0.006	0.0319	0.0319
Brugia malayi	MAP kinase sur-1	0.0062	0.0331	0.0324
Mycobacterium ulcerans	putative regulatory protein	0.0043	0.02	0.0105
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0319	0.0466
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0331	0.0331
Echinococcus granulosus	RUN	0.0023	0.0051	0.0044
Trypanosoma cruzi	DNA polymerase eta, putative	0.0017	0.0007	0.0007
Leishmania major	cytochrome p450-like protein	0.0029	0.0097	0.0097
Echinococcus granulosus	intermediate filament protein	0.0033	0.0121	0.0114
Echinococcus multilocularis	cathepsin L cysteine protease	0.006	0.0319	0.0312
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0012	0.0005
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0024	0.0063	0.0063
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0319	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0147	0.014
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0182	0.1203	0.1197
Onchocerca volvulus		0.006	0.0319	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0029	0.0022
Plasmodium vivax	multidomain scavenger receptor, putative	0.0023	0.0051	0.0774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Echinococcus multilocularis	lamin dm0	0.0033	0.0121	0.0114
Trypanosoma brucei	DNA polymerase IV, putative	0.0048	0.0231	0.0224
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Schistosoma mansoni	single-minded	0.0059	0.0311	0.0304
Brugia malayi	hypothetical protein	0.0023	0.0051	0.0044
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0147	0.014
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.0109	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0051	0.0044
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0045	0.0209	0.5
Brugia malayi	Cathepsin L-like precursor	0.006	0.0319	0.0312
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0227	0.6564
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0331	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0197	0.1314	0.1308
Schistosoma mansoni	patched 1	0.0268	0.183	0.1824
Echinococcus granulosus	lamin	0.0033	0.0121	0.0114
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0331	0.0324
Schistosoma mansoni	loxhd1	0.0023	0.0051	0.0044
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0064	0.035	0.0343
Brugia malayi	Cathepsin L-like cysteine proteinase	0.004	0.0176	0.0169
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase	0.1395	1	1
Brugia malayi	bHLH-PAS transcription factor	0.0043	0.02	0.0193
Echinococcus granulosus	cathepsin l cysteine peptidase	0.006	0.0319	0.0312
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.006	0.0319	0.0312
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0097	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Echinococcus granulosus	sterol regulatory element binding protein	0.0268	0.183	0.1824
Onchocerca volvulus	Cathepsin F homolog	0.006	0.0319	1
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0655	0.463	1
Loa Loa (eye worm)	inositol-1	0.0045	0.0209	0.0202
Loa Loa (eye worm)	hypothetical protein	0.002	0.0029	0.0022
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0331	0.0331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Leishmania major	DNA polymerase kappa, putative	0.0024	0.0063	0.0063
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0024	0.0063	0.3315
Leishmania major	DNA polymerase eta, putative	0.0017	0.0007	0.0007
Echinococcus multilocularis	protein dispatched 1	0.0268	0.183	0.1824
Schistosoma mansoni	lamin	0.0033	0.0121	0.0114
Brugia malayi	polk-prov protein	0.0036	0.0147	0.014
Trypanosoma cruzi	cruzipain precursor, putative	0.002	0.0029	0.0029
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0109	0.3259
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.006	0.0319	1
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Schistosoma mansoni	lipoxygenase	0.0023	0.0051	0.0044
Entamoeba histolytica	cysteine proteinase, putative	0.004	0.0176	0.5404
Brugia malayi	cathepsin F-like cysteine proteinase	0.002	0.0029	0.0022
Trypanosoma cruzi	cysteine peptidase, putative	0.006	0.0319	0.0319
Brugia malayi	Cathepsin L-like precursor	0.006	0.0319	0.0312
Trypanosoma cruzi	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.1395	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.006	0.0319	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0051	0.0044
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0045	0.0209	0.0113
Trypanosoma brucei	cytochrome P450, putative	0.0029	0.0097	0.0089
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0051	0.0044
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0231	0.0224
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0045	0.0209	0.022
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Leishmania major	cathepsin L-like protease	0.006	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.004	0.0176	0.0169
Trypanosoma brucei	protein kinase, putative	0.0062	0.0331	0.0324
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0331	1
Echinococcus multilocularis	cysteine protease	0.006	0.0319	0.0312
Trypanosoma brucei	DNA polymerase kappa, putative	0.0036	0.0147	0.014
Echinococcus granulosus	lamin dm0	0.0033	0.0121	0.0114
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Entamoeba histolytica	cysteine proteinase 1, putative	0.0031	0.0109	0.3259
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0208	0.1396	0.1396
Giardia lamblia	3-hydroxy-3-methylglutaryl-coenzyme A reductase	0.0655	0.463	1
Plasmodium vivax	unspecified product	0.0031	0.0109	0.2757
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0331	0.0331
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.006	0.0319	0.0466
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0048	0.0231	0.0231
Schistosoma mansoni	lipoxygenase	0.0064	0.035	0.0343
Loa Loa (eye worm)	acetyltransferase	0.0175	0.1154	0.1148
Loa Loa (eye worm)	hypothetical protein	0.006	0.0319	0.0312
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0176	0.0168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0319	0.0466
Loa Loa (eye worm)	ctsf protein	0.006	0.0319	0.0312
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.004	0.0175	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0036	0.0029
Brugia malayi	Cathepsin L-like precursor	0.006	0.0319	0.0312
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0109	0.0109
Onchocerca volvulus		0.006	0.0319	1
Entamoeba histolytica	cysteine proteinase, putative	0.006	0.0319	1
Trypanosoma cruzi	cysteine protease, putative	0.0031	0.0109	0.0109
Echinococcus multilocularis	Polycystic kidney disease protein	0.0023	0.0051	0.0044
Onchocerca volvulus		0.006	0.0319	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Onchocerca volvulus		0.006	0.0319	1
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.0109	0.0102
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.006	0.0319	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0258	0.0251
Loa Loa (eye worm)	hypothetical protein	0.004	0.0176	0.0169
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0258	0.4057
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0268	0.183	0.1824
Trichomonas vaginalis	3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative	0.0655	0.463	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0228	0.1539	0.1539
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0331	0.0324
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0045	0.0209	0.0209
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0258	0.0331
Echinococcus granulosus	Polycystic kidney disease protein	0.0023	0.0051	0.0044
Schistosoma mansoni	inositol monophosphatase	0.0045	0.0209	0.0202
Brugia malayi	Doublecortin family protein	0.0023	0.0051	0.0044
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0268	0.183	0.1824
Trichomonas vaginalis	inositol monophosphatase, putative	0.0045	0.0209	0.022
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.1154	0.1148
Echinococcus granulosus	inositol monophosphatase 1	0.0045	0.0209	0.0202
Brugia malayi	Papain family cysteine protease containing protein	0.006	0.0319	0.0312
Leishmania major	3-hydroxy-3-methylglutaryl-CoA reductase	0.1395	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.004	0.0176	0.0169
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0227	0.036
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0231	0.0224
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0231	0.0224
Echinococcus granulosus	dna polymerase kappa	0.0048	0.0231	0.0224
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.0097	0.0097
Echinococcus granulosus	cathepsin l1	0.006	0.0319	0.0312
Trypanosoma brucei	3-hydroxy-3-methylglutaryl-CoA reductase, putative	0.1395	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0231	0.0224
Brugia malayi	Cathepsin L-like precursor	0.002	0.0029	0.0022
Trichomonas vaginalis	DNA polymerase eta, putative	0.0048	0.0231	0.027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0231	0.0224
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0331	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0121	0.0114
Onchocerca volvulus		0.006	0.0319	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.004	0.0175	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0319	0.0466
Leishmania major	cathepsin L-like protease	0.0228	0.1539	0.1539
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Entamoeba histolytica	cysteine proteinase 2	0.0031	0.0109	0.3259
Schistosoma mansoni	cathepsin F (C01 family)	0.006	0.0319	0.0312
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0025	0.0018
Schistosoma mansoni	cathepsin F (C01 family)	0.006	0.0319	0.0312
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0331	0.0492
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0319	0.0466
Onchocerca volvulus		0.006	0.0319	1
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.006	0.0319	0.0466
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0051	0.0044
Trypanosoma cruzi	cysteine peptidase, putative	0.0228	0.1539	0.1539
Trypanosoma cruzi	cysteine proteinase, putative	0.0031	0.0109	0.0109
Onchocerca volvulus	Cathepsin L homolog	0.006	0.0319	1
Schistosoma mansoni	polycystin 1-related	0.0023	0.0051	0.0044
Mycobacterium ulcerans	DNA polymerase IV	0.0048	0.0231	0.0136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0319	0.0466
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0331	0.0324
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0331	0.0588
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0097	0.0089
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0109	0.3259
Trypanosoma brucei	unspecified product	0.004	0.0176	0.0168
Echinococcus multilocularis	RUN	0.0023	0.0051	0.0044
Echinococcus granulosus	cysteine protease	0.0031	0.0109	0.0102
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0231	0.0224
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0231	0.0224
Echinococcus multilocularis	cathepsin L cysteine protease	0.006	0.0319	0.0312
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0048	0.0231	0.0231
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0097	0.0089
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0319	0.0466
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0227	0.705
Schistosoma mansoni	rab6-interacting	0.0023	0.0051	0.0044
Onchocerca volvulus		0.006	0.0319	1
Echinococcus multilocularis	musashi	0.0033	0.0121	0.0114
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0097	0.0089
Brugia malayi	Cathepsin L-like precursor	0.006	0.0319	0.0312
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0031	0.0109	0.0109
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.006	0.0319	0.0312
Echinococcus multilocularis	inositol monophosphatase 1	0.0045	0.0209	0.0202
Echinococcus multilocularis	hydroxymethylglutaryl coenzyme A reductase	0.1395	1	1
Brugia malayi	intermediate filament protein	0.0033	0.0121	0.0114
Schistosoma mansoni	cathepsin s	0.002	0.0029	0.0022
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0121	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0051	0.0044
Echinococcus granulosus	Protein patched homolog 1	0.0268	0.183	0.1824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Leishmania major	cathepsin L-like protease	0.0228	0.1539	0.1539
Onchocerca volvulus	Cathepsin L homolog	0.006	0.0319	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0045	0.0209	0.0209
Echinococcus granulosus	Niemann Pick C1 protein	0.0268	0.183	0.1824
Loa Loa (eye worm)	CYP4Cod1	0.0029	0.0097	0.0089
Onchocerca volvulus		0.004	0.0176	0.4647
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0121	0.0114
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0012	0.0005
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0121	0.0114
Leishmania major	cathepsin L-like protease	0.006	0.0319	0.0319
Leishmania major	cathepsin L-like protease	0.006	0.0319	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0268	0.183	0.1824
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.006	0.0319	0.0312
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0231	0.0224
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0048	0.0231	0.027
Schistosoma mansoni	cathepsin F (C01 family)	0.004	0.0176	0.0169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0109	0.0102
Brugia malayi	Cathepsin L-like precursor	0.006	0.0319	0.0312
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.1119	0.1112
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0109	0.3259
Loa Loa (eye worm)	hypothetical protein	0.1395	1	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0268	0.183	0.1824
Onchocerca volvulus		0.0043	0.02	0.5563
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0025	0.0018
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0109	0.3259
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0258	0.4057
Brugia malayi	Cathepsin L-like precursor	0.006	0.0319	0.0312
Brugia malayi	hypoxia-induced factor 1	0.0182	0.1203	0.1197
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0117	0.011
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0025	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Schistosoma mansoni	aryl hydrocarbon receptor	0.0059	0.0311	0.0304
Brugia malayi	cathepsin L-like precursor	0.004	0.0176	0.0169
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0331	0.0492
Schistosoma mansoni	hydroxymethylglutaryl-CoA reductase (NADPH)	0.1395	1	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0331	0.0324
Trypanosoma brucei	DNA polymerase IV, putative	0.0048	0.0231	0.0224
Trypanosoma brucei	DNA polymerase kappa, putative	0.0048	0.0231	0.0224
Brugia malayi	CHE-14 protein	0.0268	0.183	0.1824
Echinococcus granulosus	cathepsin L cysteine protease	0.0031	0.0109	0.0102
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.1154	0.1148
Echinococcus granulosus	cathepsin l1	0.004	0.0176	0.0169
Echinococcus multilocularis	transfer RNA-Lys	0.0043	0.02	0.0193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Brugia malayi	hypothetical protein	0.0197	0.1314	0.1308
Plasmodium vivax	vivapain-3	0.0031	0.0109	0.2757
Trypanosoma cruzi	cysteine peptidase, putative	0.0228	0.1539	0.1539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.002	0.0029	0.0022
Trypanosoma cruzi	major cysteine proteinase, putative	0.0179	0.1185	0.1185
Loa Loa (eye worm)	doublecortin family protein	0.0023	0.0051	0.0044
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.0109	0.0102
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.0109	0.0102
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.006	0.0319	0.0466
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0331	0.0331
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Echinococcus granulosus	cathepsin L	0.0031	0.0109	0.0102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Echinococcus granulosus	cathepsin L cysteine proteinase	0.006	0.0319	0.0312
Schistosoma mansoni	hypothetical protein	0.0023	0.0051	0.0044
Echinococcus multilocularis	lamin	0.0033	0.0121	0.0114
Mycobacterium ulcerans	hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase	0.1395	1	1
Brugia malayi	Cathepsin L-like precursor	0.004	0.0176	0.0169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.1539	0.1533
Echinococcus multilocularis	cathepsin L	0.0031	0.0109	0.0102
Leishmania major	cathepsin L-like protease	0.006	0.0319	0.0319
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.004	0.0176	0.0148
Leishmania major	cathepsin L-like protease	0.0228	0.1539	0.1539
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Loa Loa (eye worm)	fibroinase	0.006	0.0319	0.0312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.006	0.0319	0.0466
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0029	0.0022
Plasmodium falciparum	cysteine proteinase falcipain 3	0.006	0.0319	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0031	0.0109	0.0109
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0045	0.0209	0.022
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0048	0.0231	0.0231
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0331	0.0324
Plasmodium vivax	vivapain-2	0.006	0.0319	1
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0109	0.3259
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.0109	0.0102
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0258	0.79
Mycobacterium ulcerans	DNA polymerase IV	0.0048	0.0231	0.0136
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.002	0.0029	0.0022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3503285

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2075759