Detailed information for compound 2075877

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.431 | Formula: C22H24F4N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.Fc1ccc(cc1)N1CCC2(CC1)OCC(C2)OCc1cccnc1
  • InChi: 1S/C20H23FN2O2.C2HF3O2/c21-17-3-5-18(6-4-17)23-10-7-20(8-11-23)12-19(15-25-20)24-14-16-2-1-9-22-13-16;3-2(4,5)1(6)7/h1-6,9,13,19H,7-8,10-12,14-15H2;(H,6,7)
  • InChiKey: GTUALFVJZKGZAY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0019 0.0047 0.0263
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0056 0.0866
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) doublecortin family protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0018 0.0044 0.0043
Brugia malayi regulator of G-protein signaling rgs-7 0.0013 0.0017 0.0036
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0059 0.0254 0.0254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0128 0.0128
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Echinococcus multilocularis lysosomal alpha glucosidase 0.0089 0.0408 0.0408
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Echinococcus multilocularis beta adrenergic receptor kinase 0.0014 0.0018 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0018 0.0018
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0019 0.0292
Schistosoma mansoni ap endonuclease 0.0021 0.0056 0.0056
Schistosoma mansoni ap endonuclease 0.0021 0.0056 0.0056
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0104 0.0483 0.752
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1957 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0056 0.0866
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Echinococcus multilocularis neutral alpha glucosidase AB 0.002 0.0051 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0018 0.0018
Brugia malayi Peptidase family M1 containing protein 0.0104 0.0483 0.1055
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0059 0.0254 0.0253
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0058 0.0901
Entamoeba histolytica serine/threonine protein kinase, putative 0.0066 0.0285 0.5763
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0056 0.5
Schistosoma mansoni sodium-bile acid cotransporter related 0.0038 0.0145 0.0144
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0104 0.0483 0.2846
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0285 0.0285
Schistosoma mansoni alpha-glucosidase 0.0077 0.0344 0.0343
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.022 0.0219
Onchocerca volvulus 0.0104 0.0483 0.3556
Loa Loa (eye worm) hypothetical protein 0.0071 0.0313 0.0313
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0053 0.0814
Brugia malayi hypothetical protein 0.0014 0.0019 0.0041
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Schistosoma mansoni lipoxygenase 0.0032 0.0113 0.0113
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0115 0.0601
Schistosoma mansoni hypothetical protein 0.002 0.0053 0.0052
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0104 0.0483 0.752
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0029 0.0097 0.021
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0104 0.0483 0.752
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0021 0.0058 0.0013
Brugia malayi hypothetical protein 0.0011 0.0007 0.0015
Onchocerca volvulus Huntingtin homolog 0.0071 0.0313 0.2288
Schistosoma mansoni loxhd1 0.0011 0.0007 0.0007
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0021 0.0058 0.0251
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0032 0.0113 0.1758
Echinococcus multilocularis microtubule associated protein 2 0.0391 0.1957 0.1957
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0128 0.0128
Loa Loa (eye worm) transcription factor SMAD2 0.0083 0.0374 0.0374
Echinococcus multilocularis RUN 0.0011 0.0007 0.0007
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0032 0.0113 0.0113
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0056 0.0238
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Echinococcus granulosus expressed protein 0.0259 0.1279 0.1279
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0104 0.0483 0.0482
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0115 0.0601
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0019 0.0292
Schistosoma mansoni cpg binding protein 0.0037 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Loa Loa (eye worm) RGS-3 protein 0.0013 0.0017 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.002 0.0051 0.0205
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0056 0.0315
Onchocerca volvulus 0.0034 0.0126 0.0884
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0104 0.0483 0.752
Echinococcus multilocularis PHD finger protein rhinoceros 0.002 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0104 0.0483 0.0482
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0104 0.0483 0.752
Onchocerca volvulus 0.0035 0.0129 0.0909
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0071 0.0313 0.0313
Brugia malayi Inositol-1 0.0021 0.0058 0.0126
Echinococcus multilocularis axis inhibition protein axin 0.0013 0.0017 0.0017
Toxoplasma gondii aminopeptidase N, putative 0.0104 0.0483 0.752
Giardia lamblia Kinase, PLK 0.0066 0.0285 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0104 0.0483 0.752
Echinococcus multilocularis axis inhibition protein axin 0.0013 0.0017 0.0017
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0056 0.0056
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.022 0.048
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0104 0.0483 0.752
Schistosoma mansoni hypothetical protein 0.0215 0.1055 0.1055
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Schistosoma mansoni lipoxygenase 0.0011 0.0007 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.022 0.022
Brugia malayi jmjC domain containing protein 0.0026 0.0085 0.0185
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0014 0.0018 0.0039
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0013 0.0017 0.0017
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0104 0.0483 0.752
Plasmodium vivax multidomain scavenger receptor, putative 0.0011 0.0007 0.0109
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0056 0.0056
Schistosoma mansoni axis inhibition protein axin 0.0013 0.0017 0.0017
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1957 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0066 0.0285 0.208
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0104 0.0483 0.752
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0066 0.0285 0.0285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.022 0.0219
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.002 0.0051 0.0719
Echinococcus granulosus RUN 0.0011 0.0007 0.0007
Schistosoma mansoni lamin 0.0034 0.0126 0.0125
Schistosoma mansoni glutaminase 0.0332 0.1653 0.1653
Schistosoma mansoni aldehyde dehydrogenase 0.0032 0.0113 0.0113
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.0289 0.0289
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.002 0.0053 0.0052
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0129 0.0128
Echinococcus granulosus neutral alpha glucosidase AB 0.002 0.0051 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0128 0.0128
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0013 0.0017 0.0017
Echinococcus multilocularis lamin 0.0034 0.0126 0.0126
Loa Loa (eye worm) MH2 domain-containing protein 0.0083 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0029 0.0097 0.0096
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0021 0.0058 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0014 0.0018 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.002 0.005 0.0108
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0104 0.0483 0.752
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0376 0.1879 0.1879
Echinococcus granulosus lysosomal alpha glucosidase 0.0089 0.0408 0.0408
Echinococcus multilocularis regulator of G protein signaling 0.0013 0.0017 0.0017
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.0289 0.0289
Schistosoma mansoni rab6-interacting 0.0011 0.0007 0.0007
Echinococcus multilocularis aminopeptidase N 0.0104 0.0483 0.0483
Trypanosoma brucei aminopeptidase, putative 0.0104 0.0483 0.752
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0034 0.0033
Schistosoma mansoni hypothetical protein 0.0215 0.1055 0.1055
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0013 0.0017 0.0017
Brugia malayi cytoplasmic intermediate filament protein 0.0018 0.0044 0.0094
Loa Loa (eye worm) intermediate filament protein 0.0034 0.0126 0.0125
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0014 0.0018 0.0018
Echinococcus granulosus sodium bile acid cotransporter 0.0094 0.0431 0.0431
Plasmodium falciparum LCCL domain-containing protein 0.0011 0.0007 0.0109
Echinococcus granulosus peregrin 0.002 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Echinococcus granulosus aminopeptidase N 0.0104 0.0483 0.0483
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0118 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0085 0.0084
Echinococcus multilocularis regulator of G protein signaling 7 0.0013 0.0017 0.0017
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0059 0.0254 0.0253
Loa Loa (eye worm) dihydrofolate reductase 0.0353 0.1761 0.1761
Brugia malayi Doublecortin family protein 0.0011 0.0007 0.0015
Mycobacterium ulcerans glutaminase 0.0332 0.1653 0.9366
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Trypanosoma cruzi polo-like protein kinase, putative 0.0066 0.0285 0.4444
Echinococcus multilocularis geminin 0.0215 0.1055 0.1055
Loa Loa (eye worm) TATA binding protein associated factor 0.0104 0.0483 0.0482
Echinococcus granulosus regulator of G protein signaling 3 0.0013 0.0017 0.0017
Echinococcus multilocularis lysosomal alpha glucosidase 0.0089 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Onchocerca volvulus Huntingtin homolog 0.0071 0.0313 0.2288
Entamoeba histolytica aminopeptidase, putative 0.0104 0.0483 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0129 0.0281
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0059 0.0254 0.0253
Loa Loa (eye worm) hypothetical protein 0.0104 0.0483 0.0482
Echinococcus granulosus geminin 0.0215 0.1055 0.1055
Schistosoma mansoni inositol monophosphatase 0.0021 0.0058 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0034 0.0126 0.0125
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0104 0.0483 0.2846
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Trypanosoma brucei polo-like protein kinase 0.0066 0.0285 0.4444
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.022 0.022
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Brugia malayi PXA domain containing protein 0.0013 0.0017 0.0036
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Trypanosoma cruzi Aminopeptidase M1, putative 0.0104 0.0483 0.752
Trypanosoma brucei glucosidase, putative 0.002 0.0051 0.0782
Schistosoma mansoni jumonji/arid domain-containing protein 0.0026 0.0085 0.0084
Echinococcus multilocularis musashi 0.0034 0.0126 0.0126
Brugia malayi MH2 domain containing protein 0.0083 0.0374 0.0818
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0135 0.0642 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0017 0.0034 0.0034
Brugia malayi regulator of G-protein signaling egl-10 0.0013 0.0017 0.0036
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0058 0.0901
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0013 0.0017 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0056 0.0238
Schistosoma mansoni axis inhibition protein axin 0.0013 0.0017 0.0017
Echinococcus granulosus sodium bile acid cotransporter 0.0094 0.0431 0.0431
Echinococcus multilocularis regulator of G protein signaling 3 0.0013 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0051 0.0782
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0104 0.0483 0.752
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0032 0.0113 0.064
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0021 0.0058 0.0251
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Brugia malayi hypothetical protein 0.0071 0.0313 0.0685
Brugia malayi Sodium Bile acid symporter family protein 0.0094 0.0431 0.0943
Plasmodium vivax ataxin-2 like protein, putative 0.0014 0.0019 0.0292
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Loa Loa (eye worm) hypothetical protein 0.0094 0.0431 0.0431
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0128 0.0128
Plasmodium falciparum phd finger protein, putative 0.002 0.0053 0.0814
Brugia malayi serine/threonine-protein kinase plk-2 0.0066 0.0285 0.0624
Brugia malayi Angiotensin-converting enzyme family protein 0.0376 0.1879 0.4112
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.1175 0.1175
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0017 0.0034 0.0034
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0353 0.1761 1
Loa Loa (eye worm) glutaminase 2 0.0332 0.1653 0.1653
Schistosoma mansoni hypothetical protein 0.002 0.005 0.0049
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0013 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0052
Brugia malayi hypothetical protein 0.0013 0.0017 0.0036
Trichomonas vaginalis inositol monophosphatase, putative 0.0021 0.0058 0.0251
Onchocerca volvulus 0.0272 0.1344 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0018 0.0018
Echinococcus granulosus axis inhibition protein axin 0.0013 0.0017 0.0017
Brugia malayi hypothetical protein 0.0013 0.0017 0.0036
Onchocerca volvulus 0.0094 0.0431 0.3172
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0059 0.0254 0.0254
Brugia malayi Peptidase family M1 containing protein 0.0104 0.0483 0.1055
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0104 0.0483 0.752
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Echinococcus granulosus Polycystic kidney disease protein 0.0011 0.0007 0.0007
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0032 0.0113 0.0113
Loa Loa (eye worm) PXA domain-containing protein 0.0013 0.0017 0.0017
Schistosoma mansoni cpg binding protein 0.0037 0.0139 0.0139
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0019 0.0292
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0066 0.0285 0.4444
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0104 0.0483 0.0482
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0011 0.0011
Brugia malayi PHD-finger family protein 0.002 0.0053 0.0114
Onchocerca volvulus 0.0104 0.0483 0.3556
Trichomonas vaginalis glutaminase, putative 0.0332 0.1653 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0058 0.0901
Brugia malayi intermediate filament protein 0.0034 0.0126 0.0274
Schistosoma mansoni aminopeptidase A (M01 family) 0.0104 0.0483 0.0482
Echinococcus multilocularis inositol monophosphatase 1 0.0021 0.0058 0.0058
Trypanosoma brucei Aminopeptidase M1, putative 0.0104 0.0483 0.752
Echinococcus granulosus jumonji domain containing protein 0.0028 0.0093 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.022 0.022
Brugia malayi hypothetical protein 0.0104 0.0483 0.1055
Echinococcus granulosus dihydrofolate reductase 0.0353 0.1761 0.1761
Echinococcus granulosus PHD finger protein rhinoceros 0.002 0.0053 0.0053
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0053 0.0814
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1384 0.7055 0.7055
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.003
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0044 0.0096
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Loa Loa (eye worm) aminopeptidase N 0.0104 0.0483 0.0482
Schistosoma mansoni lamin 0.0034 0.0126 0.0125
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.002 0.0051 0.0205
Echinococcus multilocularis dnaJ subfamily B 0.0216 0.1057 0.1057
Schistosoma mansoni alpha glucosidase 0.002 0.0051 0.005
Echinococcus granulosus regulator of G protein signaling 3 0.0013 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0126 0.0125
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1957 1 1
Echinococcus granulosus regulator of G protein signaling 7 0.0013 0.0017 0.0017
Brugia malayi Glycosyl hydrolases family 31 protein 0.002 0.0051 0.011
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0353 0.1761 1
Onchocerca volvulus 0.0035 0.0128 0.0902
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0007 0.0007
Brugia malayi jmjC domain containing protein 0.0066 0.0289 0.0632
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.002 0.0051 0.0719
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0053 0.0052
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0066 0.0285 0.4444
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0128 0.0128
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.004 0.0152 0.0825
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0104 0.0483 0.0482
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0019
Brugia malayi Intermediate filament tail domain containing protein 0.0034 0.0126 0.0274
Brugia malayi hypothetical protein 0.0011 0.0007 0.0015
Schistosoma mansoni microtubule-associated protein tau 0.0391 0.1957 0.1957
Toxoplasma gondii LsmAD domain-containing protein 0.0014 0.0019 0.0292
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0104 0.0483 0.752
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0353 0.1761 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0066 0.0285 0.0285
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.0337 0.0337
Echinococcus granulosus sodium bile acid cotransporter 0.0094 0.0431 0.0431
Trypanosoma brucei PAB1-binding protein , putative 0.0014 0.0019 0.0292
Onchocerca volvulus Alhambra homolog 0.002 0.0053 0.0339
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0056 0.0866
Trypanosoma brucei Aminopeptidase M1, putative 0.0104 0.0483 0.752
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Echinococcus granulosus regulator of G protein signaling 7 0.0013 0.0017 0.0017
Schistosoma mansoni polycystin 1-related 0.0011 0.0007 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0128 0.0128
Brugia malayi Pre-SET motif family protein 0.0239 0.1175 0.2571
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0056 0.0866
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Leishmania major alpha glucosidase II subunit, putative 0.002 0.0051 0.0782
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.022 0.0219
Brugia malayi Calcitonin receptor-like protein seb-1 0.0029 0.0097 0.021
Echinococcus granulosus intermediate filament protein 0.0034 0.0126 0.0126
Echinococcus granulosus beta-adrenergic receptor kinase 0.0014 0.0018 0.0018
Brugia malayi glutaminase DH11.1 0.0332 0.1653 0.3617
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.0113 0.0336
Echinococcus granulosus cpg binding protein 0.0037 0.0139 0.0139
Trichomonas vaginalis sucrase-isomaltase, putative 0.002 0.0051 0.0205
Loa Loa (eye worm) hypothetical protein 0.0034 0.0122 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.022 0.022
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0056 0.0142
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0021 0.0058 0.0883
Echinococcus multilocularis sodium bile acid cotransporter 0.0094 0.0431 0.0431
Echinococcus granulosus microtubule associated protein 2 0.0391 0.1957 0.1957
Toxoplasma gondii aminopeptidase n, putative 0.0104 0.0483 0.752
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Toxoplasma gondii aldehyde dehydrogenase 0.0032 0.0113 0.1758
Schistosoma mansoni jumonji/arid domain-containing protein 0.0026 0.0085 0.0084
Schistosoma mansoni inositol monophosphatase 0.0021 0.0058 0.0058
Brugia malayi dihydrofolate reductase family protein 0.0353 0.1761 0.3854
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0049
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0128 0.1989
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0066 0.0285 0.0285
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0011 0.001
Echinococcus granulosus lamin dm0 0.0034 0.0126 0.0126
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0089 0.0408 0.0407
Echinococcus multilocularis expressed protein 0.0259 0.1279 0.1279
Schistosoma mansoni aldehyde dehydrogenase 0.0032 0.0113 0.0113
Loa Loa (eye worm) glutaminase 0.0332 0.1653 0.1653
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.004 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0035 0.0128 0.0128
Schistosoma mansoni sodium-bile acid cotransporter related 0.0094 0.0431 0.0431
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0104 0.0483 0.0483
Chlamydia trachomatis dihydrofolate reductase 0.0353 0.1761 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Brugia malayi A-kinase anchor protein 10, precursor 0.0013 0.0017 0.0036
Echinococcus granulosus Regulator of G protein signaling 20 0.0013 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.004 0.0152 0.0152
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0032 0.0113 0.0113
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0011 0.0011
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0056 0.0866
Trypanosoma cruzi aminopeptidase, putative 0.0104 0.0483 0.752
Schistosoma mansoni rab6-interacting 0.0011 0.0007 0.0007
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0029 0.0097 0.0096
Brugia malayi Glycosyl hydrolases family 31 protein 0.0089 0.0408 0.0891
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0104 0.0483 0.2846
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0058 0.0901
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0059 0.0254 0.0254
Echinococcus multilocularis jumonji domain containing protein 0.0028 0.0093 0.0093
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0056 0.0122
Toxoplasma gondii exonuclease III APE 0.0021 0.0056 0.0866
Echinococcus multilocularis regulator of G protein signaling 7 0.0013 0.0017 0.0017
Trypanosoma cruzi aminopeptidase, putative 0.0104 0.0483 0.752
Schistosoma mansoni cpg binding protein 0.0035 0.0129 0.0128
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0059 0.0254 0.0253
Echinococcus granulosus inositol monophosphatase 1 0.0021 0.0058 0.0058
Schistosoma mansoni dihydrofolate reductase 0.0353 0.1761 0.1761
Leishmania major hypothetical protein, conserved 0.0014 0.0019 0.0292
Trichomonas vaginalis set domain proteins, putative 0.0272 0.1344 0.8111
Loa Loa (eye worm) peptidase family M1 containing protein 0.0104 0.0483 0.0482
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Brugia malayi Melibiase family protein 0.004 0.0152 0.0332
Schistosoma mansoni jumonji domain containing protein 0.0053 0.0219 0.0219
Plasmodium vivax hypothetical protein, conserved 0.002 0.0053 0.0814
Echinococcus granulosus dnaJ subfamily B 0.0216 0.1057 0.1057
Plasmodium vivax SET domain protein, putative 0.0035 0.0128 0.1989
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0056 0.0835
Echinococcus multilocularis dihydrofolate reductase 0.0353 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0126
Schistosoma mansoni hypothetical protein 0.0216 0.1057 0.1056
Schistosoma mansoni sodium-bile acid cotransporter 0.0056 0.0236 0.0235
Toxoplasma gondii aminopeptidase N protein 0.0104 0.0483 0.752
Onchocerca volvulus 0.0052 0.0214 0.1547
Echinococcus granulosus lamin 0.0034 0.0126 0.0126
Echinococcus multilocularis lamin dm0 0.0034 0.0126 0.0126
Schistosoma mansoni z-protein (S1r protein) 0.0013 0.0017 0.0017
Brugia malayi Dihydrofolate reductase 0.0353 0.1761 0.3854
Echinococcus granulosus lysine specific demethylase 5A 0.0026 0.0085 0.0085
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0056 0.0056
Echinococcus multilocularis peregrin 0.002 0.0053 0.0053
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0104 0.0483 0.752
Loa Loa (eye worm) hypothetical protein 0.0104 0.0483 0.0482
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.002 0.0051 0.0782
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.022 0.0219
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0032 0.0113 0.0113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0128 0.0128
Onchocerca volvulus 0.0034 0.0126 0.0884
Onchocerca volvulus 0.0104 0.0483 0.3556
Brugia malayi hypothetical protein 0.0104 0.0483 0.1055
Mycobacterium ulcerans aminopeptidase N PepN 0.0104 0.0483 0.2502
Echinococcus multilocularis Polycystic kidney disease protein 0.0011 0.0007 0.0007
Schistosoma mansoni alpha-glucosidase 0.0077 0.0344 0.0343
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.004 0.0152 0.0152
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0056 0.0866
Echinococcus multilocularis sodium bile acid cotransporter 0.0094 0.0431 0.0431
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0019 0.0292
Brugia malayi Pre-SET motif family protein 0.0035 0.0128 0.0279
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0297 0.4616
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.0113 0.0336
Echinococcus multilocularis cpg binding protein 0.0037 0.0139 0.0139
Schistosoma mansoni intermediate filament proteins 0.0034 0.0126 0.0125
Echinococcus granulosus axis inhibition protein axin 0.0013 0.0017 0.0017
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.002 0.0051 0.005
Brugia malayi hypothetical protein 0.09 0.457 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0013 0.0017 0.0036
Trichomonas vaginalis maltase-glucoamylase, putative 0.002 0.0051 0.0205
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Echinococcus multilocularis sodium bile acid cotransporter 0.0094 0.0431 0.0431
Brugia malayi Peptidase family M1 containing protein 0.0104 0.0483 0.1055
Brugia malayi Regulator of G protein signaling domain containing protein 0.0013 0.0017 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0051 0.0782
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.0113 0.0336
Schistosoma mansoni kinase 0.0033 0.012 0.0119
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0163 0.0163
Echinococcus multilocularis lysine specific demethylase 5A 0.0024 0.0075 0.0075
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0021 0.0058 0.0901
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Brugia malayi Bromodomain containing protein 0.002 0.0053 0.0114
Toxoplasma gondii melibiase subfamily protein 0.0059 0.0254 0.3946
Loa Loa (eye worm) inositol-1 0.0021 0.0058 0.0058
Echinococcus multilocularis regulator of G protein signaling 3 0.0013 0.0017 0.0017
Echinococcus multilocularis Regulator of G protein signaling 20 0.0013 0.0017 0.0017
Mycobacterium ulcerans aminopeptidase N PepN 0.0104 0.0483 0.2502
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0013 0.0017 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Brugia malayi PXA domain containing protein 0.0013 0.0017 0.0036
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Brugia malayi TATA binding protein associated factor 0.0104 0.0483 0.1055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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