Detailed information for compound 2075877

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.431 | Formula: C22H24F4N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.75 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.Fc1ccc(cc1)N1CCC2(CC1)OCC(C2)OCc1cccnc1
  • InChi: 1S/C20H23FN2O2.C2HF3O2/c21-17-3-5-18(6-4-17)23-10-7-20(8-11-23)12-19(15-25-20)24-14-16-2-1-9-22-13-16;3-2(4,5)1(6)7/h1-6,9,13,19H,7-8,10-12,14-15H2;(H,6,7)
  • InChiKey: GTUALFVJZKGZAY-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0104 0.0483 0.752
Brugia malayi hypothetical protein 0.0011 0.0007 0.0015
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Brugia malayi A-kinase anchor protein 10, precursor 0.0013 0.0017 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.002 0.0053 0.0052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0029 0.0097 0.0096
Toxoplasma gondii aminopeptidase n, putative 0.0104 0.0483 0.752
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0021 0.0058 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0353 0.1761 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.022 0.0219
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0056 0.0056
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0021 0.0058 0.0251
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.0337 0.0337
Entamoeba histolytica serine/threonine protein kinase, putative 0.0066 0.0285 0.5763
Brugia malayi hypothetical protein 0.09 0.457 1
Brugia malayi Dihydrofolate reductase 0.0353 0.1761 0.3854
Echinococcus granulosus dihydrofolate reductase 0.0353 0.1761 0.1761
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0059 0.0254 0.0253
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0128 0.0128
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0128 0.0128
Echinococcus granulosus PHD finger protein rhinoceros 0.002 0.0053 0.0053
Echinococcus granulosus beta-adrenergic receptor kinase 0.0014 0.0018 0.0018
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0013 0.0017 0.0017
Onchocerca volvulus 0.0034 0.0126 0.0884
Echinococcus multilocularis beta adrenergic receptor kinase 0.0014 0.0018 0.0018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0129 0.0128
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0128 0.0128
Brugia malayi Pre-SET motif family protein 0.0239 0.1175 0.2571
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0056 0.0238
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0019 0.0292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.022 0.022
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0021 0.0058 0.0901
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0058 0.0901
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.002 0.0051 0.0719
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0104 0.0483 0.752
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0014 0.0018 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0026 0.0085 0.0084
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0034 0.0122 0.0122
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0104 0.0483 0.752
Schistosoma mansoni cpg binding protein 0.0035 0.0129 0.0128
Trichomonas vaginalis glutaminase, putative 0.0332 0.1653 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0032 0.0113 0.0113
Trypanosoma cruzi Aminopeptidase M1, putative 0.0104 0.0483 0.752
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0014 0.0019 0.0292
Loa Loa (eye worm) MH2 domain-containing protein 0.0083 0.0374 0.0374
Schistosoma mansoni hypothetical protein 0.002 0.0053 0.0052
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0032 0.0113 0.064
Leishmania major hypothetical protein, conserved 0.0014 0.0019 0.0292
Brugia malayi PXA domain containing protein 0.0013 0.0017 0.0036
Schistosoma mansoni hypothetical protein 0.0215 0.1055 0.1055
Brugia malayi hypothetical protein 0.0104 0.0483 0.1055
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.0113 0.0336
Echinococcus multilocularis lysosomal alpha glucosidase 0.0089 0.0408 0.0408
Echinococcus multilocularis RUN 0.0011 0.0007 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0017 0.0034 0.0034
Echinococcus multilocularis sodium bile acid cotransporter 0.0094 0.0431 0.0431
Echinococcus granulosus regulator of G protein signaling 3 0.0013 0.0017 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0056 0.0866
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0032 0.0113 0.0113
Trichomonas vaginalis maltase-glucoamylase, putative 0.002 0.0051 0.0205
Toxoplasma gondii melibiase subfamily protein 0.0059 0.0254 0.3946
Echinococcus multilocularis geminin 0.0215 0.1055 0.1055
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.004 0.0152 0.0825
Trypanosoma cruzi polo-like protein kinase, putative 0.0066 0.0285 0.4444
Loa Loa (eye worm) hypothetical protein 0.0029 0.0097 0.0096
Loa Loa (eye worm) hypothetical protein 0.0071 0.0313 0.0313
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Echinococcus granulosus lamin dm0 0.0034 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0104 0.0483 0.0482
Leishmania major alpha glucosidase II subunit, putative 0.002 0.0051 0.0782
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0013 0.0017 0.0017
Echinococcus granulosus axis inhibition protein axin 0.0013 0.0017 0.0017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0032 0.0113 0.1758
Onchocerca volvulus 0.0035 0.0128 0.0902
Schistosoma mansoni sodium-bile acid cotransporter related 0.0094 0.0431 0.0431
Trypanosoma brucei polo-like protein kinase 0.0066 0.0285 0.4444
Brugia malayi Bromodomain containing protein 0.002 0.0053 0.0114
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.003
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0019 0.0292
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.003
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0104 0.0483 0.0482
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0104 0.0483 0.752
Brugia malayi hypothetical protein 0.0104 0.0483 0.1055
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0032 0.0113 0.0113
Echinococcus multilocularis PHD finger protein rhinoceros 0.002 0.0053 0.0053
Echinococcus granulosus geminin 0.0215 0.1055 0.1055
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0104 0.0483 0.0482
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Echinococcus granulosus peregrin 0.002 0.0053 0.0053
Brugia malayi Glycosyl hydrolases family 31 protein 0.002 0.0051 0.011
Loa Loa (eye worm) glutaminase 2 0.0332 0.1653 0.1653
Onchocerca volvulus Alhambra homolog 0.002 0.0053 0.0339
Brugia malayi Glycosyl hydrolases family 31 protein 0.0089 0.0408 0.0891
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0104 0.0483 0.752
Plasmodium vivax SET domain protein, putative 0.0035 0.0128 0.1989
Schistosoma mansoni dihydrofolate reductase 0.0353 0.1761 0.1761
Schistosoma mansoni loxhd1 0.0011 0.0007 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0066 0.0285 0.4444
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0011 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0056 0.0866
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0056 0.0866
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0032 0.0113 0.0113
Brugia malayi cytoplasmic intermediate filament protein 0.0018 0.0044 0.0094
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Echinococcus granulosus lamin 0.0034 0.0126 0.0126
Echinococcus granulosus neutral alpha glucosidase AB 0.002 0.0051 0.0051
Brugia malayi hypothetical protein 0.0014 0.0019 0.0041
Loa Loa (eye worm) RGS-3 protein 0.0013 0.0017 0.0017
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0014 0.0018 0.0039
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0115 0.0601
Brugia malayi glutaminase DH11.1 0.0332 0.1653 0.3617
Echinococcus multilocularis regulator of G protein signaling 7 0.0013 0.0017 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0115 0.0601
Brugia malayi Regulator of G protein signaling domain containing protein 0.0013 0.0017 0.0036
Chlamydia trachomatis dihydrofolate reductase 0.0353 0.1761 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.002 0.0051 0.0719
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0014 0.0018 0.0018
Loa Loa (eye worm) TATA binding protein associated factor 0.0104 0.0483 0.0482
Plasmodium falciparum LCCL domain-containing protein 0.0011 0.0007 0.0109
Toxoplasma gondii aminopeptidase N protein 0.0104 0.0483 0.752
Loa Loa (eye worm) aminopeptidase N 0.0104 0.0483 0.0482
Loa Loa (eye worm) PXA domain-containing protein 0.0013 0.0017 0.0017
Echinococcus multilocularis cpg binding protein 0.0037 0.0139 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0128 0.0128
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0066 0.0285 0.0285
Echinococcus granulosus aminopeptidase N 0.0104 0.0483 0.0483
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1957 1 1
Loa Loa (eye worm) intermediate filament protein 0.0034 0.0126 0.0125
Brugia malayi TATA binding protein associated factor 0.0104 0.0483 0.1055
Schistosoma mansoni lamin 0.0034 0.0126 0.0125
Brugia malayi regulator of G-protein signaling egl-10 0.0013 0.0017 0.0036
Echinococcus multilocularis regulator of G protein signaling 3 0.0013 0.0017 0.0017
Brugia malayi regulator of G-protein signaling rgs-7 0.0013 0.0017 0.0036
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0007 0.0007
Schistosoma mansoni rab6-interacting 0.0011 0.0007 0.0007
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0104 0.0483 0.752
Loa Loa (eye worm) hypothetical protein 0.0104 0.0483 0.0482
Echinococcus granulosus RUN 0.0011 0.0007 0.0007
Schistosoma mansoni jumonji domain containing protein 0.0053 0.0219 0.0219
Schistosoma mansoni alpha-glucosidase 0.0077 0.0344 0.0343
Echinococcus granulosus Polycystic kidney disease protein 0.0011 0.0007 0.0007
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Toxoplasma gondii exonuclease III APE 0.0021 0.0056 0.0866
Echinococcus granulosus sodium bile acid cotransporter 0.0094 0.0431 0.0431
Brugia malayi jmjC domain containing protein 0.0026 0.0085 0.0185
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0007
Schistosoma mansoni ap endonuclease 0.0021 0.0056 0.0056
Trypanosoma cruzi aminopeptidase, putative 0.0104 0.0483 0.752
Echinococcus multilocularis regulator of G protein signaling 7 0.0013 0.0017 0.0017
Echinococcus granulosus lysosomal alpha glucosidase 0.0089 0.0408 0.0408
Echinococcus multilocularis lamin dm0 0.0034 0.0126 0.0126
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0013 0.0017 0.0017
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0066 0.0285 0.0285
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.002 0.0051 0.0205
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0104 0.0483 0.752
Brugia malayi intermediate filament protein 0.0034 0.0126 0.0274
Schistosoma mansoni alpha glucosidase 0.002 0.0051 0.005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.004 0.0152 0.0152
Schistosoma mansoni rab6-interacting 0.0011 0.0007 0.0007
Echinococcus multilocularis peregrin 0.002 0.0053 0.0053
Brugia malayi serine/threonine-protein kinase plk-2 0.0066 0.0285 0.0624
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0056 0.0866
Loa Loa (eye worm) hypothetical protein 0.0035 0.0128 0.0128
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Plasmodium vivax ataxin-2 like protein, putative 0.0014 0.0019 0.0292
Schistosoma mansoni microtubule-associated protein tau 0.0391 0.1957 0.1957
Brugia malayi jmjC domain containing protein 0.0066 0.0289 0.0632
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0044 0.0096
Brugia malayi Pre-SET motif family protein 0.0035 0.0128 0.0279
Schistosoma mansoni hypothetical protein 0.002 0.005 0.0049
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0007 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0056 0.0866
Echinococcus granulosus inositol monophosphatase 1 0.0021 0.0058 0.0058
Brugia malayi Angiotensin-converting enzyme family protein 0.0376 0.1879 0.4112
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0104 0.0483 0.752
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.0113 0.0336
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0013 0.0017 0.0036
Brugia malayi PXA domain containing protein 0.0013 0.0017 0.0036
Echinococcus multilocularis jumonji domain containing protein 0.0028 0.0093 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0032 0.0113 0.0336
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0104 0.0483 0.752
Onchocerca volvulus 0.0052 0.0214 0.1547
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Echinococcus multilocularis Regulator of G protein signaling 20 0.0013 0.0017 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.022 0.0219
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0019 0.0047 0.0263
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1957 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.022 0.022
Onchocerca volvulus Huntingtin homolog 0.0071 0.0313 0.2288
Schistosoma mansoni cpg binding protein 0.0037 0.0139 0.0139
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0059 0.0254 0.0254
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0056 0.0142
Loa Loa (eye worm) hypothetical protein 0.004 0.0152 0.0152
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0163 0.0163
Echinococcus multilocularis axis inhibition protein axin 0.0013 0.0017 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0058 0.0901
Schistosoma mansoni alpha-glucosidase 0.0077 0.0344 0.0343
Trypanosoma cruzi aminopeptidase, putative 0.0104 0.0483 0.752
Loa Loa (eye worm) peptidase family M1 containing protein 0.0104 0.0483 0.0482
Echinococcus multilocularis inositol monophosphatase 1 0.0021 0.0058 0.0058
Brugia malayi Peptidase family M1 containing protein 0.0104 0.0483 0.1055
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0018 0.0018
Brugia malayi latrophilin 2 splice variant baaae 0.002 0.005 0.0108
Echinococcus granulosus expressed protein 0.0259 0.1279 0.1279
Brugia malayi hypothetical protein 0.0071 0.0313 0.0685
Echinococcus multilocularis lysosomal alpha glucosidase 0.0089 0.0408 0.0408
Schistosoma mansoni hypothetical protein 0.0215 0.1055 0.1055
Brugia malayi MH2 domain containing protein 0.0083 0.0374 0.0818
Echinococcus multilocularis dnaJ subfamily B 0.0216 0.1057 0.1057
Onchocerca volvulus 0.0034 0.0126 0.0884
Onchocerca volvulus 0.0094 0.0431 0.3172
Schistosoma mansoni aldehyde dehydrogenase 0.0032 0.0113 0.0113
Plasmodium vivax multidomain scavenger receptor, putative 0.0011 0.0007 0.0109
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0017 0.0034 0.0034
Brugia malayi Peptidase family M1 containing protein 0.0104 0.0483 0.1055
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0021 0.0058 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0018 0.0018
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0059 0.0254 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Loa Loa (eye worm) inositol-1 0.0021 0.0058 0.0058
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0104 0.0483 0.752
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0104 0.0483 0.752
Echinococcus granulosus sodium bile acid cotransporter 0.0094 0.0431 0.0431
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0051 0.0782
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0021 0.0058 0.0883
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0353 0.1761 1
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0053 0.0814
Onchocerca volvulus 0.0035 0.0129 0.0909
Brugia malayi PHD-finger family protein 0.002 0.0053 0.0114
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Echinococcus granulosus microtubule associated protein 2 0.0391 0.1957 0.1957
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0104 0.0483 0.0482
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0126
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0066 0.0285 0.4444
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0128 0.0128
Schistosoma mansoni aldehyde dehydrogenase 0.0032 0.0113 0.0113
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0059 0.0254 0.0254
Schistosoma mansoni glutaminase 0.0332 0.1653 0.1653
Brugia malayi hypothetical protein 0.0011 0.0007 0.0015
Schistosoma mansoni axis inhibition protein axin 0.0013 0.0017 0.0017
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0059 0.0254 0.0253
Brugia malayi CXXC zinc finger family protein 0.0035 0.0129 0.0281
Mycobacterium ulcerans aminopeptidase N PepN 0.0104 0.0483 0.2502
Trichomonas vaginalis set domain proteins, putative 0.0272 0.1344 0.8111
Loa Loa (eye worm) dihydrofolate reductase 0.0353 0.1761 0.1761
Trichomonas vaginalis sucrase-isomaltase, putative 0.002 0.0051 0.0205
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0029 0.0097 0.021
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1957 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0024 0.0075 0.0075
Brugia malayi Sodium Bile acid symporter family protein 0.0094 0.0431 0.0943
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0128 0.0128
Echinococcus multilocularis axis inhibition protein axin 0.0013 0.0017 0.0017
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0011 0.0011
Brugia malayi dihydrofolate reductase family protein 0.0353 0.1761 0.3854
Echinococcus granulosus jumonji domain containing protein 0.0028 0.0093 0.0093
Trypanosoma brucei glucosidase, putative 0.002 0.0051 0.0782
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0053 0.0814
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0104 0.0483 0.752
Echinococcus granulosus cpg binding protein 0.0037 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0071 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0052
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0066 0.0285 0.0285
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.002 0.0051 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0085 0.0084
Toxoplasma gondii aldehyde dehydrogenase 0.0032 0.0113 0.1758
Schistosoma mansoni intermediate filament proteins 0.0034 0.0126 0.0125
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0056 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0014 0.0019 0.0292
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0089 0.0408 0.0407
Echinococcus multilocularis sodium bile acid cotransporter 0.0094 0.0431 0.0431
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.1175 0.1175
Onchocerca volvulus Huntingtin homolog 0.0071 0.0313 0.2288
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.0049
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0128 0.1989
Echinococcus multilocularis dihydrofolate reductase 0.0353 0.1761 0.1761
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0297 0.4616
Echinococcus multilocularis neutral alpha glucosidase AB 0.002 0.0051 0.0051
Brugia malayi hypothetical protein 0.0013 0.0017 0.0036
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0104 0.0483 0.2846
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0013 0.0017 0.0017
Schistosoma mansoni aminopeptidase A (M01 family) 0.0104 0.0483 0.0482
Loa Loa (eye worm) hypothetical protein 0.0094 0.0431 0.0431
Brugia malayi Inositol-1 0.0021 0.0058 0.0126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.022 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0051 0.0782
Echinococcus multilocularis sodium bile acid cotransporter 0.0094 0.0431 0.0431
Schistosoma mansoni hypothetical protein 0.0216 0.1057 0.1056
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.022 0.0219
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.002 0.0051 0.0782
Schistosoma mansoni kinase 0.0033 0.012 0.0119
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0056 0.0056
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.004 0.0152 0.0152
Schistosoma mansoni cpg binding protein 0.0037 0.0139 0.0139
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0056 0.0238
Onchocerca volvulus 0.0272 0.1344 1
Echinococcus granulosus axis inhibition protein axin 0.0013 0.0017 0.0017
Entamoeba histolytica aminopeptidase, putative 0.0104 0.0483 1
Echinococcus granulosus regulator of G protein signaling 3 0.0013 0.0017 0.0017
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0007 0.0007
Echinococcus multilocularis lamin 0.0034 0.0126 0.0126
Schistosoma mansoni sodium-bile acid cotransporter related 0.0038 0.0145 0.0144
Mycobacterium ulcerans aminopeptidase N PepN 0.0104 0.0483 0.2502
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0376 0.1879 0.1879
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0034 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0026 0.0085 0.0084
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0013 0.0017 0.0017
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0066 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.0104 0.0483 0.0482
Loa Loa (eye worm) hypothetical protein 0.0034 0.0126 0.0125
Echinococcus multilocularis regulator of G protein signaling 3 0.0013 0.0017 0.0017
Toxoplasma gondii LsmAD domain-containing protein 0.0014 0.0019 0.0292
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0056 0.0315
Echinococcus granulosus sodium bile acid cotransporter 0.0094 0.0431 0.0431
Brugia malayi Peptidase family M1 containing protein 0.0104 0.0483 0.1055
Echinococcus granulosus intermediate filament protein 0.0034 0.0126 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0018 0.0018
Schistosoma mansoni sodium-bile acid cotransporter 0.0056 0.0236 0.0235
Mycobacterium ulcerans glutaminase 0.0332 0.1653 0.9366
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0058 0.0901
Trypanosoma cruzi PAB1-binding protein , putative 0.0014 0.0019 0.0292
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.022 0.022
Schistosoma mansoni lamin 0.0034 0.0126 0.0125
Loa Loa (eye worm) doublecortin family protein 0.0011 0.0007 0.0007
Trypanosoma brucei aminopeptidase, putative 0.0104 0.0483 0.752
Schistosoma mansoni inositol monophosphatase 0.0021 0.0058 0.0058
Schistosoma mansoni axis inhibition protein axin 0.0013 0.0017 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Brugia malayi Calcitonin receptor-like protein seb-1 0.0029 0.0097 0.021
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0013 0.0017 0.0017
Brugia malayi Melibiase family protein 0.004 0.0152 0.0332
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0353 0.1761 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0104 0.0483 0.752
Onchocerca volvulus Serine\/threonine kinase homolog 0.0066 0.0285 0.208
Loa Loa (eye worm) hypothetical protein 0.0017 0.0034 0.0034
Brugia malayi Intermediate filament tail domain containing protein 0.0034 0.0126 0.0274
Echinococcus multilocularis aminopeptidase N 0.0104 0.0483 0.0483
Giardia lamblia Kinase, PLK 0.0066 0.0285 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0059 0.0254 0.0253
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0021 0.0058 0.0901
Schistosoma mansoni inositol monophosphatase 0.0021 0.0058 0.0058
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0104 0.0483 0.0483
Loa Loa (eye worm) glutaminase 0.0332 0.1653 0.1653
Echinococcus multilocularis microtubule associated protein 2 0.0391 0.1957 0.1957
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0017
Schistosoma mansoni polycystin 1-related 0.0011 0.0007 0.0007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0066 0.0289 0.0289
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0018 0.0044 0.0043
Onchocerca volvulus 0.0104 0.0483 0.3556
Onchocerca volvulus 0.0104 0.0483 0.3556
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0128 0.0128
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0056 0.0122
Echinococcus granulosus lysine specific demethylase 5A 0.0026 0.0085 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0285 0.0285
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0135 0.0642 1
Brugia malayi hypothetical protein 0.0013 0.0017 0.0036
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0053 0.0052
Onchocerca volvulus 0.0104 0.0483 0.3556
Echinococcus granulosus dnaJ subfamily B 0.0216 0.1057 0.1057
Echinococcus multilocularis Polycystic kidney disease protein 0.0011 0.0007 0.0007
Echinococcus multilocularis musashi 0.0034 0.0126 0.0126
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0059 0.0254 0.0254
Echinococcus granulosus regulator of G protein signaling 7 0.0013 0.0017 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0056 0.0835
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0056 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.002 0.0051 0.0205
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0104 0.0483 0.2846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.022 0.0219
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.022 0.048
Echinococcus granulosus Regulator of G protein signaling 20 0.0013 0.0017 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0285 0.164
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0104 0.0483 0.0483
Trichomonas vaginalis inositol monophosphatase, putative 0.0021 0.0058 0.0251
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.002 0.0051 0.0205
Echinococcus multilocularis regulator of G protein signaling 0.0013 0.0017 0.0017
Schistosoma mansoni z-protein (S1r protein) 0.0013 0.0017 0.0017
Loa Loa (eye worm) transcription factor SMAD2 0.0083 0.0374 0.0374
Echinococcus multilocularis expressed protein 0.0259 0.1279 0.1279
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0011 0.0011
Schistosoma mansoni ap endonuclease 0.0021 0.0056 0.0056
Plasmodium falciparum phd finger protein, putative 0.002 0.0053 0.0814
Toxoplasma gondii aminopeptidase N, putative 0.0104 0.0483 0.752
Schistosoma mansoni lipoxygenase 0.0011 0.0007 0.0007
Brugia malayi Doublecortin family protein 0.0011 0.0007 0.0015
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0034 0.0126 0.0125
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1384 0.7055 0.7055
Schistosoma mansoni lipoxygenase 0.0032 0.0113 0.0113
Plasmodium vivax hypothetical protein, conserved 0.002 0.0053 0.0814
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0104 0.0483 0.752
Echinococcus granulosus regulator of G protein signaling 7 0.0013 0.0017 0.0017
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0021 0.0058 0.0251
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0104 0.0483 0.752
Trypanosoma brucei Aminopeptidase M1, putative 0.0104 0.0483 0.752
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0056 0.0866
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0017 0.0017
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0135 0.0642 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0104 0.0483 0.2846

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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