Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0021 | 0.0033 | 0.0059 |
Mycobacterium ulcerans | glutaminase | 0.0158 | 0.3065 | 0.4114 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0194 | 0.3871 | 0.4692 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0021 | 0.0033 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1137 | 0.1437 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0022 | 0.005 | 0.0061 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0194 | 0.3871 | 0.4892 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.005 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0733 | 0.0888 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0184 | 0.3641 | 0.4602 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0184 | 0.3641 | 0.3641 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0059 | 0.0878 | 0.1064 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0376 | 0.7913 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0353 | 0.7403 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0353 | 0.7403 | 0.9356 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0353 | 0.7403 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0021 | 0.0033 | 0.6566 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0194 | 0.3871 | 0.4692 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.005 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0318 | 0.0318 |
Brugia malayi | hypothetical protein | 0.0022 | 0.005 | 0.0064 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0733 | 0.0926 |
Echinococcus granulosus | dihydrofolate reductase | 0.0353 | 0.7403 | 0.8972 |
Onchocerca volvulus | Huntingtin homolog | 0.0071 | 0.1137 | 0.1556 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0032 | 0.027 | 0.0328 |
Toxoplasma gondii | melibiase subfamily protein | 0.0059 | 0.0878 | 0.3433 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0733 | 0.0888 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0733 | 0.0888 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0318 | 0.1244 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2558 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.3641 | 0.4602 |
Brugia malayi | hypothetical protein | 0.0071 | 0.1137 | 0.1437 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0059 | 0.0878 | 0.0878 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.1732 | 0.21 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.004 | 0.0439 | 0.0786 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0059 | 0.0878 | 0.1064 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0184 | 0.3641 | 0.4413 |
Brugia malayi | Pre-SET motif family protein | 0.0238 | 0.4849 | 0.6129 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0021 | 0.0033 | 0.0129 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0733 | 0.0733 |
Schistosoma mansoni | alpha-glucosidase | 0.0077 | 0.1268 | 0.1537 |
Echinococcus multilocularis | geminin | 0.0098 | 0.1732 | 0.1732 |
Schistosoma mansoni | dihydrofolate reductase | 0.0353 | 0.7403 | 0.8972 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0733 | 0.0733 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0021 | 0.0033 | 0.0129 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2558 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0318 | 0.0318 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0089 | 0.1545 | 0.1545 |
Loa Loa (eye worm) | glutaminase | 0.0158 | 0.3065 | 0.3873 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0089 | 0.1545 | 0.1545 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0021 | 0.0033 | 0.004 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0089 | 0.1545 | 0.1872 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0135 | 0.2558 | 1 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.0376 | 0.7913 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.004 | 0.0439 | 0.0532 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0184 | 0.3641 | 0.4413 |
Onchocerca volvulus | Huntingtin homolog | 0.0071 | 0.1137 | 0.1556 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0353 | 0.7403 | 0.7403 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0391 | 0.8251 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0184 | 0.3641 | 0.3641 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0439 | 0.0555 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0353 | 0.7403 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0353 | 0.7403 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0021 | 0.0033 | 0.0129 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0021 | 0.0033 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0021 | 0.0033 | 0.0059 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0059 | 0.0878 | 0.1064 |
Onchocerca volvulus | 0.0271 | 0.558 | 1 | |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0109 | 0.1986 | 0.2407 |
Brugia malayi | glutaminase DH11.1 | 0.0158 | 0.3065 | 0.3873 |
Onchocerca volvulus | 0.0052 | 0.0708 | 0.074 | |
Brugia malayi | Inositol-1 | 0.0021 | 0.0033 | 0.0042 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0733 | 0.0926 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0391 | 0.8251 | 0.8251 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0059 | 0.0878 | 0.1064 |
Trichomonas vaginalis | set domain proteins, putative | 0.0271 | 0.558 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0059 | 0.0878 | 0.1064 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0238 | 0.4849 | 0.6129 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.005 | 0.0061 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0318 | 0.0386 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.005 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0318 | 0.0386 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0318 | 0.0402 |
Schistosoma mansoni | lipoxygenase | 0.0032 | 0.027 | 0.0328 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0029 | 0.0199 | 0.0251 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0029 | 0.0199 | 0.0251 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0089 | 0.1545 | 0.1952 |
Loa Loa (eye worm) | inositol-1 | 0.0021 | 0.0033 | 0.0042 |
Brugia malayi | Dihydrofolate reductase | 0.0353 | 0.7403 | 0.9356 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0021 | 0.0033 | 0.0129 |
Trichomonas vaginalis | glutaminase, putative | 0.0158 | 0.3065 | 0.5492 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.1732 | 0.21 |
Brugia malayi | hypothetical protein | 0.0089 | 0.1542 | 0.1948 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.004 | 0.0439 | 0.0532 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.029 | 0.0352 |
Entamoeba histolytica | hypothetical protein | 0.0022 | 0.005 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0184 | 0.3641 | 0.3641 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0318 | 0.0386 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0022 | 0.005 | 0.005 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0021 | 0.0033 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0318 | 0.0402 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0074 | 0.1215 | 0.1472 |
Brugia malayi | dihydrofolate reductase family protein | 0.0353 | 0.7403 | 0.9356 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0184 | 0.3641 | 0.4413 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0318 | 0.0386 |
Schistosoma mansoni | inositol monophosphatase | 0.0021 | 0.0033 | 0.004 |
Schistosoma mansoni | alpha-glucosidase | 0.0077 | 0.1268 | 0.1537 |
Schistosoma mansoni | glutaminase | 0.0158 | 0.3065 | 0.3714 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0089 | 0.1545 | 0.1952 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0194 | 0.3871 | 0.3871 |
Schistosoma mansoni | inositol monophosphatase | 0.0021 | 0.0033 | 0.004 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0184 | 0.3641 | 0.4413 |
Loa Loa (eye worm) | glutaminase 2 | 0.0158 | 0.3065 | 0.3873 |
Echinococcus granulosus | geminin | 0.0098 | 0.1732 | 0.21 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0318 | 0.0386 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0391 | 0.8251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1137 | 0.1437 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2558 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0021 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0199 | 0.0251 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0022 | 0.005 | 0.0061 |
Brugia malayi | Melibiase family protein | 0.004 | 0.0439 | 0.0555 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0059 | 0.0878 | 0.0878 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2558 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0029 | 0.0199 | 0.0251 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0135 | 0.2558 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0032 | 0.027 | 0.027 |
Onchocerca volvulus | 0.0184 | 0.3641 | 0.6315 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0733 | 0.0888 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0733 | 0.0888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.