Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | coup transcription factor | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Onchocerca volvulus | 0.0494 | 1 | 1 | |
Echinococcus multilocularis | neurogenic locus notch protein | 0.008 | 0.1175 | 0.1166 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0233 | 0.4434 | 0.4434 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0494 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0052 | 0.0573 | 0.5 |
Onchocerca volvulus | 0.0233 | 0.4434 | 0.4428 | |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Schistosoma mansoni | nuclear hormone receptor | 0.0494 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0494 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0233 | 0.4434 | 0.4428 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0494 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0494 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | conserved hypotetical protein | 0.0233 | 0.4434 | 0.4428 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.001 | 0.001 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0494 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0233 | 0.4434 | 0.4428 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0233 | 0.4434 | 0.4428 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0052 | 0.0573 | 0.5 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0233 | 0.4434 | 0.4428 |
Schistosoma mansoni | slit | 0.008 | 0.1175 | 0.1166 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0233 | 0.4434 | 0.4428 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0494 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.001 | 0.001 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0261 | 0.503 | 0.5025 |
Brugia malayi | EGF-like domain containing protein | 0.008 | 0.1175 | 0.1166 |
Schistosoma mansoni | thyroid hormone receptor | 0.0494 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Loa Loa (eye worm) | DR-78 | 0.0233 | 0.4434 | 0.4434 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1175 | 0.1175 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0494 | 1 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0052 | 0.0573 | 0.0564 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0494 | 1 | 1 |
Echinococcus multilocularis | pikachurin | 0.008 | 0.1175 | 0.1166 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0494 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0494 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0494 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0233 | 0.4434 | 0.4428 |
Loa Loa (eye worm) | abnormal epIthelia family member | 0.008 | 0.1175 | 0.1175 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Brugia malayi | nuclear hormone receptor | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.503 | 0.503 |
Schistosoma mansoni | nuclear hormone receptor | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0261 | 0.503 | 0.5025 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0261 | 0.503 | 0.503 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0494 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0052 | 0.0573 | 0.5 |
Schistosoma mansoni | cell polarity protein | 0.008 | 0.1175 | 0.1166 |
Brugia malayi | ecdysone receptor | 0.0233 | 0.4434 | 0.4428 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0494 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0233 | 0.4434 | 0.4428 |
Echinococcus granulosus | pikachurin | 0.008 | 0.1175 | 0.1166 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0494 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0494 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0233 | 0.4434 | 0.4428 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0052 | 0.0573 | 0.0573 |
Brugia malayi | hypothetical protein | 0.0261 | 0.503 | 0.5025 |
Echinococcus granulosus | slit 2 protein | 0.008 | 0.1175 | 0.1166 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0494 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0494 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0494 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0261 | 0.503 | 0.5025 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0511 | 0.0502 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.001 | 0.001 |
Onchocerca volvulus | 0.0233 | 0.4434 | 0.4428 | |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0233 | 0.4434 | 0.4428 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0052 | 0.0573 | 0.0564 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0494 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0494 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0233 | 0.4434 | 0.4428 |
Schistosoma mansoni | zinc finger protein | 0.0233 | 0.4434 | 0.4428 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Brugia malayi | nuclear receptor NHR-88 | 0.0233 | 0.4434 | 0.4428 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1175 | 0.1175 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0233 | 0.4434 | 0.4428 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0233 | 0.4434 | 0.4428 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0494 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0233 | 0.4434 | 0.4434 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0494 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0494 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0494 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0233 | 0.4434 | 0.4428 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0261 | 0.503 | 0.5025 |
Schistosoma mansoni | nuclear hormone receptor | 0.0233 | 0.4434 | 0.4428 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0052 | 0.0573 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0494 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0494 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0052 | 0.0573 | 0.0564 |
Echinococcus granulosus | FTZ F1 alpha | 0.0494 | 1 | 1 |
Brugia malayi | laminin-like protein K08C7.3 precursor | 0.008 | 0.1175 | 0.1166 |
Echinococcus granulosus | transcription factor Dp 1 | 0.003 | 0.0106 | 0.0096 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0261 | 0.503 | 0.5025 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0233 | 0.4434 | 0.4428 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.503 | 0.503 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0233 | 0.4434 | 0.4434 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0494 | 1 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0052 | 0.0573 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0494 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0494 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0494 | 1 | 1 |
Brugia malayi | laminin alpha chain | 0.008 | 0.1175 | 0.1166 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0494 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0494 | 1 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0233 | 0.4434 | 0.4428 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0233 | 0.4434 | 0.4428 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0052 | 0.0573 | 0.0564 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0494 | 1 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.008 | 0.1175 | 0.1166 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0494 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0261 | 0.503 | 0.5025 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.003 | 0.0106 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0494 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0233 | 0.4434 | 0.4428 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0261 | 0.503 | 0.5025 |
Schistosoma mansoni | thyroid hormone receptor | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1175 | 0.1175 |
Echinococcus granulosus | neurogenic locus notch protein | 0.008 | 0.1175 | 0.1166 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0261 | 0.503 | 0.5025 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.503 | 0.503 |
Schistosoma mansoni | laminin gamma-3 chain | 0.008 | 0.1175 | 0.1166 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0233 | 0.4434 | 0.4428 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0494 | 1 | 1 |
Brugia malayi | Thrombospondin N-terminal -like domain containing protein | 0.008 | 0.1175 | 0.1166 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 1 | 1 |
Brugia malayi | tailless protein | 0.0233 | 0.4434 | 0.4428 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.4434 | 0.4434 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.503 | 0.503 |
Schistosoma mansoni | chondroitin sulfate proteoglycan-related | 0.008 | 0.1175 | 0.1166 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.503 | 0.503 |
Brugia malayi | nuclear receptor NHR-88 | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0494 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0233 | 0.4434 | 0.4428 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0233 | 0.4434 | 0.4428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.