Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0387 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.0356 | 0.054 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0014 | 0.0229 | 0.0347 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.0356 | 0.054 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0071 | 0.1715 | 0.2615 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0006 | 0.0002 | 0.0003 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0013 | 0.0209 | 0.0315 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0044 | 0.1021 | 0.1533 |
Trypanosoma brucei | hypothetical protein | 0.0365 | 0.9441 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0023 | 0.0461 | 0.069 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C2, putative | 0.0365 | 0.9441 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0023 | 0.0461 | 0.069 |
Echinococcus multilocularis | RUN | 0.0016 | 0.0271 | 0.0405 |
Onchocerca volvulus | 0.0016 | 0.0271 | 0.5074 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.0356 | 0.0354 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0019 | 0.0356 | 0.0375 |
Schistosoma mansoni | lipoxygenase | 0.0016 | 0.0271 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0354 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0271 | 0.027 |
Loa Loa (eye worm) | doublecortin family protein | 0.0016 | 0.0271 | 0.027 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0011 | 0.0147 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0229 | 0.0227 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.0365 | 0.9441 | 1 |
Brugia malayi | Doublecortin family protein | 0.0016 | 0.0271 | 0.027 |
Brugia malayi | NC domain containing protein | 0.0026 | 0.0533 | 0.0531 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0071 | 0.1715 | 0.2575 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0019 | 0.0356 | 0.0375 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0019 | 0.0356 | 0.2267 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0533 | 0.0531 |
Trichomonas vaginalis | histone acetyltransferase gcn5, putative | 0.0011 | 0.0139 | 0.0799 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0044 | 0.1021 | 0.1533 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.023 | 0.5896 | 0.5895 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.0356 | 0.0354 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0011 | 0.0147 | 0.0219 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0016 | 0.0271 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0147 | 0.0145 |
Schistosoma mansoni | polycystin 1-related | 0.0016 | 0.0271 | 0.0405 |
Trypanosoma brucei | calpain, putative | 0.0365 | 0.9441 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0012 | 0.018 | 0.0178 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0023 | 0.0461 | 0.0459 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0013 | 0.0209 | 0.0315 |
Echinococcus granulosus | RUN | 0.0016 | 0.0271 | 0.0405 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0014 | 0.0229 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0354 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0033 | 0.0725 | 0.4621 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0219 | 0.5612 | 0.8434 |
Echinococcus granulosus | intermediate filament protein | 0.0023 | 0.0461 | 0.069 |
Onchocerca volvulus | 0.0019 | 0.0356 | 0.6662 | |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0255 | 0.6557 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0016 | 0.0271 | 0.0405 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0014 | 0.0229 | 0.0347 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0255 | 0.6557 | 1 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0006 | 0.0002 | 0.0011 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0033 | 0.0725 | 0.4621 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.023 | 0.5896 | 0.8861 |
Trichomonas vaginalis | histone acetyltransferase gcn5, putative | 0.0011 | 0.0139 | 0.0799 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0136 | 0.0134 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.023 | 0.5896 | 0.8861 |
Schistosoma mansoni | lipoxygenase | 0.0044 | 0.1021 | 0.1533 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.045 | 0.0448 |
Onchocerca volvulus | 0.0016 | 0.0271 | 0.5074 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0229 | 0.0227 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0019 | 0.0356 | 0.2267 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0365 | 0.9441 | 1 |
Echinococcus multilocularis | lamin | 0.0023 | 0.0461 | 0.069 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.0356 | 0.054 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0016 | 0.0271 | 0.0405 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0271 | 0.0405 |
Schistosoma mansoni | rab6-interacting | 0.0016 | 0.0271 | 0.0405 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0065 | 0.1569 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0065 | 0.1569 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0019 | 0.0356 | 0.054 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0255 | 0.6557 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0019 | 0.0356 | 0.054 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0013 | 0.0209 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0271 | 0.027 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0271 | 0.027 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0071 | 0.1715 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0259 | 0.6653 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0259 | 0.6653 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0023 | 0.0461 | 0.0459 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0016 | 0.0271 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0136 | 0.0134 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0356 | 0.054 |
Schistosoma mansoni | rab6-interacting | 0.0016 | 0.0271 | 0.0405 |
Onchocerca volvulus | 0.0023 | 0.0461 | 0.8644 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0012 | 0.018 | 0.0178 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0255 | 0.6557 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0255 | 0.6557 | 1 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0365 | 0.9441 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0365 | 0.9441 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0365 | 0.9441 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.0365 | 0.9441 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0016 | 0.0271 | 0.0405 |
Schistosoma mansoni | intermediate filament proteins | 0.0023 | 0.0461 | 0.069 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0019 | 0.0356 | 0.2267 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0229 | 0.0227 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0013 | 0.0209 | 0.0315 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0259 | 0.6653 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0016 | 0.0271 | 0.0405 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0354 |
Schistosoma mansoni | lamin | 0.0023 | 0.0461 | 0.069 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0016 | 0.0271 | 0.0414 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0023 | 0.0461 | 0.0459 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0006 | 0.0002 | 0.0012 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0365 | 0.9441 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0019 | 0.0356 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0019 | 0.0356 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0461 | 0.0459 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0071 | 0.1715 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0255 | 0.6557 | 1 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0365 | 0.9441 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0019 | 0.0356 | 0.054 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0271 | 0.027 |
Onchocerca volvulus | 0.0023 | 0.0461 | 0.8644 | |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0255 | 0.6557 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0019 | 0.0356 | 0.054 |
Echinococcus granulosus | lamin | 0.0023 | 0.0461 | 0.069 |
Schistosoma mansoni | lamin | 0.0023 | 0.0461 | 0.069 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0033 | 0.0725 | 0.4621 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0033 | 0.0725 | 0.4621 |
Toxoplasma gondii | propionate-CoA ligase | 0.0006 | 0.0002 | 0.0011 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0065 | 0.1569 | 0.2393 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0019 | 0.0356 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0019 | 0.0356 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0229 | 0.0227 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0365 | 0.9441 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0533 | 0.3109 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0071 | 0.1715 | 1 |
Onchocerca volvulus | UPF0528 protein homolog | 0.0026 | 0.0533 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.0365 | 0.9441 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0071 | 0.1715 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0016 | 0.0271 | 0.0405 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0033 | 0.0725 | 0.4621 |
Leishmania major | calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative | 0.0365 | 0.9441 | 1 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0006 | 0.0002 | 0.0003 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0255 | 0.6557 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0019 | 0.0356 | 0.0375 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0365 | 0.9441 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.023 | 0.5896 | 0.5895 |
Brugia malayi | intermediate filament protein | 0.0023 | 0.0461 | 0.0459 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0019 | 0.0356 | 0.054 |
Trypanosoma brucei | calpain-like protein, putative | 0.0365 | 0.9441 | 1 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0006 | 0.0002 | 0.0011 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0014 | 0.0229 | 0.0349 |
Echinococcus multilocularis | musashi | 0.0023 | 0.0461 | 0.069 |
Trypanosoma brucei | variant surface glycoprotein (VSG), putative | 0.0365 | 0.9441 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0229 | 0.0227 |
Schistosoma mansoni | loxhd1 | 0.0016 | 0.0271 | 0.0405 |
Trypanosoma brucei | calpain-like cysteine peptidase, putative | 0.0365 | 0.9441 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.