Detailed information for compound 2076058

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.753 | Formula: C13H18ClN3O3
  • H donors: 2 H acceptors: 2 LogP: 0.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)C1CNCCN1C(=O)COc1ccccc1.Cl
  • InChi: 1S/C13H17N3O3.ClH/c14-13(18)11-8-15-6-7-16(11)12(17)9-19-10-4-2-1-3-5-10;/h1-5,11,15H,6-9H2,(H2,14,18);1H
  • InChiKey: ZBGPKNZTFNZPAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax glutathione reductase, putative 0.0045 0.0441 0.7953
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0197 0.0298
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0114 0.1352 0.3488
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0102 0.1191 0.4422
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0047 0.0018
Echinococcus multilocularis synaptic glycoprotein sc2 0.0053 0.0547 0.0519
Leishmania major cytochrome p450-like protein 0.0015 0.0048 0.0008
Brugia malayi steroid hormone receptor 0.0216 0.2693 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0054 0.0202
Schistosoma mansoni thyroid hormone receptor 0.0216 0.2693 0.6834
Loa Loa (eye worm) hypothetical protein 0.0216 0.2693 0.7027
Echinococcus multilocularis lamin 0.0055 0.0571 0.0543
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0095 0.1097 0.4074
Loa Loa (eye worm) hypothetical protein 0.0025 0.0184 0.0409
Echinococcus multilocularis bloom syndrome protein 0.002 0.0116 0.0087
Schistosoma mansoni coup transcription factor 0.0216 0.2693 0.6834
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0321 0.5635
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0084 0.0738
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 1
Brugia malayi Nuclear hormone receptor-like 1 0.0216 0.2693 1
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0053 0.0547 0.6924
Loa Loa (eye worm) steroid hormone receptor 0.0216 0.2693 0.7027
Schistosoma mansoni nuclear receptor 0.0102 0.1191 0.298
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0165 0.2639
Brugia malayi exodeoxyribonuclease III family protein 0.0036 0.0321 0.1193
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0054 0.0474
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0054 0.0117
Echinococcus multilocularis nuclear receptor nhr 48 0.0102 0.1191 0.1165
Brugia malayi hypothetical protein 0.0114 0.1352 0.5019
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0063 0.0676 0.1658
Echinococcus multilocularis ecdysone induced protein 78C 0.0216 0.2693 0.2672
Brugia malayi Calcitonin receptor-like protein seb-1 0.0095 0.1097 0.4074
Loa Loa (eye worm) hypothetical protein 0.0053 0.0547 0.1366
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0036 0.0321 0.0518
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0114 0.135 1
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0048 0.0008
Onchocerca volvulus 0.0216 0.2693 1
Schistosoma mansoni ap endonuclease 0.0036 0.0321 0.0749
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0054 0.0147
Loa Loa (eye worm) hypothetical protein 0.0302 0.382 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0216 0.2693 0.4725
Onchocerca volvulus 0.0053 0.0547 0.1944
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0236 0.0875
Entamoeba histolytica hypothetical protein 0.0034 0.03 0.1007
Brugia malayi ecdysone receptor 0.0102 0.1191 0.4422
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0102 0.1191 0.436
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0216 0.2693 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0054 0.0117
Brugia malayi nuclear hormone receptor 0.0216 0.2693 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0441 0.0413
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0047 0.0175
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0053 0.0547 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0216 0.2693 0.6834
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0267 0.0628
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0114 0.1352 0.1326
Brugia malayi hypothetical protein 0.0114 0.1352 0.5019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0103 0.12 0.8844
Echinococcus multilocularis GPCR, family 2 0.003 0.0244 0.0216
Brugia malayi nuclear hormone receptor 0.0102 0.1191 0.4422
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0047 0.0018
Loa Loa (eye worm) thioredoxin reductase 0.0045 0.0441 0.1087
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0031 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0571 0.1428
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0063 0.0676 0.1146
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0196 0.2425 0.2403
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Plasmodium falciparum thioredoxin reductase 0.0045 0.0441 0.7883
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.03 0.0694
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Loa Loa (eye worm) hypothetical protein 0.0095 0.1097 0.2817
Schistosoma mansoni hypothetical protein 0.0065 0.0702 0.1727
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0216 0.2693 0.2672
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0244 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0216 0.2693 1
Schistosoma mansoni zinc finger protein 0.0102 0.1191 0.298
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0054 0.0056
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0244 0.0381
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0117
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0244 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0216 0.2693 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0048 0.0048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.03 0.048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0036 0.0321 0.4363
Loa Loa (eye worm) hypothetical protein 0.0114 0.1352 0.3488
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0036 0.0321 0.4363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0216 0.2693 0.7027
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Onchocerca volvulus Bile acid receptor homolog 0.0216 0.2693 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0036 0.0321 0.5481
Brugia malayi Nuclear hormone receptor-like 1 0.0114 0.1352 0.5019
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0047 0.0372
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0029 0.000000018506
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0114 0.1352 0.2345
Leishmania major hypothetical protein, conserved 0.0032 0.0276 0.3648
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0053 0.0547 0.1328
Echinococcus multilocularis neuropeptide receptor A26 0.0443 0.5668 0.5655
Mycobacterium ulcerans hypothetical protein 0.0053 0.0547 1
Echinococcus multilocularis lamin dm0 0.0055 0.0571 0.0543
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0047 0.0032
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0063 0.0676 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.03 0.0271
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0095 0.1097 0.2817
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0063 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1352 0.3488
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0047 0.0046
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0063 0.0676 1
Echinococcus granulosus neuropeptide s receptor 0.0443 0.5668 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0102 0.1191 0.1165
Schistosoma mansoni hypothetical protein 0.003 0.0244 0.0551
Plasmodium falciparum thioredoxin reductase 0.0016 0.0054 0.0147
Brugia malayi latrophilin 2 splice variant baaae 0.0065 0.0702 0.2608
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0063 0.0676 0.1705
Schistosoma mansoni thyroid hormone receptor 0.0216 0.2693 0.6834
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0053 0.0547 0.6924
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0048 0.0008
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0053 0.0547 0.0918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0216 0.2693 0.7027
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Loa Loa (eye worm) hypothetical protein 0.0216 0.2693 0.7027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0358
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0036 0.0321 0.4363
Schistosoma mansoni hypothetical protein 0.0161 0.197 0.498
Loa Loa (eye worm) hypothetical protein 0.0026 0.0197 0.0443
Brugia malayi hypothetical protein 0.0116 0.1373 0.5098
Echinococcus multilocularis FTZ F1 alpha 0.0216 0.2693 0.2672
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0036 0.0321 0.077
Echinococcus granulosus geminin 0.0161 0.197 0.3443
Loa Loa (eye worm) nuclear receptor NHR-67 0.0102 0.1191 0.3064
Schistosoma mansoni ap endonuclease 0.0036 0.0321 0.0749
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0102 0.1191 0.298
Loa Loa (eye worm) nuclear hormone receptor 0.0102 0.1191 0.3064
Trypanosoma brucei MATE efflux family protein, putative 0.0032 0.0276 0.3648
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0216 0.2693 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0165 0.1873
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0244 0.0216
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0114 0.135 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0102 0.1191 0.206
Loa Loa (eye worm) hypothetical protein 0.0114 0.1352 0.3488
Entamoeba histolytica hypothetical protein 0.0034 0.03 0.1007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0036 0.0321 0.0293
Brugia malayi nuclear receptor NHR-67 0.0102 0.1191 0.4422
Schistosoma mansoni nuclear hormone receptor 0.0102 0.1191 0.298
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0047 0.0047
Echinococcus granulosus Ankyrin 0.0014 0.0031 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0216 0.2693 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 0.7954
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0216 0.2693 0.6834
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0216 0.2693 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0216 0.2693 0.7027
Schistosoma mansoni lamin 0.0055 0.0571 0.1389
Brugia malayi nuclear receptor NHR-88 0.0102 0.1191 0.4422
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0031 0.0258 0.3349
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0054 0.0137
Echinococcus granulosus lamin 0.0055 0.0571 0.096
Trichomonas vaginalis rotamase, putative 0.0031 0.0258 0.4124
Loa Loa (eye worm) hypothetical protein 0.0216 0.2693 0.7027
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0547 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0216 0.2693 1
Schistosoma mansoni intermediate filament proteins 0.0055 0.0571 0.1389
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0053 0.0547 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0216 0.2693 0.2672
Schistosoma mansoni retinoic acid receptor RXR 0.031 0.3927 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.1191 0.1165
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0267 0.0993
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0571 0.1428
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0103 0.12 0.8844
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0031 0.0258 0.3349
Trypanosoma brucei trypanothione reductase 0.0045 0.0441 0.627
Trypanosoma cruzi membrane transporter protein, putative 0.0032 0.0276 0.3648
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Brugia malayi Cytochrome P450 family protein 0.0015 0.0048 0.0177
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0054 0.0474
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0045 0.0441 0.3025
Echinococcus multilocularis neuropeptide s receptor 0.0443 0.5668 0.5655
Schistosoma mansoni nuclear receptor nhr-48 0.0102 0.1191 0.298
Giardia lamblia Synaptic glycoprotein SC2 0.0053 0.0547 1
Schistosoma mansoni hypothetical protein 0.003 0.0244 0.0551
Brugia malayi Thioredoxin reductase 0.0045 0.0441 0.1638
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0441 0.627
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.003 0.0239 0.021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0216 0.2693 0.6834
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0216 0.2693 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0102 0.1191 0.1165
Echinococcus granulosus Nuclear hormone receptor HR96 0.0102 0.1191 0.206
Schistosoma mansoni nuclear receptor 0.0102 0.1191 0.298
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0216 0.2693 0.2672
Onchocerca volvulus 0.0055 0.0571 0.2032
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0276 0.3648
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.006 0.0079
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0048 0.0048
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 1
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0053 0.0547 0.7954
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0177 0.0389
Entamoeba histolytica hypothetical protein 0.0034 0.03 0.1007
Plasmodium falciparum glutathione reductase 0.0045 0.0441 0.7883
Brugia malayi hypothetical protein 0.0102 0.1191 0.4422
Trichomonas vaginalis rotamase, putative 0.0032 0.0267 0.4324
Loa Loa (eye worm) hypothetical protein 0.0065 0.0702 0.1776
Loa Loa (eye worm) DR-78 0.0102 0.1191 0.3064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0216 0.2693 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0137
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0054 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0216 0.2693 0.6834
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0276 0.3648
Toxoplasma gondii exonuclease III APE 0.0036 0.0321 0.5653
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 0.7954
Echinococcus granulosus expressed protein 0.0032 0.0267 0.0422
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0216 0.2693 0.4725
Brugia malayi intermediate filament protein 0.0055 0.0571 0.2119
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0036 0.0321 0.5418
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0065
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0063 0.0676 0.2509
Schistosoma mansoni nuclear hormone receptor 0.0102 0.1191 0.298
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0063 0.0676 1
Schistosoma mansoni nuclear hormone receptor 0.0216 0.2693 0.6834
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0103 0.12 0.8844
Brugia malayi hypothetical protein 0.0102 0.1191 0.4422
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0276 0.3648
Loa Loa (eye worm) hypothetical protein 0.0216 0.2693 0.7027
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0048 0.0008
Onchocerca volvulus 0.0102 0.1191 0.436
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0216 0.2693 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0557 0.1393
Brugia malayi Latrophilin receptor protein 2 0.003 0.0244 0.0907
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0216 0.2693 0.7027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0216 0.2693 0.6834
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0032 0.0276 0.0248
Trypanosoma brucei membrane transporter protein, putative 0.0032 0.0276 0.3648
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0047 0.0372
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Brugia malayi Cytochrome P450 family protein 0.0025 0.0177 0.0656
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0216 0.2693 0.4725
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0054 0.0137
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0053 0.0547 0.2031
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0165 0.1873
Brugia malayi Cytochrome P450 family protein 0.0015 0.0048 0.0177
Brugia malayi Synaptic glycoprotein SC2 0.0053 0.0547 0.2031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0244 0.0907
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0048 0.0048
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0036 0.0321 0.4363
Echinococcus multilocularis transcription factor Dp 1 0.0036 0.0328 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0267 0.4324
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0053 0.0547 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0102 0.1191 0.4422
Loa Loa (eye worm) hypothetical protein 0.0053 0.0547 0.1366
Loa Loa (eye worm) hypothetical protein 0.0055 0.0571 0.1428
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0216 0.2693 0.2672
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0216 0.2693 1
Brugia malayi isocitrate dehydrogenase 0.0015 0.0047 0.0175
Loa Loa (eye worm) hypothetical protein 0.0216 0.2693 0.7027
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0054 0.0117
Plasmodium falciparum polyprenol reductase, putative 0.0053 0.0547 1
Schistosoma mansoni hypothetical protein 0.0161 0.197 0.498
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0165 0.1873
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0032 0.0276 0.0438
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0054 0.0513
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0047 0.0018
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0045
Brugia malayi Protein kinase domain containing protein 0.0014 0.0029 0.0109
Echinococcus multilocularis Ankyrin 0.0014 0.0031 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0216 0.2693 0.4725
Echinococcus granulosus neuropeptide receptor A26 0.0443 0.5668 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0547 0.1366
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0114 0.135 1
Entamoeba histolytica hypothetical protein 0.0034 0.03 0.1007
Echinococcus multilocularis geminin 0.0161 0.197 0.1947
Brugia malayi nuclear receptor RXR 0.0102 0.1191 0.4422
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0029 0.0109
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0063 0.0676 0.0648
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0216 0.2693 1
Loa Loa (eye worm) hypothetical protein 0.0216 0.2693 0.7027
Mycobacterium tuberculosis Probable dehydrogenase 0.0103 0.12 0.8844
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0054 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0547 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.1191 0.206
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0114 0.1352 0.3393
Echinococcus granulosus synaptic glycoprotein sc2 0.0053 0.0547 0.0918
Schistosoma mansoni hypothetical protein 0.003 0.0244 0.0551
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0102 0.1191 0.3064
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0029 0.000000010465
Leishmania major trypanothione reductase 0.0045 0.0441 0.627
Echinococcus granulosus nuclear receptor nhr 48 0.0102 0.1191 0.206
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0054 0.0513
Brugia malayi Nuclear hormone receptor-like 1 0.0114 0.1352 0.5019
Brugia malayi Uncoordinated protein 44 0.0014 0.0029 0.0109
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0036 0.0321 0.1525
Schistosoma mansoni hypothetical protein 0.003 0.0244 0.0551
Brugia malayi Nuclear hormone receptor E75 0.0102 0.1191 0.4422
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0216 0.2693 0.7027
Leishmania major hypothetical protein, conserved 0.0024 0.0165 0.1873
Mycobacterium tuberculosis Probable oxidoreductase 0.0114 0.135 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0031 0.0258 0.3349
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0053 0.0547 0.6924
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0276 0.3648
Brugia malayi Death domain containing protein 0.0014 0.0029 0.0109
Schistosoma mansoni rotamase 0.0032 0.0267 0.0611
Schistosoma mansoni hypothetical protein 0.0056 0.0585 0.1426
Brugia malayi hypothetical protein 0.0034 0.03 0.1113
Schistosoma mansoni lamin 0.0055 0.0571 0.1389
Brugia malayi Nuclear hormone receptor E75 0.0102 0.1191 0.4422
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0054 0.0117
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0117
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0216 0.2693 0.4725
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0216 0.2693 0.2672
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0053 0.0547 0.1328
Echinococcus granulosus ecdysone induced protein 78C 0.0216 0.2693 0.4725
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0114 0.1352 0.3393
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0054 0.0117
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0053 0.0547 1
Brugia malayi glutathione reductase 0.0045 0.0441 0.1638
Treponema pallidum exodeoxyribonuclease (exoA) 0.0036 0.0321 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0036 0.0321 1
Brugia malayi hypothetical protein 0.0015 0.0053 0.0197
Loa Loa (eye worm) hypothetical protein 0.0216 0.2693 0.7027
Loa Loa (eye worm) hypothetical protein 0.0216 0.2693 0.7027
Brugia malayi nuclear receptor NHR-88 0.0216 0.2693 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0047 0.0018
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0321 0.5485
Echinococcus granulosus nuclear factor of activated T cells 5 0.007 0.0771 0.1316
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0216 0.2693 1
Schistosoma mansoni hypothetical protein 0.0034 0.03 0.0694
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0054 0.0147
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0029 0.000000026769
Echinococcus granulosus FTZ F1 alpha 0.0216 0.2693 0.4725
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0103 0.12 0.8844
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0216 0.2693 0.2672
Plasmodium vivax thioredoxin reductase, putative 0.0045 0.0441 0.7953
Trypanosoma brucei membrane transporter protein, putative 0.0032 0.0276 0.3648
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0053 0.0547 0.0519
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Echinococcus granulosus intermediate filament protein 0.0055 0.0571 0.096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0216 0.2693 1
Brugia malayi Steroid receptor seven-up type 2 0.0216 0.2693 1
Schistosoma mansoni RAR-like nuclear receptor 0.0216 0.2693 0.6834
Echinococcus granulosus retinoic acid receptor rxr beta a 0.031 0.3927 0.6913
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 1
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0054 0.0117
Brugia malayi hypothetical protein 0.0024 0.0165 0.0612
Echinococcus multilocularis expressed protein 0.0032 0.0267 0.0239
Onchocerca volvulus Protein ultraspiracle homolog 0.0216 0.2693 1
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0321 0.5418
Onchocerca volvulus 0.0102 0.1191 0.436
Brugia malayi orphan nuclear receptor NR2E1 0.0102 0.1191 0.4422
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0441 0.0731
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0165 0.2355
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0036 0.0321 0.2105
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0321 0.5418
Echinococcus multilocularis nuclear factor of activated T cells 5 0.007 0.0771 0.0744
Echinococcus multilocularis musashi 0.0055 0.0571 0.0543
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0571 0.2119
Loa Loa (eye worm) RecQ helicase 0.002 0.0116 0.023
Brugia malayi ecdysteroid receptor 0.0216 0.2693 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0216 0.2693 0.7027
Echinococcus granulosus lamin dm0 0.0055 0.0571 0.096
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0116 0.0432
Echinococcus granulosus GPCR family 2 0.003 0.0244 0.0381
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0053 0.0547 1
Mycobacterium tuberculosis Probable reductase 0.0103 0.12 0.8844
Schistosoma mansoni multidrug resistance protein 0.0032 0.0276 0.0634
Brugia malayi nuclear hormone receptor family member nhr-6 0.0102 0.1191 0.4422
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0165 0.2355
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0216 0.2693 0.4725
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0053 0.0547 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.1352 0.3488
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0116 0.1259
Loa Loa (eye worm) glutathione reductase 0.0045 0.0441 0.1087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0047 0.0018
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0102 0.1191 0.206
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 0.7954
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0216 0.2693 0.6834
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0087
Brugia malayi tailless protein 0.0102 0.1191 0.4422
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0236 0.0544
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0047 0.0332
Leishmania major hypothetical protein, conserved 0.0032 0.0276 0.3648
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0102 0.1191 0.298
Brugia malayi photoreceptor-specific nuclear receptor 0.0216 0.2693 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0165 0.2609
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Plasmodium vivax polyprenol reductase, putative 0.0053 0.0547 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0216 0.2693 0.6834
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0063 0.0676 1
Brugia malayi conserved hypotetical protein 0.0102 0.1191 0.4422
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0244 0.0567
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 1
Toxoplasma gondii peptidylprolyl isomerase 0.0031 0.0258 0.4425
Echinococcus granulosus transcription factor Dp 1 0.0036 0.0328 0.0529
Plasmodium falciparum glutathione reductase 0.0016 0.0054 0.0147
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0053 0.0547 0.7954
Echinococcus granulosus bloom syndrome protein 0.002 0.0116 0.0155
Loa Loa (eye worm) hypothetical protein 0.003 0.0244 0.0567
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0102 0.1191 0.436
Echinococcus granulosus thyroid hormone receptor alpha 0.0102 0.1191 0.206
Onchocerca volvulus 0.0055 0.0571 0.2032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0102 0.1191 0.1165
Toxoplasma gondii thioredoxin reductase 0.0045 0.0441 0.7962
Loa Loa (eye worm) hypothetical protein 0.0102 0.1191 0.3064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0216 0.2693 0.7027
Entamoeba histolytica hypothetical protein 0.0053 0.0547 0.6924
Brugia malayi nuclear receptor RXR 0.0114 0.1352 0.5019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0216 0.2693 0.2672
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0031 0.0258 0.3349
Loa Loa (eye worm) hypothetical protein 0.0025 0.0184 0.0409
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0276 0.3648
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0053 0.0547 0.7954
Loa Loa (eye worm) hypothetical protein 0.0114 0.1352 0.3488
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0116 0.1259
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0197 0.0169
Trypanosoma brucei membrane transporter protein, putative 0.0032 0.0276 0.3648

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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