Detailed information for compound 2076104

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 430.436 | Formula: C21H26F4N2O3
  • H donors: 1 H acceptors: 3 LogP: 1.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.O=C1CCC2(N1CC1CC1)CCCN(C2)Cc1ccccc1F
  • InChi: 1S/C19H25FN2O.C2HF3O2/c20-17-5-2-1-4-16(17)13-21-11-3-9-19(14-21)10-8-18(23)22(19)12-15-6-7-15;3-2(4,5)1(6)7/h1-2,4-5,15H,3,6-14H2;(H,6,7)
  • InChiKey: CPLVUURVEORRAF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum glutathione reductase 0.0047 0.0441 1
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0048 0.0008
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0102 0.1134 0.2914
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0244 0.0216
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0216 0.2573 1
Brugia malayi orphan nuclear receptor NR2E1 0.0102 0.1134 0.4408
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0216 0.2573 0.4511
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0267 0.798
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0029 0.0114
Brugia malayi nuclear receptor NHR-88 0.0216 0.2573 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0314 0.3807 0.67
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1097 0.4265
Loa Loa (eye worm) glutathione reductase 0.0047 0.0441 0.1087
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0114 0.1288 0.3332
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0258 0.3349
Brugia malayi Cytochrome P450 family protein 0.0016 0.0048 0.0185
Schistosoma mansoni hypothetical protein 0.0036 0.03 0.0716
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Brugia malayi tailless protein 0.0102 0.1134 0.4408
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0676 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0216 0.2573 0.2551
Loa Loa (eye worm) hypothetical protein 0.0114 0.1288 0.3321
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0054 0.025
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0321 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0216 0.2573 0.6733
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0441 0.0731
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0067
Trypanosoma brucei membrane transporter protein, putative 0.0034 0.0276 0.3648
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0216 0.2573 0.6733
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Loa Loa (eye worm) hypothetical protein 0.0099 0.1097 0.2817
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0054 0.0117
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0258 0.3349
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0216 0.2573 1
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0048 0.0008
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0441 0.627
Onchocerca volvulus Bile acid receptor homolog 0.0216 0.2573 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0029 0.000000010465
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0216 0.2573 0.2551
Loa Loa (eye worm) hypothetical protein 0.0216 0.2573 0.6709
Echinococcus granulosus lamin dm0 0.0057 0.0571 0.096
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0054 0.0186
Entamoeba histolytica hypothetical protein 0.0036 0.03 0.1007
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.135 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0321 0.6958
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0114 0.1288 0.2233
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0165 0.328
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0048 0.0008
Leishmania major trypanothione reductase 0.0047 0.0441 0.627
Echinococcus granulosus neuropeptide receptor A26 0.0461 0.5668 1
Trypanosoma brucei membrane transporter protein, putative 0.0034 0.0276 0.3648
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.135 1
Brugia malayi Nuclear hormone receptor-like 1 0.0216 0.2573 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0048 0.0048
Schistosoma mansoni thyroid hormone receptor 0.0216 0.2573 0.6733
Brugia malayi nuclear receptor RXR 0.0114 0.1288 0.5007
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0267 0.0628
Trypanosoma brucei MATE efflux family protein, putative 0.0034 0.0276 0.3648
Schistosoma mansoni nuclear receptor 0.0102 0.1134 0.2925
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0216 0.2573 0.6709
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0047 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0054 0.0117
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0216 0.2573 0.4511
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0244 0.0567
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0034 0.0276 0.0248
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0244 0.0216
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1097 0.2817
Loa Loa (eye worm) hypothetical protein 0.0068 0.0702 0.1776
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0054 0.0117
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0216 0.2573 0.6733
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0676 0.1705
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.02 0.2368 0.2346
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0031 0.0004
Brugia malayi nuclear receptor NHR-88 0.0102 0.1134 0.4408
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0048 0.0048
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.12 0.8844
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.135 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Echinococcus multilocularis musashi 0.0057 0.0571 0.0543
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0276 0.3648
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0047 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0216 0.2573 0.6709
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0102 0.1134 0.4408
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0276 0.3648
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0216 0.2573 0.6709
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0321 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0197 0.0169
Loa Loa (eye worm) hypothetical protein 0.0114 0.1288 0.3321
Brugia malayi intermediate filament protein 0.0057 0.0571 0.2218
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0116 0.0087
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0116 0.2323
Schistosoma mansoni nuclear hormone receptor 0.0216 0.2573 0.6733
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0216 0.2573 0.4511
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0441 0.3025
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0321 0.0293
Schistosoma mansoni retinoic acid receptor RXR 0.0314 0.3807 1
Schistosoma mansoni coup transcription factor 0.0216 0.2573 0.6733
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0571 0.2218
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0321 0.4363
Brugia malayi conserved hypotetical protein 0.0102 0.1134 0.4408
Loa Loa (eye worm) hypothetical protein 0.0216 0.2573 0.6709
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0216 0.2573 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0216 0.2573 0.2551
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Schistosoma mansoni lamin 0.0057 0.0571 0.1433
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0216 0.2573 1
Brugia malayi ecdysone receptor 0.0102 0.1134 0.4408
Brugia malayi hypothetical protein 0.0102 0.1134 0.4408
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0034 0.0276 0.0438
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0054 0.0644
Brugia malayi Nuclear hormone receptor-like 1 0.0114 0.1288 0.5007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0114 0.1288 0.3332
Onchocerca volvulus 0.0102 0.1134 0.4343
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0236 0.0916
Schistosoma mansoni hypothetical protein 0.0168 0.197 0.5138
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0258 0.3349
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0216 0.2573 1
Brugia malayi hypothetical protein 0.0121 0.1373 0.5336
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0244 0.0949
Echinococcus granulosus Nuclear hormone receptor HR96 0.0102 0.1134 0.1959
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Loa Loa (eye worm) DR-78 0.0102 0.1134 0.2914
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0117
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0165 0.2988
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0216 0.2573 1
Schistosoma mansoni nuclear receptor nhr-48 0.0102 0.1134 0.2925
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0321 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0321 0.4363
Brugia malayi Steroid receptor seven-up type 2 0.0216 0.2573 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.1134 0.1959
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0216 0.2573 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0258 0.3349
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0054 0.5
Schistosoma mansoni hypothetical protein 0.0168 0.197 0.5138
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0054 0.0596
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0114 0.1288 0.3321
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0047 0.0467
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0676 1
Echinococcus multilocularis neuropeptide s receptor 0.0461 0.5668 0.5655
Onchocerca volvulus 0.0102 0.1134 0.4343
Loa Loa (eye worm) hypothetical protein 0.0216 0.2573 0.6709
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0676 0.1711
Brugia malayi Cytochrome P450 family protein 0.0016 0.0048 0.0185
Schistosoma mansoni hypothetical protein 0.0068 0.0702 0.1782
Echinococcus granulosus intermediate filament protein 0.0057 0.0571 0.096
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0676 0.2626
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1097 0.4265
Loa Loa (eye worm) hypothetical protein 0.0031 0.0244 0.0567
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0676 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0102 0.1134 0.2925
Brugia malayi ecdysteroid receptor 0.0216 0.2573 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0676 0.1146
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0321 1
Echinococcus granulosus expressed protein 0.0033 0.0267 0.0422
Brugia malayi hypothetical protein 0.0025 0.0165 0.0641
Schistosoma mansoni intermediate filament proteins 0.0057 0.0571 0.1433
Loa Loa (eye worm) hypothetical protein 0.0216 0.2573 0.6709
Brugia malayi Death domain containing protein 0.0014 0.0029 0.0114
Leishmania major hypothetical protein, conserved 0.0034 0.0276 0.3648
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0676 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0102 0.1134 0.4343
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0216 0.2573 0.2551
Loa Loa (eye worm) hypothetical protein 0.0028 0.0197 0.0443
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0216 0.2573 0.2551
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Leishmania major hypothetical protein, conserved 0.0034 0.0276 0.3648
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0702 0.273
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0165 0.3315
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.03 0.0716
Trypanosoma brucei trypanothione reductase 0.0047 0.0441 0.627
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0244 0.0949
Plasmodium falciparum glutathione reductase 0.0016 0.0054 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0216 0.2573 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0102 0.1134 0.1959
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.1134 0.1108
Echinococcus multilocularis lamin 0.0057 0.0571 0.0543
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0216 0.2573 0.6733
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0197 0.0298
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0054 0.0117
Entamoeba histolytica hypothetical protein 0.0036 0.03 0.1007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Echinococcus granulosus neuropeptide s receptor 0.0461 0.5668 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.0441 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0102 0.1134 0.1108
Trypanosoma cruzi membrane transporter protein, putative 0.0034 0.0276 0.3648
Brugia malayi hypothetical protein 0.0036 0.03 0.1165
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0216 0.2573 0.6709
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Schistosoma mansoni hypothetical protein 0.0031 0.0244 0.0569
Mycobacterium tuberculosis Probable reductase 0.0107 0.12 0.8844
Echinococcus granulosus bloom syndrome protein 0.0021 0.0116 0.0155
Onchocerca volvulus 0.0057 0.0571 0.2128
Schistosoma mansoni hypothetical protein 0.0031 0.0244 0.0569
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.03 0.048
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0102 0.1134 0.1959
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0321 0.1525
Onchocerca volvulus Protein ultraspiracle homolog 0.0216 0.2573 1
Echinococcus multilocularis neuropeptide receptor A26 0.0461 0.5668 0.5655
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0441 0.1087
Loa Loa (eye worm) hypothetical protein 0.0114 0.1288 0.3321
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0047 0.0183
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0054 0.0117
Schistosoma mansoni RAR-like nuclear receptor 0.0216 0.2573 0.6733
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0054 0.0212
Toxoplasma gondii exonuclease III APE 0.0037 0.0321 0.71
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Echinococcus multilocularis geminin 0.0168 0.197 0.1947
Leishmania major hypothetical protein, conserved 0.0025 0.0165 0.1873
Onchocerca volvulus 0.0057 0.0571 0.2128
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Brugia malayi Thioredoxin reductase 0.0047 0.0441 0.1715
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0216 0.2573 0.4511
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0216 0.2573 0.2551
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Brugia malayi Nuclear hormone receptor E75 0.0102 0.1134 0.4408
Trichomonas vaginalis rotamase, putative 0.0032 0.0258 0.7611
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0276 0.3648
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0321 0.1249
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0047 0.0467
Loa Loa (eye worm) hypothetical protein 0.0025 0.0165 0.0358
Plasmodium vivax glutathione reductase, putative 0.0047 0.0441 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0045
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0029 0.000000027621
Loa Loa (eye worm) steroid hormone receptor 0.0216 0.2573 0.6709
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0047 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0321 0.7085
Echinococcus multilocularis thyroid hormone receptor alpha 0.0216 0.2573 0.2551
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0047 0.0018
Loa Loa (eye worm) hypothetical protein 0.0216 0.2573 0.6709
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0177 0.0389
Loa Loa (eye worm) hypothetical protein 0.0027 0.0184 0.0409
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.12 0.8844
Schistosoma mansoni steroid hormone receptor ad4bp 0.0216 0.2573 0.6733
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Schistosoma mansoni hypothetical protein 0.0031 0.0244 0.0569
Loa Loa (eye worm) hypothetical protein 0.0056 0.0557 0.1393
Loa Loa (eye worm) hypothetical protein 0.0216 0.2573 0.6709
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0102 0.1134 0.2925
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0258 0.5558
Trichomonas vaginalis rotamase, putative 0.0033 0.0267 0.798
Loa Loa (eye worm) hypothetical protein 0.0216 0.2573 0.6709
Onchocerca volvulus 0.0216 0.2573 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0321 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0216 0.2573 0.6733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0216 0.2573 0.6709
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0054 0.025
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0114 0.1288 0.1263
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0216 0.2573 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0321 0.0518
Brugia malayi Uncoordinated protein 44 0.0014 0.0029 0.0114
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.03 0.0271
Schistosoma mansoni hypothetical protein 0.0031 0.0244 0.0569
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0165 0.1873
Schistosoma mansoni hypothetical protein 0.0058 0.0585 0.1472
Loa Loa (eye worm) hypothetical protein 0.0102 0.1134 0.2914
Loa Loa (eye worm) hypothetical protein 0.0057 0.0571 0.1428
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0244 0.0381
Brugia malayi hypothetical protein 0.0102 0.1134 0.4408
Brugia malayi nuclear hormone receptor family member nhr-6 0.0102 0.1134 0.4408
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0054 0.0644
Loa Loa (eye worm) hypothetical protein 0.0114 0.1288 0.3321
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0216 0.2573 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0117
Loa Loa (eye worm) RecQ helicase 0.0021 0.0116 0.023
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0441 0.0413
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0276 0.3648
Schistosoma mansoni zinc finger protein 0.0102 0.1134 0.2925
Brugia malayi Nuclear hormone receptor-like 1 0.0114 0.1288 0.5007
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0054 0.025
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0031 0.0239 0.021
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0441 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.12 0.8844
Echinococcus granulosus Ankyrin 0.0014 0.0031 0.0003
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0102 0.1134 0.1108
Leishmania major cytochrome p450-like protein 0.0016 0.0048 0.0008
Brugia malayi hypothetical protein 0.0114 0.1288 0.5007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0321 0.077
Schistosoma mansoni nuclear hormone receptor 0.0102 0.1134 0.2925
Echinococcus granulosus ecdysone induced protein 78C 0.0216 0.2573 0.4511
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0676 1
Echinococcus granulosus FTZ F1 alpha 0.0216 0.2573 0.4511
Echinococcus granulosus geminin 0.0168 0.197 0.3443
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0236 0.0544
Echinococcus granulosus nuclear receptor nhr 48 0.0102 0.1134 0.1959
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0165 0.1873
Brugia malayi nuclear hormone receptor family member odr-7 0.0102 0.1134 0.4408
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0054 0.0117
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0328 0.0299
Echinococcus multilocularis FTZ F1 alpha 0.0216 0.2573 0.2551
Brugia malayi hypothetical protein 0.0016 0.0053 0.0206
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.135 1
Schistosoma mansoni multidrug resistance protein 0.0034 0.0276 0.0654
Loa Loa (eye worm) hypothetical protein 0.0216 0.2573 0.6709
Echinococcus multilocularis lamin dm0 0.0057 0.0571 0.0543
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0047 0.0018
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.12 0.8844
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0321 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0054 0.0596
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0571 0.1428
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0047 0.0047
Echinococcus granulosus lamin 0.0057 0.0571 0.096
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0216 0.2573 1
Plasmodium falciparum thioredoxin reductase 0.0016 0.0054 0.0186
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0276 0.3648
Echinococcus multilocularis expressed protein 0.0033 0.0267 0.0239
Trypanosoma brucei membrane transporter protein, putative 0.0034 0.0276 0.3648
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0771 0.0744
Schistosoma mansoni rotamase 0.0033 0.0267 0.063
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0216 0.2573 0.4511
Loa Loa (eye worm) nuclear hormone receptor 0.0102 0.1134 0.2914
Echinococcus granulosus thyroid hormone receptor alpha 0.0102 0.1134 0.1959
Toxoplasma gondii thioredoxin reductase 0.0047 0.0441 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.382 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0216 0.2573 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0571 0.1428
Brugia malayi nuclear hormone receptor 0.0216 0.2573 1
Brugia malayi nuclear receptor NHR-67 0.0102 0.1134 0.4408
Brugia malayi steroid hormone receptor 0.0216 0.2573 1
Echinococcus multilocularis Ankyrin 0.0014 0.0031 0.0002
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0328 0.0529
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0165 0.1873
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0054 0.0117
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.12 0.8844
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0216 0.2573 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0054 0.0186
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0216 0.2573 0.6709
Brugia malayi nuclear hormone receptor 0.0102 0.1134 0.4408
Entamoeba histolytica hypothetical protein 0.0036 0.03 0.1007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0184 0.0409
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0216 0.2573 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0216 0.2573 0.2551
Echinococcus multilocularis GPCR, family 2 0.0031 0.0244 0.0216
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0771 0.1316
Echinococcus granulosus GPCR family 2 0.0031 0.0244 0.0381
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0054 0.0056
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0054 0.0025
Brugia malayi Cytochrome P450 family protein 0.0026 0.0177 0.0687
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0216 0.2573 0.6733
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0116 0.0453
Loa Loa (eye worm) hypothetical protein 0.0114 0.1288 0.3321
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0047 0.0032
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0244 0.0381
Brugia malayi hypothetical protein 0.0114 0.1288 0.5007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0321 0.2105
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0102 0.1134 0.1108
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0102 0.1134 0.4343
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0036 0.03 0.1007
Schistosoma mansoni thyroid hormone receptor 0.0216 0.2573 0.6733
Brugia malayi glutathione reductase 0.0047 0.0441 0.1715
Brugia malayi isocitrate dehydrogenase 0.0016 0.0047 0.0183
Schistosoma mansoni ap endonuclease 0.0037 0.0321 0.0773
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0029 0.000000018506
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0084 0.0936
Schistosoma mansoni nuclear hormone receptor 0.0102 0.1134 0.2925
Brugia malayi Nuclear hormone receptor E75 0.0102 0.1134 0.4408
Schistosoma mansoni lamin 0.0057 0.0571 0.1433
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0116 0.2323
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0267 0.1039
Brugia malayi nuclear receptor RXR 0.0102 0.1134 0.4408
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0676 0.0648
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0216 0.2573 0.6709
Schistosoma mansoni ap endonuclease 0.0037 0.0321 0.0773
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.006 0.0082
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0165 0.2988
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0102 0.1134 0.1108
Brugia malayi photoreceptor-specific nuclear receptor 0.0216 0.2573 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0321 0.4363
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0054 0.0117
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0047 0.0047
Loa Loa (eye worm) nuclear receptor NHR-67 0.0102 0.1134 0.2914
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0216 0.2573 0.4511
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0321 0.4363
Brugia malayi Protein kinase domain containing protein 0.0014 0.0029 0.0114
Schistosoma mansoni nuclear receptor 0.0102 0.1134 0.2925
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0047 0.0018

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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