Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Peroxidasin | 0.0417 | 0.4932 | 0.4932 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0267 | 0.2803 | 0.2803 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0267 | 0.2803 | 1 |
Onchocerca volvulus | 0.0417 | 0.4932 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0417 | 0.4932 | 0.4932 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0267 | 0.2803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.4932 | 0.4932 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.2951 | 0.2951 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.0125 | 0.0125 |
Echinococcus granulosus | peroxidasin | 0.0417 | 0.4932 | 0.4932 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0267 | 0.2803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0267 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0267 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0267 | 0.2803 | 0.2803 |
Onchocerca volvulus | 0.0417 | 0.4932 | 1 | |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Brugia malayi | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0267 | 0.2803 | 0.2803 |
Onchocerca volvulus | Peroxidasin homolog | 0.0417 | 0.4932 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0267 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0772 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.2979 | 0.2979 |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.4932 | 0.4932 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Echinococcus granulosus | geminin | 0.0205 | 0.1907 | 0.1907 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0267 | 0.2803 | 0.2803 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0417 | 0.4932 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0772 | 1 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0267 | 0.2803 | 0.2803 |
Brugia malayi | Thioredoxin reductase | 0.0772 | 1 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0267 | 0.2803 | 0.2803 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0267 | 0.2803 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0196 | 0.179 | 0.179 |
Echinococcus multilocularis | peroxidasin | 0.0417 | 0.4932 | 0.4932 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Schistosoma mansoni | peroxidasin | 0.0417 | 0.4932 | 0.4932 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0267 | 0.2803 | 0.2803 |
Toxoplasma gondii | thioredoxin reductase | 0.0772 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Trypanosoma brucei | trypanothione reductase | 0.0772 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0417 | 0.4932 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0267 | 0.2803 | 0.2803 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1907 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0267 | 0.2803 | 0.2803 |
Onchocerca volvulus | Peroxidase homolog | 0.0417 | 0.4932 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0417 | 0.4932 | 0.4932 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0267 | 0.2803 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.008 | 0.0125 | 0.0125 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0772 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0417 | 0.4932 | 0.4932 |
Plasmodium falciparum | thioredoxin reductase | 0.0772 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0772 | 1 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0267 | 0.2803 | 0.2803 |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.4932 | 0.4932 |
Onchocerca volvulus | Dual oxidase homolog | 0.0417 | 0.4932 | 1 |
Onchocerca volvulus | 0.0417 | 0.4932 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.4932 | 0.4932 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0267 | 0.2803 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0417 | 0.4932 | 0.4932 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Plasmodium falciparum | glutathione reductase | 0.0267 | 0.2803 | 0.2803 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0267 | 0.2803 | 0.2803 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1907 | 0.1907 |
Treponema pallidum | NADH oxidase | 0.0267 | 0.2803 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0267 | 0.2803 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0267 | 0.2803 | 0.2803 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.008 | 0.0125 | 0.0125 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0267 | 0.2803 | 0.2803 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.0125 | 0.0125 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.0125 | 0.0125 |
Plasmodium falciparum | thioredoxin reductase | 0.0267 | 0.2803 | 0.2803 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1907 | 0.1907 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0417 | 0.4932 | 0.4932 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Loa Loa (eye worm) | glutathione reductase | 0.0772 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0772 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0772 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0772 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.008 | 0.0125 | 0.0125 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0772 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.2979 | 0.2979 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.0125 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0267 | 0.2803 | 0.2803 |
Brugia malayi | Animal haem peroxidase family protein | 0.0417 | 0.4932 | 0.4932 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.0125 | 0.0125 |
Brugia malayi | Blistered cuticle protein 3 | 0.0417 | 0.4932 | 0.4932 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0267 | 0.2803 | 0.2803 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0267 | 0.2803 | 0.2803 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0267 | 0.2803 | 0.2803 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0267 | 0.2803 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0417 | 0.4932 | 0.4932 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0267 | 0.2803 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0417 | 0.4932 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0772 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0267 | 0.2803 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.008 | 0.0125 | 0.0125 |
Schistosoma mansoni | peroxidasin | 0.0417 | 0.4932 | 0.4932 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0267 | 0.2803 | 0.2803 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0196 | 0.179 | 0.179 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0267 | 0.2803 | 0.2803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.