Detailed information for compound 207679

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.078 | Formula: C12H8AuCl2N2++
  • H donors: 0 H acceptors: 0 LogP: 4.49 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cl[Au]1(Cl)[n+]2cccc3c2c2[n+]1cccc2cc3
  • InChi: 1S/C12H8N2.Au.2ClH/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;;/h1-8H;;2*1H/q;+4;;/p-2
  • InChiKey: AKNBCTQVXBRTTK-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PHD-finger domain-containing protein 0.0041 0.0645 0.2161
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0053 0.0873 0.0873
Brugia malayi ThiF family protein 0.0032 0.0478 0.1602
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Loa Loa (eye worm) hypothetical protein 0.0016 0.0172 0.0263
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0053 0.0873 1
Plasmodium falciparum steroid dehydrogenase, putative 0.0008 0.0023 0.0078
Brugia malayi glutathione reductase 0.0028 0.0401 0.1345
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0149
Echinococcus multilocularis bloom syndrome protein 0.0016 0.0176 0.0176
Echinococcus multilocularis jumonji domain containing 1A 0.0013 0.0124 0.0124
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0063 0.1076 0.1076
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0008 0.0023 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0117 0.0355
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0023 0.0023
Loa Loa (eye worm) calcium channel 0.0063 0.1076 0.1646
Leishmania major hypothetical protein, conserved 0.0008 0.0023 0.0039
Leishmania major dihydrolipoamide dehydrogenase, putative 0.001 0.0058 0.0157
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0336 0.109
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0013 0.0117 0.0393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0013 0.0117 0.0318
Plasmodium vivax pyruvate kinase, putative 0.0046 0.0756 0.2474
Giardia lamblia Reductase, putative 0.0008 0.0023 0.0266
Loa Loa (eye worm) oxidoreductase 0.0008 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0149
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0127 0.0427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0085 0.021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0149
Loa Loa (eye worm) thioredoxin reductase 0.0028 0.0401 0.0614
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0023 0.0078
Trichomonas vaginalis ran, putative 0.0024 0.0336 0.2346
Echinococcus multilocularis phd:f box containing protein 0.0013 0.0124 0.0124
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0053 0.0873 0.2925
Plasmodium falciparum pyruvate kinase 2 0.0024 0.0328 0.1098
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0053 0.0873 0.6381
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0053 0.0873 0.1335
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0021 0.0272 0.0841
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.008 0.139 0.2126
Loa Loa (eye worm) hypothetical protein 0.0013 0.0124 0.019
Schistosoma mansoni voltage-gated cation channel 0.0063 0.1076 0.1646
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0023 0.0035
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0013 0.0124 0.0379
Plasmodium vivax glutathione reductase, putative 0.0028 0.0401 0.1277
Loa Loa (eye worm) hypothetical protein 0.0032 0.049 0.0749
Leishmania major oxidoreductase-like protein 0.0008 0.0023 0.0039
Leishmania major short chain dehydrogenase-like protein 0.0008 0.0023 0.0039
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0063 0.1076 0.1646
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0023 0.0078
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0053 0.0873 0.2897
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0023 0.0035
Onchocerca volvulus Alhambra homolog 0.0041 0.0645 0.21
Echinococcus granulosus thioredoxin glutathione reductase 0.0028 0.0408 0.0624
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Brugia malayi ThiF family protein 0.0021 0.0272 0.0913
Brugia malayi hypothetical protein 0.0078 0.1355 0.454
Loa Loa (eye worm) hypothetical protein 0.0046 0.0756 0.1156
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0032 0.0487 0.1599
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.001 0.0058 0.0118
Trypanosoma brucei DNA polymerase IV, putative 0.0013 0.0117 0.0318
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0112 0.1996 0.1996
Schistosoma mansoni carbonyl reductase 0.0008 0.0023 0.0035
Plasmodium falciparum glutathione reductase 0.0028 0.0401 0.1345
Toxoplasma gondii hypothetical protein 0.0012 0.0097 0.0326
Echinococcus granulosus ubiquitin specific protease 41 0.0053 0.0873 0.1335
Trichomonas vaginalis DNA helicase recq, putative 0.0016 0.0176 0.1148
Mycobacterium ulcerans flavoprotein disulfide reductase 0.001 0.0058 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0124 0.019
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0023 0.0039
Echinococcus multilocularis ubiquitin specific protease 41 0.0053 0.0873 0.0873
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.001 0.0058 0.0118
Loa Loa (eye worm) thymidylate synthase 0.0164 0.2984 0.4563
Loa Loa (eye worm) oxidoreductase 0.0008 0.0023 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Loa Loa (eye worm) X11 protein 0.0045 0.0734 0.1122
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0032 0.0487 0.0745
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1355 1
Schistosoma mansoni hypothetical protein 0.0041 0.0645 0.0986
Echinococcus multilocularis pyruvate kinase 0.0037 0.057 0.057
Mycobacterium ulcerans hypothetical protein 0.0016 0.0172 0.0504
Toxoplasma gondii ThiF family protein 0.0021 0.0272 0.0913
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0023 0.0078
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0164 0.2984 0.4563
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.001 0.0058 0.0118
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0023 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Entamoeba histolytica Ran family GTPase 0.0024 0.0336 0.3677
Loa Loa (eye worm) pyruvate kinase 0.0046 0.0756 0.1156
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0032 0.0478 0.0731
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.6538 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0012 0.0097 0.0251
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0023 0.0035
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0336 0.3845
Trypanosoma brucei unspecified product 0.0013 0.0117 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0032 0.0487 0.0487
Onchocerca volvulus 0.0016 0.0172 0.0504
Echinococcus multilocularis amyloid beta A4 protein 0.0045 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0016 0.0172 0.0263
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0336 0.1125
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Echinococcus granulosus pyruvate kinase 0.0024 0.0328 0.0501
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0013 0.0117 0.0355
Trichomonas vaginalis pyruvate kinase, putative 0.0046 0.0756 0.5502
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Mycobacterium ulcerans pyruvate kinase 0.0046 0.0756 0.2474
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0112 0.1996 0.3053
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0042 0.0065
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.001 0.0058 0.0118
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0016 0.0172 0.0504
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0008 0.0023 0.0078
Schistosoma mansoni pyruvate kinase 0.0046 0.0756 0.1156
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0013 0.0117 0.0179
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0013 0.0124 0.0417
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0063 0.1074 0.3548
Chlamydia trachomatis pyruvate kinase 0.0046 0.0756 1
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0023 0.0035
Toxoplasma gondii NADPH-glutathione reductase 0.001 0.0058 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0023 0.0039
Trypanosoma cruzi pyruvate kinase 2, putative 0.0046 0.0756 0.2503
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Schistosoma mansoni jumonji domain containing protein 0.0106 0.1876 0.2869
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0042 0.0065
Schistosoma mansoni importin beta-1 0.0033 0.05 0.0765
Plasmodium falciparum thioredoxin reductase 0.0028 0.0401 0.1345
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0021 0.0272 0.0272
Schistosoma mansoni ap endonuclease 0.0032 0.0487 0.0745
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0008 0.0036 0.0045
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0023 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0013 0.0124 0.019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0112 0.1996 0.3053
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0336 0.109
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Toxoplasma gondii PHD-finger domain-containing protein 0.0013 0.0127 0.0427
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0053 0.0873 0.2897
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0023 0.0039
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0008 0.0036 0.0083
Onchocerca volvulus 0.0033 0.0494 0.1589
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0013 0.0124 0.0342
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.05 0.1612
Echinococcus granulosus snurportin 1 0.0352 0.6538 1
Toxoplasma gondii hypothetical protein 0.0032 0.0478 0.1602
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0016 0.0172 0.0504
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0023 0.0023
Mycobacterium ulcerans DNA polymerase IV 0.0013 0.0117 0.0318
Leishmania major pyruvate kinase 0.0046 0.0756 0.2503
Echinococcus multilocularis voltage dependent calcium channel 0.0063 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0053 0.0873 0.1335
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0021 0.0272 0.0416
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0053 0.0873 0.1335
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0023 0.0039
Trypanosoma brucei trypanothione reductase 0.0028 0.0401 0.1277
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0085 0.021
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0058 0.0157
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0039 0.0606 0.1969
Loa Loa (eye worm) oxidoreductase 0.0008 0.0023 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0873 0.6381
Loa Loa (eye worm) oxidoreductase 0.0008 0.0023 0.0035
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.001 0.0058 0.0118
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0164 0.2984 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0032 0.0487 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0063 0.1074 0.3548
Echinococcus granulosus tumor protein p63 0.0223 0.4095 0.6263
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0032 0.0487 0.5579
Loa Loa (eye worm) hypothetical protein 0.007 0.1194 0.1826
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Echinococcus granulosus PHD finger protein rhinoceros 0.0041 0.0645 0.0986
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0133 0.2393 0.3661
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0023 0.0039
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0039 0.0606 0.2
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0063 0.1074 0.3548
Brugia malayi thymidylate synthase 0.0164 0.2984 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.001 0.0058 0.0195
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.007 0.1207 0.4
Loa Loa (eye worm) hypothetical protein 0.0033 0.05 0.0765
Loa Loa (eye worm) pyruvate kinase 0.0046 0.0756 0.1156
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0008 0.0036 0.0083
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0023 0.0039
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0172 0.054
Echinococcus granulosus voltage dependent calcium channel 0.0063 0.1076 0.1646
Leishmania major acetoin dehydrogenase e3 component-like protein 0.001 0.0058 0.0157
Onchocerca volvulus Pyruvate kinase homolog 0.0046 0.0756 0.2474
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0016 0.0172 0.0504
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.001 0.0064 0.0734
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0053 0.0873 1
Echinococcus multilocularis pyruvate kinase 0.0046 0.0756 0.0756
Brugia malayi hypothetical protein 0.0008 0.0023 0.0078
Toxoplasma gondii thioredoxin reductase 0.0028 0.0401 0.1345
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.0807 0.1234
Echinococcus granulosus oxidoreductase 0.0008 0.0023 0.0035
Echinococcus multilocularis thioredoxin glutathione reductase 0.0028 0.0408 0.0408
Leishmania major dihydrolipoamide dehydrogenase, putative 0.001 0.0058 0.0157
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0172 0.054
Trichomonas vaginalis ap endonuclease, putative 0.0032 0.0487 0.3483
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0172 0.0577
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0032 0.0487 0.1632
Trypanosoma cruzi trypanothione reductase, putative 0.001 0.0058 0.0157
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0113 0.0173
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0023 0.0023
Echinococcus multilocularis thymidylate synthase 0.0164 0.2984 0.2984
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Mycobacterium tuberculosis Probable reductase 0.0063 0.1074 0.3548
Brugia malayi ImpB/MucB/SamB family protein 0.0013 0.0117 0.0393
Schistosoma mansoni phd/f-box containing protein 0.0013 0.0124 0.019
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0063 0.1076 0.1646
Loa Loa (eye worm) RecQ helicase 0.0016 0.0176 0.0269
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0012 0.0097 0.0251
Brugia malayi jmjC domain containing protein 0.0133 0.2393 0.8022
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0046 0.0756 0.2474
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0023 0.0039
Brugia malayi exodeoxyribonuclease III family protein 0.0032 0.0487 0.1632
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0149
Echinococcus multilocularis sodium channel protein 0.0027 0.0385 0.0385
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0149
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0023 0.0266
Echinococcus granulosus voltage dependent calcium channel 0.0013 0.0127 0.0195
Echinococcus multilocularis oxidoreductase 0.0008 0.0023 0.0023
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0124 0.019
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Mycobacterium ulcerans DNA polymerase IV 0.0013 0.0117 0.0318
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0023 0.0023
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0164 0.2984 1
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0127 0.0352
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0127 0.0195
Echinococcus multilocularis jumonji domain containing protein 0.0056 0.0946 0.0946
Mycobacterium tuberculosis Hypothetical protein 0.0078 0.1355 0.4497
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0063 0.1076 0.1646
Brugia malayi jmjC domain containing protein 0.0013 0.0124 0.0417
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0023 0.0078
Schistosoma mansoni hypothetical protein 0.0352 0.6538 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0053 0.0873 0.2897
Entamoeba histolytica pyruvate kinase, putative 0.0032 0.049 0.549
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0023 0.0039
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.001 0.0058 0.0118
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0013 0.0124 0.019
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0023 0.0039
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Trypanosoma brucei DNA polymerase IV, putative 0.0013 0.0117 0.0318
Leishmania major pteridine reductase 1 0.0008 0.0023 0.0039
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.001 0.0058 0.0118
Loa Loa (eye worm) pyruvate kinase 0.001 0.0062 0.0094
Trypanosoma cruzi DNA polymerase eta, putative 0.0013 0.0117 0.0355
Trypanosoma brucei DNA polymerase eta, putative 0.0013 0.0117 0.0318
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0127 0.0195
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.008 0.139 0.139
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Plasmodium falciparum pyruvate kinase 0.0046 0.0756 0.2533
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0013 0.0127 0.0352
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0013 0.0127 0.0427
Echinococcus multilocularis lysine specific demethylase 6a 0.0013 0.0124 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0023 0.0039
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0382 0.2697
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0023 0.0035
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.008 0.139 0.2126
Trichomonas vaginalis ap endonuclease, putative 0.0032 0.0487 0.3483
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0336 0.1055
Echinococcus multilocularis dna polymerase kappa 0.0013 0.0117 0.0117
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.001 0.0058 0.0195
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0029 0.0423 0.0647
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0063 0.1076 0.1646
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0023 0.0039
Leishmania major 3-keto-dihydrosphingosine reductase 0.0008 0.0023 0.0039
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0032 0.0478 0.0731
Giardia lamblia Pyruvate kinase 0.0046 0.0756 0.8659
Echinococcus multilocularis peregrin 0.0041 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0016 0.0172 0.0263
Brugia malayi jmjC domain containing protein 0.0013 0.0124 0.0417
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.001 0.0058 0.0157
Entamoeba histolytica deoxycytidyl transferase, putative 0.0013 0.0117 0.1107
Leishmania major dehydrogenase-like protein 0.0008 0.0023 0.0039
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0063 0.1076 0.1646
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0053 0.0873 0.1335
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0023 0.0039
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0007 0.001 0.0033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.0807 0.1234
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.001 0.0064 0.0307
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Brugia malayi Bromodomain containing protein 0.0041 0.0645 0.2161
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Schistosoma mansoni ran 0.0024 0.0336 0.0513
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0063 0.1076 0.1076
Plasmodium falciparum acyl-CoA synthetase 0.0012 0.0097 0.0327
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0023 0.0035
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.008 0.139 0.4618
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0023 0.0078
Onchocerca volvulus 0.0164 0.2984 1
Echinococcus granulosus importin subunit beta 1 0.0033 0.05 0.0765
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.001 0.0058 0.0195
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0008 0.0023 0.0078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0645 0.0986
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0023 0.0039
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0164 0.2984 1
Echinococcus granulosus thymidylate synthase 0.0164 0.2984 0.4563
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0032 0.0478 0.1602
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0058 0.0157
Schistosoma mansoni carbonyl reductase 0.0008 0.0023 0.0035
Loa Loa (eye worm) jmjC domain-containing protein 0.0013 0.0124 0.019
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0023 0.0023
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0336 0.1055
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0021 0.0272 0.0841
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Giardia lamblia DINP protein human, muc B family 0.0013 0.0117 0.1343
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0014 0.0142 0.0477
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0053 0.0873 0.0873
Onchocerca volvulus 0.0012 0.011 0.0294
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0336 0.0513
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Echinococcus granulosus pyruvate kinase 0.0024 0.0328 0.0501
Echinococcus granulosus phd:f box containing protein 0.0013 0.0124 0.019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0085 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.0013 0.0117 0.0318
Brugia malayi jmjC domain containing protein 0.0049 0.0807 0.2703
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Trichomonas vaginalis glutathione reductase, putative 0.001 0.0058 0.0263
Echinococcus multilocularis pyruvate kinase 0.0024 0.0328 0.0328
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0023 0.0039
Loa Loa (eye worm) hypothetical protein 0.0043 0.07 0.1071
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.008 0.139 0.4618
Echinococcus multilocularis pyruvate kinase 0.0024 0.0328 0.0328
Brugia malayi AF-10 protein 0.0013 0.0127 0.0427
Brugia malayi RNA, U transporter 1 0.0094 0.1651 0.5533
Loa Loa (eye worm) hypothetical protein 0.0033 0.0494 0.0755
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0023 0.0039
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0117 0.0355
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0336 0.1125
Trypanosoma brucei DNA polymerase kappa, putative 0.0009 0.0042 0.0065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0058 0.0157
Schistosoma mansoni cellular tumor antigen P53 0.0033 0.0494 0.0755
Echinococcus multilocularis importin subunit beta 1 0.0033 0.05 0.05
Giardia lamblia PHD finger protein 15 0.0041 0.0645 0.7389
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0023 0.0039
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0013 0.0117 0.0117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0112 0.1996 0.3053
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0172 0.0504
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.001 0.0058 0.0195
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0072 0.1243 0.1902
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0023 0.0078
Echinococcus multilocularis snurportin 1 0.0352 0.6538 0.6538
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0023 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0117 0.0355
Leishmania major hypothetical protein, conserved 0.0008 0.0023 0.0039
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0023 0.0035
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0063 0.1074 0.3548
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0077 0.0256
Mycobacterium ulcerans thymidylate synthase 0.0164 0.2984 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0336 0.1125
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0149
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Mycobacterium tuberculosis Probable oxidoreductase 0.007 0.1207 0.4
Entamoeba histolytica recQ family helicase, putative 0.0008 0.0036 0.0156
Schistosoma mansoni phosphatidylserine receptor 0.0013 0.0124 0.019
Loa Loa (eye worm) oxidoreductase 0.0008 0.0023 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Leishmania major hypothetical protein, conserved 0.0008 0.0023 0.0039
Leishmania major hypothetical protein, conserved 0.0008 0.0023 0.0039
Brugia malayi Importin beta-1 subunit 0.0033 0.05 0.1677
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0172 0.1755
Loa Loa (eye worm) hypothetical protein 0.0013 0.0117 0.0179
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0013 0.0127 0.0352
Plasmodium vivax importin-beta 2, putative 0.0033 0.05 0.1612
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0023 0.0039
Leishmania major short chain dehydrogenase, putative 0.0008 0.0023 0.0039
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0645 0.0986
Echinococcus granulosus pyruvate kinase 0.0024 0.0328 0.0501
Schistosoma mansoni hypothetical protein 0.0013 0.0127 0.0195
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0023 0.0035
Schistosoma mansoni ap endonuclease 0.0032 0.0487 0.0745
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Loa Loa (eye worm) oxidoreductase 0.0008 0.0023 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0013 0.0117 0.0318
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0023 0.0039
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.007 0.1207 0.4
Schistosoma mansoni carbonyl reductase 0.0008 0.0023 0.0035
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0023 0.0039
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0008 0.0023 0.0078
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0164 0.2984 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0023 0.0039
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0008 0.0023 0.0039
Trichomonas vaginalis DNA polymerase eta, putative 0.0013 0.0117 0.0706
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0336 0.0336
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0023 0.0035
Schistosoma mansoni terminal deoxycytidyl transferase 0.0013 0.0117 0.0179
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0164 0.2984 1
Loa Loa (eye worm) dehydrogenase 0.0008 0.0023 0.0035
Schistosoma mansoni pyruvate kinase 0.0046 0.0756 0.1156
Loa Loa (eye worm) pyruvate kinase 0.0046 0.0756 0.1156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0058 0.0157
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0023 0.0023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.001 0.0058 0.0157
Loa Loa (eye worm) glutathione reductase 0.0028 0.0401 0.0614
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0016 0.0172 0.0504
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0023 0.0039
Brugia malayi oxidoreductase 0.0008 0.0023 0.0078
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Echinococcus granulosus pyruvate kinase 0.0046 0.0756 0.1156
Echinococcus granulosus hypothetical protein 0.0008 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0097 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0058 0.0157
Trypanosoma brucei unspecified product 0.0009 0.0042 0.0065
Schistosoma mansoni protein phosphatase 2C 0.0013 0.0124 0.019
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0032 0.0478 0.0478
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0164 0.2984 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0023 0.0039
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0023 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0172 0.0577
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0063 0.1076 0.1076
Leishmania major GTP-binding protein, putative 0.0024 0.0336 0.109
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.001 0.0058 0.0157
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.001 0.0058 0.0755
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0023 0.0039
Plasmodium falciparum importin beta, putative 0.0033 0.05 0.1677
Entamoeba histolytica acyl-coA synthetase, putative 0.0016 0.0172 0.1755
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0023 0.0039
Echinococcus granulosus dna polymerase eta 0.0013 0.0117 0.0179
Brugia malayi pyruvate kinase, muscle isozyme 0.001 0.0062 0.0206
Plasmodium vivax ubiquitin activating enzyme, putative 0.0032 0.0478 0.1537
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.001 0.0058 0.0089
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.001 0.0058 0.0089
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0032 0.0487 0.5459
Echinococcus multilocularis voltage dependent calcium channel 0.0063 0.1076 0.1076
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0127 0.0427
Mycobacterium leprae Probable pyruvate kinase PykA 0.0046 0.0756 0.2474
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0032 0.0487 0.1599
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.05 0.1677
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0032 0.0487 0.1566
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0172 0.0504
Echinococcus granulosus JmjC domain containing protein 4 0.0013 0.0124 0.019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0112 0.1996 0.669
Leishmania major 4-coumarate:coa ligase-like protein 0.0016 0.0172 0.054
Onchocerca volvulus Pyruvate kinase homolog 0.0046 0.0756 0.2474
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0008 0.0023 0.0078
Echinococcus multilocularis pyruvate kinase 0.0046 0.0756 0.0756
Loa Loa (eye worm) jmjC domain-containing protein 0.0084 0.1463 0.2238
Echinococcus granulosus pyruvate kinase 0.0046 0.0756 0.1156
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0112 0.1996 0.1996
Trichomonas vaginalis pyruvate kinase, putative 0.0046 0.0756 0.5502
Schistosoma mansoni pyruvate kinase 0.0024 0.0328 0.0501
Echinococcus granulosus jumonji domain containing protein 0.0056 0.0946 0.1447
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0016 0.0172 0.0504
Echinococcus granulosus lysine specific demethylase 6a 0.0013 0.0124 0.019
Echinococcus granulosus peregrin 0.0041 0.0645 0.0986
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0021 0.0272 0.0913
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0053 0.0873 0.2869
Onchocerca volvulus Pyruvate kinase homolog 0.0046 0.0756 0.2474
Echinococcus granulosus dna polymerase kappa 0.0013 0.0117 0.0179
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.001 0.0058 0.0755
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0023 0.0078
Brugia malayi pyruvate kinase 0.001 0.0062 0.0206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0016 0.0172 0.0504
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0013 0.0124 0.0124
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0023 0.0035
Brugia malayi jmjC domain containing protein 0.0013 0.0124 0.0417
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0013 0.0117 0.0706
Plasmodium vivax thioredoxin reductase, putative 0.0028 0.0401 0.1277
Echinococcus granulosus amyloid beta A4 protein 0.0045 0.0734 0.1122
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0032 0.0487 0.1566
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0382 0.2697
Giardia lamblia NADH oxidase lateral transfer candidate 0.001 0.0058 0.0667
Echinococcus multilocularis JmjC domain containing protein 4 0.0013 0.0124 0.0124
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0032 0.0487 0.1566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0112 0.1996 0.3053
Giardia lamblia Hypothetical protein 0.0008 0.0023 0.0266
Loa Loa (eye worm) oxidoreductase 0.0008 0.0023 0.0035
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0023 0.0039
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0023 0.0023
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0023 0.0023
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0063 0.1076 0.1646
Plasmodium falciparum glutathione reductase 0.001 0.0058 0.0195
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.001 0.0058 0.0058
Plasmodium vivax pyruvate kinase 2, putative 0.0024 0.0328 0.1028
Plasmodium falciparum thioredoxin reductase 0.001 0.0058 0.0195
Brugia malayi PHD-finger family protein 0.0013 0.0127 0.0427
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Trichomonas vaginalis DNA helicase recq, putative 0.0008 0.0036 0.0099
Echinococcus multilocularis dna polymerase eta 0.0013 0.0117 0.0117
Schistosoma mansoni amyloid beta A4 protein related 0.0045 0.0734 0.1122
Brugia malayi hypothetical protein 0.0008 0.0023 0.0078
Plasmodium falciparum JmjC domain-containing protein, putative 0.0013 0.0124 0.0417
Echinococcus granulosus lysine specific demethylase 5A 0.0049 0.0807 0.1234
Toxoplasma gondii transporter, cation channel family protein 0.0013 0.0127 0.0427
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0032 0.0487 0.1599
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0011 0.0085 0.021
Brugia malayi PHD-finger family protein 0.0041 0.0645 0.2161
Toxoplasma gondii carbonyl reductase 1, putative 0.0008 0.0023 0.0078
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0053 0.0873 0.6381
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0023 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0164 0.2984 1
Plasmodium falciparum phd finger protein, putative 0.0041 0.0645 0.2161
Echinococcus multilocularis PHD finger protein rhinoceros 0.0041 0.0645 0.0645
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0013 0.0124 0.019
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0023 0.0039
Plasmodium vivax JmjC domain containing protein 0.0013 0.0124 0.0342
Trypanosoma brucei unspecified product 0.0009 0.0042 0.0065
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0021 0.0272 0.0416
Trichomonas vaginalis DNA helicase recq1, putative 0.0016 0.0176 0.1148
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0023 0.0078
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.008 0.139 0.466
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0053 0.0873 0.1335
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0063 0.1074 0.3548
Leishmania major importin beta-1 subunit, putative 0.0027 0.0382 0.1247
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.008 0.139 0.4618
Brugia malayi jmjC domain containing protein 0.0013 0.0124 0.0417
Schistosoma mansoni ran 0.0024 0.0336 0.0513
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0382 0.1247
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.001 0.0058 0.0118
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.008 0.139 0.4639
Echinococcus granulosus jumonji domain containing 1A 0.0013 0.0124 0.019
Giardia lamblia Short-chain dehydrogenase, putative 0.0008 0.0023 0.0266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0172 0.0504
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0023 0.0023
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.001 0.0064 0.0176
Echinococcus granulosus bloom syndrome protein 0.0016 0.0176 0.0269
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0023 0.0035
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Brugia malayi Pyruvate kinase, M2 isozyme 0.0046 0.0756 0.2533
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0164 0.2984 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0046 0.0756 0.2533
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0079 0.0188
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0007 0.001 0.0033
Echinococcus multilocularis pyruvate kinase 0.0024 0.0328 0.0328
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0645 0.21
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0018 0.0217 0.0691
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0013 0.0117 0.0179
Brugia malayi Thioredoxin reductase 0.0028 0.0401 0.1345
Leishmania major DNA polymerase eta, putative 0.0013 0.0117 0.0355
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0013 0.0117 0.0179
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0382 0.2697
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0133 0.2393 0.2393
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Toxoplasma gondii pyruvate kinase PyKII 0.0024 0.0328 0.1098
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0014 0.014 0.0468
Plasmodium vivax acyl-CoA synthetase, putative 0.0012 0.0097 0.0251
Loa Loa (eye worm) pyruvate kinase-PB 0.0032 0.049 0.0749
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0035
Brugia malayi hypothetical protein 0.0043 0.07 0.2347
Treponema pallidum exodeoxyribonuclease (exoA) 0.0032 0.0487 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0028 0.0401 0.1277
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0063 0.1076 0.1076
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.001 0.0058 0.0118
Loa Loa (eye worm) voltage-dependent calcium channel 0.0013 0.0127 0.0195
Trypanosoma brucei pyruvate kinase 1 0.0046 0.0756 0.2474
Entamoeba histolytica hypothetical protein 0.0027 0.0382 0.4228
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0078 0.1355 0.4519
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0027 0.0385 0.0589
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0023 0.0035
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0012 0.0097 0.0563
Trypanosoma brucei pyruvate kinase 1, putative 0.0046 0.0756 0.2474
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0023 0.0039
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0021 0.0272 0.0877
Leishmania major hypothetical protein, conserved 0.0013 0.0124 0.0379
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0023 0.0035
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0041 0.0645 0.0986
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Leishmania major pyruvate kinase 0.0046 0.0756 0.2503
Trypanosoma cruzi pyruvate kinase 2, putative 0.0046 0.0756 0.2503
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.001 0.0058 0.0157
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Leishmania major DNA polymerase kappa, putative 0.0013 0.0117 0.0355
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0124 0.019
Giardia lamblia Pyruvate kinase 0.0024 0.0328 0.3754
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Loa Loa (eye worm) oxidoreductase 0.0008 0.0023 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Trypanosoma cruzi DNA polymerase kappa, putative 0.0013 0.0117 0.0355
Echinococcus multilocularis lysine specific demethylase 5A 0.0049 0.0807 0.0807
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0336 0.0513
Mycobacterium ulcerans acyl-CoA synthetase 0.0016 0.0172 0.0504
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0127 0.0195
Mycobacterium tuberculosis Probable dehydrogenase 0.0063 0.1074 0.3548
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0172 0.0577
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0023 0.0035
Loa Loa (eye worm) dehydrogenase 0.0008 0.0023 0.0035
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0023 0.0023
Brugia malayi Bloom's syndrome protein homolog 0.0016 0.0176 0.059
Leishmania major hypothetical protein, conserved 0.0008 0.0023 0.0039
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0016 0.0172 0.0504
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0023 0.0035
Loa Loa (eye worm) ThiF family protein 0.0021 0.0272 0.0416
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0063 0.1076 0.3606
Echinococcus granulosus hypothetical protein 0.0008 0.0023 0.0035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Toxoplasma gondii pyruvate kinase PyK1 0.0046 0.0756 0.2533
Echinococcus multilocularis tumor protein p63 0.0223 0.4095 0.4095
Loa Loa (eye worm) hypothetical protein 0.008 0.1385 0.2118
Toxoplasma gondii exonuclease III APE 0.0032 0.0487 0.1632
Loa Loa (eye worm) oxidoreductase 0.0008 0.0023 0.0035
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.004 0.0643 0.2156
Leishmania major short chain dehydrogenase, putative 0.0008 0.0023 0.0039
Entamoeba histolytica acyl-CoA synthetase, putative 0.0016 0.0172 0.1755
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0023 0.0039
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0013 0.0124 0.0379
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0401 0.1311
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0023 0.0078
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0032 0.0487 0.0745
Loa Loa (eye worm) hypothetical protein 0.0032 0.0478 0.0731
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0023 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0112 0.1996 0.3053
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0117 0.0318
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.001 0.0064 0.0481
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.05 0.1612
Leishmania major ubiquitin-activating enzyme-like protein 0.0021 0.0272 0.0877
Toxoplasma gondii PHD-finger domain-containing protein 0.0041 0.0645 0.2161
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0023 0.0078
Schistosoma mansoni DNA polymerase eta 0.0013 0.0117 0.0179
Leishmania major trypanothione reductase 0.0028 0.0401 0.1311
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0023 0.0023
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0023 0.0035
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.007 0.1207 0.4
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0032 0.0487 0.1566
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0112 0.1996 0.3053
Trichomonas vaginalis mercuric reductase, putative 0.001 0.0058 0.0263
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.0807 0.1234
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0013 0.0124 0.0417
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0023 0.0039

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.49 uM cytotoxic activity toward A2780 ovarian human cell line resistant (R) to cisplatin in experiment 5 ChEMBL. 11000008
IC50 (functional) = 3.8 uM cytotoxic activity toward A2780 ovarian human cell line sensitive (S) to cisplatin in experiment 5 ChEMBL. 11000008
Ratio (functional) = 0.92 Ratio of cytotoxic activity against resistant cell line to that of sensitive cell line ChEMBL. 11000008

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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