Detailed information for compound 2076875

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 458.475 | Formula: C21H29F3N4O4
  • H donors: 3 H acceptors: 4 LogP: -0.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(F)(F)F.CC(NC(=O)N1CCC2(CC1)N(CCNC2=O)Cc1ccccc1)C
  • InChi: 1S/C19H28N4O2.C2HF3O2/c1-15(2)21-18(25)22-11-8-19(9-12-22)17(24)20-10-13-23(19)14-16-6-4-3-5-7-16;3-2(4,5)1(6)7/h3-7,15H,8-14H2,1-2H3,(H,20,24)(H,21,25);(H,6,7)
  • InChiKey: VKYYRDUZNMPALB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Brugia malayi Fibulin-1 precursor 0.0108 0.0025 0.0025
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.031 0.098 0.0868
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0815 0.3361 0.3361
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0481 0.1788 0.1767
Schistosoma mansoni cathepsin F (C01 family) 0.1496 0.6571 0.6571
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0335 0.1098 0.1098
Onchocerca volvulus 0.0109 0.0033 0.0036
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1503 0.6602 0.6602
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Echinococcus granulosus growth factor receptor bound protein 2 0.0856 0.3555 0.3539
Trypanosoma cruzi metacaspase 5, putative 0.0236 0.0631 0.0514
Loa Loa (eye worm) TK/ROR protein kinase 0.0617 0.2427 0.2427
Loa Loa (eye worm) hypothetical protein 0.0119 0.0077 0.0077
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Onchocerca volvulus 0.1503 0.6602 1
Echinococcus multilocularis caspase 8 0.0236 0.0631 0.0607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Brugia malayi aspartic protease BmAsp-2, identical 0.0119 0.0077 0.0077
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.1098 0.0787
Brugia malayi cathepsin F-like cysteine proteinase 0.048 0.1781 0.1781
Loa Loa (eye worm) hypothetical protein 0.048 0.1781 0.1781
Toxoplasma gondii microneme protein MIC17B 0.0109 0.0033 0.0011
Echinococcus multilocularis Mastin 0.0343 0.1134 0.1111
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Plasmodium falciparum plasmepsin I 0.0481 0.1788 0.2634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Loa Loa (eye worm) calpain family protein 1 0.0486 0.181 0.181
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Brugia malayi Trypsin family protein 0.0343 0.1134 0.1134
Echinococcus multilocularis cathepsin L cysteine protease 0.1496 0.6571 0.6562
Echinococcus granulosus calpain 0.0183 0.0383 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.1016 0.4308 0.4308
Onchocerca volvulus 0.0109 0.0033 0.0036
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0335 0.1098 0.1512
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Brugia malayi hypothetical protein 0.0343 0.1134 0.1134
Echinococcus granulosus calpain A 0.0183 0.0383 0.0359
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Echinococcus multilocularis cysteine protease 0.1496 0.6571 0.6562
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1923 0.2176
Toxoplasma gondii microneme protein, putative 0.0109 0.0033 0.0011
Onchocerca volvulus 0.0212 0.0518 0.0772
Plasmodium vivax aspartyl proteinase, putative 0.0481 0.1788 0.2634
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0335 0.1098 0.0787
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Toxoplasma gondii kringle domain-containing protein 0.0617 0.2427 0.3669
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Toxoplasma gondii aspartyl protease ASP3 0.0162 0.0284 0.0395
Brugia malayi Cathepsin L-like cysteine proteinase 0.1016 0.4308 0.4308
Echinococcus multilocularis growth factor receptor bound protein 2 0.0856 0.3555 0.3539
Onchocerca volvulus 0.0652 0.2591 0.3916
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0192 0.0425 0.0401
Echinococcus granulosus glycoprotein Antigen 5 0.0343 0.1134 0.1111
Brugia malayi calpain 5 0.0128 0.0123 0.0123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Echinococcus granulosus Tolloid protein 1 0.018 0.0365 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1496 0.6571 1
Brugia malayi Trypsin family protein 0.0343 0.1134 0.1134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Onchocerca volvulus 0.0119 0.0077 0.0104
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Brugia malayi Cathepsin L-like precursor 0.1016 0.4308 0.4308
Echinococcus granulosus thymidylate synthase 0.0652 0.2591 0.2572
Brugia malayi aspartic protease BmAsp-1, identical 0.0119 0.0077 0.0077
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0508 0.1914 0.1893
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0343 0.1134 0.1111
Toxoplasma gondii microneme protein MIC17C 0.0109 0.0033 0.0011
Onchocerca volvulus 0.0109 0.0033 0.0036
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Onchocerca volvulus 0.0109 0.0033 0.0036
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0085 0.0085
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0335 0.1098 0.1572
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1496 0.6571 0.6562
Plasmodium falciparum serine repeat antigen 5 0.0335 0.1098 0.1572
Onchocerca volvulus 0.0335 0.1098 0.1652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1496 0.6571 0.6571
Onchocerca volvulus 0.1496 0.6571 0.9953
Plasmodium falciparum serine repeat antigen 4 0.0335 0.1098 0.1572
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Echinococcus multilocularis cathepsin b 0.2223 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni hypothetical protein 0.0617 0.2427 0.2427
Echinococcus multilocularis calpain 0.0183 0.0383 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0335 0.1098 0.0787
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0108 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Trypanosoma brucei metacaspase MCA2 0.0236 0.0631 0.0787
Onchocerca volvulus 0.0119 0.0077 0.0104
Loa Loa (eye worm) hypothetical protein 0.0303 0.0946 0.0946
Echinococcus multilocularis dihydrofolate reductase 0.0266 0.0771 0.0748
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Toxoplasma gondii cathepsin CPC2 0.0376 0.1291 0.1934
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.018 0.0365 0.0365
Trypanosoma brucei metacaspase 0.0236 0.0631 0.0787
Loa Loa (eye worm) calpain 5 0.0128 0.0123 0.0123
Brugia malayi Cathepsin L-like precursor 0.1016 0.4308 0.4308
Schistosoma mansoni cathepsin F (C01 family) 0.1016 0.4308 0.4308
Onchocerca volvulus Cathepsin F homolog 0.1496 0.6571 0.9953
Loa Loa (eye worm) hypothetical protein 0.0431 0.155 0.155
Chlamydia trachomatis dihydrofolate reductase 0.0266 0.0771 0.5
Echinococcus granulosus tissue type plasminogen activator 0.0617 0.2427 0.2407
Onchocerca volvulus 0.1496 0.6571 0.9953
Toxoplasma gondii hypothetical protein 0.0109 0.0033 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1016 0.4308 0.6191
Echinococcus granulosus caspase 0.0531 0.2022 0.2002
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) calpain family protein 1 0.0358 0.1206 0.1206
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0376 0.1291 0.1869
Echinococcus granulosus caspase 8 0.0236 0.0631 0.0607
Echinococcus multilocularis tissue type plasminogen activator 0.0617 0.2427 0.2407
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0335 0.1098 0.1572
Loa Loa (eye worm) hypothetical protein 0.0117 0.0068 0.0068
Echinococcus granulosus cathepsin b 0.2223 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Plasmodium falciparum serine repeat antigen 9 0.0335 0.1098 0.1572
Onchocerca volvulus 0.0109 0.0033 0.0036
Brugia malayi cathepsin L-like cysteine proteinase 0.0335 0.1098 0.1098
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Schistosoma mansoni calpain-7 (C02 family) 0.0183 0.0383 0.0383
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2223 1 1
Entamoeba histolytica cysteine proteinase 2 0.0815 0.3361 0.5021
Brugia malayi calpain 7 0.0183 0.0383 0.0383
Schistosoma mansoni calpain (C02 family) 0.0183 0.0383 0.0383
Echinococcus multilocularis cathepsin L 0.0815 0.3361 0.3344
Echinococcus granulosus cathepsin L 0.0335 0.1098 0.1075
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Brugia malayi STAT protein, DNA binding domain containing protein 0.0373 0.1275 0.1275
Loa Loa (eye worm) hypothetical protein 0.0119 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0443 0.1607 0.2355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0919 0.3851 0.5782
Brugia malayi cathepsin Z-like cysteine proteinase 0.051 0.1923 0.1923
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0335 0.1098 0.1572
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Leishmania major metacaspase, putative 0.0236 0.0631 0.0787
Trypanosoma cruzi cysteine protease, putative 0.0815 0.3361 0.3278
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1496 0.6571 1
Loa Loa (eye worm) dihydrofolate reductase 0.0266 0.0771 0.0771
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Loa Loa (eye worm) hypothetical protein 0.1503 0.6602 0.6602
Loa Loa (eye worm) fibroinase 0.1496 0.6571 0.6571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2223 1 1
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0652 0.2591 0.2591
Echinococcus multilocularis hypothetical protein 0.0183 0.0383 0.0359
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Trypanosoma brucei antigen, putative 0.0183 0.0383 0.0403
Trypanosoma cruzi cysteine peptidase, putative 0.0815 0.3361 0.3278
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1512 0.6645 0.6645
Plasmodium falciparum cysteine proteinase falcipain 1 0.0815 0.3361 0.5056
Onchocerca volvulus Cathepsin L homolog 0.1496 0.6571 0.9953
Brugia malayi fibroinase precursor 0.0335 0.1098 0.1098
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Plasmodium vivax plasmepsin IV, putative 0.0481 0.1788 0.2634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1016 0.4308 0.6191
Onchocerca volvulus 0.0617 0.2427 0.3667
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2223 1 1
Plasmodium falciparum plasmepsin VI 0.0481 0.1788 0.2634
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) STAT protein 0.0373 0.1275 0.1275
Mycobacterium ulcerans hypothetical protein 0.0343 0.1134 0.1993
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0815 0.3361 0.3361
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0352 0.1177 0.1177
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0481 0.1788 0.2693
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.577
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0481 0.1788 0.1788
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.0631 0.0631
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Loa Loa (eye worm) hypothetical protein 0.1016 0.4308 0.4308
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Echinococcus granulosus enteropeptidase 0.0343 0.1134 0.1111
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0919 0.3851 0.5422
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0335 0.1098 0.1572
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0335 0.1098 0.1098
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Schistosoma mansoni cathepsin D (A01 family) 0.1458 0.6394 0.6394
Trypanosoma cruzi metacaspase 5, putative 0.0236 0.0631 0.0514
Onchocerca volvulus 0.1016 0.4308 0.6521
Loa Loa (eye worm) aspartyl protease 6 0.0119 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0192 0.0425 0.0425
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Giardia lamblia Cathepsin B precursor 0.051 0.1923 0.2996
Echinococcus granulosus caspase 2 0.0448 0.163 0.1609
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0403
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.048 0.1781 0.1781
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0617 0.2427 0.3618
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Schistosoma mansoni cathepsin B (C01 family) 0.0335 0.1098 0.1098
Schistosoma mansoni memapsin-2 (A01 family) 0.0119 0.0077 0.0077
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Brugia malayi Pepsin A precursor 0.0119 0.0077 0.0077
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0815 0.3361 0.3361
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0343 0.1134 0.1111
Onchocerca volvulus 0.1496 0.6571 0.9953
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0815 0.3361 0.5021
Toxoplasma gondii hypothetical protein 0.0109 0.0033 0.0011
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0531 0.2022 0.2002
Brugia malayi Kringle domain containing protein 0.0617 0.2427 0.2427
Echinococcus granulosus apoptotic protease activating factor 1 0.0212 0.0518 0.0494
Brugia malayi Cathepsin L-like precursor 0.048 0.1781 0.1781
Echinococcus granulosus cathepsin l1 0.1016 0.4308 0.4294
Loa Loa (eye worm) cysteine protease 0.1496 0.6571 0.6571
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Plasmodium falciparum cysteine repeat modular protein 1 0.0617 0.2427 0.3618
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0335 0.1098 0.1098
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0236 0.0631 0.0925
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0443 0.1607 0.1847
Echinococcus multilocularis calpain 7 (C02 family) 0.0183 0.0383 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0918 0.3844 0.58
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1496 0.6571 1
Schistosoma mansoni hypothetical protein 0.0212 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.1503 0.6602 0.6602
Loa Loa (eye worm) hypothetical protein 0.0617 0.2427 0.2427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0815 0.3361 0.5021
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0376 0.1291 0.0701
Schistosoma mansoni cathepsin F (C01 family) 0.1496 0.6571 0.6571
Schistosoma mansoni growth factor receptor-bound protein 0.0856 0.3555 0.3555
Loa Loa (eye worm) hypothetical protein 0.0448 0.163 0.163
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2223 1 1
Brugia malayi Dihydrofolate reductase 0.0266 0.0771 0.0771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Echinococcus granulosus cathepsin L 0.0815 0.3361 0.3344
Brugia malayi thymidylate synthase 0.0652 0.2591 0.2591
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.051 0.1923 0.1923
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Onchocerca volvulus 0.0343 0.1134 0.1706
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Mycobacterium tuberculosis Possible exported protein 0.0386 0.1337 0.3106
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Schistosoma mansoni hypothetical protein 0.0343 0.1134 0.1134
Plasmodium vivax vivapain-2 0.1496 0.6571 1
Onchocerca volvulus Cathepsin L homolog 0.1496 0.6571 0.9953
Toxoplasma gondii aspartyl protease 0.0119 0.0077 0.008
Echinococcus multilocularis cathepsin L 0.0335 0.1098 0.1075
Trypanosoma brucei Metacaspase-4 0.0236 0.0631 0.0787
Toxoplasma gondii subtilisin SUB12 0.0109 0.0033 0.0011
Plasmodium vivax unspecified product 0.048 0.1781 0.2624
Plasmodium falciparum plasmepsin IX 0.0162 0.0284 0.0318
Loa Loa (eye worm) hypothetical protein 0.0104 0.0009 0.0009
Brugia malayi cathepsin L-like precursor 0.1016 0.4308 0.4308
Plasmodium falciparum serine repeat antigen 7 0.0335 0.1098 0.1572
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Plasmodium vivax serine-repeat antigen (SERA) 0.0335 0.1098 0.1572
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0335 0.1098 0.1572
Mycobacterium tuberculosis Hypothetical protein 0.031 0.098 0.1148
Brugia malayi calpain family protein 1 0.0486 0.181 0.181
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Brugia malayi Trypsin-like protease protein 5 0.0343 0.1134 0.1134
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0531 0.2022 0.2002
Trypanosoma cruzi cysteine peptidase, putative 0.048 0.1781 0.1679
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.1496 0.6571 0.6571
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1098 0.0787
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.048 0.1781 0.1781
Plasmodium falciparum serine repeat antigen 1 0.0335 0.1098 0.1572
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1496 0.6571 0.6562
Loa Loa (eye worm) trypsin family protein 0.0343 0.1134 0.1134
Onchocerca volvulus 0.0109 0.0033 0.0036
Onchocerca volvulus 0.0109 0.0033 0.0036
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0443 0.1607 0.2355
Loa Loa (eye worm) hypothetical protein 0.0104 0.0009 0.0009
Toxoplasma gondii PAN/Apple domain-containing protein 0.0109 0.0033 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0402 0.1414 0.1318
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Brugia malayi Cell death protein 3 precursor 0.0448 0.163 0.163
Echinococcus granulosus cathepsin L cysteine proteinase 0.1496 0.6571 0.6562
Loa Loa (eye worm) cathepsin B 0.0919 0.3851 0.3851
Onchocerca volvulus 0.0109 0.0033 0.0036
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Echinococcus multilocularis Tolloid protein 1 0.018 0.0365 0.0341
Echinococcus granulosus cathepsin b 0.2223 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0815 0.3361 0.4596
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0652 0.2591 1
Echinococcus granulosus cathepsin l1 0.1496 0.6571 0.6562
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0335 0.1098 0.1572
Echinococcus multilocularis caspase 0.0531 0.2022 0.2002
Brugia malayi Trypsin family protein 0.0343 0.1134 0.1134
Onchocerca volvulus 0.0109 0.0033 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Loa Loa (eye worm) thymidylate synthase 0.0652 0.2591 0.2591
Onchocerca volvulus 0.1496 0.6571 0.9953
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0104 0.0009 0.0009
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0343 0.1134 0.1111
Onchocerca volvulus Cell death protein 3 homolog 0.0448 0.163 0.2458
Brugia malayi hypothetical protein 0.0212 0.0518 0.0518
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0815 0.3361 0.3278
Brugia malayi Papain family cysteine protease containing protein 0.0815 0.3361 0.3361
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Schistosoma mansoni caspase-3 (C14 family) 0.0531 0.2022 0.2022
Entamoeba histolytica cysteine proteinase, putative 0.1496 0.6571 1
Schistosoma mansoni cathepsin C 0.0335 0.1098 0.1098
Mycobacterium ulcerans thymidylate synthase 0.0652 0.2591 1
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Echinococcus granulosus dihydrofolate reductase 0.0266 0.0771 0.0748
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0335 0.1098 0.1098
Toxoplasma gondii microneme protein MIC17A 0.0109 0.0033 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Entamoeba histolytica cysteine proteinase, putative 0.1016 0.4308 0.6491
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0508 0.1914 0.1893
Brugia malayi Calcium binding EGF domain containing protein 0.0108 0.0025 0.0025
Plasmodium vivax vivapain-2 0.1496 0.6571 1
Echinococcus multilocularis calpain A 0.0508 0.1914 0.1893
Onchocerca volvulus 0.116 0.4987 0.755
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0335 0.1098 0.1512
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Schistosoma mansoni caspase-7 (C14 family) 0.0448 0.163 0.163
Trypanosoma cruzi cysteine proteinase, putative 0.0815 0.3361 0.3278
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0108 0.0025 0.0025
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0343 0.1134 0.1134
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Giardia lamblia Cathepsin B precursor 0.0919 0.3851 1
Trypanosoma brucei metacaspase 5, putative 0.0236 0.0631 0.0787
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0919 0.3851 0.5782
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0335 0.1098 0.0787
Brugia malayi cathepsin L precursor 0.0335 0.1098 0.1098
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0508 0.1914 0.1914
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Echinococcus multilocularis glycoprotein Antigen 5 0.0343 0.1134 0.1111
Echinococcus multilocularis calpain family protein 1, d 0.0358 0.1206 0.1183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Brugia malayi calpain family protein 1 0.0486 0.181 0.181
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Echinococcus multilocularis apoptotic protease activating factor 1 0.0212 0.0518 0.0494
Entamoeba histolytica cysteine protease, putative 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0236 0.0631 0.0925
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Loa Loa (eye worm) hypothetical protein 0.0358 0.1206 0.1206
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0104 0.0009 0.0009
Brugia malayi Trypsin family protein 0.1503 0.6602 0.6602
Giardia lamblia Cathepsin B precursor 0.0919 0.3851 1
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Toxoplasma gondii preprocathepsin c precursor, putative 0.0443 0.1607 0.2416
Loa Loa (eye worm) papain family cysteine protease containing protein 0.048 0.1781 0.1781
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Schistosoma mansoni hypothetical protein 0.0343 0.1134 0.1134
Leishmania major hypothetical protein, conserved 0.0617 0.2427 0.3573
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Schistosoma mansoni cathepsin S (C01 family) 0.0335 0.1098 0.1098
Trypanosoma cruzi cruzipain precursor, putative 0.1496 0.6571 0.6528
Schistosoma mansoni Mername-AA248 (C02 family) 0.0183 0.0383 0.0383
Echinococcus granulosus calpain A 0.0508 0.1914 0.1893
Loa Loa (eye worm) hypothetical protein 0.0486 0.181 0.181
Onchocerca volvulus 0.0343 0.1134 0.1706
Echinococcus granulosus cathepsin L cysteine protease 0.0815 0.3361 0.3344
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0109 0.0033 0.0011
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.5834
Schistosoma mansoni calpain C (C02 family) 0.0183 0.0383 0.0383
Brugia malayi Protein kinase domain containing protein 0.0617 0.2427 0.2427
Entamoeba histolytica cysteine protease, putative 0.0335 0.1098 0.1512
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.051 0.1923 0.2176
Brugia malayi Papain family cysteine protease containing protein 0.1496 0.6571 0.6571
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Onchocerca volvulus Cathepsin L homolog 0.0335 0.1098 0.1652
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0192 0.0425 0.0401
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0183 0.0383 0.0263
Plasmodium falciparum plasmepsin X 0.0162 0.0284 0.0318
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0119 0.0077 0.008
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Echinococcus multilocularis caspase 3 0.0295 0.091 0.0887
Onchocerca volvulus 0.0303 0.0946 0.1421
Plasmodium falciparum plasmepsin IV 0.0481 0.1788 0.2634
Echinococcus granulosus caspase 3 0.0295 0.091 0.0887
Plasmodium falciparum serine repeat antigen 2 0.0335 0.1098 0.1572
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Onchocerca volvulus 0.0109 0.0033 0.0036
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Leishmania major cysteine peptidase A (CPA) 0.1496 0.6571 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.58
Echinococcus multilocularis enteropeptidase 0.0343 0.1134 0.1111
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Brugia malayi hypothetical protein 0.031 0.098 0.098
Brugia malayi Sex muscle abnormal protein 5 0.0856 0.3555 0.3555
Brugia malayi Papain family cysteine protease containing protein 0.0815 0.3361 0.3361
Plasmodium vivax unspecified product 0.0815 0.3361 0.5056
Loa Loa (eye worm) hypothetical protein 0.0343 0.1134 0.1134
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Echinococcus multilocularis cathepsin b 0.2223 1 1
Echinococcus granulosus Mastin 0.0343 0.1134 0.1111
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0192 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0175 0.0345 0.0345
Toxoplasma gondii cathepsin CPC1 0.0443 0.1607 0.2416
Echinococcus multilocularis caspase 2 0.0448 0.163 0.1609
Toxoplasma gondii cathepsin CPL 0.1496 0.6571 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1496 0.6571 0.6571
Brugia malayi cathepsin Z-like cysteine proteinase 0.051 0.1923 0.1923
Plasmodium falciparum serine repeat antigen 6 0.0335 0.1098 0.1572
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Onchocerca volvulus 0.1496 0.6571 0.9953
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0508 0.1914 0.1914
Toxoplasma gondii aspartyl protease ASP1 0.0481 0.1788 0.2693
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0236 0.0631 0.0631
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0236 0.0631 0.0925
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0919 0.3851 0.3851
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Trichomonas vaginalis conserved hypothetical protein 0.0335 0.1098 0.0787
Entamoeba histolytica cysteine proteinase 1, putative 0.0815 0.3361 0.5021
Entamoeba histolytica cysteine proteinase, putative 0.0815 0.3361 0.5021
Echinococcus granulosus cysteine protease 0.0815 0.3361 0.3344
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0443 0.1607 0.2355
Toxoplasma gondii cathepsin B 0.0919 0.3851 0.5845
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.1016 0.4308 0.4308
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Onchocerca volvulus 0.0343 0.1134 0.1706
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0486 0.181 0.181
Trypanosoma cruzi cysteine peptidase, putative 0.1496 0.6571 0.6528
Onchocerca volvulus 0.1496 0.6571 0.9953
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1016 0.4308 0.4237
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0443 0.1607 0.1607
Trypanosoma cruzi major cysteine proteinase, putative 0.0335 0.1098 0.0987
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Echinococcus granulosus transmembrane protease serine 3 0.0343 0.1134 0.1111
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.3365 0.3348
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.048 0.1781 0.1781
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Leishmania major cathepsin L-like protease 0.1496 0.6571 1
Schistosoma mansoni cathepsin D (A01 family) 0.1458 0.6394 0.6394
Brugia malayi dihydrofolate reductase family protein 0.0266 0.0771 0.0771
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0376 0.1291 0.0701
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0236 0.0631 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0335 0.1098 0.0787
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1111
Toxoplasma gondii microneme protein MIC4 0.0109 0.0033 0.0011
Onchocerca volvulus 0.0343 0.1134 0.1706
Trypanosoma cruzi hypothetical protein, conserved 0.0617 0.2427 0.2332
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1923 0.2176
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.3767
Plasmodium vivax unspecified product 0.0335 0.1098 0.1572
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.051 0.1923 0.2176
Trichomonas vaginalis conserved hypothetical protein 0.031 0.098 0.0588
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Echinococcus multilocularis thymidylate synthase 0.0652 0.2591 0.2572
Trypanosoma cruzi major cysteine proteinase, putative 0.0335 0.1098 0.0987
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Loa Loa (eye worm) hypothetical protein 0.0481 0.1788 0.1788
Entamoeba histolytica cysteine proteinase, putative 0.1496 0.6571 1
Plasmodium falciparum metacaspase-like protein 0.0236 0.0631 0.0852
Giardia lamblia Cathepsin B precursor 0.0919 0.3851 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1496 0.6571 1
Plasmodium vivax metacaspase 1, putative 0.0236 0.0631 0.0852
Schistosoma mansoni calpain-7 (C02 family) 0.0183 0.0383 0.0383
Schistosoma mansoni caspase-7 (C14 family) 0.0531 0.2022 0.2022
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0376 0.1291 0.1869
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0919 0.3851 0.3775
Onchocerca volvulus 0.0109 0.0033 0.0036
Brugia malayi Eukaryotic aspartyl protease family protein 0.0119 0.0077 0.0077
Loa Loa (eye worm) calpain 0.0183 0.0383 0.0383
Echinococcus multilocularis cathepsin L cysteine protease 0.1496 0.6571 0.6562
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0652 0.2591 1
Echinococcus multilocularis calpain 5 0.0183 0.0383 0.0359
Brugia malayi cathepsin F-like cysteine proteinase 0.0335 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Plasmodium falciparum metacaspase 1 0.0236 0.0631 0.0852
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Onchocerca volvulus 0.0343 0.1134 0.1706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1496 0.6571 1
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Schistosoma mansoni cathepsin s 0.048 0.1781 0.1781
Trypanosoma cruzi cysteine proteinase, putative 0.0815 0.3361 0.3278
Plasmodium vivax aspartyl protease, putative 0.0162 0.0284 0.0318
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0343 0.1134 0.1134
Trypanosoma brucei metacaspase MCA3 0.0236 0.0631 0.0787
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Echinococcus multilocularis transmembrane protease serine 3 0.0343 0.1134 0.1111
Plasmodium vivax vivapain-3 0.0815 0.3361 0.5056
Trypanosoma cruzi metacaspase, putative 0.0236 0.0631 0.0514
Entamoeba histolytica hypothetical protein 0.0335 0.1098 0.1512
Echinococcus granulosus cathepsin l cysteine peptidase 0.1496 0.6571 0.6562
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2223 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0481 0.1788 0.1788
Echinococcus granulosus calpain 5 0.0183 0.0383 0.0359
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0335 0.1098 0.1098
Plasmodium falciparum serine repeat antigen 3 0.0335 0.1098 0.1572
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Loa Loa (eye worm) ctsf protein 0.1496 0.6571 0.6571
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0335 0.1098 0.0787
Brugia malayi PAN domain containing protein 0.0109 0.0033 0.0033
Brugia malayi MH2 domain containing protein 0.012 0.0085 0.0085
Brugia malayi hypothetical protein 0.0119 0.0077 0.0077
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0443 0.1607 0.2355
Plasmodium falciparum serine repeat antigen 8 0.0335 0.1098 0.1572
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Plasmodium vivax vivapain-1 0.0815 0.3361 0.5056
Toxoplasma gondii PAN domain-containing protein 0.0109 0.0033 0.0011
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0119 0.0077 0.0077
Plasmodium vivax aspartyl protease, putative 0.0162 0.0284 0.0318
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0481 0.1788 0.1948
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Schistosoma mansoni growth factor receptor-bound protein 0.0856 0.3555 0.3555
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Schistosoma mansoni egf-like domain protein 0.0104 0.0009 0.0009
Schistosoma mansoni cercarial elastase (S01 family) 0.0343 0.1134 0.1134
Loa Loa (eye worm) PAN domain-containing protein 0.0109 0.0033 0.0033
Echinococcus multilocularis cysteine protease 0.1496 0.6571 0.6562
Echinococcus granulosus calpain 7 C02 family 0.0183 0.0383 0.0359
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0183 0.0383 0.0263
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0119 0.0077 0.0077
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0335 0.1098 0.1572
Brugia malayi Cathepsin L-like precursor 0.1496 0.6571 0.6571
Trypanosoma brucei calpain-like protein, putative 0.0183 0.0383 0.0403
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0343 0.1134 0.1134
Plasmodium vivax calpain, putative 0.0183 0.0383 0.0471
Plasmodium falciparum cysteine proteinase falcipain 3 0.1496 0.6571 1
Brugia malayi Papain family cysteine protease containing protein 0.0335 0.1098 0.1098
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Schistosoma mansoni dihydrofolate reductase 0.0266 0.0771 0.0771
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0481 0.1788 0.1767
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0335 0.1098 0.0787
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0918 0.3844 0.577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Plasmodium falciparum plasmepsin II 0.0481 0.1788 0.2634
Onchocerca volvulus 0.1496 0.6571 0.9953
Trypanosoma cruzi cruzipain precursor, putative 0.048 0.1781 0.1679
Plasmodium vivax serine-repeat antigen (SERA) 0.0335 0.1098 0.1572
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0815 0.3361 0.4596
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0263
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0192 0.0425 0.0425
Plasmodium vivax hypothetical protein, conserved 0.0236 0.0631 0.0852
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Entamoeba histolytica cysteine protease, putative 0.0815 0.3361 0.5021
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0183 0.0383 0.0403
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0856 0.3555 0.3555
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.0518 0.0518
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1496 0.6571 1
Giardia lamblia Encystation-specific protease 0.0376 0.1291 0.0701
Brugia malayi hypothetical protein 0.0119 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0335 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.2223 1 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0033 0.0033
Loa Loa (eye worm) bone morphogenetic protein 1b 0.018 0.0365 0.0365

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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