Detailed information for compound 2077023

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 539.468 | Formula: C23H27F6N3O5
  • H donors: 2 H acceptors: 5 LogP: 1.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.Cn1cccc1CN1CCC2(CC1)CC(C2)Oc1cccnc1
  • InChi: 1S/C19H25N3O.2C2HF3O2/c1-21-9-3-4-16(21)15-22-10-6-19(7-11-22)12-18(13-19)23-17-5-2-8-20-14-17;2*3-2(4,5)1(6)7/h2-5,8-9,14,18H,6-7,10-13,15H2,1H3;2*(H,6,7)
  • InChiKey: OFFOYZZFCPRKSY-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0536 0.7613 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0189 0.0189
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0021 0.0009 0.0012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0189 0.0248
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0032 0.0166 0.0219
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0031 0.0145 0.019
Brugia malayi Proteasome A-type and B-type family protein 0.0414 0.5816 0.5816
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0031 0.0145 0.0145
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0021 0.0009 0.0012
Leishmania major proteasome alpha 3 subunit, putative 0.0175 0.2285 0.3001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0189 0.0248
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0228 0.306 0.4019
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0041 0.0298 0.0391
Loa Loa (eye worm) hypothetical protein 0.0228 0.3066 0.3066
Onchocerca volvulus 0.004 0.0285 0.1232
Brugia malayi Protein kinase domain containing protein 0.0021 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0204 0.2703 0.355
Echinococcus multilocularis proteasome subunit beta type 6 0.0176 0.2292 0.301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0189 0.0189
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0093 0.1067 0.1401
Echinococcus granulosus nuclear factor of activated T cells 5 0.0374 0.5212 0.6846
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0023 0.0027 0.0035
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0228 0.306 0.4019
Trypanosoma brucei proteasome beta 6 subunit 0.0269 0.3663 0.4811
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0163 0.2108 0.2769
Schistosoma mansoni hypothetical protein 0.004 0.0285 0.0374
Brugia malayi ecdysteroid receptor 0.0034 0.0189 0.0189
Echinococcus granulosus proteasome subunit alpha type 6 0.0189 0.2479 0.3256
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0189 0.0189
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0189 0.0248
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0007 0.0009
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0041 0.0298 0.0391
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0166 0.0219
Echinococcus granulosus proteasome subunit alpha type 2 0.0181 0.2364 0.3104
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0175 0.2285 0.3001
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0176 0.2292 0.301
Brugia malayi proteasome subunit beta type 3 0.0169 0.2194 0.2194
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0021 0.0009 0.0012
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0536 0.7613 1
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0031 0.0145 0.019
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0035 0.0211 0.0278
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0023 0.0027 0.0035
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0175 0.2277 0.2991
Toxoplasma gondii heat shock protein hslv, putative 0.0141 0.1777 0.2334
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0169 0.2194 0.2882
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0145
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0039 0.0264 0.0347
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0181 0.2364 0.2364
Toxoplasma gondii proteasome subunit beta type, putative 0.0536 0.7613 1
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0175 0.2285 0.3001
Brugia malayi steroid hormone receptor 0.0034 0.0189 0.0189
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0188 0.2464 0.3236
Brugia malayi Proteasome A-type and B-type family protein 0.0176 0.2292 0.2292
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0022 0.0018 0.0024
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0141 0.1777 0.2334
Echinococcus granulosus proteasome prosome macropain 0.0536 0.7613 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0211 0.0278
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0177 0.2311 0.2311
Loa Loa (eye worm) hypothetical protein 0.0038 0.0259 0.0259
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.044
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0189 0.0248
Echinococcus granulosus enteropeptidase 0.004 0.0285 0.0374
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0032 0.0169 0.0222
Brugia malayi Trypsin family protein 0.004 0.0285 0.0285
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0041 0.0298 0.0391
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0007 0.0009
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Brugia malayi PCI domain containing protein 0.0032 0.0166 0.0166
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0189 0.0248
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0031 0.0145 0.019
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0204 0.2703 0.355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0189 0.0189
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0046 0.0372 0.0489
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0169 0.0222
Schistosoma mansoni carbonic anhydrase 0.0067 0.0684 0.0899
Leishmania major proteasome beta-1 subunit, putative 0.0176 0.2292 0.301
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0023 0.0027 0.0035
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0031 0.0145 0.019
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0166 0.0219
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0684 0.0899
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0023 0.0027 0.0035
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0041 0.0298 0.0391
Loa Loa (eye worm) proteasome subunit beta type 1 0.0269 0.3663 0.3663
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0177 0.2311 0.3035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0189 0.0189
Brugia malayi Proteasome A-type and B-type family protein 0.0536 0.7613 0.7613
Echinococcus multilocularis proteasome subunit alpha type 6 0.0189 0.2479 0.3256
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0536 0.7613 1
Echinococcus multilocularis proteasome subunit beta type 7 0.0414 0.5816 0.7639
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0169 0.0222
Schistosoma mansoni proteasome regulatory subunit-related 0.0035 0.0211 0.0278
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0042 0.0307 0.0404
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0034 0.0196 0.0196
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0007 0.0009
Echinococcus multilocularis glycoprotein Antigen 5 0.004 0.0285 0.0374
Entamoeba histolytica proteasome regulatory subunit, putative 0.0042 0.0307 0.0404
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0189 0.0248
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0269 0.3663 0.4811
Loa Loa (eye worm) PCI domain-containing protein 0.0035 0.0211 0.0211
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0189 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0189 0.0189
Toxoplasma gondii hypothetical protein 0.0028 0.011 0.0144
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0042 0.0307 0.0404
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.004 0.0285 0.0374
Echinococcus multilocularis netrin receptor unc 5 0.0038 0.0257 0.0338
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0169 0.0222
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0046 0.0372 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0189 0.0189
Leishmania major proteasome alpha 1 subunit, putative 0.0189 0.2479 0.3256
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0536 0.7613 0.7613
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0032 0.0169 0.0222
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0169 0.2194 0.2882
Loa Loa (eye worm) trypsin family protein 0.004 0.0285 0.0285
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0023 0.0028 0.0028
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0169 0.2194 0.2882
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Loa Loa (eye worm) hypothetical protein 0.0067 0.0684 0.0684
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0035 0.0209 0.0275
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0145 0.019
Brugia malayi proteasome subunit alpha type 6 0.0189 0.2479 0.2479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0189 0.0189
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0209 0.0209
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0189 0.0248
Leishmania major proteasome beta 5 subunit, putative 0.0536 0.7613 1
Leishmania major proteasome beta 3 subunit, putative 0.0169 0.2194 0.2882
Brugia malayi Kringle domain containing protein 0.0021 0.0007 0.0007
Echinococcus granulosus Ankyrin 0.0038 0.0259 0.0341
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0169 0.2194 0.2882
Brugia malayi Adhesion regulating molecule conserved region family protein 0.01 0.1176 0.1176
Toxoplasma gondii PCI domain-containing protein 0.0042 0.0307 0.0404
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0269 0.3663 0.4811
Leishmania major proteasome beta 2 subunit, putative 0.0204 0.2703 0.355
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0021 0.0009 0.0012
Echinococcus granulosus proteasome subunit beta type 7 0.0414 0.5816 0.7639
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0042 0.0307 0.0404
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Leishmania major proteasome alpha 7 subunit, putative 0.0177 0.2311 0.3035
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0163 0.2108 0.2769
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0141 0.1777 0.2334
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0189 0.0189
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0169 0.2194 0.2882
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0205 0.2717 0.3568
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0021 0.0009 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0163 0.2108 0.2769
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0189 0.0189
Onchocerca volvulus 0.0034 0.0189 0.0817
Giardia lamblia Proteasome subunit beta type 3 0.0169 0.2194 0.2882
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0684 0.0684
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0021 0.0009 0.0012
Toxoplasma gondii proteasome subunit alpha1, putative 0.0189 0.2479 0.3256
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0009 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0189 0.0248
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.044
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0023 0.0028 0.0037
Giardia lamblia 20S proteasome alpha subunit 3 0.0175 0.2285 0.3001
Brugia malayi Proteasome subunit alpha type 7-1 0.0228 0.306 0.306
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0042 0.0307 0.0404
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0168 0.2168 0.2848
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0031 0.0145 0.019
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0228 0.306 0.4019
Plasmodium vivax proteasome subunit beta type-2, putative 0.0204 0.2703 0.355
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0009 0.0012
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0536 0.7613 1
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0414 0.5816 0.7639
Echinococcus granulosus carbonic anhydrase 0.0067 0.0684 0.0899
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0009 0.0012
Leishmania major proteasome alpha 1 subunit, putative 0.0175 0.2277 0.2991
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0023 0.0028 0.0037
Brugia malayi Trypsin family protein 0.004 0.0285 0.0285
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.011 0.011
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0204 0.2703 0.355
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0269 0.3663 0.4811
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0181 0.2364 0.3104
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0169 0.0222
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0169 0.0222
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0032 0.0169 0.0169
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0023 0.0028 0.0037
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0168 0.2168 0.2848
Brugia malayi Proteasome/cyclosome repeat family protein 0.0034 0.0196 0.0196
Brugia malayi nuclear receptor NHR-88 0.0034 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0067 0.0684 0.0684
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0163 0.2108 0.2769
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0145
Giardia lamblia 26S protease regulatory subunit 6A 0.0023 0.0028 0.0037
Entamoeba histolytica proteasome regulatory subunit, putative 0.0023 0.0027 0.0035
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0032 0.0169 0.0169
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0188 0.2464 0.3236
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0031 0.0145 0.019
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0684 0.0899
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0181 0.2364 0.3104
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0189 0.0248
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0023 0.0028 0.0037
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0021 0.0009 0.0012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0189 0.0248
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0035 0.0209 0.0275
Entamoeba histolytica proteasome regulatory subunit, putative 0.0039 0.0264 0.0347
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.01 0.1176 0.1545
Schistosoma mansoni hypothetical protein 0.0032 0.0166 0.0219
Loa Loa (eye worm) hypothetical protein 0.0698 1 1
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0031 0.0145 0.019
Schistosoma mansoni hypothetical protein 0.0093 0.1067 0.1401
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0039 0.0264 0.0264
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0189 0.0817
Schistosoma mansoni hypothetical protein 0.0038 0.0257 0.0338
Giardia lamblia 20S proteasome alpha subunit 6 0.0175 0.2277 0.2991
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0209 0.0275
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0228 0.306 0.4019
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0169 0.2194 0.2882
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0039 0.0264 0.0347
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0684 0.0899
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0177 0.2311 0.3035
Loa Loa (eye worm) RPN-3 protein 0.0042 0.0307 0.0307
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0032 0.0166 0.0219
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0023 0.0027 0.0035
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0163 0.2108 0.2769
Brugia malayi proteasome subunit beta type 2 0.0204 0.2703 0.2703
Brugia malayi Protein kinase domain containing protein 0.0038 0.0257 0.0257
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0032 0.0169 0.0169
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0035 0.0211 0.0278
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0031 0.0145 0.019
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0023 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.004 0.0285 0.0374
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0141 0.1777 0.2334
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0035 0.0211 0.0278
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0189 0.0248
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0028 0.0037
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0168 0.2168 0.2848
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0175 0.2277 0.2991
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0257 0.0257
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0269 0.3663 0.4811
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0175 0.2277 0.2991
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0046 0.0372 0.0489
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0176 0.2292 0.301
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0189 0.0248
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0175 0.2277 0.2991
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0021 0.0009 0.0012
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0009 0.0012
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0211 0.0278
Schistosoma mansoni hypothetical protein 0.0067 0.0684 0.0899
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0169 0.0222
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0035 0.0211 0.0278
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0189 0.0817
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0169 0.2194 0.2882
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0175 0.2277 0.2991
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0021 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0041 0.0298 0.0391
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0021 0.0009 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0189 0.0189
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0269 0.3663 0.4811
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0189 0.0248
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0032 0.0169 0.0222
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0228 0.3066 0.3066
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0175 0.2277 0.2277
Brugia malayi PCI domain containing protein 0.0035 0.0211 0.0211
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0188 0.2464 0.3236
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0175 0.2285 0.3001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0189 0.0189
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0189 0.2479 0.3256
Echinococcus granulosus Proteasome subunit alpha beta 0.0177 0.2311 0.3035
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0269 0.3663 0.4811
Plasmodium falciparum proteasome subunit beta type-4 0.0168 0.2168 0.2848
Giardia lamblia 20S proteasome alpha subunit 4 0.0228 0.306 0.4019
Brugia malayi Ubiquitin interaction motif family protein 0.0023 0.0027 0.0027
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0035 0.0211 0.0278
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0032 0.0169 0.0169
Schistosoma mansoni ankyrin 23/unc44 0.0038 0.0257 0.0338
Brugia malayi Proteasome subunit alpha type 1 0.0158 0.2022 0.2022
Schistosoma mansoni hypothetical protein 0.0062 0.0616 0.0809
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0023 0.0027 0.0036
Toxoplasma gondii proteasome 26S regulatory subunit 0.0022 0.0018 0.0024
Schistosoma mansoni 26S protease regulatory subunit 0.0021 0.0009 0.0012
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0177 0.2311 0.3035
Brugia malayi Uncoordinated protein 44 0.0038 0.0257 0.0257
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0335 0.044
Loa Loa (eye worm) hypothetical protein 0.01 0.1176 0.1176
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0189 0.0248
Leishmania major carbonic anhydrase-like protein 0.0181 0.2364 0.3105
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0228 0.306 0.4019
Leishmania major hypothetical protein, conserved 0.0052 0.0466 0.0612
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0228 0.306 0.4019
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.004 0.0285 0.0374
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0204 0.2703 0.355
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0228 0.306 0.4019
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0168 0.2168 0.2848
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0042 0.0307 0.0404
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0335 0.044
Mycobacterium ulcerans proteasome PrcB 0.0536 0.7613 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0158 0.2033 0.267
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0269 0.3663 0.4811
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0175 0.2285 0.3001
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0046 0.0372 0.0372
Echinococcus granulosus carbonic anhydrase II 0.0181 0.2364 0.3105
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0024 0.0047 0.0062
Plasmodium vivax proteasome subunit beta type-6, putative 0.0176 0.2292 0.301
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0189 0.0189
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0041 0.0298 0.0391
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Toxoplasma gondii proteasome beta subunit 0.0169 0.2194 0.2882
Onchocerca volvulus 0.004 0.0285 0.1232
Loa Loa (eye worm) PCI domain-containing protein 0.0032 0.0166 0.0166
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0021 0.0009 0.0012
Giardia lamblia 20S proteasome alpha subunit 2 0.0181 0.2364 0.3104
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Schistosoma mansoni hypothetical protein 0.0228 0.3066 0.4026
Schistosoma mansoni hypothetical protein 0.004 0.0285 0.0374
Onchocerca volvulus 0.0021 0.0009 0.0038
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0177 0.2311 0.3035
Loa Loa (eye worm) proteasome regulatory particle 0.0039 0.0264 0.0264
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0163 0.2108 0.2769
Loa Loa (eye worm) hypothetical protein 0.0067 0.0684 0.0684
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0031 0.0153 0.0201
Plasmodium vivax proteasome subunit beta type-1, putative 0.0269 0.3663 0.4811
Echinococcus multilocularis transmembrane protease serine 3 0.004 0.0285 0.0374
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0181 0.2364 0.3104
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0181 0.2364 0.2364
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0145 0.019
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Brugia malayi hypothetical protein 0.0043 0.0335 0.0335
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0177 0.2311 0.3035
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0028 0.0037
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0175 0.2285 0.3001
Loa Loa (eye worm) proteasome subunit beta type 3 0.0169 0.2194 0.2194
Onchocerca volvulus 0.004 0.0285 0.1232
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0175 0.2285 0.3001
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0023 0.0028 0.0037
Schistosoma mansoni coup transcription factor 0.0034 0.0189 0.0248
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0163 0.2108 0.2769
Trichomonas vaginalis 26S proteasome subunit, putative 0.0032 0.0166 0.0219
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0175 0.2277 0.2991
Schistosoma mansoni hypothetical protein 0.0021 0.0007 0.0009
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0204 0.2703 0.355
Toxoplasma gondii proteasome subunit alpha type, putative 0.0175 0.2285 0.3001
Toxoplasma gondii PCI domain-containing protein 0.0039 0.0264 0.0347
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0209 0.0275
Giardia lamblia Proteasome subunit beta type 1 0.0269 0.3663 0.4811
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0046 0.0372 0.0489
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0168 0.2168 0.2848
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0169 0.2194 0.2882
Loa Loa (eye worm) proteasome Regulatory Particle 0.0035 0.0209 0.0209
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0169 0.0222
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0189 0.0248
Toxoplasma gondii PCI domain-containing protein 0.0032 0.0166 0.0219
Brugia malayi hypothetical protein 0.004 0.0285 0.0285
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0175 0.2277 0.2991
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Echinococcus granulosus carbonic anhydrase 0.0067 0.0684 0.0899
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0188 0.2464 0.3236
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0189 0.0248
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0021 0.0009 0.0012
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0175 0.2277 0.2991
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0189 0.0248
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0684 0.0684
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0189 0.0817
Onchocerca volvulus 0.0021 0.0009 0.0038
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0035 0.0209 0.0275
Brugia malayi proteasome subunit beta type 1 0.0269 0.3663 0.3663
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0021 0.0009 0.0012
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0042 0.0307 0.0404
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0141 0.1777 0.2334
Echinococcus multilocularis adhesion regulating molecule 1 0.01 0.1176 0.1545
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0021 0.0009 0.0012
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.2364 0.3105
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0038 0.0259 0.0341
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0189 0.0248
Echinococcus multilocularis enteropeptidase 0.004 0.0285 0.0374
Giardia lamblia Proteasome subunit beta type 2 0.0204 0.2703 0.355
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0228 0.306 0.4019
Echinococcus multilocularis geminin 0.0205 0.2717 0.3568
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0042 0.0307 0.0404
Echinococcus granulosus Proteasome subunit alpha type 7 0.0228 0.306 0.4019
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0181 0.2364 0.3104
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0168 0.2168 0.2168
Brugia malayi nuclear hormone receptor 0.0034 0.0189 0.0189
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0188 0.2464 0.3236
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0335 0.044
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0189 0.2479 0.3256
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0141 0.1777 0.2334
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0169 0.0222
Trypanosoma cruzi 20S proteasome subunit 0.0204 0.2703 0.355
Schistosoma mansoni netrin receptor unc5 0.0038 0.0257 0.0338
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0032 0.0169 0.0222
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0007 0.0009
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0189 0.2479 0.3256
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0145 0.019
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0189 0.2479 0.3256
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0536 0.7613 1
Echinococcus multilocularis Ankyrin 0.0038 0.0259 0.0341
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0204 0.2703 0.355
Echinococcus granulosus adhesion regulating molecule 1 0.01 0.1176 0.1545
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0177 0.2311 0.3035
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0188 0.2464 0.2464
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0168 0.2168 0.2848
Brugia malayi proteasome subunit alpha type 4 0.0158 0.203 0.203
Echinococcus multilocularis Mastin 0.004 0.0285 0.0374
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0189 0.0248
Plasmodium vivax proteasome subunit beta type-3, putative 0.0169 0.2194 0.2882
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0257 0.0257
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0176 0.2292 0.301
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0043 0.0335 0.044
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0228 0.306 0.4019
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0269 0.3663 0.4811
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0204 0.2703 0.355
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0046 0.0372 0.0489
Brugia malayi Proteasome/cyclosome repeat family protein 0.0034 0.0196 0.0196
Plasmodium vivax proteasome subunit beta type-7, putative 0.0163 0.2108 0.2769
Onchocerca volvulus 0.004 0.0285 0.1232
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0039 0.0264 0.0347
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0189 0.0189
Brugia malayi Probable 26S protease regulatory subunit 4 0.0021 0.0009 0.0009
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0684 0.0899
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0209 0.0275
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0032 0.0169 0.0222
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0042 0.0307 0.0404
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0009 0.0012
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0031 0.0145 0.0145
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Echinococcus granulosus proteasome subunit beta t family 0.0169 0.2194 0.2882
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0067 0.0684 0.0684
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0175 0.2285 0.3001
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.2364 0.3105
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0028 0.0037
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0189 0.0248
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0176 0.2292 0.301
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0023 0.0028 0.0037
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0175 0.2285 0.3001
Brugia malayi 20S proteasome alpha5 subunit 0.0188 0.2464 0.2464
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0209 0.0275
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Brugia malayi proteasome subunit alpha type 3 0.0177 0.2311 0.2311
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0039 0.0264 0.0347
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0181 0.2364 0.3104
Giardia lamblia 20S proteasome alpha subunit 5 0.0188 0.2464 0.3236
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0046 0.0372 0.0489
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0021 0.0009 0.0012
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0052 0.0466 0.0612
Brugia malayi Trypsin family protein 0.004 0.0285 0.0285
Giardia lamblia 20S proteasome alpha subunit 1 0.0189 0.2479 0.3256
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0039 0.0264 0.0347
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0028 0.0037
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0169 0.2194 0.2882
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0189 0.0189
Leishmania major proteasome alpha 2 subunit, putative 0.0181 0.2364 0.3104
Toxoplasma gondii proteasome regulatory subunit 0.0032 0.0169 0.0222
Plasmodium vivax proteasome subunit beta type-5, putative 0.0536 0.7613 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0046 0.0372 0.0489
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0023 0.0027 0.0035
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0041 0.0298 0.0391
Brugia malayi Trypsin family protein 0.004 0.0285 0.0285
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0038 0.0257 0.0338
Echinococcus granulosus Mastin 0.004 0.0285 0.0374
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0038 0.0257 0.0338
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.004 0.0285 0.0374
Trypanosoma brucei proteasome beta 7 subunit 0.0168 0.2168 0.2848
Giardia lamblia Hypothetical protein 0.0039 0.0264 0.0347
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0189 0.0248
Onchocerca volvulus 0.004 0.0285 0.1232
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0021 0.0009 0.0012
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0374 0.5212 0.6846
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0168 0.2168 0.2848
Echinococcus granulosus transmembrane protease serine 3 0.004 0.0285 0.0374
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0175 0.2277 0.2991
Onchocerca volvulus 0.004 0.0285 0.1232
Leishmania major proteasome beta 7 subunit, putative 0.0168 0.2168 0.2848
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0204 0.2703 0.355
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0176 0.2292 0.301
Toxoplasma gondii SAC3/GANP family protein 0.0031 0.0145 0.019
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0175 0.2277 0.2991
Echinococcus granulosus proteasome subunit beta type 6 0.0176 0.2292 0.301
Schistosoma mansoni multiubiquitin binding protein S5a 0.0023 0.0027 0.0035
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0269 0.3663 0.4811
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0684 0.0899
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0536 0.7613 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0536 0.7613 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0189 0.0189
Echinococcus granulosus carbonic anhydrase 0.0067 0.0684 0.0899
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0189 0.2479 0.3256
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.2364 0.3105
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0009 0.0012
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0032 0.0166 0.0219
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0032 0.0169 0.0222
Leishmania major proteasome beta 2 subunit, putative 0.0163 0.2108 0.2769
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0181 0.2364 0.3104
Brugia malayi Trypsin-like protease protein 5 0.004 0.0285 0.0285
Brugia malayi proteasome subunit alpha type 2 0.0181 0.2364 0.2364
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0391
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0176 0.2292 0.301
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0163 0.2108 0.2108
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0046 0.0372 0.0489
Onchocerca volvulus Netrin receptor homolog 0.0038 0.0257 0.1113
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0189 0.0248
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0175 0.2285 0.3001
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0536 0.7613 1
Plasmodium falciparum carbonic anhydrase 0.0067 0.0684 0.0899
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0176 0.2292 0.301
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.2364 0.2364
Loa Loa (eye worm) carbonic anhydrase 3 0.0181 0.2364 0.2364
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0177 0.2311 0.3035
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0204 0.2703 0.355
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0209 0.0275
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0189 0.0248
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.004 0.0285 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0189 0.0189
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0035 0.0209 0.0275
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0204 0.2703 0.355
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0204 0.2703 0.355
Toxoplasma gondii hypothetical protein 0.0067 0.0684 0.0899
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0035 0.0209 0.0275
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0009 0.0012
Loa Loa (eye worm) PAS-3 protein 0.0158 0.203 0.203
Brugia malayi 26S proteasome subunit P45 family protein 0.0021 0.0009 0.0009
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0269 0.3663 0.4811
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0188 0.2464 0.3236
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0177 0.2311 0.3035
Brugia malayi Proteasome A-type and B-type family protein 0.0168 0.2168 0.2168
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0211 0.0278
Echinococcus multilocularis proteasome (prosome, macropain) 0.0536 0.7613 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0228 0.306 0.306
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0188 0.2464 0.3236
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0536 0.7613 1
Toxoplasma gondii proteasome subunit 0.0176 0.2292 0.301
Brugia malayi 26S protease regulatory subunit 6A 0.0023 0.0028 0.0028
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0024 0.0047 0.0062
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0009 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0169 0.0222
Loa Loa (eye worm) proteasome subunit beta type 2 0.0204 0.2703 0.2703
Trypanosoma brucei carbonic anhydrase-like protein 0.0181 0.2364 0.3105
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0189 0.0189
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0032 0.0166 0.0219
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0228 0.306 0.4019
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0039 0.0264 0.0347
Onchocerca volvulus Notchless protein homolog 0.0177 0.2311 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0166 0.0219
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Echinococcus granulosus glycoprotein Antigen 5 0.004 0.0285 0.0374
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0032 0.0166 0.0219
Toxoplasma gondii peptidase, T1 family protein 0.0177 0.2311 0.3035
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0176 0.2292 0.301
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0007 0.0007
Brugia malayi proteasome subunit alpha type 1 0.0175 0.2277 0.2277
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0176 0.2292 0.2292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0189 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0007 0.0009
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0169 0.0169
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0035 0.0209 0.0275
Echinococcus granulosus subfamily T1A non peptidase ue 0.0188 0.2464 0.3236
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0141 0.1777 0.2334
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0228 0.306 0.4019
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0189 0.0248
Mycobacterium ulcerans proteasome PrcA 0.0141 0.1777 0.2036
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0141 0.1777 0.2334
Giardia lamblia 20S proteasome alpha subunit 7 0.0177 0.2311 0.3035
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.2364 0.3105
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0039 0.0264 0.0347
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0042 0.0307 0.0307
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0023 0.0028 0.0037
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0684 0.0684
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0189 0.2479 0.3256
Loa Loa (eye worm) RPT-2 protein 0.0021 0.0009 0.0009
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0163 0.2108 0.2769
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0163 0.2108 0.2769
Trypanosoma brucei proteasome alpha 7 subunit 0.0177 0.2311 0.3035
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0189 0.0189
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0035 0.0211 0.0278
Echinococcus multilocularis proteasome subunit alpha type 2 0.0181 0.2364 0.3104
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0189 0.0248
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0093 0.1067 0.1401
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0023 0.0028 0.0037
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0064 0.0635 0.2747
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0189 0.2479 0.2479
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0032 0.0166 0.0219
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.017 0.2209 0.2901
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0175 0.2285 0.3001
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0189 0.2479 0.3256
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0039 0.0264 0.0347
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0181 0.2364 0.2364
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0189 0.2479 0.3256
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0684 0.0684
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0189 0.0248
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0189 0.0248
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.044
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0145 0.019
Brugia malayi Death domain containing protein 0.0038 0.0257 0.0257
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0168 0.2168 0.2848
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0189 0.0248
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0141 0.1777 0.5
Schistosoma mansoni 26S proteasome subunit S9 0.0039 0.0264 0.0347
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0228 0.306 0.4019
Echinococcus multilocularis carbonic anhydrase II 0.0181 0.2364 0.3105
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0169 0.0222
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0684 0.0899
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Echinococcus granulosus netrin receptor unc 5 0.0038 0.0257 0.0338
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0189 0.0248
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0034 0.0196 0.0258
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0032 0.0169 0.0222
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0169 0.0222
Onchocerca volvulus 0.0021 0.0007 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0189 0.0189
Plasmodium vivax proteasome subunit beta type-4, putative 0.0168 0.2168 0.2848
Echinococcus granulosus geminin 0.0205 0.2717 0.3568
Echinococcus granulosus death domain containing protein 0.0038 0.0257 0.0338
Leishmania major hypothetical protein, conserved 0.0021 0.0007 0.0009
Plasmodium falciparum proteasome subunit beta type-5 0.0536 0.7613 1
Schistosoma mansoni hypothetical protein 0.0205 0.2717 0.3568
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0175 0.2285 0.3001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0257 0.0257
Giardia lamblia 26S protease regulatory subunit 6B 0.0021 0.0009 0.0012
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0022 0.0018 0.0024
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0181 0.2364 0.3104
Toxoplasma gondii proteasome subunit alpha type, putative 0.0087 0.0975 0.1281
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0141 0.1777 0.2334
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0035 0.0211 0.0278
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0021 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0007
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0188 0.2464 0.3236
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.01 0.1176 0.1545
Leishmania major proteasome alpha 7 subunit, putative 0.0228 0.306 0.4019
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0209 0.0275
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0177 0.2311 0.3035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0189 0.0189
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0684 0.0684
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0189 0.0248

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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