Detailed information for compound 2077023

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 539.468 | Formula: C23H27F6N3O5
  • H donors: 2 H acceptors: 5 LogP: 1.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.Cn1cccc1CN1CCC2(CC1)CC(C2)Oc1cccnc1
  • InChi: 1S/C19H25N3O.2C2HF3O2/c1-21-9-3-4-16(21)15-22-10-6-19(7-11-22)12-18(13-19)23-17-5-2-8-20-14-17;2*3-2(4,5)1(6)7/h2-5,8-9,14,18H,6-7,10-13,15H2,1H3;2*(H,6,7)
  • InChiKey: OFFOYZZFCPRKSY-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0189 0.0189
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0176 0.2292 0.301
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0536 0.7613 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0189 0.0817
Echinococcus granulosus death domain containing protein 0.0038 0.0257 0.0338
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0141 0.1777 0.2334
Schistosoma mansoni hypothetical protein 0.004 0.0285 0.0374
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0188 0.2464 0.3236
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0175 0.2285 0.3001
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0158 0.2033 0.267
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0038 0.0257 0.0338
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0269 0.3663 0.4811
Schistosoma mansoni ankyrin 23/unc44 0.0038 0.0257 0.0338
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0684 0.0899
Toxoplasma gondii proteasome subunit alpha type, putative 0.0175 0.2285 0.3001
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0035 0.0211 0.0278
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0177 0.2311 0.3035
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0189 0.0248
Loa Loa (eye worm) hypothetical protein 0.0067 0.0684 0.0684
Entamoeba histolytica proteasome regulatory subunit, putative 0.0039 0.0264 0.0347
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0141 0.1777 0.2334
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0042 0.0307 0.0404
Brugia malayi Trypsin family protein 0.004 0.0285 0.0285
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0189 0.0189
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0189 0.0248
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0189 0.0248
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0023 0.0028 0.0037
Loa Loa (eye worm) proteasome Regulatory Particle 0.0035 0.0209 0.0209
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0269 0.3663 0.4811
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0032 0.0169 0.0222
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0189 0.0248
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0189 0.0248
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0536 0.7613 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0181 0.2364 0.2364
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0039 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0145
Echinococcus multilocularis carbonic anhydrase II 0.0181 0.2364 0.3105
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0141 0.1777 0.2334
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0163 0.2108 0.2108
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0021 0.0009 0.0012
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0031 0.0145 0.019
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0021 0.0009 0.0012
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0046 0.0372 0.0372
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0189 0.0248
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0391
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0204 0.2703 0.355
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0209 0.0275
Echinococcus granulosus carbonic anhydrase II 0.0181 0.2364 0.3105
Leishmania major proteasome beta-1 subunit, putative 0.0176 0.2292 0.301
Giardia lamblia 20S proteasome alpha subunit 1 0.0189 0.2479 0.3256
Schistosoma mansoni hypothetical protein 0.0205 0.2717 0.3568
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0023 0.0028 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0189 0.0189
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0189 0.0248
Loa Loa (eye worm) hypothetical protein 0.0067 0.0684 0.0684
Brugia malayi Protein kinase domain containing protein 0.0021 0.0007 0.0007
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0188 0.2464 0.3236
Loa Loa (eye worm) hypothetical protein 0.0698 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Echinococcus granulosus transmembrane protease serine 3 0.004 0.0285 0.0374
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0684 0.0899
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0684 0.0899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0189 0.0189
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0189 0.0248
Loa Loa (eye worm) RPN-3 protein 0.0042 0.0307 0.0307
Brugia malayi proteasome subunit alpha type 1 0.0175 0.2277 0.2277
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0176 0.2292 0.301
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0181 0.2364 0.3104
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0021 0.0009 0.0012
Toxoplasma gondii PCI domain-containing protein 0.0042 0.0307 0.0404
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0035 0.0211 0.0278
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0035 0.0211 0.0278
Echinococcus multilocularis adhesion regulating molecule 1 0.01 0.1176 0.1545
Giardia lamblia Hypothetical protein 0.0039 0.0264 0.0347
Echinococcus multilocularis netrin receptor unc 5 0.0038 0.0257 0.0338
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0168 0.2168 0.2848
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0166 0.0219
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0257 0.0257
Brugia malayi Proteasome A-type and B-type family protein 0.0176 0.2292 0.2292
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0189 0.0189
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0188 0.2464 0.2464
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0028 0.0037
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.004 0.0285 0.0374
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0684 0.0684
Echinococcus multilocularis proteasome subunit beta type 7 0.0414 0.5816 0.7639
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0141 0.1777 0.2334
Toxoplasma gondii proteasome regulatory subunit 0.0032 0.0169 0.0222
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0023 0.0027 0.0035
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0034 0.0196 0.0196
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0189 0.0248
Giardia lamblia 26S protease regulatory subunit 6B 0.0021 0.0009 0.0012
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0269 0.3663 0.4811
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0536 0.7613 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.2364 0.3105
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0175 0.2285 0.3001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0335 0.044
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0228 0.306 0.4019
Trypanosoma brucei proteasome beta 7 subunit 0.0168 0.2168 0.2848
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0181 0.2364 0.2364
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0031 0.0145 0.0145
Loa Loa (eye worm) proteasome regulatory particle 0.0039 0.0264 0.0264
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0211 0.0278
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0141 0.1777 0.2334
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0042 0.0307 0.0404
Brugia malayi hypothetical protein 0.0043 0.0335 0.0335
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0031 0.0145 0.019
Brugia malayi Proteasome subunit alpha type 1 0.0158 0.2022 0.2022
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0023 0.0027 0.0035
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0181 0.2364 0.3104
Toxoplasma gondii SAC3/GANP family protein 0.0031 0.0145 0.019
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0188 0.2464 0.3236
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0007 0.0007
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0176 0.2292 0.301
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0189 0.0189
Brugia malayi PCI domain containing protein 0.0032 0.0166 0.0166
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0169 0.0222
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0031 0.0145 0.019
Plasmodium vivax proteasome subunit beta type-6, putative 0.0176 0.2292 0.301
Echinococcus granulosus geminin 0.0205 0.2717 0.3568
Leishmania major carbonic anhydrase-like protein 0.0181 0.2364 0.3105
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0009 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0189 0.0248
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0269 0.3663 0.4811
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0181 0.2364 0.3104
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.004 0.0285 0.0285
Trypanosoma brucei carbonic anhydrase-like protein 0.0181 0.2364 0.3105
Schistosoma mansoni hypothetical protein 0.0043 0.0335 0.044
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0189 0.0248
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0163 0.2108 0.2769
Echinococcus granulosus glycoprotein Antigen 5 0.004 0.0285 0.0374
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0536 0.7613 1
Echinococcus granulosus proteasome subunit beta type 6 0.0176 0.2292 0.301
Schistosoma mansoni 26S proteasome subunit S9 0.0039 0.0264 0.0347
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0335 0.044
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0039 0.0264 0.0347
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0168 0.2168 0.2848
Echinococcus multilocularis glycoprotein Antigen 5 0.004 0.0285 0.0374
Onchocerca volvulus 0.004 0.0285 0.1232
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0169 0.0222
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0046 0.0372 0.0489
Echinococcus granulosus proteasome subunit beta t family 0.0169 0.2194 0.2882
Brugia malayi proteasome subunit alpha type 2 0.0181 0.2364 0.2364
Brugia malayi 26S proteasome subunit P45 family protein 0.0021 0.0009 0.0009
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0021 0.0009 0.0012
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0175 0.2277 0.2991
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0169 0.2194 0.2882
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0168 0.2168 0.2848
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0209 0.0275
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0064 0.0635 0.2747
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0189 0.2479 0.2479
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0031 0.0145 0.019
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0046 0.0372 0.0489
Schistosoma mansoni hypothetical protein 0.0038 0.0257 0.0338
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0169 0.2194 0.2882
Echinococcus granulosus proteasome subunit beta type 7 0.0414 0.5816 0.7639
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0177 0.2311 0.2311
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0039 0.0264 0.0347
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0021 0.0009 0.0012
Loa Loa (eye worm) proteasome subunit beta type 2 0.0204 0.2703 0.2703
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0536 0.7613 1
Schistosoma mansoni hypothetical protein 0.0067 0.0684 0.0899
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0176 0.2292 0.301
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0169 0.0222
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0374 0.5212 0.6846
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0189 0.0248
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0035 0.0211 0.0278
Leishmania major proteasome beta 7 subunit, putative 0.0168 0.2168 0.2848
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0175 0.2285 0.3001
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Onchocerca volvulus 0.0034 0.0189 0.0817
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0189 0.0189
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Brugia malayi 26S protease regulatory subunit 6A 0.0023 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.044
Brugia malayi nuclear receptor NHR-88 0.0034 0.0189 0.0189
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0175 0.2277 0.2991
Brugia malayi proteasome subunit alpha type 6 0.0189 0.2479 0.2479
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Brugia malayi Death domain containing protein 0.0038 0.0257 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0189 0.0189
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0169 0.2194 0.2882
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0032 0.0169 0.0169
Toxoplasma gondii proteasome 26S regulatory subunit 0.0022 0.0018 0.0024
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0145 0.019
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0067 0.0684 0.0684
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0093 0.1067 0.1401
Giardia lamblia 20S proteasome alpha subunit 7 0.0177 0.2311 0.3035
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0023 0.0027 0.0035
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0209 0.0275
Echinococcus granulosus proteasome subunit alpha type 2 0.0181 0.2364 0.3104
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.0041 0.0298 0.0391
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0021 0.0009 0.0012
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0031 0.0145 0.0145
Plasmodium vivax proteasome subunit beta type-3, putative 0.0169 0.2194 0.2882
Echinococcus granulosus proteasome prosome macropain 0.0536 0.7613 1
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0684 0.0899
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0169 0.2194 0.2882
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0175 0.2277 0.2991
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0023 0.0028 0.0037
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0177 0.2311 0.3035
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0052 0.0466 0.0612
Toxoplasma gondii proteasome subunit beta type, putative 0.0536 0.7613 1
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0175 0.2277 0.2991
Schistosoma mansoni netrin receptor unc5 0.0038 0.0257 0.0338
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.044
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0269 0.3663 0.4811
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0046 0.0372 0.0489
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0041 0.0298 0.0391
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0042 0.0307 0.0404
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.0041 0.0298 0.0391
Echinococcus multilocularis proteasome (prosome, macropain) 0.0536 0.7613 1
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0009 0.0012
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0169 0.2194 0.2882
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0046 0.0372 0.0489
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0023 0.0028 0.0028
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0257 0.0257
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0536 0.7613 0.7613
Schistosoma mansoni hypothetical protein 0.0093 0.1067 0.1401
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0189 0.0248
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0163 0.2108 0.2769
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0007 0.0009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0189 0.0248
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0032 0.0169 0.0222
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0169 0.0222
Echinococcus granulosus nuclear factor of activated T cells 5 0.0374 0.5212 0.6846
Leishmania major proteasome alpha 7 subunit, putative 0.0177 0.2311 0.3035
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0189 0.0248
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0175 0.2285 0.3001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0189 0.0248
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0189 0.2479 0.3256
Echinococcus multilocularis enteropeptidase 0.004 0.0285 0.0374
Echinococcus multilocularis Mastin 0.004 0.0285 0.0374
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.004 0.0285 0.0374
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0209 0.0209
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0189 0.0248
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0023 0.0028 0.0037
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0145 0.019
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0141 0.1777 0.2334
Toxoplasma gondii PCI domain-containing protein 0.0032 0.0166 0.0219
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0177 0.2311 0.3035
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0021 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.01 0.1176 0.1176
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0009 0.0012
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0168 0.2168 0.2848
Leishmania major proteasome alpha 1 subunit, putative 0.0175 0.2277 0.2991
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0145 0.019
Echinococcus multilocularis transmembrane protease serine 3 0.004 0.0285 0.0374
Toxoplasma gondii hypothetical protein 0.0067 0.0684 0.0899
Brugia malayi Proteasome A-type and B-type family protein 0.0536 0.7613 0.7613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0189 0.0189
Brugia malayi Proteasome/cyclosome repeat family protein 0.0034 0.0196 0.0196
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0175 0.2285 0.3001
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0169 0.2194 0.2882
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Giardia lamblia Proteasome subunit beta type 3 0.0169 0.2194 0.2882
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0189 0.0817
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0204 0.2703 0.355
Leishmania major proteasome alpha 2 subunit, putative 0.0181 0.2364 0.3104
Echinococcus granulosus adhesion regulating molecule 1 0.01 0.1176 0.1545
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.0041 0.0298 0.0391
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0039 0.0264 0.0347
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0175 0.2277 0.2991
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0023 0.0028 0.0037
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0175 0.2277 0.2277
Brugia malayi ecdysteroid receptor 0.0034 0.0189 0.0189
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Leishmania major proteasome alpha 3 subunit, putative 0.0175 0.2285 0.3001
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0035 0.0211 0.0278
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0009 0.0012
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0169 0.2194 0.2882
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0209 0.0275
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0032 0.0169 0.0222
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0684 0.0899
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0175 0.2277 0.2991
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0021 0.0007 0.0009
Entamoeba histolytica proteasome regulatory subunit, putative 0.0023 0.0027 0.0035
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0684 0.0899
Brugia malayi Proteasome A-type and B-type family protein 0.0414 0.5816 0.5816
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0028 0.0037
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0176 0.2292 0.301
Giardia lamblia 20S proteasome alpha subunit 6 0.0175 0.2277 0.2991
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0189 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0189 0.0189
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0536 0.7613 1
Onchocerca volvulus 0.004 0.0285 0.1232
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0189 0.0189
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0189 0.2479 0.3256
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0163 0.2108 0.2769
Toxoplasma gondii heat shock protein hslv, putative 0.0141 0.1777 0.2334
Trypanosoma cruzi 20S proteasome subunit 0.0204 0.2703 0.355
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0031 0.0145 0.019
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0163 0.2108 0.2769
Echinococcus multilocularis Ankyrin 0.0038 0.0259 0.0341
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0168 0.2168 0.2848
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0189 0.0248
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0021 0.0009 0.0012
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0228 0.306 0.4019
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0228 0.306 0.4019
Leishmania major proteasome beta 5 subunit, putative 0.0536 0.7613 1
Giardia lamblia 20S proteasome alpha subunit 3 0.0175 0.2285 0.3001
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0034 0.0196 0.0258
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0032 0.0169 0.0222
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0181 0.2364 0.3104
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0189 0.0248
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0228 0.306 0.306
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.2364 0.3105
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0032 0.0166 0.0219
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Echinococcus multilocularis proteasome subunit alpha type 2 0.0181 0.2364 0.3104
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0169 0.0169
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0189 0.0248
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0028 0.0037
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0024 0.0047 0.0062
Brugia malayi proteasome subunit beta type 2 0.0204 0.2703 0.2703
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0209 0.0275
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0169 0.0222
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Leishmania major proteasome alpha 1 subunit, putative 0.0189 0.2479 0.3256
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0009 0.0012
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0188 0.2464 0.3236
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0009 0.0012
Schistosoma mansoni multiubiquitin binding protein S5a 0.0023 0.0027 0.0035
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0228 0.3066 0.3066
Schistosoma mansoni hypothetical protein 0.0228 0.3066 0.4026
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0189 0.2479 0.3256
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0175 0.2277 0.2991
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0181 0.2364 0.3104
Brugia malayi hypothetical protein 0.004 0.0285 0.0285
Mycobacterium ulcerans proteasome PrcA 0.0141 0.1777 0.2036
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0009 0.0012
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0168 0.2168 0.2848
Echinococcus granulosus proteasome subunit alpha type 6 0.0189 0.2479 0.3256
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0168 0.2168 0.2168
Onchocerca volvulus 0.0021 0.0009 0.0038
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0175 0.2285 0.3001
Brugia malayi PCI domain containing protein 0.0035 0.0211 0.0211
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0141 0.1777 0.2334
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0023 0.0028 0.0037
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Onchocerca volvulus 0.0021 0.0009 0.0038
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0204 0.2703 0.355
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0032 0.0166 0.0219
Plasmodium falciparum proteasome subunit beta type-4 0.0168 0.2168 0.2848
Brugia malayi proteasome subunit beta type 3 0.0169 0.2194 0.2194
Echinococcus granulosus Ankyrin 0.0038 0.0259 0.0341
Giardia lamblia 26S protease regulatory subunit 6A 0.0023 0.0028 0.0037
Echinococcus granulosus netrin receptor unc 5 0.0038 0.0257 0.0338
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0211 0.0278
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0035 0.0209 0.0275
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0189 0.0248
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0189 0.2479 0.3256
Echinococcus granulosus carbonic anhydrase 0.0067 0.0684 0.0899
Loa Loa (eye worm) hypothetical protein 0.0028 0.011 0.011
Brugia malayi 20S proteasome alpha5 subunit 0.0188 0.2464 0.2464
Leishmania major proteasome beta 2 subunit, putative 0.0163 0.2108 0.2769
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0168 0.2168 0.2848
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0046 0.0372 0.0489
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0032 0.0166 0.0219
Toxoplasma gondii PCI domain-containing protein 0.0039 0.0264 0.0347
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0181 0.2364 0.3104
Toxoplasma gondii peptidase, T1 family protein 0.0177 0.2311 0.3035
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0093 0.1067 0.1401
Brugia malayi proteasome subunit alpha type 3 0.0177 0.2311 0.2311
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0175 0.2285 0.3001
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0141 0.1777 0.5
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0035 0.0211 0.0278
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0032 0.0169 0.0222
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0188 0.2464 0.3236
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0228 0.306 0.4019
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0189 0.0248
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.0041 0.0298 0.0391
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0176 0.2292 0.301
Schistosoma mansoni 26S protease regulatory subunit 0.0021 0.0009 0.0012
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0228 0.306 0.4019
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0023 0.0027 0.0036
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0189 0.0248
Toxoplasma gondii hypothetical protein 0.0028 0.011 0.0144
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.0041 0.0298 0.0391
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0009
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0228 0.306 0.4019
Onchocerca volvulus 0.004 0.0285 0.1232
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0035 0.0209 0.0275
Brugia malayi Proteasome subunit alpha type 7-1 0.0228 0.306 0.306
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0035 0.0211 0.0278
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0038 0.0259 0.0341
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0038 0.0257 0.0338
Toxoplasma gondii proteasome subunit alpha1, putative 0.0189 0.2479 0.3256
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0189 0.2479 0.3256
Brugia malayi Trypsin family protein 0.004 0.0285 0.0285
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0009 0.0012
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0039 0.0264 0.0347
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Leishmania major proteasome alpha 7 subunit, putative 0.0228 0.306 0.4019
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0007 0.0009
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0046 0.0372 0.0489
Brugia malayi Trypsin family protein 0.004 0.0285 0.0285
Echinococcus granulosus Mastin 0.004 0.0285 0.0374
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0021 0.0009 0.0012
Brugia malayi proteasome subunit beta type 1 0.0269 0.3663 0.3663
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0536 0.7613 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0177 0.2311 0.3035
Schistosoma mansoni hypothetical protein 0.0032 0.0166 0.0219
Leishmania major hypothetical protein, conserved 0.0021 0.0007 0.0009
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0032 0.0169 0.0169
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0042 0.0307 0.0404
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0169 0.0222
Onchocerca volvulus Notchless protein homolog 0.0177 0.2311 1
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0028 0.0037
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0039 0.0264 0.0347
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.01 0.1176 0.1545
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0189 0.0248
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0169 0.0222
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0188 0.2464 0.3236
Brugia malayi Trypsin-like protease protein 5 0.004 0.0285 0.0285
Brugia malayi nuclear hormone receptor 0.0034 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Onchocerca volvulus 0.004 0.0285 0.1232
Echinococcus granulosus carbonic anhydrase 0.0067 0.0684 0.0899
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0228 0.306 0.4019
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0177 0.2311 0.3035
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0032 0.0169 0.0222
Loa Loa (eye worm) PCI domain-containing protein 0.0032 0.0166 0.0166
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0204 0.2703 0.355
Loa Loa (eye worm) trypsin family protein 0.004 0.0285 0.0285
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0032 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0205 0.2717 0.3568
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0177 0.2311 0.3035
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0177 0.2311 0.3035
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0269 0.3663 0.4811
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0175 0.2277 0.2991
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0269 0.3663 0.4811
Brugia malayi Adhesion regulating molecule conserved region family protein 0.01 0.1176 0.1176
Loa Loa (eye worm) hypothetical protein 0.0228 0.3066 0.3066
Trypanosoma brucei proteasome alpha 7 subunit 0.0177 0.2311 0.3035
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0169 0.2194 0.2882
Brugia malayi Trypsin family protein 0.004 0.0285 0.0285
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0204 0.2703 0.355
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0023 0.0027 0.0035
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0031 0.0153 0.0201
Plasmodium falciparum cysteine repeat modular protein 1 0.0021 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0257 0.0257
Plasmodium vivax proteasome subunit beta type-1, putative 0.0269 0.3663 0.4811
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0189 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0062 0.0616 0.0809
Schistosoma mansoni coup transcription factor 0.0034 0.0189 0.0248
Giardia lamblia 20S proteasome alpha subunit 4 0.0228 0.306 0.4019
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0035 0.0209 0.0275
Brugia malayi Proteasome A-type and B-type family protein 0.0168 0.2168 0.2168
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0188 0.2464 0.3236
Onchocerca volvulus 0.004 0.0285 0.1232
Entamoeba histolytica proteasome regulatory subunit, putative 0.0042 0.0307 0.0404
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0032 0.0169 0.0222
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0032 0.0166 0.0219
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0228 0.306 0.4019
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0166 0.0219
Brugia malayi Protein kinase domain containing protein 0.0038 0.0257 0.0257
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0007 0.0009
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0189 0.2479 0.3256
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0042 0.0307 0.0404
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0269 0.3663 0.4811
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0536 0.7613 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0177 0.2311 0.3035
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.2364 0.3105
Brugia malayi Proteasome/cyclosome repeat family protein 0.0034 0.0196 0.0196
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0684 0.0684
Onchocerca volvulus 0.004 0.0285 0.1232
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0023 0.0027 0.0035
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0166 0.0219
Echinococcus granulosus subfamily T1A non peptidase ue 0.0188 0.2464 0.3236
Plasmodium vivax proteasome subunit beta type-7, putative 0.0163 0.2108 0.2769
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0189 0.0248
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0035 0.0209 0.0275
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0035 0.0209 0.0275
Echinococcus granulosus Proteasome subunit alpha beta 0.0177 0.2311 0.3035
Trichomonas vaginalis 26S proteasome subunit, putative 0.0032 0.0166 0.0219
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0169 0.0222
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0021 0.0009 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0189 0.0189
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0175 0.2285 0.3001
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0031 0.0145 0.019
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0684 0.0684
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0684 0.0684
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0035 0.0209 0.0275
Plasmodium vivax proteasome subunit beta type-5, putative 0.0536 0.7613 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0204 0.2703 0.355
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0163 0.2108 0.2769
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0163 0.2108 0.2769
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0189 0.0189
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0145 0.019
Loa Loa (eye worm) RPT-2 protein 0.0021 0.0009 0.0009
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.2364 0.3105
Schistosoma mansoni carbonic anhydrase 0.0067 0.0684 0.0899
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0042 0.0307 0.0307
Loa Loa (eye worm) proteasome subunit beta type 3 0.0169 0.2194 0.2194
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0023 0.0027 0.0035
Schistosoma mansoni hypothetical protein 0.0021 0.0007 0.0009
Leishmania major proteasome beta 3 subunit, putative 0.0169 0.2194 0.2882
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0163 0.2108 0.2769
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0189 0.0189
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0189 0.0189
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0189 0.0248
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0228 0.306 0.4019
Loa Loa (eye worm) PCI domain-containing protein 0.0035 0.0211 0.0211
Loa Loa (eye worm) proteasome subunit beta type 1 0.0269 0.3663 0.3663
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0141 0.1777 0.2334
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0021 0.0009 0.0012
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0189 0.2479 0.3256
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0021 0.0009 0.0012
Brugia malayi Ubiquitin interaction motif family protein 0.0023 0.0027 0.0027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0189 0.0248
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0181 0.2364 0.2364
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0032 0.0169 0.0169
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0023 0.0028 0.0037
Mycobacterium ulcerans proteasome PrcB 0.0536 0.7613 1
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0021 0.0009 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0189 0.0189
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0041 0.0298 0.0391
Onchocerca volvulus Netrin receptor homolog 0.0038 0.0257 0.1113
Brugia malayi Uncoordinated protein 44 0.0038 0.0257 0.0257
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0181 0.2364 0.3104
Leishmania major proteasome beta 2 subunit, putative 0.0204 0.2703 0.355
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0189 0.0189
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0046 0.0372 0.0489
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0021 0.0009 0.0012
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0021 0.0009 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0189 0.0189
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0536 0.7613 1
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0031 0.0145 0.019
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0042 0.0307 0.0404
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0204 0.2703 0.355
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0335 0.044
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0176 0.2292 0.301
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0228 0.306 0.4019
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0211 0.0278
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0023 0.0028 0.0037
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0032 0.0166 0.0219
Plasmodium falciparum carbonic anhydrase 0.0067 0.0684 0.0899
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0032 0.0166 0.0219
Giardia lamblia Proteasome subunit beta type 2 0.0204 0.2703 0.355
Plasmodium vivax proteasome subunit beta type-4, putative 0.0168 0.2168 0.2848
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0046 0.0372 0.0489
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0189 0.0817
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0209 0.0275
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0039 0.0264 0.0347
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.004 0.0285 0.0374
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0204 0.2703 0.355
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0039 0.0264 0.0347
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0021 0.0009 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.004 0.0285 0.0374
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0169 0.0222
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0042 0.0307 0.0404
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.004 0.0285 0.0374
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0177 0.2311 0.3035
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0042 0.0307 0.0404
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0031 0.0145 0.019
Plasmodium vivax proteasome subunit beta type-2, putative 0.0204 0.2703 0.355
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0189 0.0189
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0052 0.0466 0.0612
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Echinococcus multilocularis proteasome subunit beta type 6 0.0176 0.2292 0.301
Brugia malayi steroid hormone receptor 0.0034 0.0189 0.0189
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0168 0.2168 0.2848
Brugia malayi proteasome subunit alpha type 4 0.0158 0.203 0.203
Echinococcus granulosus enteropeptidase 0.004 0.0285 0.0374
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0023 0.0028 0.0037
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.044
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0021 0.0009 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0189 0.0189
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0046 0.0372 0.0372
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.044
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0188 0.2464 0.3236
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0204 0.2703 0.355
Brugia malayi Kringle domain containing protein 0.0021 0.0007 0.0007
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0169 0.0222
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0189 0.0248
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0024 0.0047 0.0062
Giardia lamblia 20S proteasome alpha subunit 5 0.0188 0.2464 0.3236
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0189 0.0248
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0188 0.2464 0.3236
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0204 0.2703 0.355
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0181 0.2364 0.2364
Echinococcus multilocularis proteasome subunit alpha type 6 0.0189 0.2479 0.3256
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0007 0.0009
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0168 0.2168 0.2848
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0228 0.306 0.4019
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0022 0.0018 0.0024
Onchocerca volvulus 0.0021 0.0007 0.0031
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0189 0.2479 0.3256
Plasmodium falciparum proteasome subunit beta type-5 0.0536 0.7613 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0163 0.2108 0.2769
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.01 0.1176 0.1545
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0175 0.2277 0.2991
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0269 0.3663 0.4811
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0176 0.2292 0.2292
Echinococcus granulosus Proteasome subunit alpha type 7 0.0228 0.306 0.4019
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0169 0.2194 0.2882
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.017 0.2209 0.2901
Echinococcus multilocularis geminin 0.0205 0.2717 0.3568
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0175 0.2285 0.3001
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0269 0.3663 0.4811
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0169 0.0222
Toxoplasma gondii proteasome subunit alpha type, putative 0.0087 0.0975 0.1281
Giardia lamblia Proteasome subunit beta type 1 0.0269 0.3663 0.4811
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0175 0.2285 0.3001
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0176 0.2292 0.301
Toxoplasma gondii proteasome subunit 0.0176 0.2292 0.301
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0228 0.306 0.4019
Loa Loa (eye worm) hypothetical protein 0.0067 0.0684 0.0684
Loa Loa (eye worm) PAS-3 protein 0.0158 0.203 0.203
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.2364 0.2364
Schistosoma mansoni proteasome regulatory subunit-related 0.0035 0.0211 0.0278
Brugia malayi Probable 26S protease regulatory subunit 4 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0038 0.0259 0.0259
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0039 0.0264 0.0347
Echinococcus granulosus carbonic anhydrase 0.0067 0.0684 0.0899
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0204 0.2703 0.355
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.004 0.0285 0.0374
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0285
Schistosoma mansoni hypothetical protein 0.004 0.0285 0.0374
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0414 0.5816 0.7639
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0175 0.2277 0.2991
Giardia lamblia 20S proteasome alpha subunit 2 0.0181 0.2364 0.3104
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0175 0.2285 0.3001
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0022 0.0018 0.0024
Toxoplasma gondii proteasome beta subunit 0.0169 0.2194 0.2882
Trypanosoma brucei proteasome beta 6 subunit 0.0269 0.3663 0.4811
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0189 0.0189
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0163 0.2108 0.2769
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0189

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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