TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.427 | Formula: C15H23F3N4O6S
H donors: 2 H acceptors: 5 LogP: -2.95 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(F)(F)F.COCCN1CCCn2c(C1)nc(CNS(=O)(=O)C)cc2=O
InChi: 1S/C13H22N4O4S.C2HF3O2/c1-21-7-6-16-4-3-5-17-12(10-16)15-11(8-13(17)18)9-14-22(2,19)20;3-2(4,5)1(6)7/h8,14H,3-7,9-10H2,1-2H3;(H,6,7)
InChiKey: XBSVCEURHDARHE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	calpain-like protein, putative	0.0114	0.0411	0.0237
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0179	0.0847	0.0847
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0147	0.0635	0.0635
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0319	0.1799	0.1799
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0421	0.2488	0.2488
Plasmodium vivax	vivapain-3	0.0334	0.1899	0.4995
Plasmodium falciparum	serine repeat antigen 5	0.0147	0.0635	0.1582
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0147	0.0635	0.1582
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0114	0.0411	0.0236
Loa Loa (eye worm)	hypothetical protein	0.1533	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.1529	0.9971	0.9971
Plasmodium vivax	calpain, putative	0.0114	0.0411	0.0976
Trypanosoma cruzi	cysteine peptidase, putative	0.0608	0.3752	0.3638
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0411	0.0236
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0608	0.3752	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1529	0.9971	0.9971
Echinococcus granulosus	calpain	0.0114	0.0411	0.0411
Schistosoma mansoni	cathepsin F (C01 family)	0.0608	0.3752	0.3752
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0635	0.0635
Brugia malayi	Papain family cysteine protease containing protein	0.0147	0.0635	0.0635
Brugia malayi	Papain family cysteine protease containing protein	0.0147	0.0635	0.0635
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0608	0.3752	1
Echinococcus multilocularis	hypothetical protein	0.0114	0.0411	0.0411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Entamoeba histolytica	hypothetical protein	0.0147	0.0635	0.1276
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1533	1	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0181	0.0861	0.0861
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0334	0.1899	0.1751
Brugia malayi	cathepsin L-like cysteine proteinase	0.0147	0.0635	0.0635
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Schistosoma mansoni	cathepsin D (A01 family)	0.0179	0.0847	0.0847
Schistosoma mansoni	cathepsin F (C01 family)	0.0608	0.3752	0.3752
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0635	0.1276
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0576	0.3531	0.3414
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0411	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0904	0.0904
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0635	0.1276
Echinococcus granulosus	calpain 7 C02 family	0.0114	0.0411	0.0411
Schistosoma mansoni	dopamine-beta-monooxygenase	0.0124	0.0476	0.0476
Plasmodium falciparum	serine repeat antigen 1	0.0147	0.0635	0.1582
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0147	0.0635	0.1276
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0147	0.0635	0.1582
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0608	0.3752	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0147	0.0635	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0635	0.0635
Entamoeba histolytica	cysteine proteinase 2	0.0334	0.1899	0.4813
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0114	0.0411	0.0411
Echinococcus granulosus	calpain A	0.0114	0.0411	0.0411
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0608	0.3752	1
Echinococcus granulosus	cathepsin b	0.1533	1	1
Plasmodium vivax	vivapain-2	0.0608	0.3752	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1533	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.1899	0.4995
Brugia malayi	Cathepsin L-like precursor	0.0421	0.2488	0.2488
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0233	0.1214	0.1214
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Leishmania major	cathepsin L-like protease	0.0608	0.3752	0.3648
Echinococcus multilocularis	cathepsin L	0.0334	0.1899	0.1899
Entamoeba histolytica	cysteine proteinase, putative	0.0608	0.3752	1
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Onchocerca volvulus		0.0608	0.3752	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0187	0.0904	0.0904
Onchocerca volvulus		0.0608	0.3752	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.1899	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0635	0.0635
Schistosoma mansoni	growth factor receptor-bound protein	0.0181	0.0861	0.0861
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Plasmodium falciparum	serine repeat antigen 7	0.0147	0.0635	0.1582
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0181	0.0861	0.0861
Plasmodium vivax	vivapain-2	0.0608	0.3752	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.1899	0.1756
Echinococcus multilocularis	cathepsin L	0.0147	0.0635	0.0635
Schistosoma mansoni	calpain-7 (C02 family)	0.0114	0.0411	0.0411
Brugia malayi	Cathepsin L-like precursor	0.0421	0.2488	0.2488
Echinococcus multilocularis	calpain 5	0.0114	0.0411	0.0411
Schistosoma mansoni	cathepsin F (C01 family)	0.0421	0.2488	0.2488
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0187	0.0904	0.0738
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Echinococcus multilocularis	cathepsin b	0.1533	1	1
Trypanosoma brucei	calpain-like protein, putative	0.0114	0.0411	0.0237
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.2488	0.6587
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0608	0.3752	0.3752
Onchocerca volvulus	Cathepsin L homolog	0.0608	0.3752	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0147	0.0635	0.0635
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0147	0.0635	0.0635
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0147	0.0635	0.1582
Loa Loa (eye worm)	calpain	0.0114	0.0411	0.0411
Leishmania major	cathepsin L-like protease	0.0608	0.3752	0.3648
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0147	0.0635	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0233	0.1214	0.1214
Trypanosoma brucei	calpain-like protein, putative	0.0114	0.0411	0.0237
Echinococcus granulosus	growth factor receptor bound protein 2	0.0181	0.0861	0.0861
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0635	0.1582
Trypanosoma cruzi	cysteine peptidase, putative	0.0334	0.1899	0.1751
Echinococcus granulosus	cathepsin L	0.0147	0.0635	0.0635
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0233	0.1214	0.1214
Schistosoma mansoni	calpain (C02 family)	0.0114	0.0411	0.0411
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0411	0.0236
Onchocerca volvulus		0.0421	0.2488	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Toxoplasma gondii	cathepsin CPC1	0.0147	0.0635	0.1582
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0608	0.3752	0.3752
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0147	0.0635	0.1582
Loa Loa (eye worm)	calpain family protein 1	0.0222	0.1144	0.1144
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0635	0.0635
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0608	0.3752	0.3752
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0147	0.0635	0.1582
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0147	0.0635	0.0635
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0576	0.3531	0.3531
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0124	0.0476	0.0476
Echinococcus granulosus	calpain A	0.032	0.1801	0.1801
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0635	0.0635
Plasmodium falciparum	serine repeat antigen 2	0.0147	0.0635	0.1582
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Trypanosoma brucei	antigen, putative	0.0114	0.0411	0.0237
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0608	0.3752	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0576	0.3531	0.3423
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.2488	0.6587
Loa Loa (eye worm)	hypothetical protein	0.0608	0.3752	0.3752
Trypanosoma cruzi	major cysteine proteinase, putative	0.0147	0.0635	0.0464
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0147	0.0635	0.1582
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0114	0.0411	0.0237
Onchocerca volvulus	Cathepsin L homolog	0.0608	0.3752	1
Brugia malayi	Cathepsin L-like precursor	0.0608	0.3752	0.3752
Entamoeba histolytica	cysteine proteinase 1, putative	0.0334	0.1899	0.4813
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1342	0.8708	0.8684
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0635	0.1276
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0608	0.3752	1
Giardia lamblia	Cathepsin B precursor	0.0576	0.3531	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0411	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0904	0.0904
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0334	0.1899	0.1899
Trypanosoma cruzi	cysteine protease, putative	0.0334	0.1899	0.1751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0147	0.0635	0.1582
Onchocerca volvulus		0.0608	0.3752	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Loa Loa (eye worm)	fibroinase	0.0608	0.3752	0.3752
Giardia lamblia	Cathepsin B precursor	0.0576	0.3531	1
Brugia malayi	calpain 7	0.0114	0.0411	0.0411
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0147	0.0635	0.0635
Echinococcus multilocularis	calpain 7 (C02 family)	0.0114	0.0411	0.0411
Brugia malayi	Cathepsin L-like precursor	0.0608	0.3752	0.3752
Schistosoma mansoni	cathepsin s	0.0187	0.0904	0.0904
Onchocerca volvulus		0.0608	0.3752	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0608	0.3752	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0319	0.1799	0.1799
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.1899	0.4813
Loa Loa (eye worm)	hypothetical protein	0.0421	0.2488	0.2488
Plasmodium falciparum	serine repeat antigen 3	0.0147	0.0635	0.1582
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0411	0.0236
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0411	0.0236
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0608	0.3752	1
Toxoplasma gondii	cathepsin CPC2	0.0147	0.0635	0.1582
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0635	0.1582
Echinococcus granulosus	cathepsin l1	0.0421	0.2488	0.2488
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0635	0.0635
Trypanosoma cruzi	cysteine proteinase, putative	0.0334	0.1899	0.1751
Onchocerca volvulus		0.0608	0.3752	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0147	0.0635	0.1582
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1533	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0334	0.1899	0.1756
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0635	0.1582
Brugia malayi	Papain family cysteine protease containing protein	0.0147	0.0635	0.0635
Plasmodium falciparum	serine repeat antigen 8	0.0147	0.0635	0.1582
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0233	0.1214	0.1214
Schistosoma mansoni	cathepsin C	0.0147	0.0635	0.0635
Entamoeba histolytica	cysteine protease, putative	0.0608	0.3752	1
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0635	0.1276
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0061	0.0049	0.0049
Brugia malayi	Papain family cysteine protease containing protein	0.0608	0.3752	0.3752
Trypanosoma cruzi	cysteine peptidase, putative	0.0187	0.0904	0.0738
Brugia malayi	Sex muscle abnormal protein 5	0.0181	0.0861	0.0861
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0608	0.3752	0.3752
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0147	0.0635	0.1582
Schistosoma mansoni	growth factor receptor-bound protein	0.0181	0.0861	0.0861
Schistosoma mansoni	cathepsin S (C01 family)	0.0147	0.0635	0.0635
Echinococcus granulosus	cysteine protease	0.0334	0.1899	0.1899
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Trypanosoma cruzi	major cysteine proteinase, putative	0.1067	0.6855	0.6797
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0635	0.1582
Brugia malayi	Cathepsin L-like precursor	0.0608	0.3752	0.3752
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0635	0.0635
Schistosoma mansoni	calpain-7 (C02 family)	0.0114	0.0411	0.0411
Echinococcus multilocularis	cathepsin L cysteine protease	0.0608	0.3752	0.3752
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0635	0.1276
Loa Loa (eye worm)	cathepsin B	0.0576	0.3531	0.3531
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0608	0.3752	1
Brugia malayi	calpain family protein 1	0.0302	0.1683	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0222	0.1144	0.1144
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0319	0.1799	0.1799
Brugia malayi	Papain family cysteine protease containing protein	0.0334	0.1899	0.1899
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0233	0.1214	0.1214
Echinococcus granulosus	calpain 5	0.0114	0.0411	0.0411
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0411	0.0236
Echinococcus granulosus	cathepsin l1	0.0608	0.3752	0.3752
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1533	1	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0063	0.0064	0.0064
Brugia malayi	calpain family protein 1	0.0302	0.1683	0.1683
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0608	0.3752	1
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0476	0.0476
Loa Loa (eye worm)	calpain 5	0.008	0.0179	0.0179
Plasmodium vivax	serine-repeat antigen (SERA)	0.0147	0.0635	0.1582
Brugia malayi	Papain family cysteine protease containing protein	0.0334	0.1899	0.1899
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0411	0.0236
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0411	0.0237
Onchocerca volvulus		0.0608	0.3752	1
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0061	0.0049	0.0049
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0147	0.0635	0.1582
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0187	0.0904	0.0904
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0576	0.3531	0.9405
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Loa Loa (eye worm)	hypothetical protein	0.0302	0.1683	0.1683
Brugia malayi	Cathepsin L-like precursor	0.0187	0.0904	0.0904
Brugia malayi	fibroinase precursor	0.0147	0.0635	0.0635
Plasmodium falciparum	serine repeat antigen 4	0.0147	0.0635	0.1582
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Brugia malayi	Cathepsin L-like precursor	0.0608	0.3752	0.3752
Plasmodium falciparum	serine repeat antigen 9	0.0147	0.0635	0.1582
Loa Loa (eye worm)	cysteine protease	0.0608	0.3752	0.3752
Brugia malayi	cathepsin F-like cysteine proteinase	0.0147	0.0635	0.0635
Echinococcus granulosus	cathepsin L cysteine protease	0.0334	0.1899	0.1899
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0334	0.1899	0.1899
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0147	0.0635	0.1582
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0302	0.1683	0.1683
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0147	0.0635	0.1582
Loa Loa (eye worm)	calpain family protein 1	0.0302	0.1683	0.1683
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0635	0.0635
Giardia lamblia	Cathepsin B precursor	0.0576	0.3531	1
Leishmania major	cysteine peptidase A (CPA)	0.0608	0.3752	0.3648
Trypanosoma cruzi	cysteine peptidase, putative	0.1529	0.9971	0.9971
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0334	0.1899	0.4995
Echinococcus multilocularis	cysteine protease	0.0608	0.3752	0.3752
Echinococcus granulosus	cathepsin L	0.0334	0.1899	0.1899
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0147	0.0635	0.1582
Trypanosoma cruzi	cysteine peptidase, putative	0.1529	0.9971	0.9971
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0635	0.1276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0608	0.3752	1
Echinococcus granulosus	cathepsin b	0.1533	1	1
Toxoplasma gondii	cathepsin CPL	0.0608	0.3752	1
Loa Loa (eye worm)	hypothetical protein	0.0421	0.2488	0.2488
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Leishmania major	cathepsin L-like protease	0.1529	0.9971	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0411	0.0237
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Plasmodium vivax	vivapain-1	0.0334	0.1899	0.4995
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0147	0.0635	0.1582
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.1899	0.4813
Brugia malayi	cathepsin L-like precursor	0.0421	0.2488	0.2488
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0147	0.0635	0.1276
Brugia malayi	Cathepsin L-like precursor	0.0608	0.3752	0.3752
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0608	0.3752	1
Leishmania major	cathepsin L-like protease	0.1529	0.9971	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0147	0.0635	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0635	0.0635
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Echinococcus multilocularis	cathepsin b	0.1533	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0608	0.3752	0.3752
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0635	0.1582
Plasmodium vivax	unspecified product	0.0187	0.0904	0.2307
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0147	0.0635	0.0635
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0147	0.0635	0.1582
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0319	0.1799	0.1799
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0147	0.0635	0.1582
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0635	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0268	0.1451	0.1451
Onchocerca volvulus		0.0188	0.0912	0.089
Plasmodium vivax	serine-repeat antigen (SERA)	0.0147	0.0635	0.1582
Brugia malayi	calpain 5	0.008	0.0179	0.0179
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0608	0.3752	0.3752
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0635	0.1582
Onchocerca volvulus		0.0608	0.3752	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0147	0.0635	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0421	0.2488	0.2488
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0411	0.0237
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0147	0.0635	0.1582
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0576	0.3531	0.3423
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0147	0.0635	0.1582
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0147	0.0635	0.0635
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0147	0.0635	0.1582
Schistosoma mansoni	peptidylglycine monooxygenase	0.0124	0.0476	0.0476
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Echinococcus multilocularis	calpain	0.0114	0.0411	0.0411
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1533	1	1
Leishmania major	cathepsin L-like protease	0.0608	0.3752	0.3648
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0049	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0608	0.3752	1
Plasmodium falciparum	serine repeat antigen 6	0.0147	0.0635	0.1582
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0334	0.1899	0.1899
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0334	0.1899	0.4995
Toxoplasma gondii	cathepsin B	0.0576	0.3531	0.9405
Entamoeba histolytica	cysteine proteinase, putative	0.0334	0.1899	0.4813
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0635	0.1582
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0061	0.0049	0.0049
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0114	0.0411	0.0236
Echinococcus multilocularis	calpain A	0.032	0.1801	0.1801
Schistosoma mansoni	cathepsin B (C01 family)	0.0147	0.0635	0.0635
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0635	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0635	0.0635
Leishmania major	cathepsin L-like protease	0.0608	0.3752	0.3648
Leishmania major	cathepsin L-like protease	0.0608	0.3752	0.3648
Entamoeba histolytica	cysteine proteinase, putative	0.0421	0.2488	0.6463
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0114	0.0411	0.0237
Entamoeba histolytica	cysteine proteinase, putative	0.0608	0.3752	1
Echinococcus multilocularis	cysteine protease	0.0608	0.3752	0.3752
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1529	0.9971	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0187	0.0904	0.0904
Entamoeba histolytica	cysteine protease, putative	0.0334	0.1899	0.4813
Brugia malayi	Cathepsin L-like precursor	0.0608	0.3752	0.3752
Brugia malayi	cathepsin L precursor	0.0147	0.0635	0.0635
Leishmania major	cathepsin L-like protease	0.1529	0.9971	1
Loa Loa (eye worm)	ctsf protein	0.0608	0.3752	0.3752
Plasmodium vivax	unspecified product	0.0334	0.1899	0.4995
Plasmodium vivax	unspecified product	0.0147	0.0635	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0904	0.0904
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0608	0.3752	1
Trypanosoma brucei	calpain-like protein, putative	0.0114	0.0411	0.0237
Onchocerca volvulus	Cathepsin F homolog	0.0608	0.3752	1
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0061	0.0049	0.0049
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0608	0.3752	0.3752
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0147	0.0635	0.1582
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0147	0.0635	0.1582
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0147	0.0635	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0188	0.0912	0.0912
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0147	0.0635	0.1582
Schistosoma mansoni	calpain C (C02 family)	0.0114	0.0411	0.0411
Echinococcus multilocularis	calpain family protein 1, d	0.0222	0.1144	0.1144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0608	0.3752	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0334	0.1899	0.1751
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0061	0.0052	0.0052
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0147	0.0635	0.0635

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3501477

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2077480