Detailed information for compound 2077599

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.857 | Formula: C17H23ClN6O
  • H donors: 2 H acceptors: 4 LogP: 1.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNCC(=O)N1CCC(C1)c1ccnc(n1)Nc1ccc(cn1)C.Cl
  • InChi: 1S/C17H22N6O.ClH/c1-12-3-4-15(20-9-12)22-17-19-7-5-14(21-17)13-6-8-23(11-13)16(24)10-18-2;/h3-5,7,9,13,18H,6,8,10-11H2,1-2H3,(H,19,20,21,22);1H
  • InChiKey: NJCSGGNIYZNJOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0038 0.0347 0.0871
Leishmania major DNA polymerase eta, putative 0.0019 0.0088 0.0071
Brugia malayi tubulin alpha chain - mouse 0.0206 0.2642 0.3462
Trypanosoma brucei epsilon tubulin 0.015 0.1883 0.5043
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.0506
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0062 0.0058
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.1416 0.1839
Echinococcus multilocularis lysosomal alpha glucosidase 0.0148 0.1854 0.1933
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0037 0.0325 0.1784
Plasmodium falciparum alpha tubulin 2 0.0206 0.2642 0.7038
Brugia malayi follicle stimulating hormone receptor 0.0566 0.758 1
Trypanosoma brucei beta tubulin 0.015 0.1883 0.5043
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1416 0.362
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0062 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0037 0.0325 0.0265
Schistosoma mansoni tubulin subunit beta 0.0285 0.3728 0.3859
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0142 0.0187
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0142 0.0151
Leishmania major trypanothione reductase 0.011 0.1335 0.3471
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0037 0.0325 0.1784
Trypanosoma brucei zeta tubulin 0.0065 0.0718 0.1912
Schistosoma mansoni microtubule-associated protein tau 0.071 0.9562 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.0506
Echinococcus multilocularis beta tubulin 0.0285 0.3728 0.3894
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0038 0.0347 0.0423
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.0145 0.0192
Brugia malayi Tubulin beta chain 0.0065 0.0718 0.0914
Trypanosoma brucei alpha tubulin 0.0206 0.2642 0.7083
Echinococcus granulosus beta tubulin 0.0285 0.3728 0.3894
Trypanosoma brucei alpha tubulin, putative 0.0085 0.0989 0.264
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0319 0.0795
Brugia malayi PXA domain containing protein 0.0023 0.0142 0.0151
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1629 0.2148
Loa Loa (eye worm) hypothetical protein 0.0116 0.1416 0.1868
Schistosoma mansoni calcium-activated potassium channel 0.0249 0.3239 0.3345
Echinococcus multilocularis lamin 0.0028 0.0204 0.0206
Trichomonas vaginalis set domain proteins, putative 0.0287 0.3756 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0038 0.0347 0.0777
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2642 0.6962
Echinococcus multilocularis GA binding protein alpha chain 0.008 0.0918 0.0954
Leishmania major epsilon tubulin, putative 0.015 0.1883 0.4967
Schistosoma mansoni gabp alpha 0.008 0.0918 0.0902
Brugia malayi glutathione reductase 0.011 0.1335 0.1731
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0038 0.0347 0.0777
Loa Loa (eye worm) tubulin beta chain 0.0285 0.3728 0.4918
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0142 0.0085
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0285 0.3728 0.3894
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0566 0.758 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0328 0.432 0.4513
Echinococcus multilocularis Tubulin beta 2C chain 0.0285 0.3728 0.3894
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0204 0.0269
Echinococcus granulosus alpha tubulin 0.0206 0.2642 0.2758
Schistosoma mansoni tubulin subunit alpha 0.0206 0.2642 0.2717
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0088 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0274 0.0578
Mycobacterium tuberculosis Conserved protein 0.0116 0.1416 0.1362
Trypanosoma brucei epsilon tubulin 0.015 0.1883 0.5043
Echinococcus multilocularis tubulin alpha 0.015 0.1883 0.1963
Leishmania major beta tubulin 0.0285 0.3728 1
Brugia malayi tubulin alpha-2 chain 0.0206 0.2642 0.3462
Brugia malayi beta-lactamase 0.0116 0.1416 0.1839
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0037 0.0325 0.1784
Trichomonas vaginalis tubulin beta chain, putative 0.0285 0.3728 0.9923
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0251 0.3271 0.3228
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.008 0.0918 0.1212
Brugia malayi Tubulin alpha chain 0.0206 0.2642 0.3462
Giardia lamblia Histone acetyltransferase GCN5 0.0091 0.107 0.2698
Echinococcus granulosus tubulin alpha 1C chain 0.0206 0.2642 0.2758
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0148 0.1854 0.2446
Trichomonas vaginalis tubulin, putative 0.0085 0.0989 0.2454
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0038 0.0347 0.0916
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.316 0.33
Giardia lamblia Alpha-tubulin 0.0206 0.2642 0.7017
Brugia malayi Cytochrome P450 family protein 0.0037 0.0325 0.0395
Leishmania major beta tubulin 0.0285 0.3728 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0285 0.3728 0.4918
Echinococcus multilocularis Tubulin alpha 1 chain 0.0206 0.2642 0.2758
Mycobacterium tuberculosis Conserved protein 0.0116 0.1416 0.1362
Echinococcus granulosus Tubulin beta 2C chain 0.0285 0.3728 0.3894
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0088 0.0029
Schistosoma mansoni tubulin subunit epsilon 0.015 0.1883 0.1917
Loa Loa (eye worm) hypothetical protein 0.014 0.1748 0.2306
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.1416 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0038 0.0347 0.0711
Schistosoma mansoni hypothetical protein 0.0324 0.4265 0.4424
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0251 0.3271 0.3228
Echinococcus granulosus Tubulin beta 2C chain 0.0285 0.3728 0.3894
Brugia malayi Cytochrome P450 family protein 0.0125 0.1543 0.2007
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0337 0.4449 0.4649
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0037 0.0325 0.0265
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0038 0.0347 0.0356
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0062 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0319 0.0271
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3279 0.4326
Schistosoma mansoni alpha tubulin 0.0206 0.2642 0.2717
Trypanosoma cruzi polo-like protein kinase, putative 0.0086 0.1001 0.2561
Toxoplasma gondii LsmAD domain-containing protein 0.0084 0.097 0.2553
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.1416 0.1362
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0142 0.0141
Plasmodium vivax glutathione reductase, putative 0.011 0.1335 0.3533
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0116 0.1416 0.1868
Schistosoma mansoni alpha-glucosidase 0.0127 0.1572 0.159
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0142 0.0085
Leishmania major beta tubulin 0.0285 0.3728 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0084 0.097 0.2476
Echinococcus multilocularis microtubule associated protein 2 0.071 0.9562 1
Loa Loa (eye worm) beta-tubulin 0.0285 0.3728 0.4918
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0142 0.0151
Trichomonas vaginalis tubulin gamma chain, putative 0.0065 0.0718 0.1715
Plasmodium falciparum thioredoxin reductase 0.0038 0.0347 0.0777
Leishmania major zeta tubulin, putative 0.0065 0.0718 0.1788
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0142 0.0085
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0142 0.0085
Onchocerca volvulus Serine\/threonine kinase homolog 0.0086 0.1001 0.2244
Entamoeba histolytica tubulin alpha chain, putative 0.0206 0.2642 0.7017
Brugia malayi Tubulin gamma chain 0.015 0.1883 0.2457
Echinococcus granulosus tubulin alpha 0.015 0.1883 0.1963
Brugia malayi acetyltransferase, GNAT family protein 0.0337 0.4449 0.5855
Mycobacterium ulcerans cell division protein FtsZ 0.0065 0.0718 0.4738
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0088 0.0081
Onchocerca volvulus 0.0116 0.1416 0.3413
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.0338 0.0346
Toxoplasma gondii alpha tubulin TUBA1 0.0206 0.2642 0.7068
Plasmodium falciparum tubulin beta chain 0.0285 0.3728 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0251 0.3271 0.3228
Loa Loa (eye worm) tubulin beta-2A chain 0.0285 0.3728 0.4918
Trypanosoma cruzi tubulin delta chain 0.0065 0.0718 0.1788
Leishmania major beta tubulin 0.0285 0.3728 1
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0274 0.0578
Leishmania major beta tubulin 0.0285 0.3728 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0099 0.1184 0.313
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0037 0.0325 0.1784
Trypanosoma cruzi epsilon tubulin, putative 0.015 0.1883 0.4967
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0142 0.0145
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0037 0.0325 0.1784
Trypanosoma cruzi PAB1-binding protein , putative 0.0084 0.097 0.2476
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0088 0.0085
Brugia malayi Cytochrome P450 family protein 0.0077 0.0874 0.1121
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0142 0.0141
Leishmania major beta tubulin 0.0285 0.3728 1
Echinococcus multilocularis tubulin delta chain 0.0065 0.0718 0.0744
Loa Loa (eye worm) hypothetical protein 0.0027 0.0197 0.026
Leishmania major cytochrome p450-like protein 0.0037 0.0325 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0142 0.0145
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0124 0.0098
Echinococcus granulosus cytochrome P450 2K1 0.0037 0.0325 0.0333
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0319 0.0326
Brugia malayi Pre-SET motif family protein 0.0036 0.0319 0.0386
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.0338 0.0346
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0319 0.0326
Leishmania major gamma-tubulin 0.015 0.1883 0.4967
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0037 0.0325 0.0265
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0037 0.0325 0.0717
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1416 0.362
Echinococcus multilocularis lamin dm0 0.0028 0.0204 0.0206
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.0506
Leishmania major cytochrome p450-like protein 0.0077 0.0874 0.2214
Brugia malayi Ets-domain containing protein 0.008 0.0918 0.118
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1416 0.3694
Loa Loa (eye worm) hypothetical protein 0.0116 0.1416 0.1868
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0062 0.0151
Trypanosoma cruzi cytochrome P450, putative 0.0077 0.0874 0.2214
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0142 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.1001 0.2488
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.1001 0.2488
Echinococcus granulosus GA binding protein alpha chain 0.008 0.0918 0.0954
Leishmania major beta tubulin 0.0285 0.3728 1
Schistosoma mansoni hypothetical protein 0.0037 0.0325 0.0278
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.0989 0.2454
Mycobacterium tuberculosis Probable oxidoreductase 0.0279 0.3655 0.3616
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.1416 0.1362
Trypanosoma cruzi beta tubulin, putative 0.0285 0.3728 1
Toxoplasma gondii NADPH-glutathione reductase 0.0038 0.0347 0.0871
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0251 0.3271 0.3228
Echinococcus granulosus small conductance calcium activated potassium 0.0324 0.4265 0.4456
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.1416 0.1362
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0204 0.0269
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0088 0.0071
Schistosoma mansoni tubulin subunit beta 0.0285 0.3728 0.3859
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2642 0.6962
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0142 0.0141
Onchocerca volvulus 0.0085 0.0989 0.2209
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.1001 0.2488
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0406 0.0867
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0037 0.0325 0.0717
Plasmodium vivax hypothetical protein, conserved 0.0116 0.1416 0.3754
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0033 0.0274 0.0361
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0084
Echinococcus granulosus tubulin alpha chain 0.0206 0.2642 0.2758
Schistosoma mansoni hypothetical protein 0.0685 0.9217 0.9636
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.0506
Entamoeba histolytica hypothetical protein 0.004 0.0376 0.079
Entamoeba histolytica tubulin gamma chain 0.015 0.1883 0.4931
Schistosoma mansoni hypothetical protein 0.0685 0.9217 0.9636
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0038 0.0347 0.0356
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0504 0.0631
Trichomonas vaginalis tubulin epsilon chain, putative 0.0285 0.3728 0.9923
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.0187
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0037 0.0325 0.1784
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0062 0.0058
Trichomonas vaginalis tubulin, putative 0.0065 0.0718 0.1715
Loa Loa (eye worm) RecQ helicase 0.0022 0.0124 0.0164
Leishmania major beta tubulin 0.0285 0.3728 1
Trichomonas vaginalis tubulin beta chain, putative 0.0085 0.0989 0.2454
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0099 0.1184 0.313
Loa Loa (eye worm) hypothetical protein 0.0243 0.316 0.4169
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0142 0.0145
Schistosoma mansoni tubulin subunit delta 0.0065 0.0718 0.0691
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0121 0.1477 0.1948
Trichomonas vaginalis sucrase-isomaltase, putative 0.0033 0.0274 0.0506
Leishmania major beta tubulin 0.0285 0.3728 1
Leishmania major beta tubulin 0.0285 0.3728 1
Plasmodium vivax ataxin-2 like protein, putative 0.0084 0.097 0.2548
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0142 0.0141
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0038 0.0347 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0088 0.0221
Schistosoma mansoni hypothetical protein 0.005 0.0504 0.0466
Echinococcus multilocularis neutral alpha glucosidase AB 0.0033 0.0274 0.0279
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0099 0.1184 0.3126
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0037 0.0325 0.0265
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0062 0.0058
Trypanosoma brucei tubulin gamma chain 0.015 0.1883 0.5043
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0142 0.0145
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2642 0.6962
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0065 0.0718 0.1871
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0038 0.0347 0.1948
Trypanosoma brucei beta tubulin 0.0285 0.3728 1
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2642 0.6962
Brugia malayi hypothetical protein 0.0084 0.097 0.1248
Echinococcus multilocularis tubulin gamma 1 chain 0.015 0.1883 0.1963
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0142 0.0085
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0062 0.0058
Trypanosoma cruzi epsilon tubulin, putative 0.015 0.1883 0.4967
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0037 0.0325 0.0265
Brugia malayi cytochrome P450 0.0037 0.0325 0.0395
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0037 0.0325 0.0717
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0337 0.4449 0.4619
Echinococcus granulosus dna polymerase eta 0.0019 0.0088 0.0085
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0062 0.0095
Echinococcus multilocularis Tubulin beta 2C chain 0.0285 0.3728 0.3894
Leishmania major beta tubulin 0.0285 0.3728 1
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1416 0.362
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0142 0.0141
Loa Loa (eye worm) beta-lactamase 0.0116 0.1416 0.1868
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0037 0.0325 0.0265
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2642 0.2758
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0142 0.0141
Brugia malayi hypothetical protein 0.0023 0.0142 0.0151
Giardia lamblia Epsilon tubulin 0.0065 0.0718 0.1729
Schistosoma mansoni hypothetical protein 0.0037 0.0338 0.0291
Echinococcus multilocularis hypothetical protein 0.0206 0.2642 0.2758
Plasmodium falciparum alpha tubulin 1 0.0206 0.2642 0.7038
Onchocerca volvulus 0.0036 0.0319 0.0324
Echinococcus granulosus tubulin alpha chain 0.0206 0.2642 0.2758
Mycobacterium tuberculosis Conserved protein 0.0116 0.1416 0.1362
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.015 0.1883 0.5018
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0145 0.0089
Giardia lamblia Gamma tubulin 0.015 0.1883 0.4931
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0088 0.0071
Brugia malayi hypothetical protein 0.0243 0.316 0.4148
Loa Loa (eye worm) glutathione reductase 0.011 0.1335 0.1761
Echinococcus granulosus thioredoxin glutathione reductase 0.011 0.1335 0.1389
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0142 0.0141
Schistosoma mansoni tubulin subunit alpha 0.0206 0.2642 0.2717
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0037 0.0325 0.1784
Entamoeba histolytica hypothetical protein 0.0023 0.0142 0.0146
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.1416 0.1475
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0251 0.3271 0.8845
Loa Loa (eye worm) hypothetical protein 0.0028 0.0204 0.0269
Echinococcus granulosus Tubulin alpha 1 chain 0.0206 0.2642 0.2758
Brugia malayi beta-tubulin, identical 0.0285 0.3728 0.49
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0062 0.0046
Giardia lamblia Kinase, PLK 0.0086 0.1001 0.2507
Echinococcus multilocularis tubulin subunit beta 0.0285 0.3728 0.3894
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1416 0.3694
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.1001 0.2488
Loa Loa (eye worm) hypothetical protein 0.0384 0.5091 0.6716
Onchocerca volvulus 0.0287 0.3756 1
Echinococcus multilocularis beta tubulin 0.0285 0.3728 0.3894
Loa Loa (eye worm) BEN-1 protein 0.0285 0.3728 0.4918
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.1416 0.3789
Plasmodium vivax tubulin alpha chain, putative 0.0206 0.2642 0.7066
Plasmodium vivax thioredoxin reductase, putative 0.011 0.1335 0.3533
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.0989 0.2454
Trypanosoma brucei alpha tubulin 0.0206 0.2642 0.7083
Echinococcus multilocularis Tubulin beta 2C chain 0.0285 0.3728 0.3894
Entamoeba histolytica tubulin family protein 0.0285 0.3728 1
Toxoplasma gondii beta tubulin 0.0285 0.3728 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0206 0.2642 0.2758
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Trichomonas vaginalis tubulin epsilon chain, putative 0.0206 0.2642 0.6962
Onchocerca volvulus 0.005 0.0504 0.0845
Loa Loa (eye worm) hypothetical protein 0.0131 0.1624 0.2142
Brugia malayi Fli-1 protein 0.0242 0.3148 0.4132
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.1416 0.1362
Echinococcus granulosus tubulin alpha 3 chain 0.0206 0.2642 0.2758
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0037 0.0325 0.0857
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0376 0.0331
Echinococcus granulosus neutral alpha glucosidase AB 0.0033 0.0274 0.0279
Loa Loa (eye worm) tubulin alpha chain 0.0206 0.2642 0.3485
Echinococcus granulosus Tubulin beta 2C chain 0.0285 0.3728 0.3894
Leishmania major beta tubulin 0.0285 0.3728 1
Plasmodium falciparum glutathione reductase 0.011 0.1335 0.3471
Toxoplasma gondii cytochrome p450 superfamily protein 0.0037 0.0325 0.0812
Echinococcus multilocularis tubulin alpha 3 chain 0.0206 0.2642 0.2758
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0037 0.0325 0.0265
Echinococcus granulosus Tubulin alpha 1 chain 0.0206 0.2642 0.2758
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0037 0.0325 0.0265
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0874 0.1153
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0085 0.0989 0.2454
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0124 0.0129
Plasmodium falciparum tubulin delta chain, putative 0.0065 0.0718 0.1788
Schistosoma mansoni intermediate filament proteins 0.0028 0.0204 0.015
Plasmodium falciparum ataxin-2 like protein, putative 0.0084 0.097 0.2476
Entamoeba histolytica hypothetical protein 0.004 0.0376 0.079
Plasmodium falciparum tubulin epsilon chain, putative 0.015 0.1883 0.4967
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0145 0.0089
Schistosoma mansoni tubulin subunit beta 0.0065 0.0718 0.0691
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0037 0.0325 0.0265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0347 0.0777
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0088 0.0117
Echinococcus multilocularis geminin 0.0685 0.9217 0.9639
Brugia malayi Tubulin beta-1 chain 0.0285 0.3728 0.49
Schistosoma mansoni kinase 0.0044 0.0422 0.038
Loa Loa (eye worm) tubulin alpha-3 chain 0.0121 0.1477 0.1948
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0319 0.0271
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0088 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0037 0.0325 0.0265
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.0187
Loa Loa (eye worm) alpha-tubulin 0.0206 0.2642 0.3485
Loa Loa (eye worm) acetyltransferase 0.0337 0.4449 0.587
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0037 0.0325 0.0265
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0142 0.0141
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0037 0.0325 0.1784
Trypanosoma cruzi polo-like protein kinase, putative 0.0086 0.1001 0.2561
Plasmodium falciparum glutathione reductase 0.0038 0.0347 0.0777
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0142 0.0141
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0142 0.0151
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.011 0.1335 0.128
Trypanosoma cruzi alpha tubulin, putative 0.0206 0.2642 0.7038
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.1416 0.1362
Mycobacterium tuberculosis Probable dehydrogenase 0.0251 0.3271 0.3228
Trypanosoma brucei beta tubulin 0.0285 0.3728 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0037 0.0325 0.1784
Echinococcus multilocularis Tubulin beta 2C chain 0.0285 0.3728 0.3894
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0142 0.0085
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.1001 0.2488
Entamoeba histolytica hypothetical protein 0.004 0.0376 0.079
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1416 0.362
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0124 0.0098
Schistosoma mansoni tubulin subunit alpha 0.0206 0.2642 0.2717
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.1416 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0037 0.0325 0.0265
Echinococcus granulosus tubulin beta 1 chain 0.0285 0.3728 0.3894
Echinococcus granulosus intermediate filament protein 0.0028 0.0204 0.0206
Trypanosoma cruzi tubulin gamma chain 0.015 0.1883 0.4967
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2642 0.6962
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0037 0.0325 0.1784
Schistosoma mansoni alpha tubulin 0.0206 0.2642 0.2717
Brugia malayi Tubulin alpha chain 0.0065 0.0718 0.0914
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Schistosoma mansoni alpha tubulin 0.0206 0.2642 0.2717
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0142 0.0151
Trichomonas vaginalis tubulin epsilon chain, putative 0.0065 0.0718 0.1715
Echinococcus multilocularis tubulin epsilon chain 0.015 0.1883 0.1963
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0028 0.0208 0.0239
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0301 0.0307
Brugia malayi Pre-SET motif family protein 0.0252 0.3279 0.4305
Brugia malayi alpha-tubulin 0.0206 0.2642 0.3462
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0121 0.1477 0.3785
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0037 0.0325 0.1784
Echinococcus multilocularis lysosomal alpha glucosidase 0.0148 0.1854 0.1933
Schistosoma mansoni alpha-glucosidase 0.0127 0.1572 0.159
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.0145 0.0089
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0037 0.0325 0.1784
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0062 0.0102
Echinococcus multilocularis tubulin alpha 1C chain 0.0206 0.2642 0.2758
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.0187
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Trichomonas vaginalis tubulin beta chain, putative 0.0206 0.2642 0.6962
Trypanosoma brucei beta tubulin 0.0285 0.3728 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0037 0.0325 0.0265
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Brugia malayi hypothetical protein 0.004 0.0376 0.0462
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0037 0.0325 0.1784
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0142 0.0085
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0088 0.0026
Brugia malayi Cytochrome P450 family protein 0.0077 0.0874 0.1121
Loa Loa (eye worm) tubulin beta chain 0.0065 0.0718 0.0947
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0142 0.0085
Echinococcus granulosus tubulin alpha chain 0.0206 0.2642 0.2758
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Echinococcus granulosus lamin dm0 0.0028 0.0204 0.0206
Loa Loa (eye worm) thioredoxin reductase 0.011 0.1335 0.1761
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0124 0.0123
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0038 0.0347 0.0777
Loa Loa (eye worm) hypothetical protein 0.0324 0.4265 0.5626
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0037 0.0325 0.1784
Plasmodium falciparum ataxin-2 like protein, putative 0.0084 0.097 0.2476
Leishmania major hypothetical protein, conserved 0.0084 0.097 0.2476
Trypanosoma cruzi zeta tubulin, putative 0.0065 0.0718 0.1788
Echinococcus multilocularis 0.0037 0.0325 0.0333
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0037 0.0325 0.1784
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0206 0.2642 0.6962
Schistosoma mansoni lamin 0.0028 0.0204 0.015
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0065 0.0718 0.1715
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0038 0.0347 0.0301
Trichomonas vaginalis glutathione reductase, putative 0.0038 0.0347 0.0705
Plasmodium vivax tubulin epsilon chain, putative 0.015 0.1883 0.5015
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0038 0.0347 0.0777
Loa Loa (eye worm) tubulin alpha-2 chain 0.0206 0.2642 0.3485
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0347 0.0777
Trichomonas vaginalis tubulin epsilon chain, putative 0.0285 0.3728 0.9923
Brugia malayi hypothetical protein 0.0147 0.1844 0.2406
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0142 0.0145
Plasmodium vivax tubulin gamma chain, putative 0.015 0.1883 0.5015
Loa Loa (eye worm) tubulin gamma chain 0.015 0.1883 0.2484
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0088 0.007
Loa Loa (eye worm) alpha-tubulin isotype 2 0.014 0.1748 0.2306
Entamoeba histolytica acetyltransferase, GNAT family 0.0091 0.107 0.2698
Plasmodium vivax tubulin beta chain, putative 0.0285 0.3728 1
Echinococcus granulosus tubulin alpha chain 0.0206 0.2642 0.2758
Brugia malayi Tubulin beta chain 0.0085 0.0989 0.1273
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0347 0.0777
Echinococcus multilocularis small conductance calcium activated potassium 0.0324 0.4265 0.4456
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0406 0.0867
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Trypanosoma brucei PAB1-binding protein , putative 0.0084 0.097 0.2589
Entamoeba histolytica tubulin family protein 0.0285 0.3728 1
Echinococcus granulosus tubulin subunit beta 0.0285 0.3728 0.3894
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.316 0.33
Brugia malayi hypothetical protein 0.0023 0.0142 0.0151
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0088 0.0029
Brugia malayi isocitrate dehydrogenase 0.0017 0.0062 0.0046
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0279 0.3655 0.3616
Mycobacterium ulcerans lipase LipD 0.0116 0.1416 1
Schistosoma mansoni cytochrome P450 0.0037 0.0325 0.0278
Echinococcus multilocularis Tubulin alpha 1 chain 0.0206 0.2642 0.2758
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0142 0.0145
Schistosoma mansoni survival motor neuron protein 0.005 0.0504 0.0466
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0037 0.0325 0.0265
Brugia malayi Tubulin alpha-2 chain 0.0206 0.2642 0.3462
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0037 0.0325 0.1784
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0274 0.0506
Echinococcus granulosus dna polymerase kappa 0.0019 0.0088 0.0085
Schistosoma mansoni DNA polymerase eta 0.0019 0.0088 0.0029
Leishmania major DNA polymerase kappa, putative 0.0019 0.0088 0.0071
Echinococcus granulosus Tubulin alpha 1 chain 0.0206 0.2642 0.2758
Leishmania major beta tubulin 0.0285 0.3728 1
Leishmania major beta tubulin 0.0285 0.3728 1
Onchocerca volvulus 0.0116 0.1416 0.3413
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0037 0.0325 0.0265
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0142 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Trypanosoma brucei alpha tubulin 0.0206 0.2642 0.7083
Trichomonas vaginalis tubulin alpha chain, putative 0.015 0.1883 0.4892
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0319 0.0271
Toxoplasma gondii beta-tubulin, putative 0.0285 0.3728 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0037 0.0325 0.0265
Trypanosoma cruzi zeta tubulin, putative 0.0065 0.0718 0.1788
Echinococcus granulosus geminin 0.0685 0.9217 0.9639
Echinococcus multilocularis dna polymerase eta 0.0019 0.0088 0.0085
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0086 0.1001 0.104
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0319 0.0326
Trypanosoma brucei trypanothione reductase 0.011 0.1335 0.3569
Echinococcus granulosus peroxisome assembly protein 26 0.0206 0.2642 0.2758
Mycobacterium ulcerans beta-lactamase 0.0116 0.1416 1
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0142 0.0141
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0142 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0037 0.0325 0.1784
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0142 0.0145
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0037 0.0325 0.1784
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0037 0.0325 0.1784
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2642 0.2758
Echinococcus granulosus expressed protein 0.0452 0.6021 0.6294
Trypanosoma brucei zeta tubulin, putative 0.0065 0.0718 0.1912
Echinococcus granulosus histone acetyltransferase KAT2B 0.0099 0.1184 0.1232
Leishmania major beta tubulin 0.0285 0.3728 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0285 0.3728 0.9923
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0347 0.0777
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0077 0.0874 0.5917
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0038 0.0347 0.0777
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0347 0.0777
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0038 0.0347 0.0777
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0718 0.1715
Plasmodium falciparum histone acetyltransferase GCN5 0.0091 0.107 0.275
Trichomonas vaginalis mercuric reductase, putative 0.0038 0.0347 0.0705
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0037 0.0325 0.0717
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0319 0.0271
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0038 0.0347 0.1948
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0033 0.0274 0.0674
Mycobacterium leprae cell division protein FtsZ 0.0065 0.0718 0.1178
Loa Loa (eye worm) BEN-1 protein 0.0285 0.3728 0.4918
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0037 0.0325 0.1784
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0142 0.0141
Treponema pallidum cell division protein FtsZ 0.0065 0.0718 1
Echinococcus multilocularis tubulin beta 1 chain 0.0285 0.3728 0.3894
Trichomonas vaginalis tubulin gamma chain, putative 0.015 0.1883 0.4892
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.1001 0.0989
Plasmodium falciparum thioredoxin reductase 0.011 0.1335 0.3471
Echinococcus granulosus tubulin epsilon chain 0.015 0.1883 0.1963
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1416 0.362
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1416 0.1426
Loa Loa (eye worm) hypothetical protein 0.0116 0.1416 0.1868
Giardia lamblia Beta tubulin 0.0285 0.3728 1
Echinococcus granulosus Tubulin beta 2C chain 0.0285 0.3728 0.3894
Schistosoma mansoni tubulin subunit beta 0.0285 0.3728 0.3859
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.0145 0.0145
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1416 0.1426
Brugia malayi hypothetical protein 0.0169 0.2144 0.2802
Echinococcus granulosus microtubule associated protein 2 0.071 0.9562 1
Trypanosoma brucei beta tubulin 0.0285 0.3728 1
Brugia malayi MH2 domain containing protein 0.0132 0.1629 0.212
Echinococcus granulosus bloom syndrome protein 0.0022 0.0124 0.0123
Schistosoma mansoni calcium-activated potassium channel 0.0324 0.4265 0.4424
Echinococcus granulosus lamin 0.0028 0.0204 0.0206
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0274 0.0506
Leishmania major cytochrome p450-like protein 0.0037 0.0325 0.0717
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0142 0.0141
Loa Loa (eye worm) hypothetical protein 0.0169 0.2144 0.2828
Mycobacterium tuberculosis Probable reductase 0.0251 0.3271 0.3228
Onchocerca volvulus 0.0169 0.2144 0.5461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0347 0.0777
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.0145 0.0157
Loa Loa (eye worm) hypothetical protein 0.0206 0.2642 0.3485
Entamoeba histolytica tubulin alpha-1 chain 0.0206 0.2642 0.7017
Echinococcus multilocularis peroxisome assembly protein 26 0.0206 0.2642 0.2758
Brugia malayi serine/threonine-protein kinase plk-2 0.0086 0.1001 0.1289
Loa Loa (eye worm) cytochrome P450 family protein 0.0125 0.1543 0.2036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.0187
Trypanosoma cruzi cytochrome P450, putative 0.0077 0.0874 0.2214
Brugia malayi Thioredoxin reductase 0.011 0.1335 0.1731
Onchocerca volvulus 0.0086 0.0998 0.2235
Schistosoma mansoni tubulin subunit beta 0.0285 0.3728 0.3859
Onchocerca volvulus 0.0116 0.1416 0.3413
Loa Loa (eye worm) hypothetical protein 0.0036 0.0319 0.0421
Entamoeba histolytica hypothetical protein 0.0023 0.0142 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0117
Giardia lamblia Delta tubulin 0.0065 0.0718 0.1729
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0037 0.0325 0.0265
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0376 0.0386
Brugia malayi Tubulin alpha-2 chain 0.0206 0.2642 0.3462
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.1001 0.2488
Trichomonas vaginalis CAMK family protein kinase 0.0086 0.1001 0.2488
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0062 0.0058
Brugia malayi PXA domain containing protein 0.0023 0.0142 0.0151
Echinococcus multilocularis expressed protein 0.0452 0.6021 0.6294
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0274 0.051
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.1416 0.1362
Trichomonas vaginalis tubulin gamma chain, putative 0.015 0.1883 0.4892
Brugia malayi Ets-domain containing protein 0.008 0.0918 0.118
Entamoeba histolytica serine/threonine protein kinase, putative 0.0086 0.1001 0.2507
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0088 0.0221
Brugia malayi hypothetical protein 0.0054 0.0563 0.071
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0037 0.0325 0.0265
Schistosoma mansoni alpha glucosidase 0.0033 0.0274 0.0224
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0038 0.0347 0.0287
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0142 0.0187
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2642 0.2758
Loa Loa (eye worm) hypothetical protein 0.0116 0.1416 0.1868
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0027 0.0036
Schistosoma mansoni tubulin subunit beta 0.0285 0.3728 0.3859
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0038 0.0347 0.0777
Echinococcus multilocularis thioredoxin glutathione reductase 0.011 0.1335 0.1389
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0037 0.0325 0.0265
Loa Loa (eye worm) alpha-tubulin 0.0206 0.2642 0.3485
Echinococcus multilocularis Tubulin alpha 1 chain 0.0206 0.2642 0.2758
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.1416 0.1475
Leishmania major beta tubulin 0.0285 0.3728 1
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0142 0.0187
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0038 0.0347 0.0916
Schistosoma mansoni tubulin subunit alpha 0.0065 0.0718 0.0691
Trichomonas vaginalis tubulin, putative 0.0085 0.0989 0.2454
Echinococcus granulosus tubulin beta 4A class IVa 0.0285 0.3728 0.3894
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0142 0.0141
Schistosoma mansoni tubulin subunit gamma 0.015 0.1883 0.1917
Mycobacterium leprae conserved hypothetical protein 0.0116 0.1416 0.3276
Entamoeba histolytica hypothetical protein 0.0023 0.0142 0.0146
Trichomonas vaginalis esterase, putative 0.0116 0.1416 0.362
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Echinococcus multilocularis tubulin subunit TubB 0.0206 0.2642 0.2758
Brugia malayi intermediate filament protein 0.0028 0.0204 0.0234
Entamoeba histolytica hypothetical protein 0.004 0.0376 0.079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.0187
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0088 0.0026
Leishmania major beta tubulin 0.0285 0.3728 1
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1629 0.2148
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2642 0.2758
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0037 0.0325 0.0265
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0088 0.0071
Loa Loa (eye worm) hypothetical protein 0.0116 0.1416 0.1868
Loa Loa (eye worm) tubulin alpha 2 0.014 0.1748 0.2306
Leishmania major beta tubulin 0.0285 0.3728 1
Schistosoma mansoni tubulin subunit beta 0.0285 0.3728 0.3859
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0038 0.0347 0.0916
Loa Loa (eye worm) tubulin alpha chain 0.0206 0.2642 0.3485
Trichomonas vaginalis maltase-glucoamylase, putative 0.0033 0.0274 0.0506
Loa Loa (eye worm) hypothetical protein 0.004 0.0372 0.0491
Loa Loa (eye worm) cytochrome P450 0.0037 0.0325 0.0429
Loa Loa (eye worm) hypothetical protein 0.0084 0.097 0.1279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0088 0.0071
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0274 0.0506
Leishmania major hypothetical protein, conserved 0.0116 0.1416 0.3694
Loa Loa (eye worm) hypothetical protein 0.0118 0.1439 0.1898
Echinococcus granulosus tubulin delta chain 0.0065 0.0718 0.0744
Echinococcus multilocularis tubulin alpha 1C chain 0.0206 0.2642 0.2758
Echinococcus granulosus lysosomal alpha glucosidase 0.0148 0.1854 0.1933
Trichomonas vaginalis tubulin epsilon chain, putative 0.0206 0.2642 0.6962
Trichomonas vaginalis bromodomain-containing protein, putative 0.0099 0.1184 0.2986
Loa Loa (eye worm) tubulin alpha 2 0.0055 0.0583 0.0768
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0038 0.0347 0.0777
Trypanosoma brucei alpha tubulin 0.0206 0.2642 0.7083
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0204 0.0234
Loa Loa (eye worm) hypothetical protein 0.0062 0.0673 0.0888
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.014 0.1748 0.4524
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0086 0.1001 0.2561
Schistosoma mansoni hypothetical protein 0.004 0.0376 0.0331
Trypanosoma cruzi tubulin delta chain 0.0065 0.0718 0.1788
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0038 0.0347 0.1948
Toxoplasma gondii beta-1 tubulin, putative 0.0285 0.3728 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0088 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0088 0.0221
Brugia malayi beta-lactamase family protein 0.0116 0.1416 0.1839
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0038 0.0347 0.0916
Loa Loa (eye worm) hypothetical protein 0.0023 0.0142 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0718 0.1715
Echinococcus granulosus tubulin subunit TubB 0.0206 0.2642 0.2758
Echinococcus granulosus beta tubulin 0.0285 0.3728 0.3894
Trichomonas vaginalis tubulin, putative 0.0285 0.3728 0.9923
Toxoplasma gondii alpha-tubulin I, putative 0.0206 0.2642 0.7068
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0279 0.3655 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0285 0.3728 0.9923
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0274 0.051
Loa Loa (eye worm) fli-1 protein 0.0242 0.3148 0.4153
Plasmodium falciparum tubulin gamma chain 0.015 0.1883 0.4967
Trypanosoma brucei unspecified product 0.0019 0.0088 0.0221
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0065 0.0718 0.1871
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0874 0.1153
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.1416 0.1868
Echinococcus multilocularis Tubulin beta 2C chain 0.0285 0.3728 0.3894
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0038 0.0347 0.0777
Brugia malayi beta-lactamase family protein 0.0116 0.1416 0.1839
Toxoplasma gondii ABC1 family protein 0.0116 0.1416 0.3758
Echinococcus granulosus tubulin gamma 1 chain 0.015 0.1883 0.1963
Loa Loa (eye worm) tubulin alpha 2 0.014 0.1748 0.2306
Brugia malayi Glycosyl hydrolases family 31 protein 0.0033 0.0274 0.0327
Toxoplasma gondii thioredoxin reductase 0.011 0.1335 0.3537
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0038 0.0347 0.0865
Echinococcus granulosus Tubulin beta 2C chain 0.0285 0.3728 0.3894
Loa Loa (eye worm) hypothetical protein 0.0068 0.076 0.1002
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0142 0.0141
Loa Loa (eye worm) CYP4Cod1 0.0077 0.0874 0.1153
Trypanosoma brucei cytochrome P450, putative 0.0077 0.0874 0.2332
Trypanosoma cruzi trypanothione reductase, putative 0.011 0.1335 0.3471
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0088 0.0071
Trichomonas vaginalis tubulin alpha chain, putative 0.0085 0.0989 0.2454
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0142 0.0085
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0062 0.0151
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0142 0.0141
Plasmodium vivax delta tubulin, putative 0.0065 0.0718 0.1866
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0279 0.3655 0.3616
Loa Loa (eye worm) tubulin beta-4 chain 0.0285 0.3728 0.4918
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0065 0.0718 1
Plasmodium vivax tubulin alpha chain, putative 0.0206 0.2642 0.7066
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0088 0.0081
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0142 0.0085
Trypanosoma brucei tubulin delta chain 0.0065 0.0718 0.1912
Trypanosoma brucei polo-like protein kinase 0.0086 0.1001 0.2673
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0142 0.0141
Schistosoma mansoni lamin 0.0028 0.0204 0.015
Echinococcus granulosus tubulin alpha 3 chain 0.0206 0.2642 0.2758
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0376 0.0386
Plasmodium vivax SET domain protein, putative 0.0036 0.0319 0.0789
Echinococcus multilocularis tubulin alpha chain 0.0206 0.2642 0.2758
Mycobacterium ulcerans hypothetical protein 0.0116 0.1416 1
Giardia lamblia Beta tubulin 0.0285 0.3728 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0088 0.0221
Mycobacterium tuberculosis Cell division protein FtsZ 0.0065 0.0718 0.0659
Giardia lamblia Beta tubulin 0.0285 0.3728 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0088 0.0071
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0038 0.0347 0.0865
Echinococcus granulosus tubulin alpha chain 0.0206 0.2642 0.2758
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0062 0.0001
Echinococcus granulosus tubulin alpha 1C chain 0.0206 0.2642 0.2758
Leishmania major alpha tubulin 0.0206 0.2642 0.7038
Trypanosoma brucei glucosidase, putative 0.0033 0.0274 0.072
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0028 0.0208 0.0239
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0086 0.1001 0.132
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0086 0.1001 0.104
Leishmania major alpha glucosidase II subunit, putative 0.0033 0.0274 0.0578
Giardia lamblia Alpha-tubulin 0.0206 0.2642 0.7017
Schistosoma mansoni ets-related 0.0242 0.3148 0.3249
Mycobacterium leprae Probable lipase LipE 0.0116 0.1416 0.3276
Leishmania major delta tubulin, putative 0.0065 0.0718 0.1788
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0099 0.1184 0.2986
Trypanosoma brucei epsilon tubulin 0.015 0.1883 0.5043
Brugia malayi Cell division protein ftsZ 0.0065 0.0718 0.0914
Brugia malayi Glycosyl hydrolases family 31 protein 0.0148 0.1854 0.2419
Echinococcus multilocularis musashi 0.0028 0.0204 0.0206
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.1416 0.1362
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.0145 0.0192

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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