Detailed information for compound 2077867

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.917 | Formula: C18H31ClN4O2
  • H donors: 0 H acceptors: 3 LogP: 2.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nnc(o1)CN1CCC(CC1)C1CCCCCN1C(=O)C.Cl
  • InChi: 1S/C18H30N4O2.ClH/c1-3-17-19-20-18(24-17)13-21-11-8-15(9-12-21)16-7-5-4-6-10-22(16)14(2)23;/h15-16H,3-13H2,1-2H3;1H
  • InChiKey: BMKAGJZGTDUTBB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.018 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0209 0.021
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0021 0.0021
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.3142 0.4479
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0209 0.0207
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0021 0.0018
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0209 0.0271
Schistosoma mansoni nuclear hormone receptor 0.0043 0.1013 0.1424
Brugia malayi hypothetical protein 0.0197 0.6711 0.6726
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.1081 0.1083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Brugia malayi Nuclear hormone receptor E75 0.002 0.018 0.0178
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.014 0.014
Leishmania major protein kinase, putative 0.0021 0.0217 0.0869
Schistosoma mansoni amine GPCR 0.0021 0.0209 0.0271
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0493 0.0494
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0209 0.021
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0269 0.027
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0479 0.129
Onchocerca volvulus 0.0043 0.1013 0.1013
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0209 0.021
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.3712 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0493 0.0494
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0209 0.021
Onchocerca volvulus 0.0021 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus multilocularis lamin 0.0029 0.0493 0.0494
Loa Loa (eye worm) hypothetical protein 0.0029 0.0493 0.0494
Brugia malayi GnHR receptor homolog 0.0021 0.0209 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0955 0.0955
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0209 0.0271
Brugia malayi hypothetical protein 0.002 0.018 0.0178
Schistosoma mansoni intermediate filament proteins 0.0029 0.0493 0.0678
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1658 0.166
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0209 0.021
Brugia malayi G-protein coupled receptor 0.0021 0.0209 0.0207
Schistosoma mansoni biogenic amine receptor 0.0021 0.0209 0.0271
Schistosoma mansoni hypothetical protein 0.0062 0.1742 0.247
Brugia malayi Serotonin receptor 0.0021 0.0209 0.0207
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0209 0.021
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0209 0.021
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0209 0.0271
Schistosoma mansoni nuclear hormone receptor 0.002 0.018 0.0229
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0209 0.021
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0209 0.0271
Brugia malayi hypothetical protein 0.0028 0.0471 0.047
Loa Loa (eye worm) glutathione reductase 0.0046 0.1123 0.1125
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0083 0.0083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.1013 0.1016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.018 0.0178
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.1013 0.1013
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0209 0.0271
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0972 0.0973
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0209 0.021
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0209 0.021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.1013 0.1016
Brugia malayi steroid hormone receptor 0.0043 0.1013 0.1013
Echinococcus granulosus geminin 0.0205 0.6989 0.7006
Onchocerca volvulus 0.0021 0.0209 0.0209
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0209 0.021
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1145 0.1148
Brugia malayi Uncoordinated protein 44 0.0017 0.0077 0.0075
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0083 0.2498 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0269 0.027
Loa Loa (eye worm) dihydrofolate reductase 0.0024 0.0323 0.0324
Echinococcus multilocularis amino acids transporter 0.0029 0.0493 0.0494
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0479 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0493 0.0492
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0083 0.2498 1
Onchocerca volvulus 0.0058 0.1586 0.1586
Brugia malayi Thioredoxin reductase 0.0046 0.1123 0.1123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2143 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Leishmania major cytochrome p450-like protein 0.0019 0.0142 0.057
Brugia malayi nuclear receptor RXR 0.0023 0.0269 0.0268
Brugia malayi nuclear hormone receptor 0.002 0.018 0.0178
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0269 0.0268
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0209 0.021
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.018 0.0181
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.018 0.0181
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.1013 0.1424
Brugia malayi G protein-coupled receptor 0.0021 0.0209 0.0207
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.018 0.0181
Brugia malayi dihydrofolate reductase family protein 0.0024 0.0323 0.0322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1658 0.1662
Echinococcus granulosus lamin 0.0029 0.0493 0.0494
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0209 0.021
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus granulosus somatostatin receptor 0.0021 0.0209 0.021
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0083 0.2498 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.014 0.014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.1013 0.1013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0767 0.1071
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.9976 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.3283 0.8837
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.018 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0767 0.1071
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0083 0.0089
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0767 0.0769
Brugia malayi Dihydrofolate reductase 0.0024 0.0323 0.0322
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.1013 0.1016
Brugia malayi G-protein coupled receptor 0.0021 0.0209 0.0207
Onchocerca volvulus 0.0021 0.0209 0.0209
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2143 1
Loa Loa (eye worm) amino acid permease 0.0029 0.0493 0.0494
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Brugia malayi hypothetical protein 0.002 0.018 0.0178
Onchocerca volvulus 0.0021 0.0209 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0077 0.0075
Loa Loa (eye worm) hypothetical protein 0.0043 0.1013 0.1016
Brugia malayi tailless protein 0.002 0.018 0.0178
Onchocerca volvulus 0.0021 0.0209 0.0209
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.1081 0.1081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0209 0.0271
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0767 0.3012
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.3712 1
Echinococcus multilocularis Large neutral amino acids transporter small 0.0029 0.0493 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.1013 0.1016
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.1013 0.1016
Schistosoma mansoni neuropeptide receptor 0.0021 0.0209 0.0271
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.018 0.0181
Echinococcus multilocularis cationic amino acid transporter 0.0029 0.0493 0.0494
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.2143 0.8565
Echinococcus multilocularis dihydrofolate reductase 0.0024 0.0323 0.0324
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.018 0.0181
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.018 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.1013 0.1013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0209 0.021
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0142 0.057
Schistosoma mansoni amine GPCR 0.0021 0.0209 0.0271
Schistosoma mansoni thyroid hormone receptor 0.0043 0.1013 0.1424
Echinococcus granulosus FTZ F1 alpha 0.0043 0.1013 0.1016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus multilocularis musashi 0.0029 0.0493 0.0494
Onchocerca volvulus 0.0021 0.0209 0.0209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Onchocerca volvulus 0.0021 0.0209 0.0209
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus granulosus lamin dm0 0.0029 0.0493 0.0494
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1123 0.4493
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Schistosoma mansoni hypothetical protein 0.0205 0.6989 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0209 0.0271
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1658 0.166
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0209 0.021
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0028 0.0471 0.1886
Onchocerca volvulus 0.0021 0.0209 0.0209
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.018 0.0181
Loa Loa (eye worm) DR-78 0.002 0.018 0.0181
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.0209 0.0209
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.2143 0.575
Onchocerca volvulus 0.0021 0.0209 0.0209
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0269 0.0268
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.1013 0.1013
Echinococcus granulosus hypothetical protein 0.0021 0.0209 0.021
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0209 0.021
Echinococcus granulosus neuropeptide receptor 0.0021 0.0209 0.021
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0209 0.021
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.1013 0.1016
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0209 0.021
Brugia malayi nuclear receptor NHR-88 0.002 0.018 0.0178
Brugia malayi Latrophilin receptor protein 2 0.0019 0.014 0.0137
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0083
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.1013 0.1016
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0479 0.1849
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.1013 0.1013
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0209 0.021
Echinococcus granulosus neuropeptide receptor 0.0021 0.0209 0.021
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0209 0.021
Schistosoma mansoni opsin-like receptor 0.0021 0.0209 0.0271
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0139 0.4574 0.4585
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0209 0.021
Brugia malayi neuropeptide F receptor 0.0021 0.0209 0.0207
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2143 1
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Brugia malayi Dopamine receptor protein 2 0.0021 0.0209 0.0207
Mycobacterium tuberculosis Hypothetical protein 0.0028 0.0471 0.122
Schistosoma mansoni adenoreceptor 0.0021 0.0209 0.0271
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0209 0.021
Plasmodium falciparum glutathione reductase 0.0046 0.1123 0.4447
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0083
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0209 0.021
Schistosoma mansoni neuropeptide receptor 0.0021 0.0209 0.0271
Onchocerca volvulus 0.01 0.3142 0.3142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0479 0.2158
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.1013 0.1424
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.2719 0.2725
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.1013 0.1013
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0209 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0471 0.0471
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0021 0.0021
Brugia malayi nuclear receptor NHR-88 0.0043 0.1013 0.1013
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0209 0.021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0021 0.0083
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0209 0.0207
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0077 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0209 0.021
Onchocerca volvulus 0.0043 0.1041 0.1041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.1013 0.1016
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0209 0.021
Brugia malayi Cytochrome P450 family protein 0.0019 0.0142 0.014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0083
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2143 0.3045
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0023 0.0269 0.027
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.3283 0.8844
Echinococcus multilocularis somatostatin receptor 0.0021 0.0209 0.021
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0209 0.021
Echinococcus granulosus g protein coupled receptor 0.0021 0.0209 0.021
Brugia malayi hypothetical protein 0.0286 0.9976 1
Schistosoma mansoni hypothetical protein 0.0019 0.014 0.017
Schistosoma mansoni zinc finger protein 0.002 0.018 0.0229
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0209 0.021
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.1013 0.1424
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.1013 0.1016
Echinococcus granulosus thymidylate synthase 0.0059 0.1611 0.1615
Schistosoma mansoni amine GPCR 0.0021 0.0209 0.0271
Brugia malayi sulfakinin receptor protein 0.0021 0.0209 0.0207
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.1013 0.1013
Brugia malayi nuclear hormone receptor 0.0043 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0863 0.0866
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0021 0.0083
Loa Loa (eye worm) hypothetical protein 0.0043 0.1013 0.1016
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.018 0.0178
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.1013 0.1424
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.3283 0.8837
Onchocerca volvulus 0.0021 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0023 0.0269 0.027
Onchocerca volvulus 0.0021 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0023 0.0269 0.027
Echinococcus multilocularis serotonin receptor 0.0021 0.0209 0.021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1228 0.1231
Schistosoma mansoni lamin 0.0029 0.0493 0.0678
Schistosoma mansoni thyroid hormone receptor 0.0043 0.1013 0.1424
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.1013 0.1016
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.3142 0.315
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.3142 0.315
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0024 0.0323 0.082
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.1013 0.1424
Schistosoma mansoni opsin-like receptor 0.0021 0.0209 0.0271
Brugia malayi hypothetical protein 0.0023 0.0269 0.0268
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.014 0.014
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0209 0.0207
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0209 0.021
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1123 0.4447
Mycobacterium ulcerans putative regulatory protein 0.0043 0.1041 0.4809
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0718 0.072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.1013 0.1016
Entamoeba histolytica amino acid permease, putative 0.0029 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.018 0.0181
Schistosoma mansoni hypothetical protein 0.0019 0.014 0.017
Schistosoma mansoni nuclear receptor 0.002 0.018 0.0229
Mycobacterium tuberculosis Probable reductase 0.0104 0.3283 0.8837
Plasmodium vivax SET domain protein, putative 0.0036 0.0767 0.3012
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0209 0.021
Schistosoma mansoni hypothetical protein 0.0021 0.0209 0.0271
Schistosoma mansoni lamin 0.0029 0.0493 0.0678
Schistosoma mansoni hypothetical protein 0.0019 0.014 0.017
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4758 0.4769
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0479 0.1916
Brugia malayi Nuclear hormone receptor E75 0.002 0.018 0.0178
Brugia malayi RE15519p 0.0021 0.0209 0.0207
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0209 0.0207
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0043 0.1013 0.1016
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.1081 0.1083
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0269 0.0357
Onchocerca volvulus 0.0029 0.0493 0.0493
Onchocerca volvulus 0.0036 0.0767 0.0767
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4758 0.4769
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.014 0.014
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0021 0.0021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0209 0.021
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0209 0.0271
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0209 0.0271
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.018 0.018
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.1013 0.1016
Brugia malayi AKH receptor 0.0021 0.0209 0.0207
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0209 0.021
Onchocerca volvulus 0.0059 0.1611 0.1611
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0209 0.021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.1013 0.1013
Schistosoma mansoni neuropeptide receptor 0.0021 0.0209 0.0271
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0479 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0209 0.0271
Loa Loa (eye worm) hypothetical protein 0.0041 0.0955 0.0958
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Schistosoma mansoni neuropeptide receptor 0.0021 0.0209 0.0271
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0059 0.1611 0.4342
Loa Loa (eye worm) hypothetical protein 0.0036 0.0767 0.0769
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0209 0.021
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.1013 0.1013
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.3712 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Schistosoma mansoni nuclear receptor 0.002 0.018 0.0229
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0209 0.021
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0002 0.0002
Echinococcus granulosus fmrfamide receptor 0.0021 0.0209 0.021
Echinococcus multilocularis amino acid permease 0.0029 0.0493 0.0494
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0209 0.0271
Echinococcus granulosus allatostatin A receptor 0.0021 0.0209 0.021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0209 0.021
Brugia malayi ecdysone receptor 0.002 0.018 0.0178
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0209 0.021
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.018 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1228 0.1733
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0021 0.0083
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0209 0.021
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0162 0.5407 0.542
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0083
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.018 0.0178
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.1605 0.2273
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.2143 0.2148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0209 0.0271
Brugia malayi glutathione reductase 0.0046 0.1123 0.1123
Echinococcus granulosus yl amino acid transporter 2 0.0029 0.0493 0.0494
Trichomonas vaginalis set domain proteins, putative 0.0286 0.9995 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0209 0.0271
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0209 0.0271
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.018 0.0181
Echinococcus multilocularis serotonin receptor 0.0021 0.0209 0.021
Echinococcus granulosus sex peptide receptor 0.0021 0.0209 0.021
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0209 0.021
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.1013 0.1016
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2143 0.3045
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0077 0.0077
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0209 0.0271
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0209 0.021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1228 0.1231
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0209 0.021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.1013 0.1016
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0209 0.021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1228 0.1231
Brugia malayi hypothetical protein 0.0023 0.0269 0.0268
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0209 0.0271
Loa Loa (eye worm) hypothetical protein 0.0043 0.1013 0.1016
Brugia malayi Amino acid permease family protein 0.0029 0.0493 0.0492
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.018 0.0181
Brugia malayi nuclear receptor NHR-67 0.002 0.018 0.0178
Plasmodium falciparum thioredoxin reductase 0.0046 0.1123 0.4447
Onchocerca volvulus 0.0029 0.0493 0.0493
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0142 0.0574
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.1013 0.1424
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0767 0.0769
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0269 0.027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0209 0.0271
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0021 0.0434
Brugia malayi putative neuropeptide receptor 0.0021 0.0209 0.0207
Echinococcus granulosus amino acids transporter 0.0029 0.0493 0.0494
Brugia malayi Death domain containing protein 0.0017 0.0077 0.0075
Echinococcus granulosus g protein coupled receptor 0.0021 0.0209 0.021
Schistosoma mansoni hypothetical protein 0.0205 0.6989 1
Schistosoma mansoni biogenic amine receptor 0.0021 0.0209 0.0271
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0059 0.1611 0.2283
Brugia malayi nuclear receptor RXR 0.002 0.018 0.0178
Loa Loa (eye worm) thymidylate synthase 0.0059 0.1611 0.1615
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.014
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0479 0.1849
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.1041 0.1044
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.018 0.0181
Schistosoma mansoni amine GPCR 0.0021 0.0209 0.0271
Leishmania major trypanothione reductase 0.0046 0.1123 0.4493
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0021 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0209 0.021
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.1013 0.1013
Schistosoma mansoni retinoic acid receptor RXR 0.0162 0.5407 0.773
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0077 0.0077
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0083 0.2498 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0209 0.021
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.018 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.1013 0.1013
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0021 0.0209 0.0271
Schistosoma mansoni hypothetical protein 0.0021 0.0209 0.0271
Onchocerca volvulus 0.0021 0.0209 0.0209
Onchocerca volvulus 0.0029 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0197 0.6711 0.6727
Brugia malayi MH2 domain containing protein 0.0144 0.4758 0.4768
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0209 0.021
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0209 0.021
Onchocerca volvulus 0.0021 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Onchocerca volvulus 0.002 0.018 0.018
Schistosoma mansoni dihydrofolate reductase 0.0024 0.0323 0.0434
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0479 0.1241
Echinococcus multilocularis Ankyrin 0.0018 0.0083 0.0083
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0474 0.0475
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.1232 0.1738
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Onchocerca volvulus 0.0021 0.0209 0.0209
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0209 0.021
Schistosoma mansoni cationic amino acid transporter 0.0029 0.0493 0.0678
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.3142 0.3148
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0209 0.021
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0209 0.021
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.0209 0.0209
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0209 0.021
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0209 0.021
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0209 0.021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.1013 0.1424
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Brugia malayi Serotonin receptor 0.0021 0.0209 0.0207
Echinococcus granulosus orexin receptor type 2 0.0021 0.0209 0.021
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0142 0.057
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0209 0.021
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.2719 0.2725
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.1013 0.1013
Schistosoma mansoni nuclear hormone receptor 0.002 0.018 0.0229
Echinococcus multilocularis lamin dm0 0.0029 0.0493 0.0494
Loa Loa (eye worm) hypothetical protein 0.006 0.1658 0.1662
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0209 0.021
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0021 0.0021
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0493 0.0494
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.018 0.0178
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0479 0.1849
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.1013 0.1013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.1013 0.1424
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0767 0.1071
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0209 0.021
Brugia malayi ORL1-like opioid receptor 0.0021 0.0209 0.0207
Onchocerca volvulus 0.0021 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0209 0.021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1228 0.1231
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0209 0.021
Schistosoma mansoni single-minded 0.0059 0.1605 0.2273
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0209 0.021
Schistosoma mansoni hypothetical protein 0.0058 0.1586 0.2247
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0209 0.021
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0972 0.0973
Schistosoma mansoni cationic amino acid transporter 0.0029 0.0493 0.0678
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0209 0.021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.1013 0.1016
Brugia malayi conserved hypotetical protein 0.002 0.018 0.0178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0209 0.021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1228 0.1229
Echinococcus granulosus GPCR family 2 0.0019 0.014 0.014
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Loa Loa (eye worm) amino acid permease 0.0029 0.0493 0.0494
Loa Loa (eye worm) hypothetical protein 0.0043 0.1013 0.1016
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0083 0.2498 1
Echinococcus multilocularis cationic amino acid transporter 0.0026 0.0413 0.0414
Schistosoma mansoni cationic amino acid transporter 0.0029 0.0493 0.0678
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.018 0.0181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0083
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.3283 0.8837
Onchocerca volvulus 0.0021 0.0209 0.0209
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0209 0.0271
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0269 0.027
Schistosoma mansoni hypothetical protein 0.0021 0.0209 0.0271
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1123 0.1125
Echinococcus granulosus cationic amino acid transporter 0.0029 0.0493 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.1013 0.1016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.014 0.0137
Schistosoma mansoni hypothetical protein 0.0017 0.0077 0.0081
Brugia malayi neuropeptide F receptor 0.0021 0.0209 0.0207
Trypanosoma brucei trypanothione reductase 0.0046 0.1123 0.4447
Brugia malayi hypoxia-induced factor 1 0.0182 0.6147 0.6161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Brugia malayi hypothetical protein 0.0021 0.0209 0.0207
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0269 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.1013 0.1013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.1013 0.1016
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.2143 0.8577
Echinococcus granulosus death domain containing protein 0.0017 0.0077 0.0077
Schistosoma mansoni cationic amino acid transporter 0.0029 0.0493 0.0678
Schistosoma mansoni amine GPCR 0.0021 0.0209 0.0271
Brugia malayi Pre-SET motif family protein 0.0251 0.8713 0.8733
Echinococcus multilocularis GPCR, family 2 0.0019 0.014 0.014
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0142 0.0143
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0024 0.0323 0.1426
Brugia malayi Pre-SET motif family protein 0.0036 0.0767 0.0767
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.1232 0.1738
Brugia malayi ecdysteroid receptor 0.0043 0.1013 0.1013
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0209 0.0271
Brugia malayi intermediate filament protein 0.0029 0.0493 0.0492
Echinococcus granulosus serotonin receptor 0.0021 0.0209 0.021
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1123 0.2985
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0209 0.021
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0209 0.021
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0142 0.0143
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0209 0.021
Mycobacterium ulcerans thymidylate synthase 0.0059 0.1611 0.7496
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0269 0.027
Schistosoma mansoni survival motor neuron protein 0.0058 0.1586 0.2247
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0021 0.0083
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0209 0.021
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0209 0.021
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.018 0.0229
Echinococcus granulosus 5'partial|cationic amino acid transporter 0.0026 0.0413 0.0414
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0209 0.0271
Echinococcus granulosus g protein coupled receptor 0.0021 0.0209 0.021
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0209 0.021
Schistosoma mansoni biogenic amine receptor 0.0021 0.0209 0.0271
Brugia malayi Cytochrome P450 family protein 0.0019 0.0142 0.014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.1013 0.1013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.014 0.014
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0209 0.021
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0209 0.021
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0209 0.021
Echinococcus granulosus single minded 2 0.0048 0.1192 0.1195
Echinococcus granulosus Large neutral amino acids transporter small 0.0029 0.0493 0.0494
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0142 0.0143
Echinococcus multilocularis cationic amino acid transporter 0.0029 0.0493 0.0494
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0209 0.0271
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0209 0.0271
Echinococcus multilocularis thymidylate synthase 0.0059 0.1611 0.1615
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0083 0.2498 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus granulosus dihydrofolate reductase 0.0024 0.0323 0.0324
Toxoplasma gondii thioredoxin reductase 0.0046 0.1123 0.4447
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1228 0.1231
Echinococcus granulosus cationic amino acid transporter 0.0026 0.0413 0.0414
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.1013 0.1013
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.9976 1
Brugia malayi Dopamine receptor protein 1 0.0021 0.0209 0.0207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.0043 0.1013 0.1016
Brugia malayi Dopamine receptor 0.0021 0.0209 0.0207
Brugia malayi Melatonin receptor type 1A 0.0021 0.0209 0.0207
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1145 0.1148
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0209 0.021
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0142 0.0491
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0209 0.021
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0209 0.021
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1228 0.1733
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0024 0.0323 0.0871
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0059 0.1611 0.431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1228 0.1733
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.1013 0.1016
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Schistosoma mansoni myosin xvIII 0.0021 0.0209 0.0271
Echinococcus multilocularis Large neutral amino acids transporter small 0.0029 0.0493 0.0494
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Schistosoma mansoni netrin receptor unc5 0.0017 0.0077 0.0081
Loa Loa (eye worm) hypothetical protein 0.0043 0.1013 0.1016
Schistosoma mansoni opsin-like receptor 0.0021 0.0209 0.0271
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0209 0.0271
Brugia malayi Protein kinase domain containing protein 0.0017 0.0077 0.0075
Plasmodium vivax glutathione reductase, putative 0.0046 0.1123 0.4447
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.2143 0.2148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0767 0.1071
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8713 0.8733
Brugia malayi thymidylate synthase 0.0059 0.1611 0.1613
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0767 0.0769
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.6147 0.6162
Echinococcus multilocularis geminin 0.0205 0.6989 0.7006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0209 0.0271
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1586 0.1588
Brugia malayi bHLH-PAS transcription factor 0.0043 0.1041 0.1042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0209 0.0271
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0209 0.0271
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.1013 0.1016
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.3712 1
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0479 0.1849
Echinococcus multilocularis sex peptide receptor 0.0021 0.0209 0.021
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0209 0.0271
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.1013 0.1016
Loa Loa (eye worm) hypothetical protein 0.0286 0.9976 1
Echinococcus multilocularis cationic amino acid transporter 0.0029 0.0493 0.0494
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0479 0.1849
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0209 0.021
Onchocerca volvulus 0.002 0.018 0.018
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0479 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.1013 0.1016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Schistosoma mansoni hypothetical protein 0.0041 0.0955 0.1341
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Onchocerca volvulus 0.0021 0.0209 0.0209
Brugia malayi Amino acid permease family protein 0.0029 0.0493 0.0492
Echinococcus granulosus Ankyrin 0.0018 0.0083 0.0083
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Brugia malayi larval opioid receptor 0.0021 0.0209 0.0207
Schistosoma mansoni histamine h1 receptor 0.0021 0.0209 0.0271
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.3283 0.8837
Schistosoma mansoni hypothetical protein 0.0019 0.014 0.017
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.1081 0.1083
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.1013 0.1016
Brugia malayi PAS domain containing protein 0.0059 0.1605 0.1607
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0209 0.021
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0209 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.1013 0.1016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0021 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0209 0.0271
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0181
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.1013 0.1016
Loa Loa (eye worm) hypothetical protein 0.0043 0.1013 0.1016
Loa Loa (eye worm) hypothetical protein 0.01 0.3142 0.315
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0209 0.021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0021 0.0083
Schistosoma mansoni coup transcription factor 0.0043 0.1013 0.1424
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.3283 0.8837
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0479 0.2158
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0209 0.021
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0209 0.0207
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0209 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.1013 0.1013
Chlamydia trachomatis dihydrofolate reductase 0.0024 0.0323 0.6755
Echinococcus multilocularis y+l amino acid transporter 2 0.0029 0.0493 0.0494

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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